Comprehensive Stock Comparison
Compare Olema Pharmaceuticals, Inc. (OLMA) vs Agios Pharmaceuticals, Inc. (AGIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | OLMA | Beta 0.43 vs AGIO's 0.91, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | OLMA | +453.8% vs AGIO's -14.9% |
| Efficiency (ROA) | AGIO | -29.0% ROA vs OLMA's -42.5%, ROIC -26.6% vs -46.5% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Olema Pharmaceuticals is a clinical-stage biopharmaceutical company developing targeted therapies for women's cancers, particularly estrogen receptor-positive breast cancer. It currently generates no revenue from product sales — its funding comes from equity financing and potential future milestone payments from partnerships — and its financial model depends on advancing its lead candidate OP-1250 through clinical trials toward eventual commercialization. The company's key advantage lies in its novel dual-mechanism drug candidate that acts as both an estrogen receptor antagonist and degrader, potentially offering improved efficacy over existing therapies for resistant breast cancers.
Agios Pharmaceuticals is a biopharmaceutical company focused on developing treatments for rare genetic diseases related to cellular metabolism. It generates revenue primarily from sales of its lead drug PYRUKYND for pyruvate kinase deficiency — with additional income from research collaborations and milestone payments — while advancing a pipeline of other metabolic therapies. The company's competitive advantage lies in its deep expertise in cellular metabolism science and proprietary platform for targeting metabolic pathways in rare diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
OLMA leads in 2 of 6 categories (Financial Metrics, Risk & Volatility). AGIO leads in 1 (Profitability & Efficiency). 2 tied.
Financial Metrics (TTM)
AGIO and OLMA operate at a comparable scale, with $45M and $0 in trailing revenue.
| Metric | OLMAOlema Pharmaceuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $45M |
| EBITDAEarnings before interest/tax | -$165M | -$470M |
| Net IncomeAfter-tax profit | -$150M | -$401M |
| Free Cash FlowCash after capex | -$135M | -$414M |
| Gross MarginGross profit ÷ Revenue | — | +84.4% |
| Operating MarginEBIT ÷ Revenue | — | -10.6% |
| Net MarginNet income ÷ Revenue | — | -9.0% |
| FCF MarginFCF ÷ Revenue | — | -9.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +43.7% |
| EPS Growth (YoY)Latest quarter vs prior year | +18.3% | -111.0% |
Valuation Metrics
| Metric | OLMAOlema Pharmaceuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Market CapShares × price | $1.7B | $2.25T |
| Enterprise ValueMkt cap + debt − cash | $1.5B | $2.25T |
| Trailing P/EPrice ÷ TTM EPS | -11.00x | -4.25x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | 9999.00x |
| Price / BookPrice ÷ Book value/share | 3.48x | 1.47x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
AGIO delivers a -31.2% return on equity — every $100 of shareholder capital generates $-31 in annual profit, vs $-49 for OLMA. OLMA carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to AGIO's 0.03x.
| Metric | OLMAOlema Pharmaceuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| ROE (TTM)Return on equity | -48.8% | -31.2% |
| ROA (TTM)Return on assets | -42.5% | -29.0% |
| ROICReturn on invested capital | -46.5% | -26.6% |
| ROCEReturn on capital employed | -42.8% | -33.8% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 3 |
| Debt / EquityFinancial leverage | 0.00x | 0.03x |
| Net DebtTotal debt minus cash | -$138M | -$49M |
| Cash & Equiv.Liquid assets | $139M | $89M |
| Total DebtShort + long-term debt | $1M | $40M |
| Interest CoverageEBIT ÷ Interest expense | — | — |
Total Returns (with DRIP)
A $10,000 investment in AGIO five years ago would be worth $6,363 today (with dividends reinvested), compared to $5,986 for OLMA. Over the past 12 months, OLMA leads with a +453.8% total return vs AGIO's -14.9%. The 3-year compound annual growth rate (CAGR) favors OLMA at 80.7% vs AGIO's 6.1% — a key indicator of consistent wealth creation.
| Metric | OLMAOlema Pharmaceuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| YTD ReturnYear-to-date | -4.3% | +11.2% |
| 1-Year ReturnPast 12 months | +453.8% | -14.9% |
| 3-Year ReturnCumulative with dividends | +490.2% | +19.4% |
| 5-Year ReturnCumulative with dividends | -40.1% | -36.4% |
| 10-Year ReturnCumulative with dividends | -50.6% | -21.2% |
| CAGR (3Y)Annualised 3-year return | +80.7% | +6.1% |
Risk & Volatility
OLMA is the less volatile stock with a 0.43 beta — it tends to amplify market swings less than AGIO's 0.91 beta. A beta below 1.0 means the stock typically moves less than the S&P 500.
| Metric | OLMAOlema Pharmaceuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.43x | 0.91x |
| 52-Week HighHighest price in past year | $36.13 | $46.00 |
| 52-Week LowLowest price in past year | $2.86 | $22.24 |
| % of 52W HighCurrent price vs 52-week peak | +67.0% | +65.7% |
| RSI (14)Momentum oscillator 0–100 | 48.3 | 62.3 |
| Avg Volume (50D)Average daily shares traded | 1.1M | 948K |
Analyst Outlook
Wall Street rates OLMA as "Buy" and AGIO as "Buy". Consensus price targets imply 79.3% upside for OLMA (target: $43) vs 37.3% for AGIO (target: $42).
| Metric | OLMAOlema Pharmaceuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $43.38 | $41.50 |
| # AnalystsCovering analysts | 7 | 29 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Nov 20 | Feb 26 | Change |
|---|---|---|---|
| Olema Pharmaceutica… (OLMA) | 100 | 52.35 | -47.7% |
| Agios Pharmaceutica… (AGIO) | 100 | 60.51 | -39.5% |
Agios Pharmaceutica… (AGIO) returned -36% over 5 years vs Olema Pharmaceutica… (OLMA)'s -40%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Olema Pharmaceutica… (OLMA) | $0.00 | $0.00 | — |
| Agios Pharmaceutica… (AGIO) | $70M | $54M | -22.7% |
Agios Pharmaceuticals, Inc.'s revenue grew from $70M (2016) to $54M (2025) — a -2.8% CAGR.
Chart 3EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Olema Pharmaceutica… (OLMA) | -0.16 | -2.2 | -1275.0% |
| Agios Pharmaceutica… (AGIO) | -5.07 | -7.12 | -40.4% |
Agios Pharmaceuticals, Inc.'s EPS grew from $-5.07 (2016) to $-7.12 (2025).
Chart 4Free Cash Flow — 5 Years
Olema Pharmaceuticals, Inc. generated $-105M FCF in 2024 (-100% vs 2021). Agios Pharmaceuticals, Inc. generated $-377M FCF in 2025 (+9% vs 2021).
OLMA vs AGIO: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is OLMA or AGIO a better buy right now?
Analysts rate Olema Pharmaceuticals, Inc. (OLMA) a "Buy" — based on 7 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — OLMA or AGIO?
Over the past 5 years, Agios Pharmaceuticals, Inc. (AGIO) delivered a total return of -36.4%, compared to -40.1% for Olema Pharmaceuticals, Inc. (OLMA). A $10,000 investment in AGIO five years ago would be worth approximately $6K today (assuming dividends reinvested). Over 10 years, the gap is even starker: AGIO returned -21.2% versus OLMA's -50.6%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — OLMA or AGIO?
By beta (market sensitivity over 5 years), Olema Pharmaceuticals, Inc. (OLMA) is the lower-risk stock at 0.43β versus Agios Pharmaceuticals, Inc.'s 0.91β — meaning AGIO is approximately 108% more volatile than OLMA relative to the S&P 500. On balance sheet safety, Olema Pharmaceuticals, Inc. (OLMA) carries a lower debt/equity ratio of 0% versus 3% for Agios Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — OLMA or AGIO?
Olema Pharmaceuticals, Inc. (OLMA) is the more profitable company, earning 0.0% net margin versus -764.0% for Agios Pharmaceuticals, Inc. — meaning it keeps 0.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: OLMA leads at 0.0% versus -873.9% for AGIO. At the gross margin level — before operating expenses — AGIO leads at 88.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — OLMA or AGIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is OLMA or AGIO better for a retirement portfolio?
For long-horizon retirement investors, Olema Pharmaceuticals, Inc. (OLMA) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.43)). Both have compounded well over 10 years (OLMA: -50.6%, AGIO: -21.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between OLMA and AGIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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