Comprehensive Stock Comparison
Compare Coherus Oncology, Inc. (CHRS) vs Revolution Medicines, Inc. (RVMD) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | RVMD | Beta 0.99 vs CHRS's 1.33 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | RVMD | +150.4% vs CHRS's +50.5% |
| Efficiency (ROA) | CHRS | 30.0% ROA vs RVMD's -48.0%, ROIC -85.3% vs -54.3% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Coherus Oncology is a biopharmaceutical company that develops and commercializes cancer immunotherapies and biosimilars. It generates revenue primarily from sales of its oncology biosimilars — including UDENYCA (a Neulasta biosimilar) and CIMERLI (a Lucentis biosimilar) — along with its novel immunotherapy LOQTORZI, with oncology products driving the majority of sales. The company's competitive advantage lies in its dual focus on lower-cost biosimilars that expand patient access and novel immunotherapies that target specific cancer pathways.
Revolution Medicines is a clinical-stage biotechnology company developing precision oncology therapies targeting RAS-addicted cancers. It generates revenue primarily through research collaborations and milestone payments — notably from its partnership with Sanofi on SHP2 inhibitors — while advancing its pipeline toward potential future drug sales. The company's competitive advantage lies in its deep expertise in RAS biology and its portfolio of novel inhibitors targeting multiple RAS pathway vulnerabilities that have historically been difficult to drug.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
RVMD leads in 4 of 6 categories (Financial Metrics, Valuation Metrics). CHRS leads in 1 (Profitability & Efficiency).
Financial Metrics (TTM)
CHRS and RVMD operate at a comparable scale, with $84M and $0 in trailing revenue.
| Metric | CHRSCoherus Oncology,… | RVMDRevolution Medici… |
|---|---|---|
| RevenueTrailing 12 months | $84M | $0 |
| EBITDAEarnings before interest/tax | -$173M | -$1.2B |
| Net IncomeAfter-tax profit | $155M | -$1.1B |
| Free Cash FlowCash after capex | -$90M | -$914M |
| Gross MarginGross profit ÷ Revenue | +47.8% | — |
| Operating MarginEBIT ÷ Revenue | -2.1% | — |
| Net MarginNet income ÷ Revenue | +185.4% | — |
| FCF MarginFCF ÷ Revenue | -107.9% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | -83.7% | — |
| EPS Growth (YoY)Latest quarter vs prior year | -2.3% | -68.1% |
Valuation Metrics
| Metric | CHRSCoherus Oncology,… | RVMDRevolution Medici… |
|---|---|---|
| Market CapShares × price | $194M | $20.1B |
| Enterprise ValueMkt cap + debt − cash | $338M | $19.9B |
| Trailing P/EPrice ÷ TTM EPS | 6.68x | -17.15x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 0.73x | — |
| Price / BookPrice ÷ Book value/share | — | 11.89x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
CHRS delivers a 176.6% return on equity — every $100 of shareholder capital generates $177 in annual profit, vs $-69 for RVMD. On the Piotroski fundamental quality scale (0–9), CHRS scores 5/9 vs RVMD's 1/9, reflecting solid financial health.
| Metric | CHRSCoherus Oncology,… | RVMDRevolution Medici… |
|---|---|---|
| ROE (TTM)Return on equity | +176.6% | -69.3% |
| ROA (TTM)Return on assets | +30.0% | -48.0% |
| ROICReturn on invested capital | -85.3% | -54.3% |
| ROCEReturn on capital employed | -48.2% | -53.0% |
| Piotroski ScoreFundamental quality 0–9 | 5 | 1 |
| Debt / EquityFinancial leverage | — | 0.10x |
| Net DebtTotal debt minus cash | $144M | -$225M |
| Cash & Equiv.Liquid assets | $126M | $384M |
| Total DebtShort + long-term debt | $270M | $159M |
| Interest CoverageEBIT ÷ Interest expense | -14.50x | -49.69x |
Total Returns (with DRIP)
A $10,000 investment in RVMD five years ago would be worth $22,183 today (with dividends reinvested), compared to $1,042 for CHRS. Over the past 12 months, RVMD leads with a +150.4% total return vs CHRS's +50.5%. The 3-year compound annual growth rate (CAGR) favors RVMD at 56.2% vs CHRS's -37.3% — a key indicator of consistent wealth creation.
| Metric | CHRSCoherus Oncology,… | RVMDRevolution Medici… |
|---|---|---|
| YTD ReturnYear-to-date | +21.9% | +29.1% |
| 1-Year ReturnPast 12 months | +50.5% | +150.4% |
| 3-Year ReturnCumulative with dividends | -75.3% | +281.2% |
| 5-Year ReturnCumulative with dividends | -89.6% | +121.8% |
| 10-Year ReturnCumulative with dividends | -88.2% | +253.0% |
| CAGR (3Y)Annualised 3-year return | -37.3% | +56.2% |
Risk & Volatility
RVMD is the less volatile stock with a 0.99 beta — it tends to amplify market swings less than CHRS's 1.33 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. RVMD currently trades 82.0% from its 52-week high vs CHRS's 63.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CHRSCoherus Oncology,… | RVMDRevolution Medici… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.33x | 0.99x |
| 52-Week HighHighest price in past year | $2.62 | $124.49 |
| 52-Week LowLowest price in past year | $0.71 | $29.17 |
| % of 52W HighCurrent price vs 52-week peak | +63.8% | +82.0% |
| RSI (14)Momentum oscillator 0–100 | 44.1 | 54.1 |
| Avg Volume (50D)Average daily shares traded | 2.6M | 3.2M |
Analyst Outlook
Wall Street rates CHRS as "Buy" and RVMD as "Buy". Consensus price targets imply 260.5% upside for CHRS (target: $6) vs 19.8% for RVMD (target: $122).
| Metric | CHRSCoherus Oncology,… | RVMDRevolution Medici… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $6.02 | $122.25 |
| # AnalystsCovering analysts | 16 | 20 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Coherus Oncology, I… (CHRS) | 100 | 10.48 | -89.5% |
| Revolution Medicine… (RVMD) | 100 | 295.86 | +195.9% |
Revolution Medicine… (RVMD) returned +122% over 5 years vs Coherus Oncology, I… (CHRS)'s -90%. A $10,000 investment in RVMD 5 years ago would be worth $22,183 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Coherus Oncology, I… (CHRS) | $190M | $267M | +40.4% |
| Revolution Medicine… (RVMD) | $0.00 | $0.00 | — |
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Coherus Oncology, I… (CHRS) | -7.4% | 10.7% | +243.7% |
| Revolution Medicine… (RVMD) | -2.1% | -37.7% | -1718.4% |
Coherus Oncology, Inc.'s net margin went from -7% (2015) to 11% (2024).
Chart 4P/E Ratio History — 3 Years
| Stock | 2019 | 2024 | Change |
|---|---|---|---|
| Coherus Oncology, I… (CHRS) | 14.6 | 5.5 | -62.3% |
Coherus Oncology, Inc. has traded in a 6x–15x P/E range over 3 years; current trailing P/E is ~7x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Coherus Oncology, I… (CHRS) | -3.04 | 0.25 | +108.2% |
| Revolution Medicine… (RVMD) | -0.85 | -5.95 | -600.0% |
Chart 6Free Cash Flow — 5 Years
Coherus Oncology, Inc. generated $-20M FCF in 2024 (+47% vs 2021). Revolution Medicines, Inc. generated $-914M FCF in 2025 (-494% vs 2021).
CHRS vs RVMD: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is CHRS or RVMD a better buy right now?
Coherus Oncology, Inc. (CHRS) offers the better valuation at 6.7x trailing P/E, making it the more compelling value choice. Analysts rate Coherus Oncology, Inc. (CHRS) a "Buy" — based on 16 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CHRS or RVMD?
Over the past 5 years, Revolution Medicines, Inc. (RVMD) delivered a total return of +121.8%, compared to -89.6% for Coherus Oncology, Inc. (CHRS). A $10,000 investment in RVMD five years ago would be worth approximately $22K today (assuming dividends reinvested). Over 10 years, the gap is even starker: RVMD returned +253.0% versus CHRS's -88.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CHRS or RVMD?
By beta (market sensitivity over 5 years), Revolution Medicines, Inc. (RVMD) is the lower-risk stock at 0.99β versus Coherus Oncology, Inc.'s 1.33β — meaning CHRS is approximately 34% more volatile than RVMD relative to the S&P 500.
04Which has better profit margins — CHRS or RVMD?
Coherus Oncology, Inc. (CHRS) is the more profitable company, earning 10.7% net margin versus 0.0% for Revolution Medicines, Inc. — meaning it keeps 10.7% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: RVMD leads at 0.0% versus -41.8% for CHRS. At the gross margin level — before operating expenses — CHRS leads at 56.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — CHRS or RVMD?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is CHRS or RVMD better for a retirement portfolio?
For long-horizon retirement investors, Revolution Medicines, Inc. (RVMD) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.99), +253.0% 10Y return). Both have compounded well over 10 years (RVMD: +253.0%, CHRS: -88.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between CHRS and RVMD?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. In terms of investment character: CHRS is a small-cap deep-value stock; RVMD is a mid-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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