Comprehensive Stock Comparison
Compare PepGen Inc. (PEPG) vs Vertex Pharmaceuticals Incorporated (VRTX) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | VRTX | Beta 0.44 vs PEPG's 1.36 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | PEPG | +97.5% vs VRTX's +3.6% |
| Efficiency (ROA) | VRTX | 14.8% ROA vs PEPG's -49.2%, ROIC 22.8% vs -108.1% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
PepGen is a clinical-stage biotechnology company developing oligonucleotide therapeutics for severe neuromuscular and neurological diseases. It currently generates no revenue from product sales — its business model relies on research funding, partnerships, and future commercialization of its drug candidates if approved. The company's competitive advantage lies in its proprietary Enhanced Delivery Oligonucleotide (EDO) platform technology, which aims to improve cellular uptake and efficacy of therapeutic oligonucleotides.
Vertex Pharmaceuticals is a biotechnology company focused on developing and commercializing transformative medicines for serious diseases, with its flagship franchise targeting cystic fibrosis. It generates nearly all its revenue from CF therapies — primarily Trikafta/Kaftrio — while building a pipeline in pain, kidney disease, and type 1 diabetes. Its moat stems from deep scientific expertise in CFTR biology and a dominant, near-monopoly position in the CF treatment market.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
VRTX leads in 3 of 6 categories (Profitability & Efficiency, Total Returns). PEPG leads in 2 (Financial Metrics, Valuation Metrics).
Financial Metrics (TTM)
VRTX and PEPG operate at a comparable scale, with $11.7B and $0 in trailing revenue.
| Metric | PEPGPepGen Inc. | VRTXVertex Pharmaceut… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $11.7B |
| EBITDAEarnings before interest/tax | -$95M | $4.2B |
| Net IncomeAfter-tax profit | -$94M | $3.7B |
| Free Cash FlowCash after capex | -$86M | $3.3B |
| Gross MarginGross profit ÷ Revenue | — | +86.3% |
| Operating MarginEBIT ÷ Revenue | — | +34.1% |
| Net MarginNet income ÷ Revenue | — | +31.3% |
| FCF MarginFCF ÷ Revenue | — | +28.5% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +11.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +21.2% | +4.7% |
Valuation Metrics
| Metric | PEPGPepGen Inc. | VRTXVertex Pharmaceut… |
|---|---|---|
| Market CapShares × price | $203M | $126.2B |
| Enterprise ValueMkt cap + debt − cash | $172M | $124.8B |
| Trailing P/EPrice ÷ TTM EPS | -2.18x | 32.43x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 25.66x |
| PEG RatioP/E ÷ EPS growth rate | — | 3.91x |
| EV / EBITDAEnterprise value multiple | — | 26.63x |
| Price / SalesMarket cap ÷ Revenue | — | 10.52x |
| Price / BookPrice ÷ Book value/share | 1.66x | 6.87x |
| Price / FCFMarket cap ÷ FCF | — | 39.51x |
Profitability & Efficiency
VRTX delivers a 21.2% return on equity — every $100 of shareholder capital generates $21 in annual profit, vs $-57 for PEPG. PEPG carries lower financial leverage with a 0.16x debt-to-equity ratio, signaling a more conservative balance sheet compared to VRTX's 0.20x. On the Piotroski fundamental quality scale (0–9), VRTX scores 5/9 vs PEPG's 3/9, reflecting solid financial health.
| Metric | PEPGPepGen Inc. | VRTXVertex Pharmaceut… |
|---|---|---|
| ROE (TTM)Return on equity | -57.3% | +21.2% |
| ROA (TTM)Return on assets | -49.2% | +14.8% |
| ROICReturn on invested capital | -108.1% | +22.8% |
| ROCEReturn on capital employed | -75.3% | +23.0% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 5 |
| Debt / EquityFinancial leverage | 0.16x | 0.20x |
| Net DebtTotal debt minus cash | -$31M | $3.7B |
| Cash & Equiv.Liquid assets | $49M | $5.1B |
| Total DebtShort + long-term debt | $19M | $3.7B |
| Interest CoverageEBIT ÷ Interest expense | — | 348.55x |
Total Returns (with DRIP)
A $10,000 investment in VRTX five years ago would be worth $23,616 today (with dividends reinvested), compared to $4,825 for PEPG. Over the past 12 months, PEPG leads with a +97.5% total return vs VRTX's +3.6%. The 3-year compound annual growth rate (CAGR) favors VRTX at 19.6% vs PEPG's -25.9% — a key indicator of consistent wealth creation.
| Metric | PEPGPepGen Inc. | VRTXVertex Pharmaceut… |
|---|---|---|
| YTD ReturnYear-to-date | -13.2% | +9.9% |
| 1-Year ReturnPast 12 months | +97.5% | +3.6% |
| 3-Year ReturnCumulative with dividends | -59.3% | +71.1% |
| 5-Year ReturnCumulative with dividends | -51.7% | +136.2% |
| 10-Year ReturnCumulative with dividends | -51.7% | +481.2% |
| CAGR (3Y)Annualised 3-year return | -25.9% | +19.6% |
Risk & Volatility
VRTX is the less volatile stock with a 0.44 beta — it tends to amplify market swings less than PEPG's 1.36 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. VRTX currently trades 95.6% from its 52-week high vs PEPG's 79.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | PEPGPepGen Inc. | VRTXVertex Pharmaceut… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.36x | 0.44x |
| 52-Week HighHighest price in past year | $7.80 | $519.68 |
| 52-Week LowLowest price in past year | $0.88 | $362.50 |
| % of 52W HighCurrent price vs 52-week peak | +79.7% | +95.6% |
| RSI (14)Momentum oscillator 0–100 | 54.9 | 54.6 |
| Avg Volume (50D)Average daily shares traded | 595K | 1.2M |
Analyst Outlook
Wall Street rates PEPG as "Buy" and VRTX as "Buy". Consensus price targets imply 84.9% upside for PEPG (target: $12) vs 9.7% for VRTX (target: $545).
| Metric | PEPGPepGen Inc. | VRTXVertex Pharmaceut… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $11.50 | $545.08 |
| # AnalystsCovering analysts | 6 | 55 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +1.6% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | May 22 | Feb 26 | Change |
|---|---|---|---|
| PepGen Inc. (PEPG) | 100 | 39.41 | -60.6% |
| Vertex Pharmaceutic… (VRTX) | 100 | 175.2 | +75.2% |
Vertex Pharmaceutic… (VRTX) returned +136% over 5 years vs PepGen Inc. (PEPG)'s -52%. A $10,000 investment in VRTX 5 years ago would be worth $23,616 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| PepGen Inc. (PEPG) | $0.00 | $0.00 | — |
| Vertex Pharmaceutic… (VRTX) | $1.7B | $12.0B | +605.1% |
Vertex Pharmaceuticals Incorporated's revenue grew from $1.7B (2016) to $12.0B (2025) — a 24.2% CAGR.
Chart 3P/E Ratio History — 8 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Vertex Pharmaceutic… (VRTX) | 144.1 | 29.6 | -79.5% |
Vertex Pharmaceuticals Incorporated has traded in a 21x–144x P/E range over 8 years; current trailing P/E is ~32x.
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| PepGen Inc. (PEPG) | -0.06 | -2.85 | -4642.1% |
| Vertex Pharmaceutic… (VRTX) | -0.46 | 15.32 | +3430.4% |
Vertex Pharmaceuticals Incorporated's EPS grew from $-0.46 (2016) to $15.32 (2025).
Chart 5Free Cash Flow — 5 Years
PepGen Inc. generated $-83M FCF in 2024 (-259% vs 2021). Vertex Pharmaceuticals Incorporated generated $3B FCF in 2025 (+33% vs 2021).
PEPG vs VRTX: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is PEPG or VRTX a better buy right now?
Vertex Pharmaceuticals Incorporated (VRTX) offers the better valuation at 32.4x trailing P/E (25.7x forward), making it the more compelling value choice. Analysts rate PepGen Inc. (PEPG) a "Buy" — based on 6 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — PEPG or VRTX?
Over the past 5 years, Vertex Pharmaceuticals Incorporated (VRTX) delivered a total return of +136.2%, compared to -51.7% for PepGen Inc. (PEPG). A $10,000 investment in VRTX five years ago would be worth approximately $24K today (assuming dividends reinvested). Over 10 years, the gap is even starker: VRTX returned +481.2% versus PEPG's -51.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — PEPG or VRTX?
By beta (market sensitivity over 5 years), Vertex Pharmaceuticals Incorporated (VRTX) is the lower-risk stock at 0.44β versus PepGen Inc.'s 1.36β — meaning PEPG is approximately 208% more volatile than VRTX relative to the S&P 500. On balance sheet safety, PepGen Inc. (PEPG) carries a lower debt/equity ratio of 16% versus 20% for Vertex Pharmaceuticals Incorporated — giving it more financial flexibility in a downturn.
04Which has better profit margins — PEPG or VRTX?
Vertex Pharmaceuticals Incorporated (VRTX) is the more profitable company, earning 32.9% net margin versus 0.0% for PepGen Inc. — meaning it keeps 32.9% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: VRTX leads at 39.1% versus 0.0% for PEPG. At the gross margin level — before operating expenses — VRTX leads at 86.2%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is PEPG or VRTX more undervalued right now?
Analyst consensus price targets imply the most upside for PEPG: 84.9% to $11.50.
06Which pays a better dividend — PEPG or VRTX?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is PEPG or VRTX better for a retirement portfolio?
For long-horizon retirement investors, Vertex Pharmaceuticals Incorporated (VRTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.44), +481.2% 10Y return). Both have compounded well over 10 years (VRTX: +481.2%, PEPG: -51.7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between PEPG and VRTX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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