Comprehensive Stock Comparison
Compare FibroGen, Inc. (FGEN) vs Akari Therapeutics, Plc (AKTX) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | AKTX | Beta 0.63 vs FGEN's 1.21 |
| Dividends | FGEN | 0.3% yield; 1-year raise streak; AKTX pays no meaningful dividend |
| Momentum (1Y) | FGEN | -26.5% vs AKTX's -72.9% |
| Efficiency (ROA) | FGEN | 157.4% ROA vs AKTX's -34.7% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
FibroGen is a biopharmaceutical company focused on developing novel therapeutics for serious medical conditions like anemia and fibrotic diseases. It generates revenue primarily through collaboration agreements with major pharmaceutical partners — including Astellas and AstraZeneca — which provide upfront payments, milestone payments, and royalties on future sales. The company's competitive advantage lies in its expertise in hypoxia-inducible factor biology and connective tissue growth factor inhibition, which has produced two late-stage drug candidates with novel mechanisms of action.
Akari Therapeutics is a clinical-stage biopharmaceutical company developing advanced therapies for autoimmune and inflammatory diseases. It generates no revenue currently — its business model depends on advancing its lead candidate nomacopan through clinical trials to eventually secure regulatory approvals and commercialization partnerships. The company's key advantage lies in nomacopan's dual mechanism of action targeting both complement and leukotriene pathways — a differentiated approach that could offer superior efficacy in treating complex inflammatory conditions.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
FGEN leads in 4 of 6 categories — strongest in Financial Metrics and Valuation Metrics. 1 category is tied.
Financial Metrics (TTM)
AKTX and FGEN operate at a comparable scale, with $0 and -$118M in trailing revenue.
| Metric | FGENFibroGen, Inc. | AKTXAkari Therapeutic… |
|---|---|---|
| RevenueTrailing 12 months | -$118M | $0 |
| EBITDAEarnings before interest/tax | -$123M | -$17M |
| Net IncomeAfter-tax profit | $216M | -$16M |
| Free Cash FlowCash after capex | -$17M | -$10M |
| Gross MarginGross profit ÷ Revenue | +47.5% | — |
| Operating MarginEBIT ÷ Revenue | -5.1% | — |
| Net MarginNet income ÷ Revenue | -160.6% | — |
| FCF MarginFCF ÷ Revenue | -4.7% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | -97.7% | — |
| EPS Growth (YoY)Latest quarter vs prior year | +12.7% | -80.2% |
Valuation Metrics
| Metric | FGENFibroGen, Inc. | AKTXAkari Therapeutic… |
|---|---|---|
| Market CapShares × price | $585M | $12.6B |
| Enterprise ValueMkt cap + debt − cash | $625M | $12.6B |
| Trailing P/EPrice ÷ TTM EPS | -15.63x | -0.00x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 19.75x | — |
| Price / BookPrice ÷ Book value/share | — | 0.00x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
FGEN delivers a 12.3% return on equity — every $100 of shareholder capital generates $12 in annual profit, vs $-69 for AKTX. On the Piotroski fundamental quality scale (0–9), AKTX scores 3/9 vs FGEN's 2/9, reflecting mixed financial health.
| Metric | FGENFibroGen, Inc. | AKTXAkari Therapeutic… |
|---|---|---|
| ROE (TTM)Return on equity | +12.3% | -69.4% |
| ROA (TTM)Return on assets | +157.4% | -34.7% |
| ROICReturn on invested capital | — | -172.5% |
| ROCEReturn on capital employed | -104.8% | -142.3% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 3 |
| Debt / EquityFinancial leverage | — | 0.15x |
| Net DebtTotal debt minus cash | $40M | $661,000 |
| Cash & Equiv.Liquid assets | $50M | $3M |
| Total DebtShort + long-term debt | $90M | $3M |
| Interest CoverageEBIT ÷ Interest expense | -20.28x | -47.14x |
Total Returns (with DRIP)
A $10,000 investment in FGEN five years ago would be worth $59 today (with dividends reinvested), compared to $35 for AKTX. Over the past 12 months, FGEN leads with a -26.5% total return vs AKTX's -72.9%. The 3-year compound annual growth rate (CAGR) favors AKTX at -67.5% vs FGEN's -76.2% — a key indicator of consistent wealth creation.
| Metric | FGENFibroGen, Inc. | AKTXAkari Therapeutic… |
|---|---|---|
| YTD ReturnYear-to-date | -18.1% | -18.6% |
| 1-Year ReturnPast 12 months | -26.5% | -72.9% |
| 3-Year ReturnCumulative with dividends | -98.6% | -96.6% |
| 5-Year ReturnCumulative with dividends | -99.4% | -99.6% |
| 10-Year ReturnCumulative with dividends | -98.3% | -99.9% |
| CAGR (3Y)Annualised 3-year return | -76.2% | -67.5% |
Risk & Volatility
AKTX is the less volatile stock with a 0.63 beta — it tends to amplify market swings less than FGEN's 1.21 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. FGEN currently trades 59.5% from its 52-week high vs AKTX's 13.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | FGENFibroGen, Inc. | AKTXAkari Therapeutic… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.21x | 0.63x |
| 52-Week HighHighest price in past year | $12.60 | $1.73 |
| 52-Week LowLowest price in past year | $4.85 | $0.22 |
| % of 52W HighCurrent price vs 52-week peak | +59.5% | +13.7% |
| RSI (14)Momentum oscillator 0–100 | 39.4 | 52.2 |
| Avg Volume (50D)Average daily shares traded | 27K | 387K |
Analyst Outlook
Wall Street rates FGEN as "Hold" and AKTX as "Buy". Consensus price targets imply 12601.1% upside for AKTX (target: $30) vs 273.3% for FGEN (target: $28). FGEN is the only dividend payer here at 0.30% yield — a key consideration for income-focused portfolios.
| Metric | FGENFibroGen, Inc. | AKTXAkari Therapeutic… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Hold | Buy |
| Price TargetConsensus 12-month target | $28.00 | $30.00 |
| # AnalystsCovering analysts | 14 | 7 |
| Dividend YieldAnnual dividend ÷ price | +0.3% | — |
| Dividend StreakConsecutive years of raises | 1 | — |
| Dividend / ShareAnnual DPS | $0.02 | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| FibroGen, Inc. (FGEN) | 100 | 0.76 | -99.2% |
| Akari Therapeutics,… (AKTX) | 100 | 0.63 | -99.4% |
FibroGen, Inc. (FGEN) returned -99% over 5 years vs Akari Therapeutics,… (AKTX)'s -100%.
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| FibroGen, Inc. (FGEN) | $181M | $30M | -83.6% |
| Akari Therapeutics,… (AKTX) | $0.00 | $0.00 | — |
FibroGen, Inc.'s revenue grew from $181M (2015) to $30M (2024) — a -18.2% CAGR. Akari Therapeutics, Plc's revenue grew from $0M (2015) to $0M (2024) — a 0.0% CAGR.
Chart 3EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| FibroGen, Inc. (FGEN) | -1.42 | -0.48 | +66.2% |
| Akari Therapeutics,… (AKTX) | -10,640 | -1,660 | +84.4% |
FibroGen, Inc.'s EPS grew from $-1.42 (2015) to $-0.48 (2024). Akari Therapeutics, Plc's EPS grew from $-10640.00 (2015) to $-1660.00 (2024).
Chart 4Free Cash Flow — 5 Years
FibroGen, Inc. generated $-138M FCF in 2024 (-23% vs 2021). Akari Therapeutics, Plc generated $-13M FCF in 2024 (+33% vs 2021).
FGEN vs AKTX: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is FGEN or AKTX a better buy right now?
Analysts rate Akari Therapeutics, Plc (AKTX) a "Buy" — based on 7 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — FGEN or AKTX?
Over the past 5 years, FibroGen, Inc. (FGEN) delivered a total return of -99.4%, compared to -99.6% for Akari Therapeutics, Plc (AKTX). A $10,000 investment in FGEN five years ago would be worth approximately $59 today (assuming dividends reinvested). Over 10 years, the gap is even starker: FGEN returned -98.3% versus AKTX's -99.9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — FGEN or AKTX?
By beta (market sensitivity over 5 years), Akari Therapeutics, Plc (AKTX) is the lower-risk stock at 0.63β versus FibroGen, Inc.'s 1.21β — meaning FGEN is approximately 93% more volatile than AKTX relative to the S&P 500.
04Which has better profit margins — FGEN or AKTX?
Akari Therapeutics, Plc (AKTX) is the more profitable company, earning 0.0% net margin versus -160.6% for FibroGen, Inc. — meaning it keeps 0.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: AKTX leads at 0.0% versus -507.8% for FGEN. At the gross margin level — before operating expenses — FGEN leads at 47.5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — FGEN or AKTX?
In this comparison, FGEN (0.3% yield) pays a dividend. AKTX does not pay a meaningful dividend and should not be held primarily for income.
06Is FGEN or AKTX better for a retirement portfolio?
For long-horizon retirement investors, Akari Therapeutics, Plc (AKTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.63)). Both have compounded well over 10 years (AKTX: -99.9%, FGEN: -98.3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between FGEN and AKTX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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