Comprehensive Stock Comparison
Compare Apogee Therapeutics, Inc. (APGE) vs Kymera Therapeutics, Inc. (KYMR) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | APGE | Beta 1.10 vs KYMR's 1.31, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | KYMR | +191.4% vs APGE's +122.6% |
| Efficiency (ROA) | KYMR | -17.9% ROA vs APGE's -40.5%, ROIC -24.9% vs -38.3% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Apogee Therapeutics is a clinical-stage biotechnology company developing extended half-life monoclonal antibodies for inflammatory and immunology diseases. It generates no revenue currently but aims to monetize through future drug sales and partnerships if its lead candidates — APG777 for atopic dermatitis and APG808 for COPD — succeed in clinical trials and gain regulatory approval. The company's competitive advantage lies in its proprietary antibody engineering platform that creates longer-acting biologics with potentially improved dosing convenience and efficacy.
Kymera Therapeutics is a biopharmaceutical company developing targeted protein degraders — small molecules that harness the body's natural protein degradation system to eliminate disease-causing proteins. It generates revenue primarily through strategic partnerships and milestone payments from pharmaceutical collaborators — with potential future revenue from drug sales if clinical candidates succeed. The company's key advantage is its proprietary Pegasus platform for discovering novel protein degraders, which targets previously "undruggable" proteins and creates a pipeline of first-in-class therapies.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
KYMR leads in 3 of 6 categories (Financial Metrics, Valuation Metrics). APGE leads in 1 (Total Returns). 1 tied.
Financial Metrics (TTM)
KYMR and APGE operate at a comparable scale, with $39M and $0 in trailing revenue.
| Metric | APGEApogee Therapeuti… | KYMRKymera Therapeuti… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $39M |
| EBITDAEarnings before interest/tax | -$282M | -$349M |
| Net IncomeAfter-tax profit | -$254M | -$311M |
| Free Cash FlowCash after capex | -$238M | -$234M |
| Gross MarginGross profit ÷ Revenue | — | +100.0% |
| Operating MarginEBIT ÷ Revenue | — | -8.9% |
| Net MarginNet income ÷ Revenue | — | -7.9% |
| FCF MarginFCF ÷ Revenue | — | -6.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | -61.3% |
| EPS Growth (YoY)Latest quarter vs prior year | -29.1% | -11.4% |
Valuation Metrics
| Metric | APGEApogee Therapeuti… | KYMRKymera Therapeuti… |
|---|---|---|
| Market CapShares × price | $4.2B | $7.4B |
| Enterprise ValueMkt cap + debt − cash | $4.0B | $7.2B |
| Trailing P/EPrice ÷ TTM EPS | -21.21x | -24.76x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | 189.51x |
| Price / BookPrice ÷ Book value/share | 5.39x | 4.88x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
KYMR delivers a -19.7% return on equity — every $100 of shareholder capital generates $-20 in annual profit, vs $-43 for APGE. APGE carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to KYMR's 0.05x. On the Piotroski fundamental quality scale (0–9), KYMR scores 4/9 vs APGE's 1/9, reflecting mixed financial health.
| Metric | APGEApogee Therapeuti… | KYMRKymera Therapeuti… |
|---|---|---|
| ROE (TTM)Return on equity | -43.3% | -19.7% |
| ROA (TTM)Return on assets | -40.5% | -17.9% |
| ROICReturn on invested capital | -38.3% | -24.9% |
| ROCEReturn on capital employed | -39.2% | -27.2% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 4 |
| Debt / EquityFinancial leverage | 0.02x | 0.05x |
| Net DebtTotal debt minus cash | -$130M | -$275M |
| Cash & Equiv.Liquid assets | $142M | $357M |
| Total DebtShort + long-term debt | $12M | $82M |
| Interest CoverageEBIT ÷ Interest expense | — | -1403.21x |
Total Returns (with DRIP)
A $10,000 investment in APGE five years ago would be worth $32,972 today (with dividends reinvested), compared to $18,851 for KYMR. Over the past 12 months, KYMR leads with a +191.4% total return vs APGE's +122.6%. The 3-year compound annual growth rate (CAGR) favors APGE at 48.8% vs KYMR's 42.8% — a key indicator of consistent wealth creation.
| Metric | APGEApogee Therapeuti… | KYMRKymera Therapeuti… |
|---|---|---|
| YTD ReturnYear-to-date | -7.6% | +25.5% |
| 1-Year ReturnPast 12 months | +122.6% | +191.4% |
| 3-Year ReturnCumulative with dividends | +229.7% | +191.1% |
| 5-Year ReturnCumulative with dividends | +229.7% | +88.5% |
| 10-Year ReturnCumulative with dividends | +229.7% | +174.7% |
| CAGR (3Y)Annualised 3-year return | +48.8% | +42.8% |
Risk & Volatility
APGE is the less volatile stock with a 1.10 beta — it tends to amplify market swings less than KYMR's 1.31 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. KYMR currently trades 88.7% from its 52-week high vs APGE's 82.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | APGEApogee Therapeuti… | KYMRKymera Therapeuti… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.10x | 1.31x |
| 52-Week HighHighest price in past year | $84.56 | $103.00 |
| 52-Week LowLowest price in past year | $26.20 | $19.45 |
| % of 52W HighCurrent price vs 52-week peak | +82.8% | +88.7% |
| RSI (14)Momentum oscillator 0–100 | 48.6 | 77.9 |
| Avg Volume (50D)Average daily shares traded | 915K | 620K |
Analyst Outlook
Wall Street rates APGE as "Buy" and KYMR as "Buy". Consensus price targets imply 55.5% upside for APGE (target: $109) vs 28.4% for KYMR (target: $117).
| Metric | APGEApogee Therapeuti… | KYMRKymera Therapeuti… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $108.86 | $117.31 |
| # AnalystsCovering analysts | 7 | 26 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Jul 23 | Feb 26 | Change |
|---|---|---|---|
| Apogee Therapeutics… (APGE) | 100 | 309.14 | +209.1% |
| Kymera Therapeutics… (KYMR) | 100 | 348.8 | +248.8% |
Apogee Therapeutics… (APGE) returned +230% over 5 years vs Kymera Therapeutics… (KYMR)'s +89%. A $10,000 investment in APGE 5 years ago would be worth $32,972 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2018 | 2025 | Change |
|---|---|---|---|
| Apogee Therapeutics… (APGE) | $0.00 | $0.00 | — |
| Kymera Therapeutics… (KYMR) | $0.00 | $39M | — |
Kymera Therapeutics, Inc.'s revenue grew from $0M (2018) to $39M (2025) — a 0.0% CAGR.
Chart 3EPS Growth — 10 Years
| Stock | 2018 | 2025 | Change |
|---|---|---|---|
| Apogee Therapeutics… (APGE) | -0.79 | -3.3 | -317.7% |
| Kymera Therapeutics… (KYMR) | -0.48 | -3.69 | -668.8% |
Kymera Therapeutics, Inc.'s EPS grew from $-0.48 (2018) to $-3.69 (2025).
Chart 4Free Cash Flow — 5 Years
Apogee Therapeutics, Inc. generated $-172M FCF in 2024 (-949% vs 2022). Kymera Therapeutics, Inc. generated $-234M FCF in 2025 (-80% vs 2021).
APGE vs KYMR: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is APGE or KYMR a better buy right now?
Analysts rate Apogee Therapeutics, Inc. (APGE) a "Buy" — based on 7 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — APGE or KYMR?
Over the past 5 years, Apogee Therapeutics, Inc. (APGE) delivered a total return of +229.7%, compared to +88.5% for Kymera Therapeutics, Inc. (KYMR). A $10,000 investment in APGE five years ago would be worth approximately $33K today (assuming dividends reinvested). Over 10 years, the gap is even starker: APGE returned +229.7% versus KYMR's +174.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — APGE or KYMR?
By beta (market sensitivity over 5 years), Apogee Therapeutics, Inc. (APGE) is the lower-risk stock at 1.10β versus Kymera Therapeutics, Inc.'s 1.31β — meaning KYMR is approximately 19% more volatile than APGE relative to the S&P 500. On balance sheet safety, Apogee Therapeutics, Inc. (APGE) carries a lower debt/equity ratio of 2% versus 5% for Kymera Therapeutics, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — APGE or KYMR?
Apogee Therapeutics, Inc. (APGE) is the more profitable company, earning 0.0% net margin versus -794.4% for Kymera Therapeutics, Inc. — meaning it keeps 0.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: APGE leads at 0.0% versus -891.3% for KYMR. At the gross margin level — before operating expenses — KYMR leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — APGE or KYMR?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is APGE or KYMR better for a retirement portfolio?
For long-horizon retirement investors, Apogee Therapeutics, Inc. (APGE) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.10), +229.7% 10Y return). Both have compounded well over 10 years (APGE: +229.7%, KYMR: +174.7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between APGE and KYMR?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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