Comprehensive Stock Comparison
Compare Rigel Pharmaceuticals, Inc. (RIGL) vs TG Therapeutics, Inc. (TGTX) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | RIGL | 53.4% revenue growth vs TGTX's 40.8% |
| Value | RIGL | Lower P/E (8.8x vs 19.4x) |
| Quality / Margins | RIGL | 40.2% net margin vs TGTX's 13.3% |
| Stability / Safety | TGTX | Beta 0.43 vs RIGL's 0.86, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | RIGL | +50.7% vs TGTX's 0.0% |
| Efficiency (ROA) | RIGL | 46.7% ROA vs TGTX's 8.6%, ROIC 6.4% vs 13.3% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Rigel Pharmaceuticals is a biotechnology company that discovers and develops small molecule drugs for hematologic disorders, cancer, and rare immune diseases. It generates revenue primarily from sales of its FDA-approved drug Tavalisse for chronic immune thrombocytopenia, supplemented by milestone payments and royalties from partnership agreements. The company's competitive advantage lies in its specialized expertise in kinase inhibition—particularly spleen tyrosine kinase (SYK) targeting—and its focused pipeline addressing underserved hematologic and autoimmune conditions.
TG Therapeutics is a commercial-stage biopharmaceutical company developing and commercializing novel treatments for B-cell malignancies and autoimmune diseases. It generates revenue primarily from sales of its FDA-approved multiple sclerosis drug BRIUMVI (ublituximab) — its first commercial product — with future revenue expected from its pipeline of oncology candidates. The company's competitive advantage lies in its glycoengineered antibody platform technology, which creates potentially more effective and convenient treatments for complex diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
RIGL leads in 4 of 6 categories — strongest in Financial Metrics and Valuation Metrics. 1 category is tied.
Financial Metrics (TTM)
TGTX is the larger business by revenue, generating $454M annually — 1.6x RIGL's $282M. RIGL is the more profitable business, keeping 40.2% of every revenue dollar as net income compared to TGTX's 13.3%. On growth, TGTX holds the edge at +92.1% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | RIGLRigel Pharmaceuti… | TGTXTG Therapeutics, … |
|---|---|---|
| RevenueTrailing 12 months | $282M | $454M |
| EBITDAEarnings before interest/tax | $121M | $86M |
| Net IncomeAfter-tax profit | $113M | $60M |
| Free Cash FlowCash after capex | $68M | -$59M |
| Gross MarginGross profit ÷ Revenue | +93.1% | +87.0% |
| Operating MarginEBIT ÷ Revenue | +42.2% | +18.9% |
| Net MarginNet income ÷ Revenue | +40.2% | +13.3% |
| FCF MarginFCF ÷ Revenue | +24.2% | -13.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | +25.6% | +92.1% |
| EPS Growth (YoY)Latest quarter vs prior year | +108.1% | +2.9% |
Valuation Metrics
At 35.1x trailing earnings, RIGL trades at a 83% valuation discount to TGTX's 200.6x P/E. On an enterprise value basis, RIGL's 23.4x EV/EBITDA is more attractive than TGTX's 114.4x.
| Metric | RIGLRigel Pharmaceuti… | TGTXTG Therapeutics, … |
|---|---|---|
| Market CapShares × price | $615M | $4.8B |
| Enterprise ValueMkt cap + debt − cash | $618M | $4.8B |
| Trailing P/EPrice ÷ TTM EPS | 35.09x | 200.60x |
| Forward P/EPrice ÷ next-FY EPS est. | 8.75x | 19.40x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 23.41x | 114.40x |
| Price / SalesMarket cap ÷ Revenue | 3.43x | 14.45x |
| Price / BookPrice ÷ Book value/share | 186.88x | 21.70x |
| Price / FCFMarket cap ÷ FCF | 19.80x | — |
Profitability & Efficiency
RIGL delivers a 96.3% return on equity — every $100 of shareholder capital generates $96 in annual profit, vs $22 for TGTX. TGTX carries lower financial leverage with a 1.14x debt-to-equity ratio, signaling a more conservative balance sheet compared to RIGL's 18.24x. On the Piotroski fundamental quality scale (0–9), RIGL scores 7/9 vs TGTX's 3/9, reflecting strong financial health.
| Metric | RIGLRigel Pharmaceuti… | TGTXTG Therapeutics, … |
|---|---|---|
| ROE (TTM)Return on equity | +96.3% | +21.9% |
| ROA (TTM)Return on assets | +46.7% | +8.6% |
| ROICReturn on invested capital | +6.4% | +13.3% |
| ROCEReturn on capital employed | +29.4% | +11.0% |
| Piotroski ScoreFundamental quality 0–9 | 7 | 3 |
| Debt / EquityFinancial leverage | 18.24x | 1.14x |
| Net DebtTotal debt minus cash | $3M | $74M |
| Cash & Equiv.Liquid assets | $57M | $180M |
| Total DebtShort + long-term debt | $60M | $254M |
| Interest CoverageEBIT ÷ Interest expense | 16.09x | 3.11x |
Total Returns (with DRIP)
A $10,000 investment in RIGL five years ago would be worth $7,772 today (with dividends reinvested), compared to $6,687 for TGTX. Over the past 12 months, RIGL leads with a +50.7% total return vs TGTX's 0.0%. The 3-year compound annual growth rate (CAGR) favors RIGL at 32.0% vs TGTX's 23.4% — a key indicator of consistent wealth creation.
| Metric | RIGLRigel Pharmaceuti… | TGTXTG Therapeutics, … |
|---|---|---|
| YTD ReturnYear-to-date | -16.9% | +2.8% |
| 1-Year ReturnPast 12 months | +50.7% | 0.0% |
| 3-Year ReturnCumulative with dividends | +130.1% | +87.8% |
| 5-Year ReturnCumulative with dividends | -22.3% | -33.1% |
| 10-Year ReturnCumulative with dividends | +53.0% | +261.2% |
| CAGR (3Y)Annualised 3-year return | +32.0% | +23.4% |
Risk & Volatility
TGTX is the less volatile stock with a 0.43 beta — it tends to amplify market swings less than RIGL's 0.86 beta. A beta below 1.0 means the stock typically moves less than the S&P 500.
| Metric | RIGLRigel Pharmaceuti… | TGTXTG Therapeutics, … |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.86x | 0.43x |
| 52-Week HighHighest price in past year | $52.24 | $46.48 |
| 52-Week LowLowest price in past year | $15.50 | $25.28 |
| % of 52W HighCurrent price vs 52-week peak | +66.5% | +64.7% |
| RSI (14)Momentum oscillator 0–100 | 48.7 | 58.1 |
| Avg Volume (50D)Average daily shares traded | 347K | 1.7M |
Analyst Outlook
Wall Street rates RIGL as "Buy" and TGTX as "Buy". Consensus price targets imply 64.5% upside for TGTX (target: $50) vs 15.1% for RIGL (target: $40).
| Metric | RIGLRigel Pharmaceuti… | TGTXTG Therapeutics, … |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $40.00 | $49.50 |
| # AnalystsCovering analysts | 15 | 13 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 0 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +1.6% | +0.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 20 | Feb 26 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | 100 | 169.86 | +69.9% |
| TG Therapeutics, In… (TGTX) | 100 | 232.51 | +132.5% |
Rigel Pharmaceutica… (RIGL) returned -22% over 5 years vs TG Therapeutics, In… (TGTX)'s -33%.
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | $29M | $179M | +520.4% |
| TG Therapeutics, In… (TGTX) | $152381.00 | $329M | +215808.8% |
Rigel Pharmaceuticals, Inc.'s revenue grew from $29M (2015) to $179M (2024) — a 22.5% CAGR. TG Therapeutics, Inc.'s revenue grew from $0M (2015) to $329M (2024) — a 134.7% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | -178.1% | 9.8% | +105.5% |
| TG Therapeutics, In… (TGTX) | -413.1% | 7.1% | +101.7% |
Rigel Pharmaceuticals, Inc.'s net margin went from -178% (2015) to 10% (2024). TG Therapeutics, Inc.'s net margin went from -413% (2015) to 7% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Rigel Pharmaceutica… (RIGL) | -5.82 | 0.99 | +117.0% |
| TG Therapeutics, In… (TGTX) | -1.38 | 0.15 | +110.9% |
Rigel Pharmaceuticals, Inc.'s EPS grew from $-5.82 (2015) to $0.99 (2024). TG Therapeutics, Inc.'s EPS grew from $-1.38 (2015) to $0.15 (2024).
Chart 5Free Cash Flow — 5 Years
Rigel Pharmaceuticals, Inc. generated $31M FCF in 2024 (+492% vs 2021). TG Therapeutics, Inc. generated $-41M FCF in 2024 (+86% vs 2021).
RIGL vs TGTX: Frequently Asked Questions
9 questions · data-driven answers · updated daily
01Is RIGL or TGTX a better buy right now?
Rigel Pharmaceuticals, Inc. (RIGL) offers the better valuation at 35.1x trailing P/E (8.8x forward), making it the more compelling value choice. Analysts rate Rigel Pharmaceuticals, Inc. (RIGL) a "Buy" — based on 15 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — RIGL or TGTX?
On trailing P/E, Rigel Pharmaceuticals, Inc. (RIGL) is the cheapest at 35.1x versus TG Therapeutics, Inc. at 200.6x. On forward P/E, Rigel Pharmaceuticals, Inc. is actually cheaper at 8.8x.
03Which is the better long-term investment — RIGL or TGTX?
Over the past 5 years, Rigel Pharmaceuticals, Inc. (RIGL) delivered a total return of -22.3%, compared to -33.1% for TG Therapeutics, Inc. (TGTX). A $10,000 investment in RIGL five years ago would be worth approximately $8K today (assuming dividends reinvested). Over 10 years, the gap is even starker: TGTX returned +261.2% versus RIGL's +53.0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — RIGL or TGTX?
By beta (market sensitivity over 5 years), TG Therapeutics, Inc. (TGTX) is the lower-risk stock at 0.43β versus Rigel Pharmaceuticals, Inc.'s 0.86β — meaning RIGL is approximately 98% more volatile than TGTX relative to the S&P 500. On balance sheet safety, TG Therapeutics, Inc. (TGTX) carries a lower debt/equity ratio of 114% versus 18% for Rigel Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.
05Which has better profit margins — RIGL or TGTX?
Rigel Pharmaceuticals, Inc. (RIGL) is the more profitable company, earning 9.8% net margin versus 7.1% for TG Therapeutics, Inc. — meaning it keeps 9.8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: RIGL leads at 13.5% versus 12.7% for TGTX. At the gross margin level — before operating expenses — RIGL leads at 89.6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is RIGL or TGTX more undervalued right now?
On forward earnings alone, Rigel Pharmaceuticals, Inc. (RIGL) trades at 8.8x forward P/E versus 19.4x for TG Therapeutics, Inc. — 10.6x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for TGTX: 64.5% to $49.50.
07Which pays a better dividend — RIGL or TGTX?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is RIGL or TGTX better for a retirement portfolio?
For long-horizon retirement investors, TG Therapeutics, Inc. (TGTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.43), +261.2% 10Y return). Both have compounded well over 10 years (TGTX: +261.2%, RIGL: +53.0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between RIGL and TGTX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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