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SHPHShuttle Pharmaceuticals Holdings, Inc.
$3.46$2M
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SHPH logoShuttle Pharmaceuticals Holdings, Inc.(SHPH)Earnings, Financials & Key Ratios

SHPH•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustrySpecialty & Generic PharmaSub-IndustryTherapy-focused branded biopharma
AboutShuttle Pharmaceuticals Holdings, Inc., through its subsidiary, Shuttle Pharmaceuticals, Inc., focuses on the discovery, development, and commercialization of drugs for sensitizing cancers to radiation therapy. Its products in clinical stage include Ropidoxuridine, an oral halogenated pyrimidine to treat patients with brain tumors and soft tissue sarcomas; and Doranidazole, an injectable hypoxic cell radiation sensitizer for treatment of pancreatic, lung, and liver cancers. The company was founded in 2012 and is based in Rockville, Maryland.Show more
  • Revenue$0
  • EBITDA-$12M-51.2%
  • Net Income-$12M-28.2%
  • EPS (Diluted)-71.60+99.2%
  • ROE-791.04%-106.1%

SHPH Key Insights

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Share count reduced 84.1% through buybacks
  • ✓Trading at only 0.3x book value

✗Weaknesses

  • ✗Profits declining 70.8% over 5 years
  • ✗Weak momentum: RS Rating 2 (bottom 2%)
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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SHPH Price & Volume

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) stock price & volume — 10-year historical chart

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SHPH Growth Metrics

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-3.39%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-224.06%

Return on Capital

10 Years-650.64%
5 Years-279.14%
3 Years-346.62%
Last Year-684.56%

SHPH Recent Earnings

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
Q2 2026Latest
May 15, 2026
Metric
Actual
Est
EPS
$0.43
—
Rev
—
—
Q2 2026
Apr 1, 2026
Metric
Actual
Est
EPS
$1.29
—
Rev
—
—
Q4 2025
Nov 13, 2025
Metric
Actual
Est
EPS
$1.05
—
Rev
—
—
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$3.29
—
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 15, 2026
$0.43
—
Q2 2026Apr 1, 2026
$1.29
—
Q4 2025Nov 13, 2025
$1.05
—
Q3 2025Aug 12, 2025
$3.29
—
Based on last 12 quarters of dataView full earnings history →

SHPH Peer Comparison

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) competitors in Therapy-focused branded biopharma — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
SENS logoSENSSenseonics Holdings, Inc.Direct Competitor281.69M6.74-4.0656.89%-214.16%-130%0.68
NVCR logoNVCRNovoCure LimitedDirect Competitor1.62B14.28-11.708.28%-25.66%-50.82%0.85
AGEN logoAGENAgenus Inc.Direct Competitor124.93M3.00-882.3510.37%52.16%
ATNM logoATNMActinium Pharmaceuticals, Inc.Product Competitor32.32M1.03-0.95-260.79%-218.67%0.22
CELC logoCELCCelcuity Inc.Product Competitor4.28B87.76-23.22-244.61%1.94
ISRG logoISRGIntuitive Surgical, Inc.Supply Chain144.48B406.7851.6920.51%28.15%16.89%0.02
RMD logoRMDResMed Inc.Supply Chain27.48B188.6319.839.84%27.44%24.41%0.14
HOLX logoHOLXHologic, Inc.Supply Chain16.97B76.0130.531.74%13.18%11.01%0.52

Compare SHPH vs Peers

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SENS

Most directly comparable listed peer for SHPH.

Scale Benchmark

vs ISRG

Larger-name benchmark to compare SHPH against a more recognizable public peer.

Peer Set

Compare Top 5

vs SENS, NVCR, AGEN, ATNM

SHPH Income Statement

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
000000000
Revenue Growth %
---------
Cost of Goods Sold
18.74K18K54.95K60.83K5.97K000922.41K
COGS % of Revenue
---------
Gross Profit
-18.74K▲ 0%
-18K▲ 3.9%
-54.95K▼ 205.3%
-60.83K▼ 10.7%
-5.97K▲ 90.2%
0▲ 100.0%
0▲ 0%
0▲ 0%
-922.41K▲ 0%
Gross Margin %
---------
Gross Profit Growth %
-3.94%-205.28%-10.71%90.18%100%---
Operating Expenses
185.15K568.63K454.57K1.68M2.34M5.89M7.7M11.92M10.26M
OpEx % of Revenue
---------
Selling, General & Admin
185.99K513.06K347.75K721.18K1.29M2.38M4.08M7.86M7.65M
SG&A % of Revenue
---------
Research & Development
-83655.57K161.77K1.02M1.05M3.52M3.62M4.05M2.75M
R&D % of Revenue
---------
Other Operating Expenses
00-54.95K-60.83K0000-133.38K
Operating Income
-203.89K▲ 0%
-586.63K▼ 187.7%
-509.52K▲ 13.1%
-1.74M▼ 242.1%
-2.34M▼ 34.5%
-5.89M▼ 151.4%
-7.7M▼ 30.6%
-11.92M▼ 54.8%
-11.18M▲ 0%
Operating Margin %
---------
Operating Income Growth %
--187.72%13.14%-242.08%-34.47%-151.4%-30.61%-54.84%-
EBITDA
-185.15K-568.63K-454.57K-1.68M-2.34M-5.89M-7.69M-11.63M-10.26M
EBITDA Margin %
---------
EBITDA Growth %
--207.12%20.06%-270.05%-38.98%-151.75%-30.67%-51.18%-10.81%
D&A (Non-Cash Add-back)
18.74K18K54.95K60.83K5.97K6.81K5.46K290.11K923.43K
EBIT
-202.71K-595.22K-766.1K-1.1M-4.33M-4M-7.78M-11.65M-10.75M
Net Interest Income
00-39.63K-50.79K-670.61K-2.52M-1.32M-69.74K-69.72K
Interest Income
0000079.12K38.14K1.09K1.3K
Interest Expense
10.88K30.92K39.63K50.79K670.61K2.6M1.36M70.83K71.02K
Other Income/Expense
-9.7K-39.51K-296.21K590.86K-2.65M-700.34K-1.45M195.16K361.27K
Pretax Income
-213.59K▲ 0%
-626.14K▼ 193.1%
-805.73K▼ 28.7%
-1.15M▼ 43.0%
-5M▼ 333.6%
-6.59M▼ 32.0%
-9.14M▼ 38.7%
-11.72M▼ 28.2%
-10.82M▲ 0%
Pretax Margin %
---------
Income Tax
000000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%0%
Net Income
-213.59K▲ 0%
-626.14K▼ 193.1%
-805.73K▼ 28.7%
-1.15M▼ 43.0%
-5M▼ 333.6%
-6.59M▼ 32.0%
-9.14M▼ 38.7%
-11.72M▼ 28.2%
-10.82M▲ 0%
Net Margin %
---------
Net Income Growth %
--193.14%-28.68%-42.99%-333.64%-31.96%-38.71%-28.18%-3.39%
Net Income (Continuing)
-213.59K-626.14K-805.73K-1.15M-5M-6.59M-9.14M-11.72M-10.82M
Discontinued Operations
000000000
Minority Interest
000000000
EPS (Diluted)
-0.16▲ 0%
-0.46▼ 193.6%
-0.68▼ 48.4%
-0.95▼ 38.2%
-3.00▼ 217.5%
-4.10▼ 36.7%
-8857.30▼ 215931.7%
-71.60▲ 99.2%
-21.51▲ 0%
EPS Growth %
--193.63%-48.37%-38.16%-217.46%-36.67%-215931.71%99.19%-224.06%
EPS (Basic)
-0.16-0.46-0.68-0.95-3.00-4.10-8857.30-71.60-
Diluted Shares Outstanding
1.36M1.36M1.36M1.36M1.04M1.59M1.03M163.79K503.16K
Basic Shares Outstanding
1.36M1.36M1.36M1.36M1.04M1.59M1.03M163.79K503.16K
Dividend Payout Ratio
---------

SHPH Balance Sheet

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
102.46K613.96K341.19K509.62K8.58M5.59M2.21M502.91K2.46M
Cash & Short-Term Investments
50.71K352.39K117.15K504.75K8.42M5.46M1.92M334K1.09M
Cash Only
50.71K352.39K117.15K504.75K8.42M2.58M1.92M334K1.09M
Short-Term Investments
000002.89M000
Accounts Receivable
49.21K3.83K211.46K000000
Days Sales Outstanding
---------
Inventory
000000000
Days Inventory Outstanding
---------
Other Current Assets
0250K00014.9K001.37M
Total Non-Current Assets
18.84K7.32K202.86K142.03K75.19K358.73K295.37K9.97M9.35M
Property, Plant & Equipment
18.84K838196.38K135.55K68.71K358.73K295.37K119.7K101.46K
Fixed Asset Turnover
--------0.00x
Goodwill
000000000
Intangible Assets
00000009.84M9.24M
Long-Term Investments
000000000
Other Non-Current Assets
06.48K6.48K6.48K6.48K0012.12K0
Total Assets
121.3K▲ 0%
621.27K▲ 412.2%
544.05K▼ 12.4%
651.64K▲ 19.8%
8.65M▲ 1228.0%
5.95M▼ 31.2%
2.51M▼ 57.9%
10.48M▲ 318.0%
11.81M▲ 0%
Asset Turnover
--------0.00x
Asset Growth %
-412.19%-12.43%19.78%1227.96%-31.22%-57.89%317.99%962.05%
Total Current Liabilities
405.65K593.82K2.1M2.22M975.68K1.04M1.53M7.97M8.31M
Accounts Payable
79.1K30.73K516.97K828.31K129.25K283.31K596.6K1.45M1.79M
Days Payables Outstanding
1.54K623.163.43K4.97K7.9K---582.75
Short-Term Debt
314.38K400K686.44K849.5K685.47K596K874.48K00
Deferred Revenue (Current)
017.54K228.39K000000
Other Current Liabilities
12.16K145.54K386.31K94.03K0002M2M
Current Ratio
0.25x1.03x0.16x0.23x8.79x5.37x1.44x0.06x0.30x
Quick Ratio
0.25x1.03x0.16x0.23x8.79x5.37x1.44x0.06x0.30x
Cash Conversion Cycle
---------
Total Non-Current Liabilities
00129.38K62.44K0853.73K263.37K254.64K157.47K
Long-Term Debt
00000135.09K000
Capital Lease Obligations
00129.38K62.44K0304.13K238.09K154.95K659.48K
Deferred Tax Liabilities
000000000
Other Non-Current Liabilities
000-10414.51K25.28K99.69K23.42K
Total Liabilities
405.65K593.82K2.23M2.28M975.68K1.9M1.8M8.22M8.46M
Total Debt
314.38K400K874.28K978.88K748.3K1.09M1.17M232.15K214.01K
Net Debt
263.67K47.61K757.13K474.13K-7.67M-1.49M-746.67K-101.86K-875.93K
Debt / Equity
-14.57x--0.10x0.27x1.65x0.10x0.06x
Debt / EBITDA
---------0.02x
Net Debt / EBITDA
--------0.09x
Interest Coverage
-18.63x-19.25x-19.33x-21.69x-6.45x-1.54x-5.72x-164.49x-151.37x
Total Equity
-284.35K▲ 0%
27.46K▲ 109.7%
-1.69M▼ 6256.4%
-1.63M▲ 3.7%
7.68M▲ 571.6%
4.06M▼ 47.2%
709.15K▼ 82.5%
2.25M▲ 217.9%
3.35M▲ 0%
Equity Growth %
-109.66%-6256.38%3.68%571.58%-47.18%-82.52%217.91%775.64%
Book Value per Share
-0.210.02-1.24-1.207.422.550.6913.766.65
Total Shareholders' Equity
-284.35K27.46K-1.69M-1.63M7.68M4.06M709.15K2.25M3.35M
Common Stock
450K179939313620412057
Retained Earnings
-1.28M-1.91M-4.54M-5.8M-8.89M-25.43M-34.58M-46.3M-48.45M
Treasury Stock
000000000
Accumulated OCI
016.34K16.34K16.34K00000
Minority Interest
000000000

SHPH Cash Flow Statement

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-202.71K-566.69K-26.83K-300.34K-2.67M-5.58M-7.33M-9.48M-9.37M
Operating CF Margin %
---------
Operating CF Growth %
--179.56%95.27%-1019.36%-787.81%-109.31%-31.29%-29.4%-103.01%
Net Income
-213.59K-626.14K-805.73K-1.15M-5M-6.59M-9.14M-11.72M-10.82M
Depreciation & Amortization
18.74K18K54.95K60.83K5.97K6.81K5.46K290.11K922.44K
Stock-Based Compensation
00459.59K910.07K237.55K181.96K259.74K932.97K430.94K
Deferred Taxes
000000000
Other Non-Cash Items
58.51K63.79K256.58K-638.26K2.55M602.17K1.41M476.33K346.88K
Working Capital Changes
-9.03K16.65K7.78K519.15K-462.79K220.63K138.91K540.62K-251.15K
Change in Receivables
-30.43K45.38K164.93K211.46K0-14.9K14.9K00
Change in Inventory
000000000
Change in Payables
10.58K-48.37K-51.13K311.35K-370.38K154.06K313.3K422.99K679.43K
Cash from Investing
00-10.82K00-2.83M2.92M-3.06M-3.09M
Capital Expenditures
00-10.82K00-19.05K0-12K-48K
CapEx % of Revenue
---------
Acquisitions
000000000
Investments
---------
Other Investing
000000000
Cash from Financing
160.62K868.37K70.07K687.93K10.58M2.57M3.76M10.95M9.04M
Debt Issued (Net)
160.52K205.87K70.07K687.93K600.72K3.25M133.46K-264.42K-152.88K
Equity Issued (Net)
100912.5K0010M03.99M11.22M9.19M
Dividends Paid
000000000
Share Repurchases
000000000
Other Financing
0-250K00-17.36K-679.44K-370.95K03.9K
Net Change in Cash
-42.09K▲ 0%
301.68K▲ 816.8%
32.42K▼ 89.3%
387.6K▲ 1095.4%
7.91M▲ 1941.4%
-5.84M▼ 173.8%
-656.27K▲ 88.8%
-1.59M▼ 141.7%
-3.42M▲ 0%
Free Cash Flow
-202.71K▲ 0%
-566.69K▼ 179.6%
-37.65K▲ 93.4%
-300.34K▼ 697.7%
-2.67M▼ 787.8%
-5.6M▼ 110.0%
-7.33M▼ 30.8%
-9.48M▼ 29.4%
-9.37M▲ 0%
FCF Margin %
---------
FCF Growth %
--179.56%93.36%-697.73%-787.81%-110.03%-30.84%-29.4%-8.79%
FCF per Share
-0.15-0.42-0.03-0.22-2.58-3.52-7.10-57.89-18.63
FCF Conversion (FCF/Net Income)
0.95x0.91x0.03x0.26x0.53x0.85x0.80x0.81x0.87x
Interest Paid
001.89K29339.2K164.81K86.59K00
Taxes Paid
000000000

SHPH Key Ratios

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2018202020212022202320242025TTM
Return on Equity (ROE)
-2280.52%---165.17%-112.37%-383.84%-791.04%-408.33%
Return on Invested Capital (ROIC)
-1617.96%----343.11%-456.38%-845.14%-820.11%
Debt / Equity
14.57x--0.10x0.27x1.65x0.10x0.06x
Interest Coverage
-19.25x-19.33x-21.69x-6.45x-1.54x-5.72x-164.49x-151.37x
FCF Conversion
0.91x0.03x0.26x0.53x0.85x0.80x0.81x0.87x
Related:SHPH Dividend History·SHPH Revenue History·SHPH Price History·SHPH P/E History·SHPH Financial Ratios·SHPH Institutional Holders

SHPH SEC Filings & Documents

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 27, 2026·SEC

Material company update

May 7, 2026·SEC

Material company update

May 1, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 31, 2026·SEC

FY 2025

Feb 26, 2025·SEC

10-Q Quarterly Reports

5
FY 2026

May 15, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 13, 2025·SEC

SHPH Frequently Asked Questions

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) grew revenue by 0.0% over the past year. Growth has been modest.

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) reported a net loss of $10.8M for fiscal year 2025.

Dividend & Returns

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) has a return on equity (ROE) of -791.0%. Negative ROE indicates the company is unprofitable.

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) had negative free cash flow of $9.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SHPH back in 2017?

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