Comprehensive Stock Comparison
Compare Seer, Inc. (SEER) vs Caris Life Sciences, Inc. (CAI) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  CAI | 97.0% revenue growth vs SEER's -8.1% |
| Quality / Margins | CAI | -66.2% net margin vs SEER's -486.0% |
| Stability / Safety |  SEER | Beta 0.52 vs CAI's 1.09 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | SEER | -9.3% vs CAI's -29.1% |
| Efficiency (ROA) | SEER | -25.7% ROA vs CAI's -47.8% |
Who Each Stock Is For
Income & stability
SEERbeta 0.52
Growth exposure
CAIRev growth 97.0%, EPS growth -19.3%, 3Y rev CAGR 46.5%
Long-term compounding (10Y)
CAI-29.1% 10Y total return vs SEER's -96.7%
Sleep-well-at-night portfolio
SEERLower volatility, beta 0.52, Low D/E 7.9%, current ratio 16.53x
Defensive / Recession hedge
SEERBeta 0.52, current ratio 16.53x
Business Model
What each company does and how it makes money
Seer is a life sciences company that develops and commercializes proteomics technology to analyze proteins for research and drug discovery. It generates revenue primarily from sales of its Proteograph Product Suite — an integrated system of consumables, automation instruments, and software — to academic institutions, biopharma companies, and research laboratories. The company's competitive advantage lies in its proprietary technology platform that enables deep, unbiased proteomic analysis at scale, which could accelerate biomarker discovery and therapeutic development.
Caris Life Sciences is an AI-powered molecular diagnostics company that provides comprehensive cancer profiling services to guide treatment decisions. It generates revenue primarily from molecular testing services for oncology patients — including tissue-based and blood-based profiling — along with pharmaceutical research services for drug development partners. The company's competitive advantage lies in its extensive molecular database and proprietary AI algorithms that analyze complex biomarker data to deliver personalized cancer treatment insights.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
CAI 3SEER 2CAI4/4 metricsSEER2/3 metricsCAI5/7 metricsCAI4/6 metricsSEER2/2 metricsCAI leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). SEER leads in 2 (Valuation Metrics, Risk & Volatility).
Financial Metrics (TTM)
CAI is the larger business by revenue, generating $812M annually — 49.7x SEER's $16M. Profitability is closely matched — net margins range from -66.2% (CAI) to -4.9% (SEER).
| Metric | SEERSeer, Inc. | CAICaris Life Scienc… |
|---|---|---|
| RevenueTrailing 12 months | $16M | $812M |
| EBITDAEarnings before interest/tax | -$76M | $70M |
| Net IncomeAfter-tax profit | -$79M | -$538M |
| Free Cash FlowCash after capex | -$46M | $33M |
| Gross MarginGross profit ÷ Revenue | +40.7% | +46.2% |
| Operating MarginEBIT ÷ Revenue | -5.2% | +5.6% |
| Net MarginNet income ÷ Revenue | -4.9% | -66.2% |
| FCF MarginFCF ÷ Revenue | -2.8% | +4.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | +4.5% | — |
| EPS Growth (YoY)Latest quarter vs prior year | +8.6% | — |
Valuation Metrics
| Metric | SEERSeer, Inc. | CAICaris Life Scienc… |
|---|---|---|
| Market CapShares × price | $103M | $33.2B |
| Enterprise ValueMkt cap + debt − cash | $88M | $32.4B |
| Trailing P/EPrice ÷ TTM EPS | -1.33x | -6.17x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 62.06x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | 718.40x |
| Price / SalesMarket cap ÷ Revenue | 7.40x | 40.89x |
| Price / BookPrice ÷ Book value/share | 0.35x | 57.52x |
| Price / FCFMarket cap ÷ FCF | — | 496.41x |
Profitability & Efficiency
SEER delivers a -29.2% return on equity — every $100 of shareholder capital generates $-29 in annual profit, vs $-93 for CAI. CAI carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to SEER's 0.08x. On the Piotroski fundamental quality scale (0–9), CAI scores 5/9 vs SEER's 4/9, reflecting solid financial health.
| Metric | SEERSeer, Inc. | CAICaris Life Scienc… |
|---|---|---|
| ROE (TTM)Return on equity | -29.2% | -93.2% |
| ROA (TTM)Return on assets | -25.7% | -47.8% |
| ROICReturn on invested capital | -21.3% | — |
| ROCEReturn on capital employed | -25.9% | +7.7% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 5 |
| Debt / EquityFinancial leverage | 0.08x | 0.00x |
| Net DebtTotal debt minus cash | -$15M | -$798M |
| Cash & Equiv.Liquid assets | $41M | $798M |
| Total DebtShort + long-term debt | $26M | $169,000 |
| Interest CoverageEBIT ÷ Interest expense | — | -2.23x |
Total Returns (with DRIP)
A $10,000 investment in CAI five years ago would be worth $7,093 today (with dividends reinvested), compared to $427 for SEER. Over the past 12 months, SEER leads with a -9.3% total return vs CAI's -29.1%. The 3-year compound annual growth rate (CAGR) favors CAI at -10.8% vs SEER's -28.2% — a key indicator of consistent wealth creation.
| Metric | SEERSeer, Inc. | CAICaris Life Scienc… |
|---|---|---|
| YTD ReturnYear-to-date | +1.6% | -26.4% |
| 1-Year ReturnPast 12 months | -9.3% | -29.1% |
| 3-Year ReturnCumulative with dividends | -62.9% | -29.1% |
| 5-Year ReturnCumulative with dividends | -95.7% | -29.1% |
| 10-Year ReturnCumulative with dividends | -96.7% | -29.1% |
| CAGR (3Y)Annualised 3-year return | -28.2% | -10.8% |
Risk & Volatility
SEER is the less volatile stock with a 0.52 beta — it tends to amplify market swings less than CAI's 1.09 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. SEER currently trades 76.8% from its 52-week high vs CAI's 46.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | SEERSeer, Inc. | CAICaris Life Scienc… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.52x | 1.09x |
| 52-Week HighHighest price in past year | $2.41 | $42.50 |
| 52-Week LowLowest price in past year | $1.62 | $17.15 |
| % of 52W HighCurrent price vs 52-week peak | +76.8% | +46.7% |
| RSI (14)Momentum oscillator 0–100 | 42.7 | 38.4 |
| Avg Volume (50D)Average daily shares traded | 239K | 2.3M |
Analyst Outlook
Wall Street rates SEER as "Hold" and CAI as "Buy".
| Metric | SEERSeer, Inc. | CAICaris Life Scienc… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Hold | Buy |
| Price TargetConsensus 12-month target | — | $31.33 |
| # AnalystsCovering analysts | 4 | 6 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 4 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +11.4% | +0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Seer, Inc. (SEER) | $0.00 | $14M | — |
| Caris Life Sciences… (CAI) | $294M | $812M | +175.9% |
Caris Life Sciences, Inc.'s revenue grew from $294M (2016) to $812M (2025) — a 11.9% CAGR.
Chart 2Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Seer, Inc. (SEER) | -138.3% | -6.2% | +95.5% |
| Caris Life Sciences… (CAI) | 2.0% | -66.2% | -3351.8% |
Caris Life Sciences, Inc.'s net margin went from 2% (2016) to -66% (2025).
Chart 3EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Seer, Inc. (SEER) | -0.29 | -1.39 | -379.3% |
| Caris Life Sciences… (CAI) | 0.31 | -3.22 | -1138.7% |
Caris Life Sciences, Inc.'s EPS grew from $0.31 (2016) to $-3.22 (2025) — a NaN% CAGR.
Chart 4Free Cash Flow — 5 Years
Seer, Inc. generated $-50M FCF in 2024 (+7% vs 2021). Caris Life Sciences, Inc. generated $67M FCF in 2025 (+120% vs 2022).
SEER vs CAI: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is SEER or CAI a better buy right now?
Analysts rate Caris Life Sciences, Inc. (CAI) a "Buy" — based on 6 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — SEER or CAI?
Over the past 5 years, Caris Life Sciences, Inc. (CAI) delivered a total return of -29.1%, compared to -95.7% for Seer, Inc. (SEER). A $10,000 investment in CAI five years ago would be worth approximately $7K today (assuming dividends reinvested). Over 10 years, the gap is even starker: CAI returned -29.1% versus SEER's -96.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — SEER or CAI?
By beta (market sensitivity over 5 years), Seer, Inc. (SEER) is the lower-risk stock at 0.52β versus Caris Life Sciences, Inc.'s 1.09β — meaning CAI is approximately 110% more volatile than SEER relative to the S&P 500. On balance sheet safety, Caris Life Sciences, Inc. (CAI) carries a lower debt/equity ratio of 0% versus 8% for Seer, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — SEER or CAI?
Caris Life Sciences, Inc. (CAI) is the more profitable company, earning -66.2% net margin versus -620.9% for Seer, Inc. — meaning it keeps -66.2% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: CAI leads at 5.6% versus -717.7% for SEER. At the gross margin level — before operating expenses — SEER leads at 49.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — SEER or CAI?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is SEER or CAI better for a retirement portfolio?
For long-horizon retirement investors, Seer, Inc. (SEER) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.52)). Both have compounded well over 10 years (SEER: -96.7%, CAI: -29.1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between SEER and CAI?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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