Comprehensive Stock Comparison
Compare Abivax S.A. (ABVX) vs Can-Fite BioPharma Ltd. (CANF) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | ABVX | 133.5% revenue growth vs CANF's -9.3% |
| Quality / Margins | CANF | -15.7% net margin vs ABVX's -21.9% |
| Stability / Safety | CANF | Beta 0.36 vs ABVX's 1.07, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | ABVX | +14.8% vs CANF's +169.9% |
| Efficiency (ROA) | CANF | -114.0% ROA vs ABVX's -277.5% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Abivax is a clinical-stage biotechnology company developing novel therapies for inflammatory diseases, infectious diseases, and cancer. It generates revenue primarily through research grants and partnerships while advancing its lead candidate ABX464 through clinical trials for ulcerative colitis, Crohn's disease, and other inflammatory conditions. The company's competitive advantage lies in its proprietary small molecule platform technology that targets RNA biology to modulate inflammation and viral replication.
Can-Fite BioPharma is a clinical-stage biopharmaceutical company developing small molecule drugs targeting inflammatory diseases and cancer. It generates revenue primarily through licensing agreements and milestone payments from partners — with no commercial products yet — as it advances its lead candidates through clinical trials. The company's competitive advantage lies in its proprietary A3 adenosine receptor platform, which targets a novel pathway for treating autoimmune and inflammatory conditions.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
ABVX leads in 3 of 6 categories (Valuation Metrics, Profitability & Efficiency). CANF leads in 2 (Financial Metrics, Risk & Volatility).
Financial Metrics (TTM)
ABVX is the larger business by revenue, generating $15M annually — 27.0x CANF's $560,000. CANF is the more profitable business, keeping -15.7% of every revenue dollar as net income compared to ABVX's -21.9%. On growth, CANF holds the edge at -36.1% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ABVXAbivax S.A. | CANFCan-Fite BioPharm… |
|---|---|---|
| RevenueTrailing 12 months | $15M | $560,000 |
| EBITDAEarnings before interest/tax | -$358M | -$9M |
| Net IncomeAfter-tax profit | -$332M | -$9M |
| Free Cash FlowCash after capex | -$250M | -$8M |
| Gross MarginGross profit ÷ Revenue | +100.0% | +100.0% |
| Operating MarginEBIT ÷ Revenue | -23.7% | -16.0% |
| Net MarginNet income ÷ Revenue | -21.9% | -15.7% |
| FCF MarginFCF ÷ Revenue | -16.5% | -14.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | -40.6% | -36.1% |
| EPS Growth (YoY)Latest quarter vs prior year | -144.6% | +36.4% |
Valuation Metrics
| Metric | ABVXAbivax S.A. | CANFCan-Fite BioPharm… |
|---|---|---|
| Market CapShares × price | $9.6B | $14.2B |
| Enterprise ValueMkt cap + debt − cash | $9.5B | $14.2B |
| Trailing P/EPrice ÷ TTM EPS | -36.72x | -4.40x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 753.36x | 9999.00x |
| Price / BookPrice ÷ Book value/share | 159.73x | 6.34x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
ABVX delivers a -149.0% return on equity — every $100 of shareholder capital generates $-149 in annual profit, vs $-2 for CANF. CANF carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to ABVX's 2.40x. On the Piotroski fundamental quality scale (0–9), ABVX scores 4/9 vs CANF's 1/9, reflecting mixed financial health.
| Metric | ABVXAbivax S.A. | CANFCan-Fite BioPharm… |
|---|---|---|
| ROE (TTM)Return on equity | -149.0% | -2.1% |
| ROA (TTM)Return on assets | -2.8% | -114.0% |
| ROICReturn on invested capital | — | -4.5% |
| ROCEReturn on capital employed | -98.5% | -108.1% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 1 |
| Debt / EquityFinancial leverage | 2.40x | 0.02x |
| Net DebtTotal debt minus cash | -$47M | -$5M |
| Cash & Equiv.Liquid assets | $144M | $5M |
| Total DebtShort + long-term debt | $97M | $104,000 |
| Interest CoverageEBIT ÷ Interest expense | -21.56x | -580.71x |
Total Returns (with DRIP)
A $10,000 investment in ABVX five years ago would be worth $146,121 today (with dividends reinvested), compared to $2,351 for CANF. Over the past 12 months, ABVX leads with a +1479.2% total return vs CANF's +169.9%. The 3-year compound annual growth rate (CAGR) favors ABVX at 144.5% vs CANF's 20.6% — a key indicator of consistent wealth creation.
| Metric | ABVXAbivax S.A. | CANFCan-Fite BioPharm… |
|---|---|---|
| YTD ReturnYear-to-date | -9.3% | +2059.1% |
| 1-Year ReturnPast 12 months | +1479.2% | +169.9% |
| 3-Year ReturnCumulative with dividends | +1361.2% | +75.3% |
| 5-Year ReturnCumulative with dividends | +1361.2% | -76.5% |
| 10-Year ReturnCumulative with dividends | +1361.2% | -98.5% |
| CAGR (3Y)Annualised 3-year return | +144.5% | +20.6% |
Risk & Volatility
CANF is the less volatile stock with a 0.36 beta — it tends to amplify market swings less than ABVX's 1.07 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. CANF currently trades 96.3% from its 52-week high vs ABVX's 81.5% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ABVXAbivax S.A. | CANFCan-Fite BioPharm… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.07x | 0.36x |
| 52-Week HighHighest price in past year | $148.83 | $4.93 |
| 52-Week LowLowest price in past year | $4.77 | $0.17 |
| % of 52W HighCurrent price vs 52-week peak | +81.5% | +96.3% |
| RSI (14)Momentum oscillator 0–100 | 45.5 | 68.6 |
| Avg Volume (50D)Average daily shares traded | 1.2M | 4.3M |
Analyst Outlook
Wall Street rates ABVX as "Buy" and CANF as "Buy". Consensus price targets imply 52.6% upside for CANF (target: $7) vs 17.5% for ABVX (target: $143).
| Metric | ABVXAbivax S.A. | CANFCan-Fite BioPharm… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $142.50 | $7.25 |
| # AnalystsCovering analysts | 8 | 4 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Oct 23 | Feb 26 | Change |
|---|---|---|---|
| Abivax S.A. (ABVX) | 100 | 1,342.89 | +1242.9% |
| Can-Fite BioPharma … (CANF) | 100 | 193.9 | +93.9% |
Abivax S.A. (ABVX) returned +1.4K% over 5 years vs Can-Fite BioPharma … (CANF)'s -76%. A $10,000 investment in ABVX 5 years ago would be worth $146,121 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Abivax S.A. (ABVX) | $42000.00 | $11M | +25595.2% |
| Can-Fite BioPharma … (CANF) | $164717.00 | $674000.00 | +309.2% |
Abivax S.A.'s revenue grew from $0M (2015) to $11M (2024) — a 85.3% CAGR. Can-Fite BioPharma Ltd.'s revenue grew from $0M (2015) to $1M (2024) — a 16.9% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Abivax S.A. (ABVX) | -379.9% | -16.3% | +95.7% |
| Can-Fite BioPharma … (CANF) | -29.1% | -11.7% | +59.9% |
Abivax S.A.'s net margin went from -380% (2015) to -16% (2024). Can-Fite BioPharma Ltd.'s net margin went from -29% (2015) to -12% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Abivax S.A. (ABVX) | -1.64 | -2.8 | -70.7% |
| Can-Fite BioPharma … (CANF) | -81 | -1.08 | +98.7% |
Abivax S.A.'s EPS grew from $-1.64 (2015) to $-2.80 (2024). Can-Fite BioPharma Ltd.'s EPS grew from $-81.00 (2015) to $-1.08 (2024).
Chart 5Free Cash Flow — 5 Years
Abivax S.A. generated $-155M FCF in 2024 (-227% vs 2021). Can-Fite BioPharma Ltd. generated $-8M FCF in 2024 (+23% vs 2021).
ABVX vs CANF: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is ABVX or CANF a better buy right now?
Analysts rate Abivax S.A. (ABVX) a "Buy" — based on 8 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ABVX or CANF?
Over the past 5 years, Abivax S.A. (ABVX) delivered a total return of +1361%, compared to -76.5% for Can-Fite BioPharma Ltd. (CANF). A $10,000 investment in ABVX five years ago would be worth approximately $146K today (assuming dividends reinvested). Over 10 years, the gap is even starker: ABVX returned +1361% versus CANF's -98.5%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ABVX or CANF?
By beta (market sensitivity over 5 years), Can-Fite BioPharma Ltd. (CANF) is the lower-risk stock at 0.36β versus Abivax S.A.'s 1.07β — meaning ABVX is approximately 196% more volatile than CANF relative to the S&P 500. On balance sheet safety, Can-Fite BioPharma Ltd. (CANF) carries a lower debt/equity ratio of 2% versus 2% for Abivax S.A. — giving it more financial flexibility in a downturn.
04Which has better profit margins — ABVX or CANF?
Can-Fite BioPharma Ltd. (CANF) is the more profitable company, earning -1169.1% net margin versus -1633.1% for Abivax S.A. — meaning it keeps -1169.1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: CANF leads at -1206.2% versus -1602.9% for ABVX. At the gross margin level — before operating expenses — ABVX leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — ABVX or CANF?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is ABVX or CANF better for a retirement portfolio?
For long-horizon retirement investors, Abivax S.A. (ABVX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.07), +1361% 10Y return). Both have compounded well over 10 years (ABVX: +1361%, CANF: -98.5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between ABVX and CANF?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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