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DYAIDyadic International, Inc.
$0.78$28M
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DYAI logoDyadic International, Inc.(DYAI)Earnings, Financials & Key Ratios

DYAI•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryDrug Discovery and Antibody Platforms
AboutDyadic International, Inc., a biotechnology platform company, develops, produces, and sells enzymes and other proteins in the United States. The company utilizes its patented and proprietary C1 platform and other technologies to conduct research, development, and commercial activities for the development and manufacturing of human and animal vaccines and drugs, such as virus like particles and antigens, monoclonal antibodies, bi/tri-specific antibodies, fab antibody fragments, Fc-fusion proteins, biosimilars and/or biobetters, and other therapeutic enzymes and proteins. It offers DYAI-100, SARS-CoV-2-RBD antigen vaccine candidate towards a first-in-human Phase 1 clinical trial, is to validate to serve as proof of concept for the development of next generation multivariant COVID-19 vaccine candidates. The company has a research and development agreement with VTT Technical Research Centre of Finland, Ltd.; strategic research services agreement with Biotechnology Developments for Industry in Pharmaceuticals, S.L.U.; and collaboration with Syngene International Limited. Dyadic International, Inc. was founded in 1979 and is headquartered in Jupiter, Florida.Show more
  • Revenue$1M-64.7%
  • EBITDA-$7M-28.4%
  • Net Income-$7M-26.8%
  • EPS (Diluted)-0.23-15.0%
  • Gross Margin-88.25%-234.1%
  • EBITDA Margin-560.63%-264.2%
  • Operating Margin-579.88%-243.5%
  • Net Margin-597.63%-259.6%
  • ROE-397.8%-185.9%

DYAI Key Insights

Dyadic International, Inc. (DYAI) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

No significant strengths identified

✗Weaknesses

  • ✗High debt to equity ratio of 4.1x
  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Sales declining 5.1% over 5 years
  • ✗Shares diluted 11.3% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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DYAI Price & Volume

Dyadic International, Inc. (DYAI) stock price & volume — 10-year historical chart

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DYAI Growth Metrics

Dyadic International, Inc. (DYAI) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years14.59%
5 Years-5.11%
3 Years-25.08%
TTM-11.04%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-25.13%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-7.85%

Return on Capital

10 Years-51.11%
5 Years-83.49%
3 Years-95.76%
Last Year-104.01%

DYAI Recent Earnings

Dyadic International, Inc. (DYAI) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 1/12 qtrs (10%)●Beat Revenue 2/12 qtrs (20%)
Q2 2026Latest
May 13, 2026
Metric
Actual
Est
EPS
$0.05-25.0%
$0.04
Rev
$1M+22.9%
$903,750
Q2 2026
Mar 25, 2026
Metric
Actual
Est
EPS
$0.06-100.0%
$0.03
Rev
$564,345-58.0%
$1M
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.06-50.0%
$0.04
Rev
$1M-13.3%
$1M
Q3 2025
Aug 13, 2025
Metric
Actual
Est
EPS
$0.06+0.0%
$0.06
Rev
$463,449-69.1%
$2M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 13, 2026
$0.05vs $0.04-25.0%
$1Mvs $903,750+22.9%
Q2 2026Mar 25, 2026
$0.06vs $0.03-100.0%
$564,345vs $1M-58.0%
Q4 2025Nov 12, 2025
$0.06vs $0.04-50.0%
$1Mvs $1M-13.3%
Q3 2025Aug 13, 2025
$0.06vs $0.06+0.0%
$463,449vs $2M-69.1%
Based on last 12 quarters of dataView full earnings history →

DYAI Peer Comparison

Dyadic International, Inc. (DYAI) competitors in Drug Discovery and Antibody Platforms — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
CDXS logoCDXSCodexis, Inc.Direct Competitor233.6M2.57-5.1418.61%-40.96%-68.09%1.45
GEVO logoGEVOGevo, Inc.Direct Competitor374.85M1.54-118.49%-19.38%-7.19%0.36
TWST logoTWSTTwist Bioscience CorporationProduct Competitor5.45B87.56-67.3520.32%-19.85%-17.46%0.29
SEER logoSEERSeer, Inc.Product Competitor95.67M1.74-1.3615.57%-468.74%-26.58%0.09
BEAM logoBEAMBeam Therapeutics Inc.Product Competitor3.51B34.14-42.15120.01%-49.17%-5.89%0.24
BNGO logoBNGOBionano Genomics, Inc.Product Competitor3.83M1.17-0.24-7.37%-109.95%-71.38%0.16
MRK logoMRKMerck & Co., Inc.Supply Chain281.25B113.8715.641.18%28.12%36.14%0.96
PFE logoPFEPfizer Inc.Supply Chain143.46B25.2218.54-1.65%11.83%8.34%0.78

Compare DYAI vs Peers

Dyadic International, Inc. (DYAI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs CDXS

Most directly comparable listed peer for DYAI.

Scale Benchmark

vs MRK

Larger-name benchmark to compare DYAI against a more recognizable public peer.

Peer Set

Compare Top 5

vs CDXS, GEVO, TWST, SEER

DYAI Income Statement

Dyadic International, Inc. (DYAI) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
758.42K1.3M1.68M1.6M2.4M2.93M2.9M3.5M1.23M2.97M
Revenue Growth %
27.92%70.81%29.77%-4.71%50.06%21.9%-1.07%20.58%-64.74%-11.04%
Cost of Goods Sold
680.2K1.03M1.46M1.42M1.94M2.12M1.98M1.19M2.32M2.04M
COGS % of Revenue
89.69%79.3%86.83%88.95%80.89%72.46%68.16%34.18%188.25%-
Gross Profit
78.22K▲ 0%
268.17K▲ 242.8%
221.38K▼ 17.5%
176.99K▼ 20.0%
459.39K▲ 159.6%
807.11K▲ 75.7%
922.96K▲ 14.4%
2.3M▲ 149.3%
-1.09M▼ 147.3%
929.95K▲ 0%
Gross Margin %
10.31%20.7%13.17%11.05%19.11%27.54%31.84%65.82%-88.25%31.26%
Gross Profit Growth %
1.95%242.83%-17.45%-20.05%159.56%75.69%14.35%149.28%-147.27%-
Operating Expenses
7.45M7.84M9.5M10.2M15.19M10.97M9.15M8.2M6.06M8.02M
OpEx % of Revenue
982.85%605.18%565.35%636.9%631.78%374.46%315.74%234.64%491.63%-
Selling, General & Admin
5.03M4.52M5.52M6.08M6.7M6.42M5.82M6.13M5.76M5.92M
SG&A % of Revenue
663.27%349.12%328.36%379.84%278.62%219.14%200.67%175.51%467.56%-
Research & Development
2.2M3.32M5.42M3.87M8.39M4.5M3.3M2.04M2.15M1.91M
R&D % of Revenue
290.48%256.06%322.18%241.47%349.12%153.61%113.75%58.48%174.85%-
Other Operating Expenses
220.72K0-1.43M249.73K96.89K49.92K38.42K22.56K-1.86M183.11K
Operating Income
-7.13M▲ 0%
-7.59M▼ 6.5%
-9.28M▼ 22.3%
-10.03M▼ 8.0%
-14.73M▼ 46.9%
-10.17M▲ 31.0%
-8.23M▲ 19.0%
-5.9M▲ 28.3%
-7.15M▼ 21.1%
-7.09M▲ 0%
Operating Margin %
-939.7%-586.09%-552.18%-625.85%-612.67%-346.92%-283.9%-168.82%-579.88%-238.4%
Operating Income Growth %
-19.67%-6.53%-22.26%-8%-46.9%30.97%19.04%28.3%-21.1%-
EBITDA
249.06K-188.78K-27.73K-9.96M-11.24M-10.12M-8.19M-5.38M-6.91M-6.94M
EBITDA Margin %
32.84%-14.57%-1.65%-621.96%-467.48%-345.21%-282.58%-153.95%-560.63%-233.14%
EBITDA Growth %
269.04%-175.8%85.31%-35836.22%-12.79%9.98%19.02%34.31%-28.39%-30.41%
D&A (Non-Cash Add-back)
7.38M7.4M9.25M03.49M038.42K000
EBIT
-7.38M-7.57M-9.25M-9.96M-14.63M-10.12M-8.19M-5.38M-6.91M-6.94M
Net Interest Income
566.15K894.53K984.93K447K51.7K180.42K416.69K29.02K-171.81K-170.52K
Interest Income
00984.93K447K51.7K180.42K416.69K456.99K284.08K252.82K
Interest Expense
566.15K894.53K00000427.97K455.9K423.34K
Other Income/Expense
4.92M894.53K984.93K731.71K1.66M430.42K1.43M91.66K-218.71K-200.08K
Pretax Income
-2.2M▲ 0%
-6.7M▼ 204.1%
-8.3M▼ 23.9%
-9.29M▼ 12.0%
-13.07M▼ 40.6%
-9.74M▲ 25.5%
-6.8M▲ 30.2%
-5.81M▲ 14.5%
-7.36M▼ 26.8%
-7.29M▲ 0%
Pretax Margin %
-290.41%-517.03%-493.59%-580.18%-543.73%-332.23%-234.42%-166.19%-597.63%-245.12%
Income Tax
-66.69K-1.01M10.31K31.32K000000
Effective Tax Rate %
3.03%15.02%-0.12%-0.34%0%0%0%0%0%0%
Net Income
-2.14M▲ 0%
-5.69M▼ 166.5%
-8.31M▼ 46.0%
-9.33M▼ 12.2%
-13.07M▼ 40.2%
-9.74M▲ 25.5%
-6.8M▲ 30.2%
-5.81M▲ 14.5%
-7.36M▼ 26.8%
-7.29M▲ 0%
Net Margin %
-281.61%-439.36%-494.21%-582.13%-543.73%-332.23%-234.42%-166.19%-597.63%-245.12%
Net Income Growth %
40.82%-166.49%-45.96%-12.25%-40.16%25.52%30.2%14.51%-26.78%-25.13%
Net Income (Continuing)
-2.14M-5.69M-8.31M-9.33M-13.07M-9.74M-6.8M-5.81M-7.36M-7.29M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-0.07▲ 0%
-0.21▼ 184.2%
-0.31▼ 47.6%
-0.34▼ 9.7%
-0.47▼ 38.2%
-0.34▲ 27.7%
-0.24▲ 29.4%
-0.20▲ 16.7%
-0.23▼ 15.0%
-0.20▲ 0%
EPS Growth %
25.2%-184.17%-47.62%-9.68%-38.24%27.66%29.41%16.67%-15%-7.85%
EPS (Basic)
-0.07-0.21-0.31-0.34-0.47-0.34-0.24-0.20-0.23-
Diluted Shares Outstanding
28.92M27.67M27M27.47M27.84M28.36M28.8M29.32M32.62M36.4M
Basic Shares Outstanding
28.92M27.67M27M27.47M27.84M28.36M28.8M29.32M32.62M36.4M
Dividend Payout Ratio
----------

DYAI Balance Sheet

Dyadic International, Inc. (DYAI) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
49.62M42.75M35.64M29.78M21.01M13.42M8.07M9.83M9.9M7.7M
Cash & Short-Term Investments
47.69M41.2M34.22M29.09M20.26M12.64M7.26M9.26M7.32M6.52M
Cash Only
5.79M2.39M4.82M20.64M15.75M5.79M6.52M6.51M4.62M5.16M
Short-Term Investments
41.9M38.82M29.4M8.46M4.51M6.85M748.29K2.76M2.7M1.36M
Accounts Receivable
760.87K1.12M1.14M294.2K372.21K330K466.16K237.03K1.13M1.01M
Days Sales Outstanding
366.18315.52247.2167.0356.5241.1158.724.75333.34116.57
Inventory
1.02M253.45K00000000
Days Inventory Outstanding
544.7690.05--------
Other Current Assets
000112.25K058.28K10.08K24.25K1.23M174.24K
Total Non-Current Assets
1.13M552.75K1.81M290.93K290.83K290.75K151.9K102.61K49.07K109.68K
Property, Plant & Equipment
000000141.44K92.21K38.53K24.35K
Fixed Asset Turnover
------20.50x37.91x31.98x65.65x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
922.65K500.62K1.76M284.71K284.71K284.71K000549.04K
Other Non-Current Assets
205.74K52.14K51.31K6.22K6.12K6.04K10.46K10.4K10.54K10.51K
Total Assets
50.74M▲ 0%
43.3M▼ 14.7%
37.45M▼ 13.5%
30.07M▼ 19.7%
21.3M▼ 29.2%
13.71M▼ 35.6%
8.22M▼ 40.1%
9.93M▲ 20.8%
9.95M▲ 0.2%
7.81M▲ 0%
Asset Turnover
0.01x0.03x0.04x0.05x0.11x0.21x0.35x0.35x0.12x0.32x
Asset Growth %
-13.55%-14.67%-13.51%-19.71%-29.17%-35.62%-40.06%20.82%0.16%-16.35%
Total Current Liabilities
768.89K849.64K1.59M1.63M2.56M2.45M2.25M2.45M3.69M3.18M
Accounts Payable
520.26K309.06K793K1.01M1.55M1.28M656.45K482.32K852.02K1.06M
Days Payables Outstanding
279.18109.81198.29259.51290.57219.41121.27147.37134.06149.8
Short-Term Debt
00000000020K
Deferred Revenue (Current)
0141K78.64K0147.06K00002.45M
Other Current Liabilities
100.67K141K242K123.02K151.15K217.21K490.11K833.81K2.8M756.05K
Current Ratio
64.53x50.31x22.44x18.32x8.22x5.48x3.58x4.01x2.68x2.42x
Quick Ratio
63.21x50.01x22.44x18.32x8.22x5.48x3.58x4.01x2.68x2.42x
Cash Conversion Cycle
631.76295.76--------33.22
Total Non-Current Liabilities
520.26K309.06K00352.94K176.47K88.87K5.01M5.03M5.03M
Long-Term Debt
00000004.98M5.03M5.03M
Capital Lease Obligations
00000088.87K34.62K05.05K
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
00000176.47K0000
Total Liabilities
768.89K849.64K1.59M1.63M2.91M2.63M2.34M7.46M8.71M8.22M
Total Debt
000000136.93K5.07M5.06M5.05M
Net Debt
-5.79M-2.39M-4.82M-20.64M-15.75M-5.79M-6.38M-1.44M438.33K-102.31K
Debt / Equity
------0.02x2.05x4.11x-12.39x
Debt / EBITDA
----------0.73x
Net Debt / EBITDA
-23.23x--------0.01x
Interest Coverage
-13.03x-8.46x------12.57x-15.15x-16.38x
Total Equity
49.98M▲ 0%
42.45M▼ 15.1%
35.86M▼ 15.5%
28.45M▼ 20.7%
18.39M▼ 35.4%
11.09M▼ 39.7%
5.88M▼ 47.0%
2.47M▼ 58.0%
1.23M▼ 50.1%
-407.73K▲ 0%
Equity Growth %
-13.37%-15.06%-15.52%-20.68%-35.35%-39.71%-46.98%-57.98%-50.11%-334.56%
Book Value per Share
1.731.531.331.040.660.390.200.080.04-0.01
Total Shareholders' Equity
49.98M42.45M35.86M28.45M18.39M11.09M5.88M2.47M1.23M-407.73K
Common Stock
38.94K38.97K39.61K39.75K40.48K40.82K41.06K42.09K48.44K48.69K
Retained Earnings
-27.35M-33.04M-41.35M-50.68M-63.75M-73.48M-80.28M-86.09M-93.45M-95.41M
Treasury Stock
-16.63M-18.93M-18.93M-18.93M-18.93M-18.93M-18.93M-18.93M-18.93M-18.93M
Accumulated OCI
0000000000
Minority Interest
0000000000

DYAI Cash Flow Statement

Dyadic International, Inc. (DYAI) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-2.61M-4.41M-5.78M-6.57M-11.28M-8.08M-6.73M-3.97M-5.7M-5.72M
Operating CF Margin %
-343.64%-340.2%-344%-410.41%-469.12%-275.87%-232.05%-113.72%-462.73%-
Operating CF Growth %
56.82%-69.1%-31.21%-13.69%-71.53%28.32%16.79%40.91%-43.46%-882.81%
Net Income
-2.14M-5.69M-8.31M-9.33M-13.07M-9.74M-6.8M-5.81M-7.36M-7.29M
Depreciation & Amortization
0676.64K000000-24.17K12.35K
Stock-Based Compensation
643.43K467.2K01.65M1.78M1.89M1.24M1.13M930.18K705.15K
Deferred Taxes
0-676.64K00000000
Other Non-Cash Items
-273.09K697.42K1.4M108.91K-1.18M83.71K-1.03M-46.45K95.6K183.95K
Working Capital Changes
-840.78K119.94K1.13M990.08K1.19M-321.17K-143.21K754.53K660.79K674.46K
Change in Receivables
333.02K-59.98K218.62K1.08M-13.92K-47.17K-93.13K205.26K-857.85K-762.08K
Change in Inventory
-1.21M234.68K00000000
Change in Payables
207.43K-195.75K657.66K-53.2K549.56K-248.13K-651.17K-180.18K314.45K579.73K
Cash from Investing
103K3.33M7.71M22.12M5.22M-2.37M7.45M-1.88M82.08K866.18K
Capital Expenditures
0000000000
CapEx % of Revenue
--0%0%---0%-0%
Acquisitions
0000000000
Investments
----------
Other Investing
-812.08K3.33M00000000
Cash from Financing
-6.22M-2.3M550.19K255.47K1.23M543.59K05.85M4.96M4.94M
Debt Issued (Net)
00000005.82M00
Equity Issued (Net)
-6.22M-2.3M550.19K255.47K00024.25K4.96M4.94M
Dividends Paid
0000000000
Share Repurchases
-6.22M-2.3M00000000
Other Financing
1.44K4.5K001.23M543.59K0000
Net Change in Cash
-8.47M▲ 0%
-3.4M▲ 59.8%
2.44M▲ 171.7%
15.81M▲ 548.8%
-4.89M▼ 130.9%
-9.95M▼ 103.6%
720.76K▲ 107.2%
-8.28K▼ 101.1%
-653.25K▼ 7791.4%
335.93K▲ 0%
Free Cash Flow
-2.61M▲ 0%
-4.41M▼ 69.1%
-5.78M▼ 31.2%
-6.57M▼ 13.7%
-11.28M▼ 71.5%
-8.08M▲ 28.3%
-6.73M▲ 16.8%
-3.97M▲ 40.9%
-5.7M▼ 43.5%
-5.72M▲ 0%
FCF Margin %
-343.64%-340.2%-344%-410.41%-469.12%-275.87%-232.05%-113.72%-462.73%-192.15%
FCF Growth %
56.82%-69.1%-31.21%-13.69%-71.53%28.32%16.79%40.91%-43.46%-18.79%
FCF per Share
-0.09-0.16-0.21-0.24-0.41-0.28-0.23-0.14-0.17-0.16
FCF Conversion (FCF/Net Income)
1.22x0.77x0.70x0.71x0.86x0.83x0.99x0.68x0.77x0.78x
Interest Paid
0000000000
Taxes Paid
0000000000

DYAI Key Ratios

Dyadic International, Inc. (DYAI) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-3.97%-12.32%-21.22%-29%-55.81%-66.05%-80.11%-139.16%-397.8%-1004.96%
Return on Invested Capital (ROIC)
-11.25%-13.52%-19.58%-38.71%-211.37%-192.16%-257.5%-1669.28%-396.92%-523.01%
Gross Margin
10.31%20.7%13.17%11.05%19.11%27.54%31.84%65.82%-88.25%31.26%
Net Margin
-281.61%-439.36%-494.21%-582.13%-543.73%-332.23%-234.42%-166.19%-597.63%-245.12%
Debt / Equity
------0.02x2.05x4.11x-12.39x
Interest Coverage
-13.03x-8.46x------12.57x-15.15x-16.38x
FCF Conversion
1.22x0.77x0.70x0.71x0.86x0.83x0.99x0.68x0.77x0.78x
Revenue Growth
27.92%70.81%29.77%-4.71%50.06%21.9%-1.07%20.58%-64.74%-11.04%
Related:DYAI Dividend History·DYAI Revenue History·DYAI Price History·DYAI P/E History·DYAI Financial Ratios·DYAI Institutional Holders

DYAI SEC Filings & Documents

Dyadic International, Inc. (DYAI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 13, 2026·SEC

Material company update

Mar 30, 2026·SEC

Material company update

Mar 25, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 25, 2026·SEC

FY 2025

Mar 26, 2025·SEC

FY 2024

Mar 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 13, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 13, 2025·SEC

DYAI Frequently Asked Questions

Dyadic International, Inc. (DYAI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Dyadic International, Inc. (DYAI) reported $3.0M in revenue for fiscal year 2025. This represents a 1308% increase from $0.2M in 2003.

Dyadic International, Inc. (DYAI) saw revenue decline by 64.7% over the past year.

Dyadic International, Inc. (DYAI) reported a net loss of $7.3M for fiscal year 2025.

Dividend & Returns

Dyadic International, Inc. (DYAI) has a return on equity (ROE) of -397.8%. Negative ROE indicates the company is unprofitable.

Dyadic International, Inc. (DYAI) had negative free cash flow of $5.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in DYAI back in 2003?

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How much would $100/month in DYAI be worth today?

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