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$34.16$2.0B
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AGIO logoAgios Pharmaceuticals, Inc.(AGIO)Earnings, Financials & Key Ratios

AGIO•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutAgios Pharmaceuticals, Inc., a biopharmaceutical company, engages in the discovery and development of medicines in the field of cellular metabolism and adjacent areas of biology. The company offers PYRUKYND (mitapivat) an activator of both wild-type and a variety of mutant pyruvate kinase, PK, enzymes for the treatment of hemolytic anemias; and AG-946 that is in Phase I clinical study for treating hemolytic anemias and other indications. Agios Pharmaceuticals, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$54M+48.0%
  • EBITDA-$467M-11.2%
  • Net Income-$413M-161.3%
  • EPS (Diluted)-7.12-161.2%
  • Gross Margin78.67%-11.2%
  • EBITDA Margin-864.28%+24.9%
  • Operating Margin-873.87%+25.1%
  • Net Margin-764.01%-141.4%
  • ROE-30.2%-152.7%

AGIO Key Insights

Agios Pharmaceuticals, Inc. (AGIO) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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AGIO Price & Volume

Agios Pharmaceuticals, Inc. (AGIO) stock price & volume — 10-year historical chart

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AGIO Growth Metrics

Agios Pharmaceuticals, Inc. (AGIO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-0.9%
5 Years-
3 Years55.97%
TTM78.34%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-163.46%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-164.22%

Return on Capital

10 Years-43.27%
5 Years-34.53%
3 Years-35.59%
Last Year-33.76%

AGIO Recent Earnings

Agios Pharmaceuticals, Inc. (AGIO) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 6/12 qtrs (50%)
Q2 2026Latest
Apr 29, 2026
Metric
Actual
Est
EPS
$1.69+6.6%
$1.81
Rev
$21M+56.0%
$13M
Q1 2026
Feb 12, 2026
Metric
Actual
Est
EPS
$1.85+6.1%
$1.97
Rev
$20M+65.1%
$12M
Q4 2025
Oct 30, 2025
Metric
Actual
Est
EPS
$1.78+7.8%
$1.93
Rev
$13M+10.1%
$12M
Q3 2025
Jul 31, 2025
Metric
Actual
Est
EPS
$1.93-10.9%
$1.74
Rev
$12M+21.2%
$10M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 29, 2026
$1.69vs $1.81+6.6%
$21Mvs $13M+56.0%
Q1 2026Feb 12, 2026
$1.85vs $1.97+6.1%
$20Mvs $12M+65.1%
Q4 2025Oct 30, 2025
$1.78vs $1.93+7.8%
$13Mvs $12M+10.1%
Q3 2025Jul 31, 2025
$1.93vs $1.74-10.9%
$12Mvs $10M+21.2%
Based on last 12 quarters of dataView full earnings history →

AGIO Peer Comparison

Agios Pharmaceuticals, Inc. (AGIO) competitors in Commercial Rare Disease Biopharma — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
IONS logoIONSIonis Pharmaceuticals, Inc.Direct Competitor12.25B74.12-31.1433.87%-30.87%-58.57%5.35
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor6.55B78.9810.15114.51%-22.58%
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.7B27.44-4.7120.13%-91.03%-6.08%
FOLD logoFOLDAmicus Therapeutics, Inc.Direct Competitor4.55B14.49-164.8520.05%-4.27%-12.02%1.76
IMVT logoIMVTImmunovant, Inc.Direct Competitor7.26B35.34-12.76-68.16%0.00
RYTM logoRYTMRhythm Pharmaceuticals, Inc.Direct Competitor6.63B96.79-31.1245.83%-93.84%-204.35%1.77
SRPT logoSRPTSarepta Therapeutics, Inc.Product Competitor1.85B17.53-2.4615.58%2.98%4.89%0.91
BMRN logoBMRNBioMarin Pharmaceutical Inc.Product Competitor10.52B54.6930.3812.87%8.29%4.41%0.11

Compare AGIO vs Peers

Agios Pharmaceuticals, Inc. (AGIO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IONS

Most directly comparable listed peer for AGIO.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare AGIO against a more recognizable public peer.

Peer Set

Compare Top 5

vs IONS, PTCT, RARE, FOLD

AGIO Income Statement

Agios Pharmaceuticals, Inc. (AGIO) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
43.01M94.39M117.91M0014.24M26.82M36.5M54.03M66.05M
Revenue Growth %
-38.46%119.45%24.92%-100%--88.36%36.07%48.03%78.34%
Cost of Goods Sold
292.68M1.4M1.32M18.77M18.78M1.7M9.5M4.17M11.52M11.84M
COGS % of Revenue
680.48%1.48%1.12%--11.97%35.43%11.41%21.33%-
Gross Profit
-249.67M▲ 0%
92.99M▲ 137.2%
116.59M▲ 25.4%
-18.77M▼ 116.1%
-18.78M▼ 0.0%
12.54M▲ 166.8%
17.32M▲ 38.2%
32.33M▲ 86.7%
42.51M▲ 31.5%
54.21M▲ 0%
Gross Margin %
-580.48%98.52%98.88%--88.03%64.57%88.59%78.67%82.07%
Gross Profit Growth %
-66.15%137.25%25.38%-116.1%-0.03%166.76%38.15%86.69%31.46%-
Operating Expenses
363.81M455.47M542.93M317.14M359.64M401.58M408.81M458.07M514.64M529.74M
OpEx % of Revenue
845.84%482.55%460.45%--2820.11%1524.09%1255.06%952.54%-
Selling, General & Admin
71.12M114.14M132.03M106.12M121.44M121.67M119.9M156.78M180.28M187.06M
SG&A % of Revenue
165.36%120.93%111.98%--854.45%447.02%429.57%333.68%-
Research & Development
292.68M341.32M410.89M211.02M256.97M279.91M288.9M301.29M334.36M342.68M
R&D % of Revenue
680.48%361.62%348.48%--1965.66%1077.07%825.49%618.86%-
Other Operating Expenses
0000-18.78M00000
Operating Income
-320.79M▲ 0%
-362.48M▼ 13.0%
-426.33M▼ 17.6%
-335.92M▲ 21.2%
-378.42M▼ 12.7%
-389.05M▼ 2.8%
-391.49M▼ 0.6%
-425.74M▼ 8.7%
-472.13M▼ 10.9%
-475.53M▲ 0%
Operating Margin %
-745.84%-384.03%-361.57%---2732.07%-1459.52%-1166.47%-873.87%-719.97%
Operating Income Growth %
-59.61%-12.99%-17.62%21.21%-12.65%-2.81%-0.63%-8.75%-10.9%-
EBITDA
-314.36M-355.31M-409.71M-317.14M-359.64M-380.48M-384.86M-420.08M-466.95M-470.27M
EBITDA Margin %
-730.89%-376.44%-347.47%---2671.93%-1434.83%-1150.98%-864.28%-712.01%
EBITDA Growth %
-60.98%-13.02%-15.31%22.59%-13.4%-5.8%-1.15%-9.15%-11.16%-8.18%
D&A (Non-Cash Add-back)
6.43M7.17M16.62M18.77M18.78M8.56M6.62M5.65M5.18M5.26M
EBIT
-320.79M-346.03M-411.47M-329.31M-356.51M-389.05M-391.49M-425.74M-472.13M-475.53M
Net Interest Income
6.12M16.45M14.86M-11.22M836K12.79M33.34M48.08M56.38M51.09M
Interest Income
6.12M16.45M14.86M6.61M836K12.79M33.34M48.08M56.38M51.09M
Interest Expense
00017.83M000000
Other Income/Expense
6.12M16.45M14.86M6.61M21.91M157.25M39.4M1.14B58.34M51.91M
Pretax Income
-314.67M▲ 0%
-346.03M▼ 10.0%
-411.47M▼ 18.9%
-329.31M▲ 20.0%
-356.51M▼ 8.3%
-231.8M▲ 35.0%
-352.09M▼ 51.9%
717.97M▲ 303.9%
-413.8M▼ 157.6%
-423.62M▲ 0%
Pretax Margin %
-731.6%-366.61%-348.97%---1627.82%-1312.63%1967.15%-765.89%-641.38%
Income Tax
000000044.24M-1.02M-1.02M
Effective Tax Rate %
0%0%0%0%0%0%0%6.16%0.25%0.24%
Net Income
-314.67M▲ 0%
-346.03M▼ 10.0%
-411.47M▼ 18.9%
-327.37M▲ 20.4%
1.6B▲ 590.2%
-231.8M▼ 114.4%
-352.09M▼ 51.9%
673.73M▲ 291.4%
-412.78M▼ 161.3%
-422.6M▲ 0%
Net Margin %
-731.6%-366.61%-348.97%---1627.82%-1312.63%1845.92%-764.01%-639.84%
Net Income Growth %
-58.55%-9.97%-18.91%20.44%590.18%-114.44%-51.89%291.35%-161.27%-163.46%
Net Income (Continuing)
-314.67M-346.03M-411.47M-329.31M-356.51M-231.8M-352.09M673.73M-412.78M-422.6M
Discontinued Operations
0001.94M1.96B00000
Minority Interest
0000000000
EPS (Diluted)
-6.75▲ 0%
-6.03▲ 10.7%
-6.61▼ 9.6%
-4.74▲ 28.3%
-6.36▼ 34.2%
-4.23▲ 33.5%
-6.33▼ 49.6%
11.64▲ 283.9%
-7.12▼ 161.2%
-7.19▲ 0%
EPS Growth %
-33.14%10.67%-9.62%28.29%-34.18%33.49%-49.65%283.89%-161.17%-164.22%
EPS (Basic)
-6.75-6.03-6.61-4.74-6.36-4.23-6.3311.86-7.12-
Diluted Shares Outstanding
46.59M57.42M59.99M69M60.45M54.79M55.65M57.89M57.97M58.78M
Basic Shares Outstanding
46.59M57.42M59.99M69M60.45M54.79M55.65M56.81M57.97M58.78M
Dividend Payout Ratio
----------

AGIO Balance Sheet

Agios Pharmaceuticals, Inc. (AGIO) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
445.26M613.78M611.7M636.68M1.06B832.77M833.84M965.6M942.05M834.84M
Cash & Short-Term Investments
567.75M805.42M564.88M572.93M1.02B783.12M776.93M893.71M854.42M737.04M
Cash Only
567.75M805.42M80.93M127.44M203.13M139.26M88.2M76.25M89.13M113.6M
Short-Term Investments
00483.95M445.49M816.89M643.86M688.72M817.46M765.29M623.44M
Accounts Receivable
3.67M10.44M15.32M04.38M2.21M2.81M4.11M10.58M16.13M
Days Sales Outstanding
31.1440.3847.42--56.5438.2441.0971.4650.74
Inventory
-143.81M869K7.33M008.49M19.08M27.62M32.92M35.09M
Days Inventory Outstanding
-227.052.03K--1.82K732.612.42K1.04K1.01K
Other Current Assets
017.17M063.75M038.95M35.02M40.16M44.13M46.59M
Total Non-Current Assets
169.14M244.68M279.04M216.27M373.5M405.95M103.28M697.6M355.17M350.15M
Property, Plant & Equipment
24.43M24.32M126.11M116.07M104.23M88.12M69.79M54.55M41.23M37.76M
Fixed Asset Turnover
1.76x3.88x0.94x--0.16x0.38x0.67x1.31x1.55x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
143.81M220.12M152.93M97.61M266.38M313.87M29.43M638.32M310.01M1.32B
Other Non-Current Assets
891K238K02.6M2.9M3.96M4.06M4.72M3.93M3.93M
Total Assets
614.4M▲ 0%
858.46M▲ 39.7%
890.74M▲ 3.8%
852.95M▼ 4.2%
1.44B▲ 68.6%
1.24B▼ 13.8%
937.12M▼ 24.3%
1.66B▲ 77.5%
1.3B▼ 22.0%
1.18B▲ 0%
Asset Turnover
0.07x0.11x0.13x--0.01x0.03x0.02x0.04x0.05x
Asset Growth %
-0.76%39.72%3.76%-4.24%68.56%-13.84%-24.35%77.48%-22%21.82%
Total Current Liabilities
94.94M93.5M92.89M94.39M59.83M62.63M67.95M81.16M82.21M58.84M
Accounts Payable
22.77M17.88M21.9M17.72M16.7M18.62M9.78M16.64M18.36M13.75M
Days Payables Outstanding
28.394.67K6.07K344.62324.633.99K375.61.46K581.46533.17
Short-Term Debt
0007.41M000018.39M18.8M
Deferred Revenue (Current)
163.64M92.52M10.93M0000000
Other Current Liabilities
18.64M22.07M18.98M48.91M19.82M12.24M23.23M46.86M18.2M14.61M
Current Ratio
4.69x6.56x6.59x6.74x17.79x13.30x12.27x11.90x11.46x14.19x
Quick Ratio
6.20x6.55x6.51x6.74x17.79x13.16x11.99x11.56x11.06x13.59x
Cash Conversion Cycle
--4.4K-3.99K---2.11K395.251K532.85526.23
Total Non-Current Liabilities
143.95M77.42M157.33M359.06M85.94M75.28M58.14M41.09M21.91M17.03M
Long-Term Debt
0000000021.82M0
Capital Lease Obligations
00106.75M97.79M85.94M72M56.99M40.21M21.82M96.45M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
18.16M17.61M0261.27M03.28M1.16M880K-21.73M90K
Total Liabilities
238.89M170.92M250.21M453.45M145.76M137.9M126.1M122.24M104.11M75.88M
Total Debt
00113.66M105.2M97.09M85.66M72M56.99M62.02M35.74M
Net Debt
-567.75M-805.42M32.73M-22.24M-106.03M-53.6M-16.21M-19.26M-27.11M-77.86M
Debt / Equity
--0.18x0.26x0.08x0.08x0.09x0.04x0.05x0.03x
Debt / EBITDA
----------0.08x
Net Debt / EBITDA
---------0.17x
Interest Coverage
----18.47x------
Total Equity
375.5M▲ 0%
687.54M▲ 83.1%
640.53M▼ 6.8%
399.5M▼ 37.6%
1.29B▲ 223.4%
1.1B▼ 14.8%
811.02M▼ 26.3%
1.54B▲ 90.0%
1.19B▼ 22.6%
1.11B▲ 0%
Equity Growth %
4.72%83.1%-6.84%-37.63%223.4%-14.8%-26.33%90%-22.57%39.36%
Book Value per Share
8.0611.9710.685.7921.3720.0914.5726.6220.5818.87
Total Shareholders' Equity
375.5M687.54M640.53M399.5M1.29B1.1B811.02M1.54B1.19B1.11B
Common Stock
49K58K68K69K71K71K72K73K75K76K
Retained Earnings
-798.06M-1.1B-1.52B-1.84B-238.76M-470.56M-822.65M-148.92M-561.71M-660.82M
Treasury Stock
0000-802.49M-802.49M-802.49M-802.49M-802.49M-802.49M
Accumulated OCI
-1.39M-2.17M202K105K-1.2M-12.54M-441K-1.52M2.19M-314K
Minority Interest
0000000000

AGIO Cash Flow Statement

Agios Pharmaceuticals, Inc. (AGIO) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-285.23M-304.42M-370.62M-290.76M-407.32M-309.48M-296.06M-389.84M-372.98M-380.41M
Operating CF Margin %
-663.16%-322.52%-314.32%---2173.3%-1103.76%-1068.12%-690.34%-
Operating CF Growth %
-839.67%-6.73%-21.75%21.55%-40.09%24.02%4.33%-31.68%4.33%10.17%
Net Income
-314.67M-346.03M-411.47M-329.31M-356.51M-231.8M-352.09M673.73M-412.78M-422.6M
Depreciation & Amortization
6.43M7.17M8.09M18.77M9.24M8.56M6.62M5.65M5.18M5.26M
Stock-Based Compensation
47.81M73.36M72.37M053.51M49.3M44.77M42.85M52.55M56.73M
Deferred Taxes
00-2.14M0000000
Other Non-Cash Items
29K-3.82M8.53M17.81M-76.74M-119.1M23.69M-1.09B15.12M15.54M
Working Capital Changes
-24.83M-35.1M-46M1.97M-36.82M-16.43M-19.06M-19.77M-33.04M-35.34M
Change in Receivables
1.22M-6.1M-3.62M0-4.38M-2.21M-604K-1.3M-6.47M-12.79M
Change in Inventory
-2.08M-869K-6.46M-7.37M0-8.49M-10.58M-8.54M-5.3M-5.48M
Change in Payables
5.33M-5.49M3.72M3.33M1.86M3.44M-8.73M6.6M1.75M-426K
Cash from Investing
-57.91M-273.82M91.44M75.75M1.25B243.26M239.57M363.44M377.18M405.91M
Capital Expenditures
-4.63M-6.99M-12.17M-14.11M-5.74M-4.88M-999K-1.69M-4.32M-4.32M
CapEx % of Revenue
10.76%7.4%10.32%--34.28%3.72%4.62%7.99%6.54%
Acquisitions
00-103.47M00132.75M040K00
Investments
----------
Other Investing
-53.28M-266.84M103.47M-803K1.8B0-16.18M1.09B-10M-10M
Cash from Financing
285.11M546.02M289.61M261.52M-765.77M2.35M5.43M14.44M8.68M9.13M
Debt Issued (Net)
00-113K-336K-578K-331K0000
Equity Issued (Net)
270.25M516.21M277.2M11.32M-802.49M2.68M5.43M14.44M8.68M9.13M
Dividends Paid
0000000000
Share Repurchases
0000-802.49M00000
Other Financing
14.86M29.82M12.52M250.54M37.3M00000
Net Change in Cash
-58.03M▲ 0%
-32.22M▲ 44.5%
10.43M▲ 132.4%
46.51M▲ 345.9%
75.69M▲ 62.8%
-63.87M▼ 184.4%
-51.05M▲ 20.1%
-11.96M▲ 76.6%
12.88M▲ 207.7%
34.64M▲ 0%
Free Cash Flow
-289.86M▲ 0%
-311.41M▼ 7.4%
-382.79M▼ 22.9%
-304.87M▲ 20.4%
-413.06M▼ 35.5%
-314.36M▲ 23.9%
-297.06M▲ 5.5%
-391.53M▼ 31.8%
-377.29M▲ 3.6%
-384.73M▲ 0%
FCF Margin %
-673.92%-329.93%-324.64%---2207.58%-1107.49%-1072.73%-698.33%-582.5%
FCF Growth %
-1111.83%-7.43%-22.92%20.36%-35.49%23.9%5.5%-31.8%3.64%4.72%
FCF per Share
-6.22-5.42-6.38-4.42-6.83-5.74-5.34-6.76-6.51-6.54
FCF Conversion (FCF/Net Income)
0.91x0.88x0.90x0.89x-0.25x1.34x0.84x-0.58x0.90x0.91x
Interest Paid
0000000000
Taxes Paid
000016.08M01.57M43.15M628K-871K

AGIO Key Ratios

Agios Pharmaceuticals, Inc. (AGIO) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-85.73%-65.1%-61.97%-62.95%189.74%-19.38%-36.83%57.29%-30.2%-34.11%
Return on Invested Capital (ROIC)
---115.15%-47.96%-36.31%-26.13%-31.88%-27.57%-26.35%-30.04%
Gross Margin
-580.48%98.52%98.88%--88.03%64.57%88.59%78.67%82.07%
Net Margin
-731.6%-366.61%-348.97%---1627.82%-1312.63%1845.92%-764.01%-639.84%
Debt / Equity
--0.18x0.26x0.08x0.08x0.09x0.04x0.05x0.03x
Interest Coverage
----18.47x------
FCF Conversion
0.91x0.88x0.90x0.89x-0.25x1.34x0.84x-0.58x0.90x0.91x
Revenue Growth
-38.46%119.45%24.92%-100%--88.36%36.07%48.03%78.34%
Related:AGIO Dividend History·AGIO Revenue History·AGIO Price History·AGIO P/E History·AGIO Financial Ratios·AGIO Institutional Holders

AGIO SEC Filings & Documents

Agios Pharmaceuticals, Inc. (AGIO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 29, 2026·SEC

Material company update

Feb 12, 2026·SEC

Material company update

Jan 12, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 12, 2026·SEC

FY 2025

Feb 13, 2025·SEC

FY 2024

Feb 15, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Apr 29, 2026·SEC

FY 2025

Oct 30, 2025·SEC

FY 2025

Jul 31, 2025·SEC

AGIO Frequently Asked Questions

Agios Pharmaceuticals, Inc. (AGIO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Agios Pharmaceuticals, Inc. (AGIO) reported $66.0M in revenue for fiscal year 2025. This represents a 202% increase from $21.8M in 2011.

Agios Pharmaceuticals, Inc. (AGIO) grew revenue by 48.0% over the past year. This is strong growth.

Agios Pharmaceuticals, Inc. (AGIO) reported a net loss of $422.6M for fiscal year 2025.

Dividend & Returns

Agios Pharmaceuticals, Inc. (AGIO) has a return on equity (ROE) of -30.2%. Negative ROE indicates the company is unprofitable.

Agios Pharmaceuticals, Inc. (AGIO) had negative free cash flow of $384.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in AGIO back in 2011?

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