Comprehensive Stock Comparison
Compare Aspire Biopharma Holdings, Inc. (ASBPW) vs Caris Life Sciences, Inc. (CAI) vs Veracyte, Inc. (VCYT) vs Adaptive Biotechnologies Corporation (ADPT) vs YD Bio Limited Ordinary Shares (YDES) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  CAI | 97.0% revenue growth vs ADPT's 5.1% |
| Value |  VCYT | Better valuation composite |
| Quality / Margins | VCYT | 12.8% net margin vs ASBPW's -16K% |
| Stability / Safety |  ASBPW | Beta 0.76 vs YDES's 1.64 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) |  ADPT | +104.7% vs ASBPW's -63.8% |
| Efficiency (ROA) | VCYT | 4.7% ROA vs ASBPW's -13.2% |
Who Each Stock Is For
Income & stability
ASBPWbeta 0.76
Growth exposure
CAIRev growth 97.0%, EPS growth -19.3%, 3Y rev CAGR 46.5%
Long-term compounding (10Y)
VCYT443.8% 10Y total return vs CAI's -29.1%
Sleep-well-at-night portfolio
CAILower volatility, beta 1.09, Low D/E 0.0%, current ratio 7.85x
Defensive / Recession hedge
CAIBeta 1.09, current ratio 7.85x
Business Model
What each company does and how it makes money
Aspire Biopharma Holdings is a biotechnology company that develops advanced diagnostic solutions and molecular tests for disease detection. It generates revenue primarily through sales of its diagnostic assays and testing services to healthcare providers and research institutions. The company's competitive advantage lies in its proprietary genetic testing technology and specialized expertise in precision diagnostics.
Caris Life Sciences is an AI-powered molecular diagnostics company that provides comprehensive cancer profiling services to guide treatment decisions. It generates revenue primarily from molecular testing services for oncology patients — including tissue-based and blood-based profiling — along with pharmaceutical research services for drug development partners. The company's competitive advantage lies in its extensive molecular database and proprietary AI algorithms that analyze complex biomarker data to deliver personalized cancer treatment insights.
Veracyte is a molecular diagnostics company that develops genomic tests to improve cancer and other disease diagnosis and treatment decisions. It generates revenue primarily from diagnostic test sales — including its Afirma thyroid, Decipher prostate, and Percepta lung cancer tests — with additional income from technology licensing partnerships. The company's competitive advantage lies in its proprietary genomic classifiers and biobank of clinical samples that enable development of clinically validated tests with strong physician adoption.
Adaptive Biotechnologies is a biotechnology company that develops immune medicine platforms for diagnosing and treating diseases like cancer, autoimmune disorders, and infectious diseases. It generates revenue primarily through its clinical diagnostics segment — including its clonoSEQ test for minimal residual disease monitoring — and its translational and clinical genomics research services, with diagnostics contributing roughly 60% of revenue. The company's key advantage lies in its proprietary immune medicine platform that maps and translates the genetics of the adaptive immune system into clinical diagnostics and therapies.
YD Bio is a clinical-stage biopharmaceutical company developing exosome-based therapeutics for cancer prevention and treatment. It generates revenue primarily through research grants and partnerships — with future income expected from drug licensing and commercialization — though it's currently in pre-revenue stages as it advances its pipeline. The company's competitive advantage lies in its proprietary exosome technology platform, which targets diseases with significant unmet medical needs.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 5 stocks. BestLagging
Financial Scorecard
VCYT 2ADPT 1ASBPW 0CAI 0
YDES 0VCYT4/6 metricsVCYT5/6 metricsADPT3/6 metricsVCYT leads in 2 of 6 categories (Financial Metrics, Valuation Metrics). ADPT leads in 1 (Total Returns). 2 tied.
Financial Metrics (TTM)
CAI and YDES operate at a comparable scale, with $812M and $0 in trailing revenue. VCYT is the more profitable business, keeping 12.8% of every revenue dollar as net income compared to ASBPW's -16351.8%. On growth, ADPT holds the edge at +102.4% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ASBPWAspire Biopharma … | CAICaris Life Scienc… | VCYTVeracyte, Inc. | ADPTAdaptive Biotechn… | YDESYD Bio Limited Or… |
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $1,941 | $812M | $517M | $253M | $0 |
| EBITDAEarnings before interest/tax | -$28M | $70M | $74M | -$62M | -$3M |
| Net IncomeAfter-tax profit | -$32M | -$538M | $66M | -$80M | -$3M |
| Free Cash FlowCash after capex | -$4M | $33M | $126M | -$63M | -$1M |
| Gross MarginGross profit ÷ Revenue | +45.5% | +46.2% | +70.1% | +71.8% | +30.4% |
| Operating MarginEBIT ÷ Revenue | -10314.0% | +5.6% | +11.2% | -30.9% | -2.9% |
| Net MarginNet income ÷ Revenue | -16351.8% | -66.2% | +12.8% | -31.5% | -2.8% |
| FCF MarginFCF ÷ Revenue | -1811.5% | +4.0% | +24.4% | -24.9% | -9.3% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | — | +18.5% | +102.4% | — |
| EPS Growth (YoY)Latest quarter vs prior year | +46.0% | — | +7.3% | +126.6% | -116.0% |
Valuation Metrics
On an enterprise value basis, VCYT's 44.2x EV/EBITDA is more attractive than CAI's 718.4x.
| Metric | ASBPWAspire Biopharma … | CAICaris Life Scienc… | VCYTVeracyte, Inc. | ADPTAdaptive Biotechn… | YDESYD Bio Limited Or… |
|---|---|---|---|---|---|
| Market CapShares × price | $178,899 | $33.2B | $2.9B | $2.5B | $35M |
| Enterprise ValueMkt cap + debt − cash | $1M | $32.4B | $2.6B | $2.5B | $32M |
| Trailing P/EPrice ÷ TTM EPS | -0.01x | -6.17x | 44.23x | -15.22x | -15.09x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 62.06x | 22.03x | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | 718.40x | 44.23x | — | — |
| Price / SalesMarket cap ÷ Revenue | — | 40.89x | 5.57x | 14.02x | 68.64x |
| Price / BookPrice ÷ Book value/share | — | 57.52x | 2.23x | 11.94x | 5.32x |
| Price / FCFMarket cap ÷ FCF | — | 496.41x | 22.73x | — | — |
Profitability & Efficiency
VCYT delivers a 5.1% return on equity — every $100 of shareholder capital generates $5 in annual profit, vs $-93 for CAI. CAI carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to ADPT's 0.44x. On the Piotroski fundamental quality scale (0–9), VCYT scores 8/9 vs YDES's 3/9, reflecting strong financial health.
| Metric | ASBPWAspire Biopharma … | CAICaris Life Scienc… | VCYTVeracyte, Inc. | ADPTAdaptive Biotechn… | YDESYD Bio Limited Or… |
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | — | -93.2% | +5.1% | -39.0% | -42.7% |
| ROA (TTM)Return on assets | -13.2% | -47.8% | +4.7% | -16.2% | -100.8% |
| ROICReturn on invested capital | — | — | +4.4% | -41.6% | -63.3% |
| ROCEReturn on capital employed | — | +7.7% | +4.5% | -32.0% | -44.1% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 5 | 8 | 4 | 3 |
| Debt / EquityFinancial leverage | — | 0.00x | 0.03x | 0.44x | 0.00x |
| Net DebtTotal debt minus cash | $1M | -$798M | -$323M | $41M | -$3M |
| Cash & Equiv.Liquid assets | $3,633 | $798M | $363M | $48M | $3M |
| Total DebtShort + long-term debt | $1M | $169,000 | $40M | $89M | $22,555 |
| Interest CoverageEBIT ÷ Interest expense | -10.51x | -2.23x | — | -6.25x | -1893.69x |
Total Returns (with DRIP)
A $10,000 investment in VCYT five years ago would be worth $7,634 today (with dividends reinvested), compared to $2,583 for ASBPW. Over the past 12 months, ADPT leads with a +104.7% total return vs ASBPW's -63.8%. The 3-year compound annual growth rate (CAGR) favors ADPT at 24.8% vs ASBPW's -36.3% — a key indicator of consistent wealth creation.
| Metric | ASBPWAspire Biopharma … | CAICaris Life Scienc… | VCYTVeracyte, Inc. | ADPTAdaptive Biotechn… | YDESYD Bio Limited Or… |
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | +16.7% | -26.4% | -14.4% | +3.3% | -29.6% |
| 1-Year ReturnPast 12 months | -63.8% | -29.1% | +10.0% | +104.7% | -29.8% |
| 3-Year ReturnCumulative with dividends | -74.2% | -29.1% | +52.8% | +94.3% | -29.8% |
| 5-Year ReturnCumulative with dividends | -74.2% | -29.1% | -23.7% | -61.1% | -29.8% |
| 10-Year ReturnCumulative with dividends | -74.2% | -29.1% | +443.8% | -59.2% | -29.8% |
| CAGR (3Y)Annualised 3-year return | -36.3% | -10.8% | +15.2% | +24.8% | -11.1% |
Risk & Volatility
ASBPW is the less volatile stock with a 0.76 beta — it tends to amplify market swings less than YDES's 1.64 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ADPT currently trades 79.2% from its 52-week high vs ASBPW's 24.1% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ASBPWAspire Biopharma … | CAICaris Life Scienc… | VCYTVeracyte, Inc. | ADPTAdaptive Biotechn… | YDESYD Bio Limited Or… |
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.76x | 1.09x | 1.12x | 1.31x | 1.64x |
| 52-Week HighHighest price in past year | $0.09 | $42.50 | $50.71 | $20.76 | $25.00 |
| 52-Week LowLowest price in past year | $0.01 | $17.15 | $22.61 | $6.26 | $5.30 |
| % of 52W HighCurrent price vs 52-week peak | +24.1% | +46.7% | +71.5% | +79.2% | +33.8% |
| RSI (14)Momentum oscillator 0–100 | 49.0 | 38.4 | 39.9 | 46.2 | 36.9 |
| Avg Volume (50D)Average daily shares traded | 41K | 2.3M | 807K | 1.8M | 40K |
Analyst Outlook
Analyst consensus: CAI as "Buy", VCYT as "Buy", ADPT as "Buy". Consensus price targets imply 57.8% upside for CAI (target: $31) vs 29.3% for ADPT (target: $21).
| Metric | ASBPWAspire Biopharma … | CAICaris Life Scienc… | VCYTVeracyte, Inc. | ADPTAdaptive Biotechn… | YDESYD Bio Limited Or… |
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy | — |
| Price TargetConsensus 12-month target | — | $31.33 | $47.25 | $21.25 | — |
| # AnalystsCovering analysts | — | 6 | 20 | 17 | — |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | 4 | — | — | — |
| Dividend / ShareAnnual DPS | — | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.0% | 0.0% | 0.0% | 0.0% |
Historical Charts
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Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 25 | Mar 26 | Change |
|---|---|---|---|
| Aspire Biopharma Ho… (ASBPW) | 100 | 28.81 | -71.2% |
| Veracyte, Inc. (VCYT) | 100 | 107.3 | +7.3% |
| Adaptive Biotechnol… (ADPT) | 100 | 199.01 | +99.0% |
Veracyte, Inc. (VCYT) returned -24% over 5 years vs Aspire Biopharma Ho… (ASBPW)'s -74%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Aspire Biopharma Ho… (ASBPW) | $0.00 | $0.00 | — |
| Caris Life Sciences… (CAI) | $294M | $812M | +175.9% |
| Veracyte, Inc. (VCYT) | $65M | $517M | +694.6% |
| Adaptive Biotechnol… (ADPT) | $38M | $179M | +365.5% |
| YD Bio Limited Ordi… (YDES) | $0.00 | $510360.00 | — |
Caris Life Sciences, Inc.'s revenue grew from $294M (2016) to $812M (2025) — a 11.9% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Caris Life Sciences… (CAI) | 2.0% | -66.2% | -3351.8% |
| Veracyte, Inc. (VCYT) | -48.2% | 12.8% | +126.6% |
| Adaptive Biotechnol… (ADPT) | -111.4% | -89.1% | +20.0% |
| YD Bio Limited Ordi… (YDES) | 3.9% | -2.8% | -171.4% |
Caris Life Sciences, Inc.'s net margin went from 2% (2016) to -66% (2025). Veracyte, Inc.'s net margin went from -48% (2016) to 13% (2025).
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Aspire Biopharma Ho… (ASBPW) | -0.07 | -1.52 | -1999.4% |
| Caris Life Sciences… (CAI) | 0.31 | -3.22 | -1138.7% |
| Veracyte, Inc. (VCYT) | -1.09 | 0.82 | +175.2% |
| Adaptive Biotechnol… (ADPT) | -0.41 | -1.08 | -163.4% |
| YD Bio Limited Ordi… (YDES) | -0.17 | -0.56 | -229.4% |
Caris Life Sciences, Inc.'s EPS grew from $0.31 (2016) to $-3.22 (2025) — a NaN% CAGR.
Chart 5Free Cash Flow — 5 Years
Aspire Biopharma Holdings, Inc. generated $-0M FCF in 2024 (+95% vs 2022). Caris Life Sciences, Inc. generated $67M FCF in 2025 (+120% vs 2022).
ASBPW vs CAI vs VCYT vs ADPT vs YDES: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is ASBPW or CAI or VCYT or ADPT or YDES a better buy right now?
Veracyte, Inc. (VCYT) offers the better valuation at 44.2x trailing P/E (22.0x forward), making it the more compelling value choice. Analysts rate Caris Life Sciences, Inc. (CAI) a "Buy" — based on 6 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — ASBPW or CAI or VCYT or ADPT or YDES?
On forward P/E, Veracyte, Inc. is actually cheaper at 22.0x.
03Which is the better long-term investment — ASBPW or CAI or VCYT or ADPT or YDES?
Over the past 5 years, Veracyte, Inc. (VCYT) delivered a total return of -23.7%, compared to -74.2% for Aspire Biopharma Holdings, Inc. (ASBPW). A $10,000 investment in VCYT five years ago would be worth approximately $8K today (assuming dividends reinvested). Over 10 years, the gap is even starker: VCYT returned +443.8% versus ASBPW's -74.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — ASBPW or CAI or VCYT or ADPT or YDES?
By beta (market sensitivity over 5 years), Aspire Biopharma Holdings, Inc. (ASBPW) is the lower-risk stock at 0.76β versus YD Bio Limited Ordinary Shares's 1.64β — meaning YDES is approximately 116% more volatile than ASBPW relative to the S&P 500. On balance sheet safety, Caris Life Sciences, Inc. (CAI) carries a lower debt/equity ratio of 0% versus 44% for Adaptive Biotechnologies Corporation — giving it more financial flexibility in a downturn.
05Which has better profit margins — ASBPW or CAI or VCYT or ADPT or YDES?
Veracyte, Inc. (VCYT) is the more profitable company, earning 12.8% net margin versus -16351.8% for Aspire Biopharma Holdings, Inc. — meaning it keeps 12.8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: VCYT leads at 11.2% versus -10314.0% for ASBPW. At the gross margin level — before operating expenses — VCYT leads at 70.1%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is ASBPW or CAI or VCYT or ADPT or YDES more undervalued right now?
On forward earnings alone, Veracyte, Inc. (VCYT) trades at 22.0x forward P/E versus 62.1x for Caris Life Sciences, Inc. — 40.0x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for CAI: 57.8% to $31.33.
07Which pays a better dividend — ASBPW or CAI or VCYT or ADPT or YDES?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is ASBPW or CAI or VCYT or ADPT or YDES better for a retirement portfolio?
For long-horizon retirement investors, Veracyte, Inc. (VCYT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.12), +443.8% 10Y return). YD Bio Limited Ordinary Shares (YDES) carries a higher beta of 1.64 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (VCYT: +443.8%, YDES: -29.8%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between ASBPW and CAI and VCYT and ADPT and YDES?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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