Comprehensive Stock Comparison
Compare Rigel Pharmaceuticals, Inc. (RIGL) vs Can-Fite BioPharma Ltd. (CANF) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | RIGL | 53.4% revenue growth vs CANF's -9.3% |
| Quality / Margins | RIGL | 40.2% net margin vs CANF's -15.7% |
| Stability / Safety | CANF | Beta 0.36 vs RIGL's 0.86, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | CANF | +169.9% vs RIGL's +50.7% |
| Efficiency (ROA) | RIGL | 46.7% ROA vs CANF's -114.0%, ROIC 6.4% vs -448.3% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Rigel Pharmaceuticals is a biotechnology company that discovers and develops small molecule drugs for hematologic disorders, cancer, and rare immune diseases. It generates revenue primarily from sales of its FDA-approved drug Tavalisse for chronic immune thrombocytopenia, supplemented by milestone payments and royalties from partnership agreements. The company's competitive advantage lies in its specialized expertise in kinase inhibition—particularly spleen tyrosine kinase (SYK) targeting—and its focused pipeline addressing underserved hematologic and autoimmune conditions.
Can-Fite BioPharma is a clinical-stage biopharmaceutical company developing small molecule drugs targeting inflammatory diseases and cancer. It generates revenue primarily through licensing agreements and milestone payments from partners — with no commercial products yet — as it advances its lead candidates through clinical trials. The company's competitive advantage lies in its proprietary A3 adenosine receptor platform, which targets a novel pathway for treating autoimmune and inflammatory conditions.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
RIGL leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). CANF leads in 2 (Valuation Metrics, Risk & Volatility).
Financial Metrics (TTM)
RIGL is the larger business by revenue, generating $282M annually — 503.7x CANF's $560,000. RIGL is the more profitable business, keeping 40.2% of every revenue dollar as net income compared to CANF's -15.7%. On growth, RIGL holds the edge at +25.6% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | RIGLRigel Pharmaceuti… | CANFCan-Fite BioPharm… |
|---|---|---|
| RevenueTrailing 12 months | $282M | $560,000 |
| EBITDAEarnings before interest/tax | $121M | -$9M |
| Net IncomeAfter-tax profit | $113M | -$9M |
| Free Cash FlowCash after capex | $68M | -$8M |
| Gross MarginGross profit ÷ Revenue | +93.1% | +100.0% |
| Operating MarginEBIT ÷ Revenue | +42.2% | -16.0% |
| Net MarginNet income ÷ Revenue | +40.2% | -15.7% |
| FCF MarginFCF ÷ Revenue | +24.2% | -14.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | +25.6% | -36.1% |
| EPS Growth (YoY)Latest quarter vs prior year | +108.1% | +36.4% |
Valuation Metrics
| Metric | RIGLRigel Pharmaceuti… | CANFCan-Fite BioPharm… |
|---|---|---|
| Market CapShares × price | $615M | $14.2B |
| Enterprise ValueMkt cap + debt − cash | $618M | $14.2B |
| Trailing P/EPrice ÷ TTM EPS | 35.09x | -4.40x |
| Forward P/EPrice ÷ next-FY EPS est. | 8.75x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 23.41x | — |
| Price / SalesMarket cap ÷ Revenue | 3.43x | 9999.00x |
| Price / BookPrice ÷ Book value/share | 186.88x | 6.34x |
| Price / FCFMarket cap ÷ FCF | 19.80x | — |
Profitability & Efficiency
RIGL delivers a 96.3% return on equity — every $100 of shareholder capital generates $96 in annual profit, vs $-2 for CANF. CANF carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to RIGL's 18.24x. On the Piotroski fundamental quality scale (0–9), RIGL scores 7/9 vs CANF's 1/9, reflecting strong financial health.
| Metric | RIGLRigel Pharmaceuti… | CANFCan-Fite BioPharm… |
|---|---|---|
| ROE (TTM)Return on equity | +96.3% | -2.1% |
| ROA (TTM)Return on assets | +46.7% | -114.0% |
| ROICReturn on invested capital | +6.4% | -4.5% |
| ROCEReturn on capital employed | +29.4% | -108.1% |
| Piotroski ScoreFundamental quality 0–9 | 7 | 1 |
| Debt / EquityFinancial leverage | 18.24x | 0.02x |
| Net DebtTotal debt minus cash | $3M | -$5M |
| Cash & Equiv.Liquid assets | $57M | $5M |
| Total DebtShort + long-term debt | $60M | $104,000 |
| Interest CoverageEBIT ÷ Interest expense | 16.09x | -580.71x |
Total Returns (with DRIP)
A $10,000 investment in RIGL five years ago would be worth $7,772 today (with dividends reinvested), compared to $2,351 for CANF. Over the past 12 months, CANF leads with a +169.9% total return vs RIGL's +50.7%. The 3-year compound annual growth rate (CAGR) favors RIGL at 32.0% vs CANF's 20.6% — a key indicator of consistent wealth creation.
| Metric | RIGLRigel Pharmaceuti… | CANFCan-Fite BioPharm… |
|---|---|---|
| YTD ReturnYear-to-date | -16.9% | +2059.1% |
| 1-Year ReturnPast 12 months | +50.7% | +169.9% |
| 3-Year ReturnCumulative with dividends | +130.1% | +75.3% |
| 5-Year ReturnCumulative with dividends | -22.3% | -76.5% |
| 10-Year ReturnCumulative with dividends | +53.0% | -98.5% |
| CAGR (3Y)Annualised 3-year return | +32.0% | +20.6% |
Risk & Volatility
CANF is the less volatile stock with a 0.36 beta — it tends to amplify market swings less than RIGL's 0.86 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. CANF currently trades 96.3% from its 52-week high vs RIGL's 66.5% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | RIGLRigel Pharmaceuti… | CANFCan-Fite BioPharm… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.86x | 0.36x |
| 52-Week HighHighest price in past year | $52.24 | $4.93 |
| 52-Week LowLowest price in past year | $15.50 | $0.17 |
| % of 52W HighCurrent price vs 52-week peak | +66.5% | +96.3% |
| RSI (14)Momentum oscillator 0–100 | 48.7 | 68.6 |
| Avg Volume (50D)Average daily shares traded | 347K | 4.3M |
Analyst Outlook
Wall Street rates RIGL as "Buy" and CANF as "Buy". Consensus price targets imply 52.6% upside for CANF (target: $7) vs 15.1% for RIGL (target: $40).
| Metric | RIGLRigel Pharmaceuti… | CANFCan-Fite BioPharm… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $40.00 | $7.25 |
| # AnalystsCovering analysts | 15 | 4 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +1.6% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 20 | Feb 26 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | 100 | 169.86 | +69.9% |
| Can-Fite BioPharma … (CANF) | 100 | 33.04 | -67.0% |
Rigel Pharmaceutica… (RIGL) returned -22% over 5 years vs Can-Fite BioPharma … (CANF)'s -76%.
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | $29M | $179M | +520.4% |
| Can-Fite BioPharma … (CANF) | $164717.00 | $674000.00 | +309.2% |
Rigel Pharmaceuticals, Inc.'s revenue grew from $29M (2015) to $179M (2024) — a 22.5% CAGR. Can-Fite BioPharma Ltd.'s revenue grew from $0M (2015) to $1M (2024) — a 16.9% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | -178.1% | 9.8% | +105.5% |
| Can-Fite BioPharma … (CANF) | -29.1% | -11.7% | +59.9% |
Rigel Pharmaceuticals, Inc.'s net margin went from -178% (2015) to 10% (2024). Can-Fite BioPharma Ltd.'s net margin went from -29% (2015) to -12% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | -5.82 | 0.99 | +117.0% |
| Can-Fite BioPharma … (CANF) | -81 | -1.08 | +98.7% |
Rigel Pharmaceuticals, Inc.'s EPS grew from $-5.82 (2015) to $0.99 (2024). Can-Fite BioPharma Ltd.'s EPS grew from $-81.00 (2015) to $-1.08 (2024).
Chart 5Free Cash Flow — 5 Years
Rigel Pharmaceuticals, Inc. generated $31M FCF in 2024 (+492% vs 2021). Can-Fite BioPharma Ltd. generated $-8M FCF in 2024 (+23% vs 2021).
RIGL vs CANF: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is RIGL or CANF a better buy right now?
Rigel Pharmaceuticals, Inc. (RIGL) offers the better valuation at 35.1x trailing P/E (8.8x forward), making it the more compelling value choice. Analysts rate Rigel Pharmaceuticals, Inc. (RIGL) a "Buy" — based on 15 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — RIGL or CANF?
Over the past 5 years, Rigel Pharmaceuticals, Inc. (RIGL) delivered a total return of -22.3%, compared to -76.5% for Can-Fite BioPharma Ltd. (CANF). A $10,000 investment in RIGL five years ago would be worth approximately $8K today (assuming dividends reinvested). Over 10 years, the gap is even starker: RIGL returned +53.0% versus CANF's -98.5%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — RIGL or CANF?
By beta (market sensitivity over 5 years), Can-Fite BioPharma Ltd. (CANF) is the lower-risk stock at 0.36β versus Rigel Pharmaceuticals, Inc.'s 0.86β — meaning RIGL is approximately 138% more volatile than CANF relative to the S&P 500. On balance sheet safety, Can-Fite BioPharma Ltd. (CANF) carries a lower debt/equity ratio of 2% versus 18% for Rigel Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — RIGL or CANF?
Rigel Pharmaceuticals, Inc. (RIGL) is the more profitable company, earning 9.8% net margin versus -1169.1% for Can-Fite BioPharma Ltd. — meaning it keeps 9.8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: RIGL leads at 13.5% versus -1206.2% for CANF. At the gross margin level — before operating expenses — CANF leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is RIGL or CANF more undervalued right now?
Analyst consensus price targets imply the most upside for CANF: 52.6% to $7.25.
06Which pays a better dividend — RIGL or CANF?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is RIGL or CANF better for a retirement portfolio?
For long-horizon retirement investors, Can-Fite BioPharma Ltd. (CANF) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.36)). Both have compounded well over 10 years (CANF: -98.5%, RIGL: +53.0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between RIGL and CANF?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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