Comprehensive Stock Comparison
Compare Veracyte, Inc. (VCYT) vs Seer, Inc. (SEER) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
Selected Stocks
Add up to 10 tickers. Use presets or search to get started.
Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  VCYT | 16.0% revenue growth vs SEER's -8.1% |
| Quality / Margins | VCYT | 12.8% net margin vs SEER's -486.0% |
| Stability / Safety |  SEER | Beta 0.52 vs VCYT's 1.12 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | VCYT | +10.0% vs SEER's -9.3% |
| Efficiency (ROA) | VCYT | 4.7% ROA vs SEER's -25.7%, ROIC 4.4% vs -21.3% |
Who Each Stock Is For
Income & stability
SEERbeta 0.52
Growth exposure
VCYTRev growth 16.0%, EPS growth 164.5%, 3Y rev CAGR 20.4%
Long-term compounding (10Y)
VCYT443.8% 10Y total return vs SEER's -96.7%
Sleep-well-at-night portfolio
SEERLower volatility, beta 0.52, Low D/E 7.9%, current ratio 16.53x
Defensive / Recession hedge
SEERBeta 0.52, current ratio 16.53x
Business Model
What each company does and how it makes money
Veracyte is a molecular diagnostics company that develops genomic tests to improve cancer and other disease diagnosis and treatment decisions. It generates revenue primarily from diagnostic test sales — including its Afirma thyroid, Decipher prostate, and Percepta lung cancer tests — with additional income from technology licensing partnerships. The company's competitive advantage lies in its proprietary genomic classifiers and biobank of clinical samples that enable development of clinically validated tests with strong physician adoption.
Seer is a life sciences company that develops and commercializes proteomics technology to analyze proteins for research and drug discovery. It generates revenue primarily from sales of its Proteograph Product Suite — an integrated system of consumables, automation instruments, and software — to academic institutions, biopharma companies, and research laboratories. The company's competitive advantage lies in its proprietary technology platform that enables deep, unbiased proteomic analysis at scale, which could accelerate biomarker discovery and therapeutic development.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
VCYT 3SEER 2VCYT6/6 metricsSEER2/3 metricsVCYT7/8 metricsVCYT5/6 metricsSEER2/2 metricsVCYT leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). SEER leads in 2 (Valuation Metrics, Risk & Volatility).
Financial Metrics (TTM)
VCYT is the larger business by revenue, generating $517M annually — 31.7x SEER's $16M. VCYT is the more profitable business, keeping 12.8% of every revenue dollar as net income compared to SEER's -4.9%. On growth, VCYT holds the edge at +18.5% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | VCYTVeracyte, Inc. | SEERSeer, Inc. |
|---|---|---|
| RevenueTrailing 12 months | $517M | $16M |
| EBITDAEarnings before interest/tax | $74M | -$76M |
| Net IncomeAfter-tax profit | $66M | -$79M |
| Free Cash FlowCash after capex | $126M | -$46M |
| Gross MarginGross profit ÷ Revenue | +70.1% | +40.7% |
| Operating MarginEBIT ÷ Revenue | +11.2% | -5.2% |
| Net MarginNet income ÷ Revenue | +12.8% | -4.9% |
| FCF MarginFCF ÷ Revenue | +24.4% | -2.8% |
| Rev. Growth (YoY)Latest quarter vs prior year | +18.5% | +4.5% |
| EPS Growth (YoY)Latest quarter vs prior year | +7.3% | +8.6% |
Valuation Metrics
| Metric | VCYTVeracyte, Inc. | SEERSeer, Inc. |
|---|---|---|
| Market CapShares × price | $2.9B | $103M |
| Enterprise ValueMkt cap + debt − cash | $2.6B | $88M |
| Trailing P/EPrice ÷ TTM EPS | 44.23x | -1.33x |
| Forward P/EPrice ÷ next-FY EPS est. | 22.03x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 44.23x | — |
| Price / SalesMarket cap ÷ Revenue | 5.57x | 7.40x |
| Price / BookPrice ÷ Book value/share | 2.23x | 0.35x |
| Price / FCFMarket cap ÷ FCF | 22.73x | — |
Profitability & Efficiency
VCYT delivers a 5.1% return on equity — every $100 of shareholder capital generates $5 in annual profit, vs $-29 for SEER. VCYT carries lower financial leverage with a 0.03x debt-to-equity ratio, signaling a more conservative balance sheet compared to SEER's 0.08x. On the Piotroski fundamental quality scale (0–9), VCYT scores 8/9 vs SEER's 4/9, reflecting strong financial health.
| Metric | VCYTVeracyte, Inc. | SEERSeer, Inc. |
|---|---|---|
| ROE (TTM)Return on equity | +5.1% | -29.2% |
| ROA (TTM)Return on assets | +4.7% | -25.7% |
| ROICReturn on invested capital | +4.4% | -21.3% |
| ROCEReturn on capital employed | +4.5% | -25.9% |
| Piotroski ScoreFundamental quality 0–9 | 8 | 4 |
| Debt / EquityFinancial leverage | 0.03x | 0.08x |
| Net DebtTotal debt minus cash | -$323M | -$15M |
| Cash & Equiv.Liquid assets | $363M | $41M |
| Total DebtShort + long-term debt | $40M | $26M |
| Interest CoverageEBIT ÷ Interest expense | — | — |
Total Returns (with DRIP)
A $10,000 investment in VCYT five years ago would be worth $7,634 today (with dividends reinvested), compared to $427 for SEER. Over the past 12 months, VCYT leads with a +10.0% total return vs SEER's -9.3%. The 3-year compound annual growth rate (CAGR) favors VCYT at 15.2% vs SEER's -28.2% — a key indicator of consistent wealth creation.
| Metric | VCYTVeracyte, Inc. | SEERSeer, Inc. |
|---|---|---|
| YTD ReturnYear-to-date | -14.4% | +1.6% |
| 1-Year ReturnPast 12 months | +10.0% | -9.3% |
| 3-Year ReturnCumulative with dividends | +52.8% | -62.9% |
| 5-Year ReturnCumulative with dividends | -23.7% | -95.7% |
| 10-Year ReturnCumulative with dividends | +443.8% | -96.7% |
| CAGR (3Y)Annualised 3-year return | +15.2% | -28.2% |
Risk & Volatility
SEER is the less volatile stock with a 0.52 beta — it tends to amplify market swings less than VCYT's 1.12 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. SEER currently trades 76.8% from its 52-week high vs VCYT's 71.5% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | VCYTVeracyte, Inc. | SEERSeer, Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.12x | 0.52x |
| 52-Week HighHighest price in past year | $50.71 | $2.41 |
| 52-Week LowLowest price in past year | $22.61 | $1.62 |
| % of 52W HighCurrent price vs 52-week peak | +71.5% | +76.8% |
| RSI (14)Momentum oscillator 0–100 | 39.9 | 42.7 |
| Avg Volume (50D)Average daily shares traded | 807K | 239K |
Analyst Outlook
Wall Street rates VCYT as "Buy" and SEER as "Hold".
| Metric | VCYTVeracyte, Inc. | SEERSeer, Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Hold |
| Price TargetConsensus 12-month target | $47.25 | — |
| # AnalystsCovering analysts | 20 | 4 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +11.4% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Jan 21 | Mar 26 | Change |
|---|---|---|---|
| Veracyte, Inc. (VCYT) | 100 | 76.07 | -23.9% |
| Seer, Inc. (SEER) | 95.66 | 3.06 | -96.8% |
Veracyte, Inc. (VCYT) returned -24% over 5 years vs Seer, Inc. (SEER)'s -96%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Veracyte, Inc. (VCYT) | $65M | $517M | +694.6% |
| Seer, Inc. (SEER) | $0.00 | $14M | — |
Veracyte, Inc.'s revenue grew from $65M (2016) to $517M (2025) — a 25.9% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Veracyte, Inc. (VCYT) | -48.2% | 12.8% | +126.6% |
| Seer, Inc. (SEER) | -138.3% | -6.2% | +95.5% |
Veracyte, Inc.'s net margin went from -48% (2016) to 13% (2025).
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Veracyte, Inc. (VCYT) | -1.09 | 0.82 | +175.2% |
| Seer, Inc. (SEER) | -0.29 | -1.39 | -379.3% |
Veracyte, Inc.'s EPS grew from $-1.09 (2016) to $0.82 (2025).
Chart 5Free Cash Flow — 5 Years
Veracyte, Inc. generated $127M FCF in 2025 (+442% vs 2021). Seer, Inc. generated $-50M FCF in 2024 (+7% vs 2021).
VCYT vs SEER: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is VCYT or SEER a better buy right now?
Veracyte, Inc. (VCYT) offers the better valuation at 44.2x trailing P/E (22.0x forward), making it the more compelling value choice. Analysts rate Veracyte, Inc. (VCYT) a "Buy" — based on 20 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — VCYT or SEER?
Over the past 5 years, Veracyte, Inc. (VCYT) delivered a total return of -23.7%, compared to -95.7% for Seer, Inc. (SEER). A $10,000 investment in VCYT five years ago would be worth approximately $8K today (assuming dividends reinvested). Over 10 years, the gap is even starker: VCYT returned +443.8% versus SEER's -96.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — VCYT or SEER?
By beta (market sensitivity over 5 years), Seer, Inc. (SEER) is the lower-risk stock at 0.52β versus Veracyte, Inc.'s 1.12β — meaning VCYT is approximately 116% more volatile than SEER relative to the S&P 500. On balance sheet safety, Veracyte, Inc. (VCYT) carries a lower debt/equity ratio of 3% versus 8% for Seer, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — VCYT or SEER?
Veracyte, Inc. (VCYT) is the more profitable company, earning 12.8% net margin versus -620.9% for Seer, Inc. — meaning it keeps 12.8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: VCYT leads at 11.2% versus -717.7% for SEER. At the gross margin level — before operating expenses — VCYT leads at 70.1%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — VCYT or SEER?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is VCYT or SEER better for a retirement portfolio?
For long-horizon retirement investors, Seer, Inc. (SEER) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.52)). Both have compounded well over 10 years (SEER: -96.7%, VCYT: +443.8%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between VCYT and SEER?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
Find Stocks Like These
Explore pre-built screens for each stock's profile, or build a custom screen to find stocks that beat both.