Comprehensive Stock Comparison
Compare Arvinas, Inc. (ARVN) vs Immunome, Inc. (IMNM) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | ARVN | -0.3% revenue growth vs IMNM's -35.5% |
| Quality / Margins | ARVN | -30.8% net margin vs IMNM's -23.0% |
| Stability / Safety | ARVN | Beta 0.99 vs IMNM's 1.42, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | IMNM | +132.6% vs ARVN's -25.0% |
| Efficiency (ROA) | ARVN | -11.3% ROA vs IMNM's -74.4%, ROIC -23.1% vs -7.0% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Arvinas is a clinical-stage biopharmaceutical company pioneering targeted protein degradation therapies using its PROTAC platform. It generates revenue primarily through research collaborations and licensing deals with major pharmaceutical partners — including Pfizer and Genentech — which provide upfront payments, milestone payments, and potential future royalties. The company's key advantage is its proprietary PROTAC technology platform, which enables the targeted degradation of disease-causing proteins that traditional drug discovery approaches cannot effectively address.
Immunome is a biopharmaceutical company that discovers and develops antibody therapeutics for cancer and infectious diseases. It generates revenue primarily through research collaborations and licensing agreements — with no commercial products yet — as it advances its pipeline of antibody candidates. The company's key advantage lies in its proprietary discovery platform that identifies human antibodies from patient immune responses, potentially yielding more effective and safer therapeutic candidates.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
ARVN leads in 3 of 6 categories (Financial Metrics, Valuation Metrics). IMNM leads in 1 (Total Returns). 1 tied.
Financial Metrics (TTM)
ARVN is the larger business by revenue, generating $263M annually — 27.1x IMNM's $10M. Profitability is closely matched — net margins range from -30.8% (ARVN) to -23.0% (IMNM). On growth, ARVN holds the edge at -84.0% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ARVNArvinas, Inc. | IMNMImmunome, Inc. |
|---|---|---|
| RevenueTrailing 12 months | $263M | $10M |
| EBITDAEarnings before interest/tax | -$114M | -$232M |
| Net IncomeAfter-tax profit | -$81M | -$223M |
| Free Cash FlowCash after capex | -$276M | -$192M |
| Gross MarginGross profit ÷ Revenue | -151.8% | -4.2% |
| Operating MarginEBIT ÷ Revenue | -45.1% | -24.2% |
| Net MarginNet income ÷ Revenue | -30.8% | -23.0% |
| FCF MarginFCF ÷ Revenue | -105.0% | -19.8% |
| Rev. Growth (YoY)Latest quarter vs prior year | -84.0% | -100.0% |
| EPS Growth (YoY)Latest quarter vs prior year | -74.6% | +16.7% |
Valuation Metrics
| Metric | ARVNArvinas, Inc. | IMNMImmunome, Inc. |
|---|---|---|
| Market CapShares × price | $975M | $2.0B |
| Enterprise ValueMkt cap + debt − cash | $841M | $1.9B |
| Trailing P/EPrice ÷ TTM EPS | -10.37x | -4.37x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 3.71x | 221.74x |
| Price / BookPrice ÷ Book value/share | 1.98x | 7.08x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
ARVN delivers a -18.6% return on equity — every $100 of shareholder capital generates $-19 in annual profit, vs $-84 for IMNM. ARVN carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to IMNM's 0.03x. On the Piotroski fundamental quality scale (0–9), ARVN scores 4/9 vs IMNM's 1/9, reflecting mixed financial health.
| Metric | ARVNArvinas, Inc. | IMNMImmunome, Inc. |
|---|---|---|
| ROE (TTM)Return on equity | -18.6% | -84.4% |
| ROA (TTM)Return on assets | -11.3% | -74.4% |
| ROICReturn on invested capital | -23.1% | -7.0% |
| ROCEReturn on capital employed | -16.5% | -195.6% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 1 |
| Debt / EquityFinancial leverage | 0.02x | 0.03x |
| Net DebtTotal debt minus cash | -$134M | -$139M |
| Cash & Equiv.Liquid assets | $143M | $143M |
| Total DebtShort + long-term debt | $9M | $5M |
| Interest CoverageEBIT ÷ Interest expense | — | — |
Total Returns (with DRIP)
A $10,000 investment in IMNM five years ago would be worth $5,472 today (with dividends reinvested), compared to $1,717 for ARVN. Over the past 12 months, IMNM leads with a +132.6% total return vs ARVN's -25.0%. The 3-year compound annual growth rate (CAGR) favors IMNM at 68.5% vs ARVN's -24.3% — a key indicator of consistent wealth creation.
| Metric | ARVNArvinas, Inc. | IMNMImmunome, Inc. |
|---|---|---|
| YTD ReturnYear-to-date | +15.7% | +5.0% |
| 1-Year ReturnPast 12 months | -25.0% | +132.6% |
| 3-Year ReturnCumulative with dividends | -56.7% | +378.3% |
| 5-Year ReturnCumulative with dividends | -82.8% | -45.3% |
| 10-Year ReturnCumulative with dividends | -17.3% | +62.5% |
| CAGR (3Y)Annualised 3-year return | -24.3% | +68.5% |
Risk & Volatility
ARVN is the less volatile stock with a 0.99 beta — it tends to amplify market swings less than IMNM's 1.42 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMNM currently trades 79.1% from its 52-week high vs ARVN's 70.1% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ARVNArvinas, Inc. | IMNMImmunome, Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.99x | 1.42x |
| 52-Week HighHighest price in past year | $18.93 | $27.65 |
| 52-Week LowLowest price in past year | $5.90 | $5.15 |
| % of 52W HighCurrent price vs 52-week peak | +70.1% | +79.1% |
| RSI (14)Momentum oscillator 0–100 | 58.3 | 42.9 |
| Avg Volume (50D)Average daily shares traded | 621K | 1.5M |
Analyst Outlook
Wall Street rates ARVN as "Buy" and IMNM as "Buy". Consensus price targets imply 61.4% upside for IMNM (target: $35) vs -0.8% for ARVN (target: $13).
| Metric | ARVNArvinas, Inc. | IMNMImmunome, Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $13.17 | $35.29 |
| # AnalystsCovering analysts | 26 | 9 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +9.4% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Nov 20 | Feb 26 | Change |
|---|---|---|---|
| Arvinas, Inc. (ARVN) | 100 | 63.24 | -36.8% |
| Immunome, Inc. (IMNM) | 81.64 | 194.35 | +138.1% |
Immunome, Inc. (IMNM) returned -45% over 5 years vs Arvinas, Inc. (ARVN)'s -83%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Arvinas, Inc. (ARVN) | $7M | $263M | +3837.6% |
| Immunome, Inc. (IMNM) | $0.00 | $9M | — |
Arvinas, Inc.'s revenue grew from $7M (2016) to $263M (2025) — a 50.4% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Arvinas, Inc. (ARVN) | -2.2% | -30.8% | -1329.9% |
| Immunome, Inc. (IMNM) | -7.6% | -32.4% | -325.3% |
Arvinas, Inc.'s net margin went from -2% (2016) to -31% (2025).
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Arvinas, Inc. (ARVN) | -7.56 | -1.28 | +83.1% |
| Immunome, Inc. (IMNM) | -7.18 | -5 | +30.4% |
Arvinas, Inc.'s EPS grew from $-7.56 (2016) to $-1.28 (2025).
Chart 5Free Cash Flow — 5 Years
Arvinas, Inc. generated $-276M FCF in 2025 (-150% vs 2021). Immunome, Inc. generated $-164M FCF in 2024 (-798% vs 2021).
ARVN vs IMNM: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is ARVN or IMNM a better buy right now?
Analysts rate Arvinas, Inc. (ARVN) a "Buy" — based on 26 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ARVN or IMNM?
Over the past 5 years, Immunome, Inc. (IMNM) delivered a total return of -45.3%, compared to -82.8% for Arvinas, Inc. (ARVN). A $10,000 investment in IMNM five years ago would be worth approximately $5K today (assuming dividends reinvested). Over 10 years, the gap is even starker: IMNM returned +62.5% versus ARVN's -17.3%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ARVN or IMNM?
By beta (market sensitivity over 5 years), Arvinas, Inc. (ARVN) is the lower-risk stock at 0.99β versus Immunome, Inc.'s 1.42β — meaning IMNM is approximately 43% more volatile than ARVN relative to the S&P 500. On balance sheet safety, Arvinas, Inc. (ARVN) carries a lower debt/equity ratio of 2% versus 3% for Immunome, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — ARVN or IMNM?
Arvinas, Inc. (ARVN) is the more profitable company, earning -30.8% net margin versus -32.4% for Immunome, Inc. — meaning it keeps -30.8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ARVN leads at -45.1% versus -33.8% for IMNM. At the gross margin level — before operating expenses — IMNM leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — ARVN or IMNM?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is ARVN or IMNM better for a retirement portfolio?
For long-horizon retirement investors, Arvinas, Inc. (ARVN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.99)). Both have compounded well over 10 years (ARVN: -17.3%, IMNM: +62.5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between ARVN and IMNM?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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