Comprehensive Stock Comparison
Compare CureVac N.V. (CVAC) vs Regeneron Pharmaceuticals, Inc. (REGN) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | CVAC | 9.0% revenue growth vs REGN's 1.0% |
| Value | CVAC | Lower P/E (6.5x vs 17.3x) |
| Quality / Margins | CVAC | 37.9% net margin vs REGN's 31.4% |
| Stability / Safety | REGN | Beta 0.58 vs CVAC's 0.90 |
| Dividends | REGN | 0.4% yield; 1-year raise streak; CVAC pays no meaningful dividend |
| Momentum (1Y) | CVAC | +50.3% vs REGN's +12.4% |
| Efficiency (ROA) | CVAC | 28.1% ROA vs REGN's 11.1%, ROIC 65.0% vs 12.4% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
CureVac is a clinical-stage biopharmaceutical company developing mRNA-based vaccines and cancer immunotherapies. It generates revenue primarily through research collaborations and grants — having partnered with companies like GSK and Bayer — while advancing its pipeline toward commercialization. Its key advantage lies in proprietary mRNA technology platforms optimized for stability and immune response, though it faces intense competition from established mRNA leaders.
Regeneron Pharmaceuticals is a biotechnology company that discovers, develops, and commercializes innovative medicines for serious diseases. It generates revenue primarily from sales of its flagship products — EYLEA for eye diseases (~60% of revenue) and Dupixent for inflammatory conditions (~30%) — with additional income from collaborations and royalties. The company's competitive advantage lies in its proprietary VelocImmune technology platform for creating human antibodies and its deep expertise in genetic research, which enables rapid drug discovery and development.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
CVAC leads in 3 of 6 categories (Financial Metrics, Valuation Metrics). REGN leads in 2 (Total Returns, Risk & Volatility).
Financial Metrics (TTM)
REGN is the larger business by revenue, generating $14.3B annually — 28.1x CVAC's $511M. CVAC is the more profitable business, keeping 37.9% of every revenue dollar as net income compared to REGN's 31.4%. On growth, REGN holds the edge at +2.5% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | CVACCureVac N.V. | REGNRegeneron Pharmac… |
|---|---|---|
| RevenueTrailing 12 months | $511M | $14.3B |
| EBITDAEarnings before interest/tax | $226M | $4.2B |
| Net IncomeAfter-tax profit | $194M | $4.5B |
| Free Cash FlowCash after capex | $196M | $3.2B |
| Gross MarginGross profit ÷ Revenue | +94.8% | +86.3% |
| Operating MarginEBIT ÷ Revenue | +40.8% | +25.7% |
| Net MarginNet income ÷ Revenue | +37.9% | +31.4% |
| FCF MarginFCF ÷ Revenue | +38.4% | +22.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | -91.4% | +2.5% |
| EPS Growth (YoY)Latest quarter vs prior year | +18.8% | -2.5% |
Valuation Metrics
At 6.5x trailing earnings, CVAC trades at a 66% valuation discount to REGN's 18.8x P/E. On an enterprise value basis, CVAC's 3.1x EV/EBITDA is more attractive than REGN's 21.6x.
| Metric | CVACCureVac N.V. | REGNRegeneron Pharmac… |
|---|---|---|
| Market CapShares × price | $1.0B | $107.6B |
| Enterprise ValueMkt cap + debt − cash | $607M | $91.4B |
| Trailing P/EPrice ÷ TTM EPS | 6.47x | 18.84x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 17.25x |
| PEG RatioP/E ÷ EPS growth rate | — | 2.98x |
| EV / EBITDAEnterprise value multiple | 3.09x | 21.64x |
| Price / SalesMarket cap ÷ Revenue | 1.96x | 7.50x |
| Price / BookPrice ÷ Book value/share | 1.51x | 2.72x |
| Price / FCFMarket cap ÷ FCF | 12.58x | 26.36x |
Profitability & Efficiency
CVAC delivers a 33.0% return on equity — every $100 of shareholder capital generates $33 in annual profit, vs $14 for REGN. CVAC carries lower financial leverage with a 0.06x debt-to-equity ratio, signaling a more conservative balance sheet compared to REGN's 0.09x.
| Metric | CVACCureVac N.V. | REGNRegeneron Pharmac… |
|---|---|---|
| ROE (TTM)Return on equity | +33.0% | +14.4% |
| ROA (TTM)Return on assets | +28.1% | +11.1% |
| ROICReturn on invested capital | +65.0% | +12.4% |
| ROCEReturn on capital employed | +26.7% | +10.8% |
| Piotroski ScoreFundamental quality 0–9 | 7 | 7 |
| Debt / EquityFinancial leverage | 0.06x | 0.09x |
| Net DebtTotal debt minus cash | -$443M | -$16.2B |
| Cash & Equiv.Liquid assets | $482M | $18.9B |
| Total DebtShort + long-term debt | $39M | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | 547.87x | 120.42x |
Total Returns (with DRIP)
A $10,000 investment in REGN five years ago would be worth $16,977 today (with dividends reinvested), compared to $485 for CVAC. Over the past 12 months, CVAC leads with a +50.3% total return vs REGN's +12.4%. The 3-year compound annual growth rate (CAGR) favors REGN at 1.1% vs CVAC's -18.6% — a key indicator of consistent wealth creation.
| Metric | CVACCureVac N.V. | REGNRegeneron Pharmac… |
|---|---|---|
| YTD ReturnYear-to-date | -0.2% | +0.8% |
| 1-Year ReturnPast 12 months | +50.3% | +12.4% |
| 3-Year ReturnCumulative with dividends | -46.1% | +3.4% |
| 5-Year ReturnCumulative with dividends | -95.2% | +69.8% |
| 10-Year ReturnCumulative with dividends | -91.7% | +104.7% |
| CAGR (3Y)Annualised 3-year return | -18.6% | +1.1% |
Risk & Volatility
REGN is the less volatile stock with a 0.58 beta — it tends to amplify market swings less than CVAC's 0.90 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 95.2% from its 52-week high vs CVAC's 81.5% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CVACCureVac N.V. | REGNRegeneron Pharmac… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.90x | 0.58x |
| 52-Week HighHighest price in past year | $5.72 | $821.11 |
| 52-Week LowLowest price in past year | $2.48 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +81.5% | +95.2% |
| RSI (14)Momentum oscillator 0–100 | 47.8 | 49.1 |
| Avg Volume (50D)Average daily shares traded | 1.2M | 687K |
Analyst Outlook
Wall Street rates CVAC as "Hold" and REGN as "Buy". Consensus price targets imply 350.6% upside for CVAC (target: $21) vs 9.7% for REGN (target: $857). REGN is the only dividend payer here at 0.44% yield — a key consideration for income-focused portfolios.
| Metric | CVACCureVac N.V. | REGNRegeneron Pharmac… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Hold | Buy |
| Price TargetConsensus 12-month target | $21.00 | $857.17 |
| # AnalystsCovering analysts | 8 | 48 |
| Dividend YieldAnnual dividend ÷ price | — | +0.4% |
| Dividend StreakConsecutive years of raises | — | 1 |
| Dividend / ShareAnnual DPS | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +3.2% |
Historical Charts
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Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Aug 20 | Jan 26 | Change |
|---|---|---|---|
| CureVac N.V. (CVAC) | 100 | 8.35 | -91.6% |
| Regeneron Pharmaceu… (REGN) | 100 | 130.98 | +31.0% |
Regeneron Pharmaceu… (REGN) returned +70% over 5 years vs CureVac N.V. (CVAC)'s -95%. A $10,000 investment in REGN 5 years ago would be worth $16,977 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CureVac N.V. (CVAC) | $13M | $535M | +4058.0% |
| Regeneron Pharmaceu… (REGN) | $4.9B | $14.3B | +195.1% |
Regeneron Pharmaceuticals, Inc.'s revenue grew from $4.9B (2016) to $14.3B (2025) — a 12.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CureVac N.V. (CVAC) | -5.5% | 30.3% | +647.5% |
| Regeneron Pharmaceu… (REGN) | 18.4% | 31.4% | +70.5% |
Regeneron Pharmaceuticals, Inc.'s net margin went from 18% (2016) to 31% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Regeneron Pharmaceu… (REGN) | 36.4 | 18.6 | -48.9% |
Regeneron Pharmaceuticals, Inc. has traded in a 9x–36x P/E range over 9 years; current trailing P/E is ~19x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CureVac N.V. (CVAC) | -0.4 | 0.72 | +280.0% |
| Regeneron Pharmaceu… (REGN) | 7.7 | 41.48 | +438.7% |
Regeneron Pharmaceuticals, Inc.'s EPS grew from $7.70 (2016) to $41.48 (2025) — a 21% CAGR.
Chart 6Free Cash Flow — 5 Years
CureVac N.V. generated $83M FCF in 2024 (+110% vs 2021). Regeneron Pharmaceuticals, Inc. generated $4B FCF in 2025 (-38% vs 2021).
CVAC vs REGN: Frequently Asked Questions
9 questions · data-driven answers · updated daily
01Is CVAC or REGN a better buy right now?
CureVac N.V. (CVAC) offers the better valuation at 6.5x trailing P/E, making it the more compelling value choice. Analysts rate Regeneron Pharmaceuticals, Inc. (REGN) a "Buy" — based on 48 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — CVAC or REGN?
On trailing P/E, CureVac N.V. (CVAC) is the cheapest at 6.5x versus Regeneron Pharmaceuticals, Inc. at 18.8x.
03Which is the better long-term investment — CVAC or REGN?
Over the past 5 years, Regeneron Pharmaceuticals, Inc. (REGN) delivered a total return of +69.8%, compared to -95.2% for CureVac N.V. (CVAC). A $10,000 investment in REGN five years ago would be worth approximately $17K today (assuming dividends reinvested). Over 10 years, the gap is even starker: REGN returned +104.7% versus CVAC's -91.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — CVAC or REGN?
By beta (market sensitivity over 5 years), Regeneron Pharmaceuticals, Inc. (REGN) is the lower-risk stock at 0.58β versus CureVac N.V.'s 0.90β — meaning CVAC is approximately 56% more volatile than REGN relative to the S&P 500. On balance sheet safety, CureVac N.V. (CVAC) carries a lower debt/equity ratio of 6% versus 9% for Regeneron Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.
05Which has better profit margins — CVAC or REGN?
Regeneron Pharmaceuticals, Inc. (REGN) is the more profitable company, earning 31.4% net margin versus 30.3% for CureVac N.V. — meaning it keeps 31.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: CVAC leads at 33.2% versus 25.7% for REGN. At the gross margin level — before operating expenses — REGN leads at 86.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is CVAC or REGN more undervalued right now?
Analyst consensus price targets imply the most upside for CVAC: 350.6% to $21.00.
07Which pays a better dividend — CVAC or REGN?
In this comparison, REGN (0.4% yield) pays a dividend. CVAC does not pay a meaningful dividend and should not be held primarily for income.
08Is CVAC or REGN better for a retirement portfolio?
For long-horizon retirement investors, Regeneron Pharmaceuticals, Inc. (REGN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.58), +104.7% 10Y return). Both have compounded well over 10 years (REGN: +104.7%, CVAC: -91.7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between CVAC and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. In terms of investment character: CVAC is a small-cap deep-value stock; REGN is a mid-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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