Comprehensive Stock Comparison
Compare OS Therapies Incorporated (OSTX) vs Regeneron Pharmaceuticals, Inc. (REGN) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | REGN | Beta 0.58 vs OSTX's 0.81 |
| Dividends | OSTX | 100.0% yield, 1-year raise streak, vs REGN's 0.4% |
| Momentum (1Y) | REGN | +12.4% vs OSTX's -10.9% |
| Efficiency (ROA) | REGN | 11.1% ROA vs OSTX's -204.2% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
OS Therapies is a clinical-stage biopharmaceutical company developing novel treatments for osteosarcoma and other solid tumors. It aims to generate revenue through future drug sales and potential licensing deals — primarily from its lead candidate OST-HER2 (an off-the-shelf immunotherapy) and its tunable antibody-drug conjugate platform. The company's competitive advantage lies in its specialized focus on osteosarcoma — a rare pediatric cancer with limited treatment options — and its proprietary plug-and-play ADC technology with pH-sensitive linkers.
Regeneron Pharmaceuticals is a biotechnology company that discovers, develops, and commercializes innovative medicines for serious diseases. It generates revenue primarily from sales of its flagship products — EYLEA for eye diseases (~60% of revenue) and Dupixent for inflammatory conditions (~30%) — with additional income from collaborations and royalties. The company's competitive advantage lies in its proprietary VelocImmune technology platform for creating human antibodies and its deep expertise in genetic research, which enables rapid drug discovery and development.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
REGN leads in 4 of 6 categories (Financial Metrics, Profitability & Efficiency). OSTX leads in 1 (Analyst Outlook). 1 tied.
Financial Metrics (TTM)
REGN and OSTX operate at a comparable scale, with $14.3B and $0 in trailing revenue.
| Metric | OSTXOS Therapies Inco… | REGNRegeneron Pharmac… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $14.3B |
| EBITDAEarnings before interest/tax | -$19M | $4.2B |
| Net IncomeAfter-tax profit | -$18M | $4.5B |
| Free Cash FlowCash after capex | -$13M | $3.2B |
| Gross MarginGross profit ÷ Revenue | — | +86.3% |
| Operating MarginEBIT ÷ Revenue | — | +25.7% |
| Net MarginNet income ÷ Revenue | — | +31.4% |
| FCF MarginFCF ÷ Revenue | — | +22.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +2.5% |
| EPS Growth (YoY)Latest quarter vs prior year | -16.7% | -2.5% |
Valuation Metrics
| Metric | OSTXOS Therapies Inco… | REGNRegeneron Pharmac… |
|---|---|---|
| Market CapShares × price | $49M | $107.6B |
| Enterprise ValueMkt cap + debt − cash | $43M | $91.4B |
| Trailing P/EPrice ÷ TTM EPS | -2.83x | 18.84x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 17.25x |
| PEG RatioP/E ÷ EPS growth rate | — | 2.98x |
| EV / EBITDAEnterprise value multiple | — | 21.64x |
| Price / SalesMarket cap ÷ Revenue | — | 7.50x |
| Price / BookPrice ÷ Book value/share | 37.81x | 2.72x |
| Price / FCFMarket cap ÷ FCF | — | 26.36x |
Profitability & Efficiency
REGN delivers a 14.4% return on equity — every $100 of shareholder capital generates $14 in annual profit, vs $-4 for OSTX. On the Piotroski fundamental quality scale (0–9), REGN scores 7/9 vs OSTX's 3/9, reflecting strong financial health.
| Metric | OSTXOS Therapies Inco… | REGNRegeneron Pharmac… |
|---|---|---|
| ROE (TTM)Return on equity | -3.9% | +14.4% |
| ROA (TTM)Return on assets | -2.0% | +11.1% |
| ROICReturn on invested capital | — | +12.4% |
| ROCEReturn on capital employed | -7.5% | +10.8% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 7 |
| Debt / EquityFinancial leverage | — | 0.09x |
| Net DebtTotal debt minus cash | -$6M | -$16.2B |
| Cash & Equiv.Liquid assets | $6M | $18.9B |
| Total DebtShort + long-term debt | $0 | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | -2418.83x | 120.42x |
Total Returns (with DRIP)
A $10,000 investment in REGN five years ago would be worth $16,977 today (with dividends reinvested), compared to $5,857 for OSTX. Over the past 12 months, REGN leads with a +12.4% total return vs OSTX's -10.9%. The 3-year compound annual growth rate (CAGR) favors REGN at 1.1% vs OSTX's -16.3% — a key indicator of consistent wealth creation.
| Metric | OSTXOS Therapies Inco… | REGNRegeneron Pharmac… |
|---|---|---|
| YTD ReturnYear-to-date | +9.7% | +0.8% |
| 1-Year ReturnPast 12 months | -10.9% | +12.4% |
| 3-Year ReturnCumulative with dividends | -41.4% | +3.4% |
| 5-Year ReturnCumulative with dividends | -41.4% | +69.8% |
| 10-Year ReturnCumulative with dividends | -41.4% | +104.7% |
| CAGR (3Y)Annualised 3-year return | -16.3% | +1.1% |
Risk & Volatility
REGN is the less volatile stock with a 0.58 beta — it tends to amplify market swings less than OSTX's 0.81 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 95.2% from its 52-week high vs OSTX's 57.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | OSTXOS Therapies Inco… | REGNRegeneron Pharmac… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.81x | 0.58x |
| 52-Week HighHighest price in past year | $2.57 | $821.11 |
| 52-Week LowLowest price in past year | $1.12 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +57.2% | +95.2% |
| RSI (14)Momentum oscillator 0–100 | 57.9 | 49.1 |
| Avg Volume (50D)Average daily shares traded | 510K | 687K |
Analyst Outlook
For income investors, OSTX offers the higher dividend yield at 100.00% vs REGN's 0.44%.
| Metric | OSTXOS Therapies Inco… | REGNRegeneron Pharmac… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $857.17 |
| # AnalystsCovering analysts | — | 48 |
| Dividend YieldAnnual dividend ÷ price | +100.0% | +0.4% |
| Dividend StreakConsecutive years of raises | 1 | 1 |
| Dividend / ShareAnnual DPS | $1.50 | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +3.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Aug 24 | Feb 26 | Change |
|---|---|---|---|
| OS Therapies Incorp… (OSTX) | 100 | 55.38 | -44.6% |
| Regeneron Pharmaceu… (REGN) | 100 | 69.07 | -30.9% |
Regeneron Pharmaceu… (REGN) returned +70% over 5 years vs OS Therapies Incorp… (OSTX)'s -41%. A $10,000 investment in REGN 5 years ago would be worth $16,977 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| OS Therapies Incorp… (OSTX) | $0.00 | $0.00 | — |
| Regeneron Pharmaceu… (REGN) | $4.9B | $14.3B | +195.1% |
Regeneron Pharmaceuticals, Inc.'s revenue grew from $4.9B (2016) to $14.3B (2025) — a 12.8% CAGR.
Chart 3P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Regeneron Pharmaceu… (REGN) | 36.4 | 18.6 | -48.9% |
Regeneron Pharmaceuticals, Inc. has traded in a 9x–36x P/E range over 9 years; current trailing P/E is ~19x.
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| OS Therapies Incorp… (OSTX) | -0 | -0.52 | -74185.7% |
| Regeneron Pharmaceu… (REGN) | 7.7 | 41.48 | +438.7% |
Regeneron Pharmaceuticals, Inc.'s EPS grew from $7.70 (2016) to $41.48 (2025) — a 21% CAGR.
Chart 5Free Cash Flow — 5 Years
OS Therapies Incorporated generated $-7M FCF in 2024 (-65% vs 2021). Regeneron Pharmaceuticals, Inc. generated $4B FCF in 2025 (-38% vs 2021).
OSTX vs REGN: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is OSTX or REGN a better buy right now?
Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 18.8x trailing P/E (17.3x forward), making it the more compelling value choice. Analysts rate Regeneron Pharmaceuticals, Inc. (REGN) a "Buy" — based on 48 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — OSTX or REGN?
Over the past 5 years, Regeneron Pharmaceuticals, Inc. (REGN) delivered a total return of +69.8%, compared to -41.4% for OS Therapies Incorporated (OSTX). A $10,000 investment in REGN five years ago would be worth approximately $17K today (assuming dividends reinvested). Over 10 years, the gap is even starker: REGN returned +104.7% versus OSTX's -41.4%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — OSTX or REGN?
By beta (market sensitivity over 5 years), Regeneron Pharmaceuticals, Inc. (REGN) is the lower-risk stock at 0.58β versus OS Therapies Incorporated's 0.81β — meaning OSTX is approximately 40% more volatile than REGN relative to the S&P 500.
04Which has better profit margins — OSTX or REGN?
Regeneron Pharmaceuticals, Inc. (REGN) is the more profitable company, earning 31.4% net margin versus 0.0% for OS Therapies Incorporated — meaning it keeps 31.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REGN leads at 25.7% versus 0.0% for OSTX. At the gross margin level — before operating expenses — REGN leads at 86.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — OSTX or REGN?
All stocks in this comparison pay dividends. OS Therapies Incorporated (OSTX) offers the highest yield at 100.0%, versus 0.4% for Regeneron Pharmaceuticals, Inc. (REGN).
06Is OSTX or REGN better for a retirement portfolio?
For long-horizon retirement investors, OS Therapies Incorporated (OSTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.81), 100.0% yield). Both have compounded well over 10 years (OSTX: -41.4%, REGN: +104.7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between OSTX and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. In terms of investment character: OSTX is a small-cap income-oriented stock; REGN is a mid-cap quality compounder stock. OSTX pays a dividend while REGN does not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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