Comprehensive Stock Comparison
Compare Adaptive Biotechnologies Corporation (ADPT) vs Regeneron Pharmaceuticals, Inc. (REGN) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  ADPT | 5.1% revenue growth vs REGN's 1.0% |
| Quality / Margins |  REGN | 31.4% net margin vs ADPT's -31.5% |
| Stability / Safety | REGN | Beta 0.58 vs ADPT's 1.31, lower leverage |
| Dividends | REGN | 0.4% yield; 1-year raise streak; ADPT pays no meaningful dividend |
| Momentum (1Y) | ADPT | +104.7% vs REGN's +15.1% |
| Efficiency (ROA) | REGN | 11.1% ROA vs ADPT's -16.2%, ROIC 12.4% vs -41.6% |
Who Each Stock Is For
Income & stability
REGNDividend streak 1 yrs, beta 0.58, yield 0.4%
Growth exposure
ADPTRev growth 5.1%, EPS growth 30.8%, 3Y rev CAGR 5.1%
Long-term compounding (10Y)
REGN94.0% 10Y total return vs ADPT's -59.2%
Sleep-well-at-night portfolio
REGNLower volatility, beta 0.58, Low D/E 8.7%, current ratio 4.77x
Defensive / Recession hedge
REGNBeta 0.58, yield 0.4%, current ratio 4.77x
Business Model
What each company does and how it makes money
Adaptive Biotechnologies is a biotechnology company that develops immune medicine platforms for diagnosing and treating diseases like cancer, autoimmune disorders, and infectious diseases. It generates revenue primarily through its clinical diagnostics segment — including its clonoSEQ test for minimal residual disease monitoring — and its translational and clinical genomics research services, with diagnostics contributing roughly 60% of revenue. The company's key advantage lies in its proprietary immune medicine platform that maps and translates the genetics of the adaptive immune system into clinical diagnostics and therapies.
Regeneron Pharmaceuticals is a biotechnology company that discovers, develops, and commercializes innovative medicines for serious diseases. It generates revenue primarily from sales of its flagship products — EYLEA for eye diseases (~60% of revenue) and Dupixent for inflammatory conditions (~30%) — with additional income from collaborations and royalties. The company's competitive advantage lies in its proprietary VelocImmune technology platform for creating human antibodies and its deep expertise in genetic research, which enables rapid drug discovery and development.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
REGN 4ADPT 1REGN4/6 metricsREGN2/3 metricsREGN8/9 metricsADPT4/6 metricsREGN2/2 metricsREGN leads in 4 of 6 categories (Financial Metrics, Valuation Metrics). ADPT leads in 1 (Total Returns).
Financial Metrics (TTM)
REGN is the larger business by revenue, generating $14.3B annually — 56.7x ADPT's $253M. REGN is the more profitable business, keeping 31.4% of every revenue dollar as net income compared to ADPT's -31.5%. On growth, ADPT holds the edge at +102.4% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ADPTAdaptive Biotechn… | REGNRegeneron Pharmac… |
|---|---|---|
| RevenueTrailing 12 months | $253M | $14.3B |
| EBITDAEarnings before interest/tax | -$62M | $4.2B |
| Net IncomeAfter-tax profit | -$80M | $4.5B |
| Free Cash FlowCash after capex | -$63M | $3.2B |
| Gross MarginGross profit ÷ Revenue | +71.8% | +86.3% |
| Operating MarginEBIT ÷ Revenue | -30.9% | +25.7% |
| Net MarginNet income ÷ Revenue | -31.5% | +31.4% |
| FCF MarginFCF ÷ Revenue | -24.9% | +22.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | +102.4% | +2.5% |
| EPS Growth (YoY)Latest quarter vs prior year | +126.6% | -2.5% |
Valuation Metrics
| Metric | ADPTAdaptive Biotechn… | REGNRegeneron Pharmac… |
|---|---|---|
| Market CapShares × price | $2.5B | $108.4B |
| Enterprise ValueMkt cap + debt − cash | $2.5B | $92.2B |
| Trailing P/EPrice ÷ TTM EPS | -15.22x | 18.99x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 17.38x |
| PEG RatioP/E ÷ EPS growth rate | — | 3.00x |
| EV / EBITDAEnterprise value multiple | — | 21.83x |
| Price / SalesMarket cap ÷ Revenue | 14.02x | 7.55x |
| Price / BookPrice ÷ Book value/share | 11.94x | 2.74x |
| Price / FCFMarket cap ÷ FCF | — | 26.56x |
Profitability & Efficiency
REGN delivers a 14.4% return on equity — every $100 of shareholder capital generates $14 in annual profit, vs $-39 for ADPT. REGN carries lower financial leverage with a 0.09x debt-to-equity ratio, signaling a more conservative balance sheet compared to ADPT's 0.44x. On the Piotroski fundamental quality scale (0–9), REGN scores 7/9 vs ADPT's 4/9, reflecting strong financial health.
| Metric | ADPTAdaptive Biotechn… | REGNRegeneron Pharmac… |
|---|---|---|
| ROE (TTM)Return on equity | -39.0% | +14.4% |
| ROA (TTM)Return on assets | -16.2% | +11.1% |
| ROICReturn on invested capital | -41.6% | +12.4% |
| ROCEReturn on capital employed | -32.0% | +10.8% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 7 |
| Debt / EquityFinancial leverage | 0.44x | 0.09x |
| Net DebtTotal debt minus cash | $41M | -$16.2B |
| Cash & Equiv.Liquid assets | $48M | $18.9B |
| Total DebtShort + long-term debt | $89M | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | -6.25x | 120.42x |
Total Returns (with DRIP)
A $10,000 investment in REGN five years ago would be worth $17,161 today (with dividends reinvested), compared to $3,893 for ADPT. Over the past 12 months, ADPT leads with a +104.7% total return vs REGN's +15.1%. The 3-year compound annual growth rate (CAGR) favors ADPT at 24.8% vs REGN's 0.5% — a key indicator of consistent wealth creation.
| Metric | ADPTAdaptive Biotechn… | REGNRegeneron Pharmac… |
|---|---|---|
| YTD ReturnYear-to-date | +3.3% | +1.6% |
| 1-Year ReturnPast 12 months | +104.7% | +15.1% |
| 3-Year ReturnCumulative with dividends | +94.3% | +1.5% |
| 5-Year ReturnCumulative with dividends | -61.1% | +71.6% |
| 10-Year ReturnCumulative with dividends | -59.2% | +94.0% |
| CAGR (3Y)Annualised 3-year return | +24.8% | +0.5% |
Risk & Volatility
REGN is the less volatile stock with a 0.58 beta — it tends to amplify market swings less than ADPT's 1.31 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 95.9% from its 52-week high vs ADPT's 79.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ADPTAdaptive Biotechn… | REGNRegeneron Pharmac… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.31x | 0.58x |
| 52-Week HighHighest price in past year | $20.76 | $821.11 |
| 52-Week LowLowest price in past year | $6.26 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +79.2% | +95.9% |
| RSI (14)Momentum oscillator 0–100 | 46.2 | 47.5 |
| Avg Volume (50D)Average daily shares traded | 1.8M | 762K |
Analyst Outlook
Wall Street rates ADPT as "Buy" and REGN as "Buy". Consensus price targets imply 29.3% upside for ADPT (target: $21) vs 8.8% for REGN (target: $857). REGN is the only dividend payer here at 0.43% yield — a key consideration for income-focused portfolios.
| Metric | ADPTAdaptive Biotechn… | REGNRegeneron Pharmac… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $21.25 | $857.17 |
| # AnalystsCovering analysts | 17 | 48 |
| Dividend YieldAnnual dividend ÷ price | — | +0.4% |
| Dividend StreakConsecutive years of raises | — | 1 |
| Dividend / ShareAnnual DPS | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +3.2% |
Historical Charts
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Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Mar 26 | Change |
|---|---|---|---|
| Adaptive Biotechnol… (ADPT) | 100 | 58.58 | -41.4% |
| Regeneron Pharmaceu… (REGN) | 100 | 161.99 | +62.0% |
Regeneron Pharmaceu… (REGN) returned +72% over 5 years vs Adaptive Biotechnol… (ADPT)'s -61%. A $10,000 investment in REGN 5 years ago would be worth $17,161 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Adaptive Biotechnol… (ADPT) | $38M | $179M | +365.5% |
| Regeneron Pharmaceu… (REGN) | $4.9B | $14.3B | +195.1% |
Regeneron Pharmaceuticals, Inc.'s revenue grew from $4.9B (2016) to $14.3B (2025) — a 12.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Adaptive Biotechnol… (ADPT) | -111.4% | -89.1% | +20.0% |
| Regeneron Pharmaceu… (REGN) | 18.4% | 31.4% | +70.5% |
Regeneron Pharmaceuticals, Inc.'s net margin went from 18% (2016) to 31% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Regeneron Pharmaceu… (REGN) | 36.4 | 18.6 | -48.9% |
Regeneron Pharmaceuticals, Inc. has traded in a 9x–36x P/E range over 9 years; current trailing P/E is ~19x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Adaptive Biotechnol… (ADPT) | -0.41 | -1.08 | -163.4% |
| Regeneron Pharmaceu… (REGN) | 7.7 | 41.48 | +438.7% |
Regeneron Pharmaceuticals, Inc.'s EPS grew from $7.70 (2016) to $41.48 (2025) — a 21% CAGR.
Chart 6Free Cash Flow — 5 Years
Adaptive Biotechnologies Corporation generated $-99M FCF in 2024 (+61% vs 2021). Regeneron Pharmaceuticals, Inc. generated $4B FCF in 2025 (-38% vs 2021).
ADPT vs REGN: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is ADPT or REGN a better buy right now?
Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 19.0x trailing P/E (17.4x forward), making it the more compelling value choice. Analysts rate Adaptive Biotechnologies Corporation (ADPT) a "Buy" — based on 17 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ADPT or REGN?
Over the past 5 years, Regeneron Pharmaceuticals, Inc. (REGN) delivered a total return of +71.6%, compared to -61.1% for Adaptive Biotechnologies Corporation (ADPT). A $10,000 investment in REGN five years ago would be worth approximately $17K today (assuming dividends reinvested). Over 10 years, the gap is even starker: REGN returned +94.0% versus ADPT's -59.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ADPT or REGN?
By beta (market sensitivity over 5 years), Regeneron Pharmaceuticals, Inc. (REGN) is the lower-risk stock at 0.58β versus Adaptive Biotechnologies Corporation's 1.31β — meaning ADPT is approximately 127% more volatile than REGN relative to the S&P 500. On balance sheet safety, Regeneron Pharmaceuticals, Inc. (REGN) carries a lower debt/equity ratio of 9% versus 44% for Adaptive Biotechnologies Corporation — giving it more financial flexibility in a downturn.
04Which has better profit margins — ADPT or REGN?
Regeneron Pharmaceuticals, Inc. (REGN) is the more profitable company, earning 31.4% net margin versus -89.1% for Adaptive Biotechnologies Corporation — meaning it keeps 31.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REGN leads at 25.7% versus -90.8% for ADPT. At the gross margin level — before operating expenses — REGN leads at 86.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is ADPT or REGN more undervalued right now?
Analyst consensus price targets imply the most upside for ADPT: 29.3% to $21.25.
06Which pays a better dividend — ADPT or REGN?
In this comparison, REGN (0.4% yield) pays a dividend. ADPT does not pay a meaningful dividend and should not be held primarily for income.
07Is ADPT or REGN better for a retirement portfolio?
For long-horizon retirement investors, Regeneron Pharmaceuticals, Inc. (REGN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.58)). Both have compounded well over 10 years (REGN: +94.0%, ADPT: -59.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between ADPT and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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