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Annexon, Inc. (ANNX) 10-Year Financial Performance & Capital Metrics

ANNX • • Industrial / General
HealthcareBiotechnologyAutoimmune & Inflammatory DiseasesDermatology & Autoimmune
AboutAnnexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops therapeutics for autoimmune, neurodegenerative, and ophthalmic disorders. The company's C1q is an initiating molecule of the classical complement pathway that targets distinct disease processes, such as antibody-mediated autoimmune disease and complement-mediated neurodegeneration. Its product candidates include ANX005, a monoclonal antibody, which is in Phase II/III clinical trials to treat patients with guillain- barré syndrome; Phase II trial in patients with warm autoimmune hemolytic anemia; and Phase II clinical trial for Huntington's disease and amyotrophic lateral sclerosis. The company is also developing ANX009 that is in Phase Ib trial in patients with lupus nephritis; and ANX007, which is in Phase II clinical trials to treat patients with geographic atrophy. In addition, it develops ANX105, an investigational monoclonal antibody targeting neurodegenerative indications; and ANX1502, an investigational oral small molecule for the treatment of certain autoimmune indications. The company was incorporated in 2011 and is headquartered in Brisbane, California.Show more
  • Revenue $0
  • EBITDA -$151M -6.4%
  • Net Income -$138M -3.0%
  • EPS (Diluted) -1.01 +42.9%
  • Gross Margin -
  • EBITDA Margin -
  • Operating Margin -
  • Net Margin -
  • ROE -50.84% +8.8%
  • ROIC -70.17% +41.1%
  • Debt/Equity 0.10 -21.0%
  • Interest Coverage -
Technical Analysis

Key Insights

Based on financial data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Momentum leader: RS Rating 96 (top 4%)

✗Weaknesses

  • ✗Weak Piotroski F-Score: 3/9
  • ✗Shares diluted 81.6% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

Price & Volume

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Growth Metrics

Revenue CAGR

10Y-
5Y-
3Y-
TTM-

Profit (Net Income) CAGR

10Y-
5Y-
3Y-
TTM-76.19%

EPS CAGR

10Y-
5Y-
3Y-
TTM-34.29%

ROCE

10Y Avg-100.22%
5Y Avg-46.98%
3Y Avg-53.18%
Latest-51.42%

Peer Comparison

Dermatology & Autoimmune
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Sector-Specific
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AUPHAurinia Pharmaceuticals Inc.1.96B14.87378.3733.97%29.28%21.28%2.25%0.21
ARGXargenx SE50.33B813.2463.6378.6%23.34%15.14%0.01
INVAInnoviva, Inc.1.48B19.7654.8915.54%32.78%12.61%12.75%0.65
GLPGGalapagos N.V.2.24B34.0330.3814.99%-151.94%-15.16%0.00
PTGXProtagonist Therapeutics, Inc.5.3B84.7520.046.24%21.94%7.11%3.45%0.02
ALMSAlumis Inc. Common Stock2.84B24.17-2.33-11.08%-63.71%0.12
PHATPhathom Pharmaceuticals, Inc.1.17B14.98-2.8380.01%-186.53%
ORKAOruka Therapeutics, Inc.1.57B32.50-6.51-22.44%0.00

Profit & Loss

Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Sales/Revenue+00000000
Revenue Growth %--------
Cost of Goods Sold+271K488K000003.45M
COGS % of Revenue--------
Gross Profit+-271K-488K00000-3.45M
Gross Margin %--------
Gross Profit Growth %--0.8%1%-----
Operating Expenses+20.21M19.15M32.52M63.47M130.71M145.6M143.72M150.62M
OpEx % of Revenue--------
Selling, General & Admin2.35M3.62M7.99M14.2M30.65M30.95M28.02M34.63M
SG&A % of Revenue--------
Research & Development17.85M15.53M24.52M49.27M100.07M112.5M113.76M119.45M
R&D % of Revenue--------
Other Operating Expenses0844K0002.15M1.95M-3.45M
Operating Income+-20.48M-19.15M-32.52M-63.47M-130.71M-145.6M-143.72M-154.07M
Operating Margin %--------
Operating Income Growth %-0.06%-0.7%-0.95%-1.06%-0.11%0.01%-0.07%
EBITDA+-20.21M-18.66M-32.02M-62.8M-128.57M-143.45M-141.57M-150.62M
EBITDA Margin %--------
EBITDA Growth %-0.08%-0.72%-0.96%-1.05%-0.12%0.01%-0.06%
D&A (Non-Cash Add-back)271K488K493K667K2.14M2.15M2.15M3.45M
EBIT-20.48M-19.15M-32.52M-63.47M-130.71M-145.6M-143.72M-138.2M
Net Interest Income+000003.65M9.49M0
Interest Income370K00003.65M9.49M0
Interest Expense00000000
Other Income/Expense1.77M844K-4.66M57K390K3.65M9.49M15.87M
Pretax Income+-18.71M-18.3M-37.18M-63.41M-130.32M-141.95M-134.24M-138.2M
Pretax Margin %--------
Income Tax+1K1K4K00000
Effective Tax Rate %1%1%1%1%1%1%1%1%
Net Income+-18.71M-18.3M-37.18M-63.41M-130.32M-141.95M-134.24M-138.2M
Net Margin %--------
Net Income Growth %-0.02%-1.03%-0.71%-1.06%-0.09%0.05%-0.03%
Net Income (Continuing)-18.71M-18.3M-37.18M-63.41M-130.32M-141.95M-134.24M-138.2M
Discontinued Operations00000000
Minority Interest00000000
EPS (Diluted)+-0.49-1.60-0.97-3.70-3.34-2.60-1.77-1.01
EPS Growth %--2.27%0.39%-2.81%0.1%0.22%0.32%0.43%
EPS (Basic)-0.49-1.60-0.97-3.70-3.34-2.60-1.77-1.01
Diluted Shares Outstanding38.22M11.45M38.22M16.96M38.32M54.67M75.67M137.4M
Basic Shares Outstanding38.22M11.45M38.22M16.96M38.32M54.67M75.67M137.4M
Dividend Payout Ratio--------

Balance Sheet

Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Total Current Assets+4.89M45.71M45.41M354.01M247.69M248.1M263.86M316.46M
Cash & Short-Term Investments2.97M44.17M43.93M351.21M242.72M242.66M259.72M312.02M
Cash Only2.97M44.17M43.93M268.56M74.84M140.02M225.11M49.5M
Short-Term Investments00082.64M167.87M102.64M34.61M262.52M
Accounts Receivable582K225K79K3K0000
Days Sales Outstanding--------
Inventory00000000
Days Inventory Outstanding--------
Other Current Assets0000463K203K63K1.1M
Total Non-Current Assets+2.93M2.44M4.49M1.94M39.35M37M33.81M33.61M
Property, Plant & Equipment2.82M2.35M2.14M1.94M38.18M35.97M32.78M29.34M
Fixed Asset Turnover--------
Goodwill00000000
Intangible Assets00000000
Long-Term Investments000001.03M00
Other Non-Current Assets112K98K2.35M01.17M01.03M4.27M
Total Assets+7.82M48.15M49.9M355.95M287.04M285.1M297.67M350.07M
Asset Turnover--------
Asset Growth %-5.16%0.04%6.13%-0.19%-0.01%0.04%0.18%
Total Current Liabilities+2.92M3.33M4.93M10.62M21.74M22.36M17.93M30.51M
Accounts Payable1.52M1.27M2.37M3.73M11.15M7.42M5.49M10.43M
Days Payables Outstanding2.05K950.65-----1.1K
Short-Term Debt00000000
Deferred Revenue (Current)00000000
Other Current Liabilities971K342K366K2.93M2.06M180K5.65M5.97M
Current Ratio1.68x13.74x9.21x33.33x11.39x11.10x14.72x10.37x
Quick Ratio1.68x13.74x9.21x33.33x11.39x11.10x14.72x10.37x
Cash Conversion Cycle--------
Total Non-Current Liabilities+51.12M6.94M1.44M1.05M33.39M31.54M29.19M26.45M
Long-Term Debt0107.22M000000
Capital Lease Obligations000033.39M31.54M29.19M26.45M
Deferred Tax Liabilities00000000
Other Non-Current Liabilities51.12M-100.28M1.44M1.05M0000
Total Liabilities54.03M10.27M6.37M11.67M55.13M53.9M47.12M56.97M
Total Debt+48.97M107.22M0034.59M32.86M31.36M28.97M
Net Debt46.01M63.05M-43.93M-268.56M-40.25M-107.16M-193.75M-20.53M
Debt / Equity-2.83x--0.15x0.14x0.13x0.10x
Debt / EBITDA--------
Net Debt / EBITDA--------
Interest Coverage--------
Total Equity+-46.21M37.88M43.53M344.28M231.91M231.19M250.56M293.11M
Equity Growth %-1.82%0.15%6.91%-0.33%-0%0.08%0.17%
Book Value per Share-1.213.311.1420.306.054.233.312.13
Total Shareholders' Equity-46.21M37.88M43.53M344.28M231.91M231.19M250.56M293.11M
Common Stock3K4K4K38K39K48K78K109K
Retained Earnings-47.09M-65.4M-102.58M-165.99M-296.31M-438.26M-572.5M-710.7M
Treasury Stock-905K0000000
Accumulated OCI-26K-66K-80K-77K-180K-372K-52K10K
Minority Interest00000000

Cash Flow

Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Cash from Operations+-19.26M-17.19M-28.36M-53.09M-106.11M-116.31M-121.14M-118.01M
Operating CF Margin %--------
Operating CF Growth %-0.11%-0.65%-0.87%-1%-0.1%-0.04%0.03%
Net Income-18.71M-18.3M-37.18M-63.41M-130.32M-141.95M-134.24M-138.2M
Depreciation & Amortization271K488K493K667K3.41M2.11M2.15M2.15M
Stock-Based Compensation401K408K2.04M4.89M018.52M18.18M19.43M
Deferred Taxes00000000
Other Non-Cash Items799K-260K5.67M53K17.52M1.28M-1.43M-7.75M
Working Capital Changes-1.22M478K625K4.72M3.28M3.74M-5.8M6.36M
Change in Receivables00000000
Change in Inventory00000000
Change in Payables144K-253K931K1.51M3.86M-287K-2.08M4.94M
Cash from Investing+-567K-17K-267K-83.16M-88.24M58.44M70.7M-218.8M
Capital Expenditures-567K-17K-267K-464K-1.65M-6.53M-193K-15K
CapEx % of Revenue--------
Acquisitions--------
Investments--------
Other Investing000-82.7K064.97K00
Cash from Financing+42K58.46M28.39M360.88M1.79M122.91M135.52M161.21M
Debt Issued (Net)--------
Equity Issued (Net)--------
Dividends Paid000-6.22M0000
Share Repurchases--------
Other Financing42K121K-1.6M3.27M0-7.57M14K-665K
Net Change in Cash--------
Free Cash Flow+-19.83M-17.21M-28.63M-53.55M-107.76M-122.83M-121.33M-118.02M
FCF Margin %--------
FCF Growth %-0.13%-0.66%-0.87%-1.01%-0.14%0.01%0.03%
FCF per Share-0.52-1.50-0.75-3.16-2.81-2.25-1.60-0.86
FCF Conversion (FCF/Net Income)1.03x0.94x0.76x0.84x0.81x0.82x0.90x0.85x
Interest Paid00000000
Taxes Paid01K2K00004.89M

Key Ratios

Metric20172018201920202021202220232024
Return on Equity (ROE)--48.32%-91.35%-32.7%-45.24%-61.3%-55.73%-50.84%
Return on Invested Capital (ROIC)--28.51%-48.52%-126.41%-73.33%-69.18%-119.22%-70.17%
Debt / Equity-2.83x--0.15x0.14x0.13x0.10x
FCF Conversion1.03x0.94x0.76x0.84x0.81x0.82x0.90x0.85x

Frequently Asked Questions

Growth & Financials

Annexon, Inc. (ANNX) grew revenue by 0.0% over the past year. Growth has been modest.

Annexon, Inc. (ANNX) reported a net loss of $207.0M for fiscal year 2024.

Dividend & Returns

Annexon, Inc. (ANNX) has a return on equity (ROE) of -50.8%. Negative ROE indicates the company is unprofitable.

Annexon, Inc. (ANNX) had negative free cash flow of $176.6M in fiscal year 2024, likely due to heavy capital investments.

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