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VRTXVertex Pharmaceuticals Incorporated
$504.60$128.1B
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
VRTX logo

Vertex Pharmaceuticals Incorporated

VRTX
NASDAQ · Biotechnology
$504.60
At close - Oct 2, 4:00 PM EDT - USD
Market Cap$128.07B
P/E32.9x
52W High$560.25
Volume935.66K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Diversification Accelerates as CF Franchise Compounds Cash

Vertex's accelerating revenue growth, up 12.5% year-over-year to $3.3B in 2026Q2, is increasingly driven by new launches like Casgevy and VX-548, which may reduce historical concentration risk. Operating leverage has expanded margins to 37.4% while maintaining...

GrowthAccelerating
ProfitabilityStrong
ValuationExpensive
TechnicalsMixed
Explore valuation models
MARKET ACTION

VRTX price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

7/12 Beats

EPS beat 7 of last 12 quarters

02

Valuation risk

+16% Peers

P/E is 16% above peer median

03

Market leadership

RS 72 · Avg

Average momentum (RS Rating: 72)

04

Mixed Trend

Mixed

Price < 50DMA but > 200DMA

Next CatalystEstimated earnings · Nov 3
01

Build the investment case

Start with the evidence for owning the stock and the risks that can break the thesis.

EXECUTIVE THESIS

The Investment Case

Full Analysis
Fundamental Trajectory

Revenue growth accelerated to 12.5% year-over-year in 2026Q2, with gross margins resilient at 85.3% and operating margin expanding to 37.4% from 22.7% in 2025Q1, reflecting strong operating leverage.

Analyst Consensus+13.6% target
Buy(56 analysts)
48 Buy7 Hold1 Sell

The Bull Case

Upside Catalysts

Scientific innovation leadership

Vertex invests in scientific innovation to create transformative medicines for serious diseases, focusing on discovering and developing innovative treatments.

Strong biotech track record

Vertex was one of the first biotech firms to use rational drug design, establishing a strong reputation in the biopharmaceutical industry.

Bullish investor sentiment

There is a bullish thesis on Vertex Pharmaceuticals, indicating positive investor sentiment and potential upside for the stock.

The Bear Case

Key Downside Risks

Market performance

Price History →

Trailing total returns as of 10/3/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
VRTX+11.61%
S&P 500 (^GSPC)+12.66%
1-Year Return
VRTX+23.42%
S&P 500 (^GSPC)+15.01%
3-Year Return
VRTX+45.07%
S&P 500 (^GSPC)+79.40%
5-Year Return
VRTX+184.44%
S&P 500 (^GSPC)+81.98%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E5Y High
32.9x
Forward P/EExpansion
27.0x
EV/EBITDA100th %ile
25.5x
FCF YieldCash Flow
2.5%

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
32.9x
29.3x
100th· High
EV/EBITDA
25.5x
23.3x
100th· High
Price/FCF
40.1x
32.3x
100th· High
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
Bear$289.86-42.6%
Base (Fair)$502.25-0.5%
Bull$765.85+51.8%
$289.86 Bear$502.25 Base$765.85 Bull
Current Market Price: $504.60
Trades at a 0.5% premium to Base DCF ($502.25)
Open DCF & Valuation Models →Chart Terminal ↗

Growth & profitability

Annual revenue & EPS trend
Revenue
$12.07B+9.6% YoY
Net income
$3.95B+838.1% YoY
Free cash flow
$3.19B+504.1% YoY
Operating margin
39.4%+41.5 pts YoY
ROIC (TTM)23%
Avg ROIC 5Y-
ROE (TTM)22.5%
Piotroski Score4 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate7/12 (58%)
Revenue Beat Rate8/12 (67%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 3, 2026
$4.73-0.2%
vs $4.74
$3.3B+3.2%
vs $3.2B
Q2 2026
May 4, 2026
$4.47+5.4%
vs $4.24
$3.0B-0.2%
vs $3.0B
Q1 2026
Feb 12, 2026
$5.03-1.6%
vs $5.11
$3.2B+0.2%
vs $3.2B
Q4 2025
Nov 3, 2025
$4.80+5.0%
vs $4.57
$3.1B+0.6%
vs $3.1B
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Zacks Investment Research·1d ago
Vertex Pharmaceuticals (VRTX) Stock Falls Amid Market Uptick: What Investors Need to Know

In the latest trading session, Vertex Pharmaceuticals (VRTX) closed at $506.74, marking a -3.07% move from the previous day.

The Motley Fool·1d ago
Axsome Therapeutics vs. Vertex Pharmaceuticals: Which Biotech Stock Is a Better Buy in 2026?

Axsome Therapeutics is delivering explosive revenue growth as it scales its commercial portfolio for central nervous system disorders. Vertex Pharmaceuticals remains a highly profitable giant with absolute dominance in cystic fibrosis and expanding reach in gene therapy.

ETF Trends·2d ago
The Top HealthTech Questions Landing on Our Desks

Strong performance across the healthtech sector over the past two quarters has sparked renewed market interest in medical innovation. Given the volume of inquiries landing on our desks, we compiled this guide to answer a mix of the most frequent and most interesting questions we have received regarding our Healthcare Technology and Innovation Index (HTEC).

The Motley Fool·4d ago
2 Wall Street Analysts Think Vertex Pharmaceuticals Stock Can Soar Another 20% or More Over the Next 12 Months. Here's Why They're Right.

Vertex Pharmaceuticals is the leader in the cystic fibrosis market and has the intellectual property to maintain this dominance. The company has expanded into additional treatment areas and is awaiting a regulatory decision for another potential new product in the coming weeks.

Filtered for Vertex Pharmaceuticals IncorporatedMore Headlines
04

Compare before deciding

Benchmark VRTX against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Vertex Pharmaceuticals Incorporated (VRTX)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
VRTX logoVRTXVertex Pharmaceuticals IncorporatedCurrent
$504.60$128.07B32.949.57%32.74%22.54%—
REGN logoREGNRegeneron Pharmaceuticals, Inc.
$735.20$75.74B17.720.99%27.86%18.49%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$219.72$29.34B94.3065.19%16.82%93.61%—
BMRN logoBMRNBioMarin Pharmaceutical Inc.
$57.18$11.05B31.7712.87%2.14%1.18%—
SRPT logoSRPTSarepta Therapeutics, Inc.
$17.50$1.85B-2.4515.58%-6.93%-9.96%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$15.22$1.5B-2.6120.13%-81.79%——

Compare VRTX vs Peers

Vertex Pharmaceuticals Incorporated (VRTX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs REGN

Most directly comparable listed peer for VRTX.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare VRTX against a more recognizable public peer.

Peer Set

Compare Top 5

vs REGN, ALNY, BMRN, SRPT

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

VRTX SEC Filings & Documents

Vertex Pharmaceuticals Incorporated (VRTX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 3, 2026·SEC

Material company update

Jul 7, 2026·SEC

Material company update

May 13, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 13, 2026·SEC

FY 2025

Feb 13, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 4, 2026·SEC

FY 2026

May 5, 2026·SEC

FY 2025

Nov 4, 2025·SEC

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VRTX Frequently Asked Questions

Vertex Pharmaceuticals Incorporated (VRTX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Vertex Pharmaceuticals Incorporated's revenue?

Vertex Pharmaceuticals Incorporated (VRTX) reported $12.62B in revenue for fiscal year 2025. This represents a 94820% increase from $13.3M in 1996.

How fast is Vertex Pharmaceuticals Incorporated growing?

Vertex Pharmaceuticals Incorporated (VRTX) grew revenue by 9.6% over the past year. This is steady growth.

Is VRTX profitable?

Yes, Vertex Pharmaceuticals Incorporated (VRTX) is profitable, generating $4.41B in net income for fiscal year 2025 (32.7% net margin).

Dividend & Returns
What is VRTX's return on equity?

Vertex Pharmaceuticals Incorporated (VRTX) has a return on equity (ROE) of 22.5%. This is excellent, indicating efficient use of shareholder capital.

What is Vertex Pharmaceuticals Incorporated's free cash flow?

Vertex Pharmaceuticals Incorporated (VRTX) generated $3.80B in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in VRTX back in 1996?

Total return calculator · dividends reinvested · 30+ years of data

See returns →