Comprehensive Stock Comparison
Compare Akari Therapeutics, Plc (AKTX) vs RAPT Therapeutics, Inc. (RAPT) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | AKTX | Beta 0.63 vs RAPT's 0.78 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | RAPT | +5.4% vs AKTX's -72.9% |
| Efficiency (ROA) | AKTX | -34.7% ROA vs RAPT's -63.7%, ROIC -172.5% vs -155.7% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Akari Therapeutics is a clinical-stage biopharmaceutical company developing advanced therapies for autoimmune and inflammatory diseases. It generates no revenue currently — its business model depends on advancing its lead candidate nomacopan through clinical trials to eventually secure regulatory approvals and commercialization partnerships. The company's key advantage lies in nomacopan's dual mechanism of action targeting both complement and leukotriene pathways — a differentiated approach that could offer superior efficacy in treating complex inflammatory conditions.
RAPT Therapeutics is a clinical-stage biopharmaceutical company developing oral small molecule therapies for cancer and inflammatory diseases. It generates no revenue yet as it's in clinical trials, with future income dependent on potential drug approvals and commercialization. The company's competitive advantage lies in its targeted CCR4 antagonist platform that selectively inhibits immune cell migration to diseased tissues.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
RAPT leads in 2 of 6 categories — strongest in Financial Metrics and Total Returns. 3 categories are tied.
Financial Metrics (TTM)
AKTX and RAPT operate at a comparable scale, with $0 and $0 in trailing revenue.
| Metric | AKTXAkari Therapeutic… | RAPTRAPT Therapeutics… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $0 |
| EBITDAEarnings before interest/tax | -$17M | -$112M |
| Net IncomeAfter-tax profit | -$16M | -$106M |
| Free Cash FlowCash after capex | -$10M | -$87M |
| Gross MarginGross profit ÷ Revenue | — | — |
| Operating MarginEBIT ÷ Revenue | — | — |
| Net MarginNet income ÷ Revenue | — | — |
| FCF MarginFCF ÷ Revenue | — | — |
| Rev. Growth (YoY)Latest quarter vs prior year | — | — |
| EPS Growth (YoY)Latest quarter vs prior year | -80.2% | +82.9% |
Valuation Metrics
| Metric | AKTXAkari Therapeutic… | RAPTRAPT Therapeutics… |
|---|---|---|
| Market CapShares × price | $12.6B | $7.7B |
| Enterprise ValueMkt cap + debt − cash | $12.6B | $7.5B |
| Trailing P/EPrice ÷ TTM EPS | -0.00x | -2.27x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | — |
| Price / BookPrice ÷ Book value/share | 0.00x | 1.56x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
AKTX delivers a -69.4% return on equity — every $100 of shareholder capital generates $-69 in annual profit, vs $-70 for RAPT. RAPT carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to AKTX's 0.15x. On the Piotroski fundamental quality scale (0–9), AKTX scores 3/9 vs RAPT's 2/9, reflecting mixed financial health.
| Metric | AKTXAkari Therapeutic… | RAPTRAPT Therapeutics… |
|---|---|---|
| ROE (TTM)Return on equity | -69.4% | -69.5% |
| ROA (TTM)Return on assets | -34.7% | -63.7% |
| ROICReturn on invested capital | -172.5% | -155.7% |
| ROCEReturn on capital employed | -142.3% | -79.3% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 2 |
| Debt / EquityFinancial leverage | 0.15x | 0.02x |
| Net DebtTotal debt minus cash | $661,000 | -$165M |
| Cash & Equiv.Liquid assets | $3M | $170M |
| Total DebtShort + long-term debt | $3M | $4M |
| Interest CoverageEBIT ÷ Interest expense | -47.14x | — |
Total Returns (with DRIP)
A $10,000 investment in RAPT five years ago would be worth $3,869 today (with dividends reinvested), compared to $35 for AKTX. Over the past 12 months, RAPT leads with a +535.7% total return vs AKTX's -72.9%. The 3-year compound annual growth rate (CAGR) favors RAPT at -37.3% vs AKTX's -67.5% — a key indicator of consistent wealth creation.
| Metric | AKTXAkari Therapeutic… | RAPTRAPT Therapeutics… |
|---|---|---|
| YTD ReturnYear-to-date | -18.6% | +82.0% |
| 1-Year ReturnPast 12 months | -72.9% | +535.7% |
| 3-Year ReturnCumulative with dividends | -96.6% | -75.4% |
| 5-Year ReturnCumulative with dividends | -99.6% | -61.3% |
| 10-Year ReturnCumulative with dividends | -99.9% | -44.3% |
| CAGR (3Y)Annualised 3-year return | -67.5% | -37.3% |
Risk & Volatility
AKTX is the less volatile stock with a 0.63 beta — it tends to amplify market swings less than RAPT's 0.78 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. RAPT currently trades 100.0% from its 52-week high vs AKTX's 13.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | AKTXAkari Therapeutic… | RAPTRAPT Therapeutics… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.63x | 0.78x |
| 52-Week HighHighest price in past year | $1.73 | $57.99 |
| 52-Week LowLowest price in past year | $0.22 | $5.67 |
| % of 52W HighCurrent price vs 52-week peak | +13.7% | +100.0% |
| RSI (14)Momentum oscillator 0–100 | 52.2 | 79.2 |
| Avg Volume (50D)Average daily shares traded | 387K | 2.8M |
Analyst Outlook
Wall Street rates AKTX as "Buy" and RAPT as "Hold". Consensus price targets imply 12601.1% upside for AKTX (target: $30) vs 3.5% for RAPT (target: $60).
| Metric | AKTXAkari Therapeutic… | RAPTRAPT Therapeutics… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Hold |
| Price TargetConsensus 12-month target | $30.00 | $60.00 |
| # AnalystsCovering analysts | 7 | 15 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 20 | Feb 26 | Change |
|---|---|---|---|
| Akari Therapeutics,… (AKTX) | 100 | 0.64 | -99.4% |
| RAPT Therapeutics, … (RAPT) | 100 | 36.47 | -63.5% |
RAPT Therapeutics, … (RAPT) returned -61% over 5 years vs Akari Therapeutics,… (AKTX)'s -100%.
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Akari Therapeutics,… (AKTX) | $0.00 | $0.00 | — |
| RAPT Therapeutics, … (RAPT) | $0.00 | $0.00 | — |
Akari Therapeutics, Plc's revenue grew from $0M (2015) to $0M (2024) — a 0.0% CAGR.
Chart 3EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Akari Therapeutics,… (AKTX) | -10,640 | -1,660 | +84.4% |
| RAPT Therapeutics, … (RAPT) | -10.95 | -25.49 | -132.9% |
Akari Therapeutics, Plc's EPS grew from $-10640.00 (2015) to $-1660.00 (2024).
Chart 4Free Cash Flow — 5 Years
Akari Therapeutics, Plc generated $-13M FCF in 2024 (+33% vs 2021). RAPT Therapeutics, Inc. generated $-83M FCF in 2024 (-35% vs 2021).
AKTX vs RAPT: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is AKTX or RAPT a better buy right now?
Analysts rate Akari Therapeutics, Plc (AKTX) a "Buy" — based on 7 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — AKTX or RAPT?
Over the past 5 years, RAPT Therapeutics, Inc. (RAPT) delivered a total return of -61.3%, compared to -99.6% for Akari Therapeutics, Plc (AKTX). A $10,000 investment in RAPT five years ago would be worth approximately $4K today (assuming dividends reinvested). Over 10 years, the gap is even starker: RAPT returned -44.3% versus AKTX's -99.9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — AKTX or RAPT?
By beta (market sensitivity over 5 years), Akari Therapeutics, Plc (AKTX) is the lower-risk stock at 0.63β versus RAPT Therapeutics, Inc.'s 0.78β — meaning RAPT is approximately 23% more volatile than AKTX relative to the S&P 500. On balance sheet safety, RAPT Therapeutics, Inc. (RAPT) carries a lower debt/equity ratio of 2% versus 15% for Akari Therapeutics, Plc — giving it more financial flexibility in a downturn.
04Which has better profit margins — AKTX or RAPT?
Akari Therapeutics, Plc (AKTX) is the more profitable company, earning 0.0% net margin versus 0.0% for RAPT Therapeutics, Inc. — meaning it keeps 0.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: AKTX leads at 0.0% versus 0.0% for RAPT. At the gross margin level — before operating expenses — AKTX leads at 0.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — AKTX or RAPT?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is AKTX or RAPT better for a retirement portfolio?
For long-horizon retirement investors, Akari Therapeutics, Plc (AKTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.63)). Both have compounded well over 10 years (AKTX: -99.9%, RAPT: -44.3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between AKTX and RAPT?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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