Comprehensive Stock Comparison
Compare Sutro Biopharma, Inc. (STRO) vs ImmunityBio, Inc. (IBRX) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | IBRX | 22.7% revenue growth vs STRO's -59.6% |
| Quality / Margins | STRO | -205.2% net margin vs IBRX's -422.3% |
| Stability / Safety | STRO | Beta 1.22 vs IBRX's 1.39 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | STRO | +11.9% vs IBRX's +197.3% |
| Efficiency (ROA) | IBRX | -93.2% ROA vs STRO's -103.4% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Sutro Biopharma is a clinical-stage biotechnology company developing protein therapeutics — primarily antibody-drug conjugates — for cancer and autoimmune disorders using its proprietary cell-free manufacturing platform. It generates revenue through strategic collaborations and licensing deals with pharmaceutical partners like Merck and Celgene, which provide upfront payments, milestone fees, and potential future royalties on commercialized products. The company's key competitive advantage is its XpressCF+ platform, which enables precise engineering of complex protein therapeutics with site-specific modifications that are difficult to achieve with traditional cell-based systems.
ImmunityBio is a clinical-stage biotechnology company developing immunotherapies and vaccines for cancers and infectious diseases. It generates revenue primarily through research collaborations and licensing agreements — though as a pre-commercial biotech, it currently relies heavily on equity financing and grants to fund its clinical trials. The company's competitive advantage lies in its integrated immunotherapy platform that combines multiple immune system activation approaches — including antibody cytokine fusion proteins, natural killer cells, and T-cell therapies — which could potentially create synergistic treatment effects.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
STRO leads in 2 of 6 categories (Financial Metrics, Risk & Volatility). IBRX leads in 1 (Total Returns). 2 tied.
Financial Metrics (TTM)
STRO and IBRX operate at a comparable scale, with $106M and $83M in trailing revenue. Profitability is closely matched — net margins range from -2.1% (STRO) to -4.2% (IBRX). On growth, IBRX holds the edge at +4.3% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | STROSutro Biopharma, … | IBRXImmunityBio, Inc. |
|---|---|---|
| RevenueTrailing 12 months | $106M | $83M |
| EBITDAEarnings before interest/tax | -$178M | -$245M |
| Net IncomeAfter-tax profit | -$217M | -$349M |
| Free Cash FlowCash after capex | -$225M | -$324M |
| Gross MarginGross profit ÷ Revenue | +100.0% | +94.8% |
| Operating MarginEBIT ÷ Revenue | -175.7% | -3.2% |
| Net MarginNet income ÷ Revenue | -2.1% | -4.2% |
| FCF MarginFCF ÷ Revenue | -2.1% | -3.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | +13.8% | +4.3% |
| EPS Growth (YoY)Latest quarter vs prior year | -13.6% | +40.8% |
Valuation Metrics
| Metric | STROSutro Biopharma, … | IBRXImmunityBio, Inc. |
|---|---|---|
| Market CapShares × price | $1.7B | $9.6B |
| Enterprise ValueMkt cap + debt − cash | $1.8B | $10.0B |
| Trailing P/EPrice ÷ TTM EPS | -6.92x | -15.77x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 28.08x | 653.30x |
| Price / BookPrice ÷ Book value/share | 35.26x | — |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
On the Piotroski fundamental quality scale (0–9), IBRX scores 4/9 vs STRO's 1/9, reflecting mixed financial health.
| Metric | STROSutro Biopharma, … | IBRXImmunityBio, Inc. |
|---|---|---|
| ROE (TTM)Return on equity | -2.3% | — |
| ROA (TTM)Return on assets | -103.4% | -93.2% |
| ROICReturn on invested capital | -2.1% | — |
| ROCEReturn on capital employed | -75.4% | -88.9% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 4 |
| Debt / EquityFinancial leverage | 4.57x | — |
| Net DebtTotal debt minus cash | $14M | $361M |
| Cash & Equiv.Liquid assets | $190M | $143M |
| Total DebtShort + long-term debt | $204M | $504M |
| Interest CoverageEBIT ÷ Interest expense | -3.96x | -2.48x |
Total Returns (with DRIP)
A $10,000 investment in STRO five years ago would be worth $8,900 today (with dividends reinvested), compared to $2,937 for IBRX. Over the past 12 months, STRO leads with a +1187.4% total return vs IBRX's +197.3%. The 3-year compound annual growth rate (CAGR) favors IBRX at 58.8% vs STRO's 53.7% — a key indicator of consistent wealth creation.
| Metric | STROSutro Biopharma, … | IBRXImmunityBio, Inc. |
|---|---|---|
| YTD ReturnYear-to-date | +86.8% | +384.2% |
| 1-Year ReturnPast 12 months | +1187.4% | +197.3% |
| 3-Year ReturnCumulative with dividends | +262.9% | +300.8% |
| 5-Year ReturnCumulative with dividends | -11.0% | -70.6% |
| 10-Year ReturnCumulative with dividends | +34.7% | +42.2% |
| CAGR (3Y)Annualised 3-year return | +53.7% | +58.8% |
Risk & Volatility
STRO is the less volatile stock with a 1.22 beta — it tends to amplify market swings less than IBRX's 1.39 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. STRO currently trades 97.8% from its 52-week high vs IBRX's 78.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | STROSutro Biopharma, … | IBRXImmunityBio, Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.22x | 1.39x |
| 52-Week HighHighest price in past year | $20.93 | $12.43 |
| 52-Week LowLowest price in past year | $0.52 | $1.83 |
| % of 52W HighCurrent price vs 52-week peak | +97.8% | +78.7% |
| RSI (14)Momentum oscillator 0–100 | 72.3 | 65.0 |
| Avg Volume (50D)Average daily shares traded | 109K | 32.7M |
Analyst Outlook
Wall Street rates STRO as "Buy" and IBRX as "Buy". Consensus price targets imply 12.5% upside for IBRX (target: $11) vs -51.8% for STRO (target: $10).
| Metric | STROSutro Biopharma, … | IBRXImmunityBio, Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $9.86 | $11.00 |
| # AnalystsCovering analysts | 19 | 5 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Sutro Biopharma, In… (STRO) | 100 | 156.31 | +56.3% |
| ImmunityBio, Inc. (IBRX) | 100 | 120.2 | +20.2% |
Sutro Biopharma, In… (STRO) returned -11% over 5 years vs ImmunityBio, Inc. (IBRX)'s -71%.
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Sutro Biopharma, In… (STRO) | $60M | $62M | +3.9% |
| ImmunityBio, Inc. (IBRX) | $236000.00 | $15M | +6147.9% |
ImmunityBio, Inc.'s revenue grew from $0M (2015) to $15M (2024) — a 58.3% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Sutro Biopharma, In… (STRO) | 2.8% | -3.7% | -228.7% |
| ImmunityBio, Inc. (IBRX) | -1003.7% | -28.0% | +97.2% |
ImmunityBio, Inc.'s net margin went from -1004% (2015) to -28% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Sutro Biopharma, In… (STRO) | 3.86 | -2.96 | -176.7% |
| ImmunityBio, Inc. (IBRX) | -0.73 | -0.62 | +15.1% |
ImmunityBio, Inc.'s EPS grew from $-0.73 (2015) to $-0.62 (2024).
Chart 5Free Cash Flow — 5 Years
Sutro Biopharma, Inc. generated $-195M FCF in 2024 (-101% vs 2021). ImmunityBio, Inc. generated $-398M FCF in 2024 (-29% vs 2021).
STRO vs IBRX: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is STRO or IBRX a better buy right now?
Analysts rate Sutro Biopharma, Inc. (STRO) a "Buy" — based on 19 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — STRO or IBRX?
Over the past 5 years, Sutro Biopharma, Inc. (STRO) delivered a total return of -11.0%, compared to -70.6% for ImmunityBio, Inc. (IBRX). A $10,000 investment in STRO five years ago would be worth approximately $9K today (assuming dividends reinvested). Over 10 years, the gap is even starker: IBRX returned +42.2% versus STRO's +34.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — STRO or IBRX?
By beta (market sensitivity over 5 years), Sutro Biopharma, Inc. (STRO) is the lower-risk stock at 1.22β versus ImmunityBio, Inc.'s 1.39β — meaning IBRX is approximately 15% more volatile than STRO relative to the S&P 500.
04Which has better profit margins — STRO or IBRX?
Sutro Biopharma, Inc. (STRO) is the more profitable company, earning -366.6% net margin versus -28.0% for ImmunityBio, Inc. — meaning it keeps -366.6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: STRO leads at -384.3% versus -23.3% for IBRX. At the gross margin level — before operating expenses — IBRX leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — STRO or IBRX?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is STRO or IBRX better for a retirement portfolio?
For long-horizon retirement investors, Sutro Biopharma, Inc. (STRO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.22)). Both have compounded well over 10 years (STRO: +34.7%, IBRX: +42.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between STRO and IBRX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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