Comprehensive Stock Comparison
Compare Silexion Therapeutics Ltd. (SLXNW) vs Agios Pharmaceuticals, Inc. (AGIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety | AGIO | Beta 0.91 vs SLXNW's 1.29 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | AGIO | -14.9% vs SLXNW's -42.7% |
| Efficiency (ROA) | AGIO | -29.0% ROA vs SLXNW's -79.6% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Silexion Therapeutics is a biopharmaceutical company that develops RNA interference-based cancer drugs using its proprietary LODER delivery platform to treat solid tumors. It generates revenue through research grants, partnerships, and potential future drug sales — though currently in pre-clinical and early clinical stages without commercial products. Its key competitive advantage is the LODER delivery system, which enables targeted, sustained release of RNAi therapeutics directly to tumor sites.
Agios Pharmaceuticals is a biopharmaceutical company focused on developing treatments for rare genetic diseases related to cellular metabolism. It generates revenue primarily from sales of its lead drug PYRUKYND for pyruvate kinase deficiency — with additional income from research collaborations and milestone payments — while advancing a pipeline of other metabolic therapies. The company's competitive advantage lies in its deep expertise in cellular metabolism science and proprietary platform for targeting metabolic pathways in rare diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
AGIO leads in 4 of 6 categories (Valuation Metrics, Profitability & Efficiency). SLXNW leads in 1 (Financial Metrics).
Financial Metrics (TTM)
AGIO and SLXNW operate at a comparable scale, with $45M and $0 in trailing revenue.
| Metric | SLXNWSilexion Therapeu… | AGIOAgios Pharmaceuti… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $45M |
| EBITDAEarnings before interest/tax | -$9M | -$470M |
| Net IncomeAfter-tax profit | -$9M | -$401M |
| Free Cash FlowCash after capex | -$11M | -$414M |
| Gross MarginGross profit ÷ Revenue | — | +84.4% |
| Operating MarginEBIT ÷ Revenue | — | -10.6% |
| Net MarginNet income ÷ Revenue | — | -9.0% |
| FCF MarginFCF ÷ Revenue | — | -9.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +43.7% |
| EPS Growth (YoY)Latest quarter vs prior year | +115.7% | -111.0% |
Valuation Metrics
| Metric | SLXNWSilexion Therapeu… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Market CapShares × price | $64M | $2.25T |
| Enterprise ValueMkt cap + debt − cash | $67M | $2.25T |
| Trailing P/EPrice ÷ TTM EPS | 0.00x | -4.25x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | 9999.00x |
| Price / BookPrice ÷ Book value/share | — | 1.47x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
AGIO delivers a -31.2% return on equity — every $100 of shareholder capital generates $-31 in annual profit, vs $-133 for SLXNW. On the Piotroski fundamental quality scale (0–9), AGIO scores 3/9 vs SLXNW's 2/9, reflecting mixed financial health.
| Metric | SLXNWSilexion Therapeu… | AGIOAgios Pharmaceuti… |
|---|---|---|
| ROE (TTM)Return on equity | -132.5% | -31.2% |
| ROA (TTM)Return on assets | -79.6% | -29.0% |
| ROICReturn on invested capital | — | -26.6% |
| ROCEReturn on capital employed | -10.5% | -33.8% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 3 |
| Debt / EquityFinancial leverage | — | 0.03x |
| Net DebtTotal debt minus cash | $3M | -$49M |
| Cash & Equiv.Liquid assets | $1M | $89M |
| Total DebtShort + long-term debt | $4M | $40M |
| Interest CoverageEBIT ÷ Interest expense | -1479.89x | — |
Total Returns (with DRIP)
A $10,000 investment in AGIO five years ago would be worth $6,363 today (with dividends reinvested), compared to $2,024 for SLXNW. Over the past 12 months, AGIO leads with a -14.9% total return vs SLXNW's -42.7%. The 3-year compound annual growth rate (CAGR) favors AGIO at 6.1% vs SLXNW's -41.3% — a key indicator of consistent wealth creation.
| Metric | SLXNWSilexion Therapeu… | AGIOAgios Pharmaceuti… |
|---|---|---|
| YTD ReturnYear-to-date | +32.3% | +11.2% |
| 1-Year ReturnPast 12 months | -42.7% | -14.9% |
| 3-Year ReturnCumulative with dividends | -79.8% | +19.4% |
| 5-Year ReturnCumulative with dividends | -79.8% | -36.4% |
| 10-Year ReturnCumulative with dividends | -79.8% | -21.2% |
| CAGR (3Y)Annualised 3-year return | -41.3% | +6.1% |
Risk & Volatility
AGIO is the less volatile stock with a 0.91 beta — it tends to amplify market swings less than SLXNW's 1.29 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. AGIO currently trades 65.7% from its 52-week high vs SLXNW's 38.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | SLXNWSilexion Therapeu… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.29x | 0.91x |
| 52-Week HighHighest price in past year | $0.09 | $46.00 |
| 52-Week LowLowest price in past year | $0.02 | $22.24 |
| % of 52W HighCurrent price vs 52-week peak | +38.2% | +65.7% |
| RSI (14)Momentum oscillator 0–100 | 52.3 | 62.3 |
| Avg Volume (50D)Average daily shares traded | 49K | 948K |
Analyst Outlook
| Metric | SLXNWSilexion Therapeu… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $41.50 |
| # AnalystsCovering analysts | — | 29 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Aug 24 | Feb 26 | Change |
|---|---|---|---|
| Silexion Therapeuti… (SLXNW) | 100 | 24.94 | -75.1% |
| Agios Pharmaceutica… (AGIO) | 100 | 89.72 | -10.3% |
Agios Pharmaceutica… (AGIO) returned -36% over 5 years vs Silexion Therapeuti… (SLXNW)'s -80%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Silexion Therapeuti… (SLXNW) | $0.00 | $0.00 | — |
| Agios Pharmaceutica… (AGIO) | $70M | $54M | -22.7% |
Agios Pharmaceuticals, Inc.'s revenue grew from $70M (2016) to $54M (2025) — a -2.8% CAGR.
Chart 3EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Silexion Therapeuti… (SLXNW) | -0.12 | 25.49 | +21341.7% |
| Agios Pharmaceutica… (AGIO) | -5.07 | -7.12 | -40.4% |
Agios Pharmaceuticals, Inc.'s EPS grew from $-5.07 (2016) to $-7.12 (2025).
Chart 4Free Cash Flow — 5 Years
Silexion Therapeutics Ltd. generated $-8M FCF in 2024 (-498% vs 2021). Agios Pharmaceuticals, Inc. generated $-377M FCF in 2025 (+9% vs 2021).
SLXNW vs AGIO: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is SLXNW or AGIO a better buy right now?
Silexion Therapeutics Ltd. (SLXNW) offers the better valuation at 0.0x trailing P/E, making it the more compelling value choice. Analysts rate Agios Pharmaceuticals, Inc. (AGIO) a "Buy" — based on 29 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — SLXNW or AGIO?
Over the past 5 years, Agios Pharmaceuticals, Inc. (AGIO) delivered a total return of -36.4%, compared to -79.8% for Silexion Therapeutics Ltd. (SLXNW). A $10,000 investment in AGIO five years ago would be worth approximately $6K today (assuming dividends reinvested). Over 10 years, the gap is even starker: AGIO returned -21.2% versus SLXNW's -79.8%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — SLXNW or AGIO?
By beta (market sensitivity over 5 years), Agios Pharmaceuticals, Inc. (AGIO) is the lower-risk stock at 0.91β versus Silexion Therapeutics Ltd.'s 1.29β — meaning SLXNW is approximately 43% more volatile than AGIO relative to the S&P 500.
04Which has better profit margins — SLXNW or AGIO?
Silexion Therapeutics Ltd. (SLXNW) is the more profitable company, earning 0.0% net margin versus -764.0% for Agios Pharmaceuticals, Inc. — meaning it keeps 0.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: SLXNW leads at 0.0% versus -873.9% for AGIO. At the gross margin level — before operating expenses — AGIO leads at 88.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — SLXNW or AGIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is SLXNW or AGIO better for a retirement portfolio?
For long-horizon retirement investors, Agios Pharmaceuticals, Inc. (AGIO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.91)). Both have compounded well over 10 years (AGIO: -21.2%, SLXNW: -79.8%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between SLXNW and AGIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. In terms of investment character: SLXNW is a small-cap deep-value stock; AGIO is a mega-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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