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Tiziana Life Sciences Ltd (TLSA) 10-Year Financial Performance & Capital Metrics

TLSA • • Industrial / General
HealthcareBiotechnologyAutoimmune & Inflammatory DiseasesDermatology & Autoimmune
AboutTiziana Life Sciences Ltd, a biotechnology company, focuses on the discovery and development of molecules to treat human diseases in oncology and immunology. The company's lead product candidate in immunology is Foralumab (TZLS-401), a human anti-CD3 monoclonal antibody (mAb) for the treatment of Crohn's, graft versus host, ulcerative colitis, multiple sclerosis, type-1 diabetes, inflammatory bowel, psoriasis, and rheumatoid arthritis diseases. It also develops Milciclib (TZLS-201), a small molecule inhibitor of various cyclin-dependent kinases, tropomycin receptor kinases, and Src family kinases controlling cell growth and malignant progression of cancer; and anti-Interleukin 6 receptor (IL6R) mAb (TZLS-501), a fully human monoclonal antibody for the treatment of IL6-induced inflammation and to treat COVID-19 patients. The company was incorporated in 1998 and is headquatered in London, the United Kingdom.Show more
  • Revenue $0
  • EBITDA -$16M +12.4%
  • Net Income -$12M +32.9%
  • EPS (Diluted) -0.22 +35.3%
  • Gross Margin -
  • EBITDA Margin -
  • Operating Margin -
  • Net Margin -
  • ROE -250.49% -77.7%
  • ROIC -481.72% -14.5%
  • Debt/Equity 0.03 -39.6%
  • Interest Coverage -2632.33 -46.4%
Technical Analysis

Key Insights

Based on financial data analysis

✓Strengths

  • ✓Company is almost debt free

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Weak momentum: RS Rating 17 (bottom 17%)
  • ✗Low quality earnings: Net income not backed by cash flow
  • ✗Trading more than 30% below 52-week high
  • ✗Expensive at 19.6x book value
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

Price & Volume

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Growth Metrics

Revenue CAGR

10Y-
5Y-
3Y-
TTM-

Profit (Net Income) CAGR

10Y-
5Y-
3Y-
TTM-56.61%

EPS CAGR

10Y-
5Y-
3Y-
TTM-70.78%

ROCE

10Y Avg-431.28%
5Y Avg-133.31%
3Y Avg-172.91%
Latest-329.69%

Peer Comparison

Dermatology & Autoimmune
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Sector-Specific
NameMarket CapCurrent PriceP/E RatioRevenue Growth 1YNet MarginROEFCF YieldDebt/Equity
AUPHAurinia Pharmaceuticals Inc.1.96B14.87378.3733.97%29.28%21.28%2.25%0.21
ARGXargenx SE50.33B813.2463.6378.6%23.34%15.14%0.01
INVAInnoviva, Inc.1.48B19.7654.8915.54%32.78%12.61%12.75%0.65
GLPGGalapagos N.V.2.24B34.0330.3814.99%-151.94%-15.16%0.00
PTGXProtagonist Therapeutics, Inc.5.3B84.7520.046.24%21.94%7.11%3.45%0.02
ALMSAlumis Inc. Common Stock2.84B24.17-2.33-11.08%-63.71%0.12
PHATPhathom Pharmaceuticals, Inc.1.17B14.98-2.8380.01%-186.53%
ORKAOruka Therapeutics, Inc.1.57B32.50-6.51-22.44%0.00

Profit & Loss

Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Sales/Revenue+0000000000
Revenue Growth %----------
Cost of Goods Sold+0000000000
COGS % of Revenue----------
Gross Profit+0000000000
Gross Margin %----------
Gross Profit Growth %----------
Operating Expenses+8.61M7.29M8.25M7.82M7.77M28.03M27.37M14.59M17.98M15.79M
OpEx % of Revenue----------
Selling, General & Admin0000013.21M855K000
SG&A % of Revenue----------
Research & Development6.29M2.96M4.67M4.34M2.91M5.99M13.21M12.96M8.11M5.23M
R&D % of Revenue----------
Other Operating Expenses2.33M4.33M3.57M3.48M4.86M8.82M13.31M1.63M9.87M10.56M
Operating Income+-8.61M-7.29M-8.25M-7.82M-7.77M-28.03M-27.37M-14.59M-17.98M-15.79M
Operating Margin %----------
Operating Income Growth %-2.12%0.15%-0.13%0.05%0.01%-2.61%0.02%0.47%-0.23%0.12%
EBITDA+-8.61M-7.28M-8.23M-7.81M-7.58M-27.94M-27.23M-14.54M-17.89M-15.67M
EBITDA Margin %----------
EBITDA Growth %-1.42%0.15%-0.13%0.05%0.03%-2.69%0.03%0.47%-0.23%0.12%
D&A (Non-Cash Add-back)08K11K12.61K198K89.76K141K51K96K124K
EBIT0-7.29M-8.25M-7.82M-7.77M-27.98M-26.48M-15.39M-17.23M-16.74M
Net Interest Income+0000-72K-312K-176K-7K1.14M808K
Interest Income00001K8K001.15M814K
Interest Expense18K9K9K9.46K73K320K176K7K10K6K
Other Income/Expense-18K-9K-9K-8.67K-73K-312K717K-811K742K-952K
Pretax Income+-8.63M-7.3M-8.26M-7.83M-7.85M-28.34M-26.66M-15.4M-17.24M-16.75M
Pretax Margin %----------
Income Tax+0-89K-1.49M-1.53M-540K-2.21M-3.24M0449K-4.88M
Effective Tax Rate %1%0.99%0.82%0.8%0.93%0.92%0.88%1%1.03%0.71%
Net Income+-8.63M-7.21M-6.77M-6.3M-7.31M-26.13M-23.42M-15.4M-17.69M-11.86M
Net Margin %----------
Net Income Growth %-1.46%0.16%0.06%0.07%-0.16%-2.58%0.1%0.34%-0.15%0.33%
Net Income (Continuing)-8.63M-7.21M-6.77M-6.3M-7.31M-26.13M-23.42M-15.4M-17.69M-11.86M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)+-0.18-0.14-0.12-0.09-0.11-0.54-0.48-0.30-0.34-0.22
EPS Growth %0.71%0.22%0.14%0.23%-0.19%-3.91%0.11%0.38%-0.13%0.35%
EPS (Basic)-0.18-0.14-0.12-0.09-0.11-0.54-0.48-0.30-0.34-0.22
Diluted Shares Outstanding46.8M53.2M58.49M68.24M68.24M48.65M48.97M50.76M50.76M53.34M
Basic Shares Outstanding46.8M53.2M58.49M68.24M68.24M48.65M48.97M50.76M50.76M53.34M
Dividend Payout Ratio----------

Balance Sheet

Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Total Current Assets+9.25M5.02M1.81M5.45M1.14M70.18M48.68M24.28M7.34M7.51M
Cash & Short-Term Investments8.9M4.7M48K4.18M153K65.82M42.19M18.12M1.18M3.72M
Cash Only8.9M4.7M48K4.18M153K65.82M42.19M18.12M1.18M3.72M
Short-Term Investments0000000000
Accounts Receivable000003.78M5.27M5.86M6.05M3.69M
Days Sales Outstanding----------
Inventory00000-2.28K0000
Days Inventory Outstanding----------
Other Current Assets347K320K1.76M1.27M991K193K0000
Total Non-Current Assets+028K18K5.52K664K480K147K2.19M4.85M3.78M
Property, Plant & Equipment028K18K5.52K334K359.51K17K389K293K187K
Fixed Asset Turnover----------
Goodwill00000-35.59K0000
Intangible Assets00000132.59K130K000
Long-Term Investments00000001.81M4.55M3.59M
Other Non-Current Assets0000330K23.49K0000
Total Assets+9.25M5.05M1.83M5.45M1.81M70.66M48.83M26.48M12.18M11.28M
Asset Turnover----------
Asset Growth %2.76%-0.45%-0.64%1.98%-0.67%38.08%-0.31%-0.46%-0.54%-0.07%
Total Current Liabilities+746K1.74M3.51M5.04M5.58M7.98M7.55M6.66M6.54M7.35M
Accounts Payable000003.37M4.41M4.96M4.14M5.58M
Days Payables Outstanding----------
Short-Term Debt216K225K234K244.3K212K2.31M1.35M122K138K106K
Deferred Revenue (Current)0000000000
Other Current Liabilities216K299K505K1.93M5.37M590.59K-1.34M-113K-124K-94K
Current Ratio12.40x2.89x0.52x1.08x0.21x8.79x6.45x3.64x1.12x1.02x
Quick Ratio12.40x2.89x0.52x1.08x0.21x8.79x6.45x3.64x1.12x1.02x
Cash Conversion Cycle----------
Total Non-Current Liabilities+530K1.44M3.01M3.11M411K290K0243K109K0
Long-Term Debt0000000000
Capital Lease Obligations00000289.79K0243K109K0
Deferred Tax Liabilities0000000000
Other Non-Current Liabilities530K1.44M3.01M3.11M411K2070000
Total Liabilities746K1.74M3.51M5.04M5.99M8.27M7.55M6.91M6.65M7.35M
Total Debt+216K225K234K244.3K623K555K1.35M365K247K106K
Net Debt-8.69M-4.48M186K-3.94M470K-65.27M-42.19M-17.76M-936K-3.62M
Debt / Equity0.03x0.07x-0.60x-0.01x0.03x0.02x0.04x0.03x
Debt / EBITDA----------
Net Debt / EBITDA----------
Interest Coverage-478.56x-809.78x-916.22x-827.33x-106.48x-87.58x-155.53x-2083.71x-1798.40x-2632.33x
Total Equity+8.5M3.31M-1.68M409.01K-4.18M62.39M41.28M19.57M5.54M3.94M
Equity Growth %3.79%-0.61%-1.51%1.24%-11.22%15.92%-0.34%-0.53%-0.72%-0.29%
Book Value per Share0.180.06-0.030.01-0.061.280.840.390.110.07
Total Shareholders' Equity8.5M3.31M-1.68M409.01K-4.18M45.71M41.28M19.57M5.54M3.94M
Common Stock9.38M2.83M3.75M6.77M4.1M97K102K102K103K111K
Retained Earnings-12.24M11.04M-29.75M-39.9M-43.15M-84.65M-108.06M-116.26M-133.68M-144.83M
Treasury Stock0000000-1.32M-1.57M0
Accumulated OCI0-8K-19K-30.73K-35K-52K119.15M115.57M117.06M116.99M
Minority Interest0000000000

Cash Flow

Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Cash from Operations+-5.7M-5.62M-5.68M-3.63M-5.29M-8.76M-16.13M-15.99M-12.42M-1.22M
Operating CF Margin %----------
Operating CF Growth %-1.46%0.01%-0.01%0.36%-0.46%-0.65%-0.84%0.01%0.22%0.9%
Net Income-8.92M-7.92M-6.57M-6.26M-7.26M-19.17M-17.36M-12.55M-14M-9.48M
Depreciation & Amortization08.79K10.68K12.62K194.77K65.93K104.52K41.57K75.97K99.09K
Stock-Based Compensation0000000000
Deferred Taxes0000000000
Other Non-Cash Items3.32M1.35M-895.98K1.08M1.55M10.56M1.7M-2.53M2.75M8.6M
Working Capital Changes-93.05K951.66K1.78M1.53M223.59K-215.69K-573.01K-948.89K-1.25M-441.1K
Change in Receivables-158.18K038.83K-142K-99.37K-342.85K317.27K-127.17K-1.14M-1.11M
Change in Inventory0000000000
Change in Payables0000000000
Cash from Investing+0-276.93K-9700-2.98K-93.25K96.36K-3.26M-991.57K-56.73K
Capital Expenditures0-38.46K-9700-2.98K-93.25K-16.31K00-15.18K
CapEx % of Revenue----------
Acquisitions----------
Investments----------
Other Investing000000112.67K-1.08M-200.21K10.45K
Cash from Financing+12.56M1.28M1.16M7.96M1.31M54.12M-17.05K-44.84K31.65K3.6M
Debt Issued (Net)----------
Equity Issued (Net)----------
Dividends Paid0000000000
Share Repurchases----------
Other Financing-750.61K000-156.02K-203.45K-112.67K-44.84K-94.17K28.33K
Net Change in Cash----------
Free Cash Flow+-5.7M-5.65M-5.68M-3.63M-5.29M-8.76M-16.15M-15.99M-12.42M-1.23M
FCF Margin %----------
FCF Growth %-1.46%0.01%-0%0.36%-0.46%-0.65%-0.84%0.01%0.22%0.9%
FCF per Share-0.12-0.11-0.10-0.05-0.08-0.18-0.33-0.31-0.24-0.02
FCF Conversion (FCF/Net Income)0.66x0.78x0.84x0.58x0.72x0.34x0.69x1.04x0.70x0.10x
Interest Paid0000000000
Taxes Paid0000000000

Key Ratios

Metric2015201620172018201920202021202220232024
Return on Equity (ROE)-167.92%-121.98%-830.17%-1540.08%--89.79%-45.18%-50.61%-140.92%-250.49%
Return on Invested Capital (ROIC)-------4572.49%-966.81%-420.58%-481.72%
Debt / Equity0.03x0.07x-0.60x-0.01x0.03x0.02x0.04x0.03x
Interest Coverage-478.56x-809.78x-916.22x-827.33x-106.48x-87.58x-155.53x-2083.71x-1798.40x-2632.33x
FCF Conversion0.66x0.78x0.84x0.58x0.72x0.34x0.69x1.04x0.70x0.10x

Frequently Asked Questions

Growth & Financials

Tiziana Life Sciences Ltd (TLSA) grew revenue by 0.0% over the past year. Growth has been modest.

Tiziana Life Sciences Ltd (TLSA) reported a net loss of $34.2M for fiscal year 2024.

Dividend & Returns

Tiziana Life Sciences Ltd (TLSA) has a return on equity (ROE) of -250.5%. Negative ROE indicates the company is unprofitable.

Tiziana Life Sciences Ltd (TLSA) had negative free cash flow of $13.6M in fiscal year 2024, likely due to heavy capital investments.

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