Comprehensive Stock Comparison
Compare Aspire Biopharma Holdings, Inc. (ASBPW) vs Agios Pharmaceuticals, Inc. (AGIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Quality / Margins |  AGIO | -9.0% net margin vs ASBPW's -16K% |
| Stability / Safety |  ASBPW | Beta 0.76 vs AGIO's 0.91 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | AGIO | -17.0% vs ASBPW's -63.8% |
| Efficiency (ROA) | AGIO | -29.0% ROA vs ASBPW's -13.2% |
Who Each Stock Is For
Income & stability
ASBPWbeta 0.76
Growth exposure
AGIORev growth 48.0%, EPS growth -161.2%, 3Y rev CAGR 56.0%
Long-term compounding (10Y)
AGIO-40.9% 10Y total return vs ASBPW's -74.2%
Sleep-well-at-night portfolio
ASBPWLower volatility, beta 0.76, current ratio 0.09x
Defensive / Recession hedge
ASBPWBeta 0.76, current ratio 0.09x
Business Model
What each company does and how it makes money
Aspire Biopharma Holdings is a biotechnology company that develops advanced diagnostic solutions and molecular tests for disease detection. It generates revenue primarily through sales of its diagnostic assays and testing services to healthcare providers and research institutions. The company's competitive advantage lies in its proprietary genetic testing technology and specialized expertise in precision diagnostics.
Agios Pharmaceuticals is a biopharmaceutical company focused on developing treatments for rare genetic diseases related to cellular metabolism. It generates revenue primarily from sales of its lead drug PYRUKYND for pyruvate kinase deficiency — with additional income from research collaborations and milestone payments — while advancing a pipeline of other metabolic therapies. The company's competitive advantage lies in its deep expertise in cellular metabolism science and proprietary platform for targeting metabolic pathways in rare diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
AGIO 4ASBPW 0AGIO4/5 metricsAGIO1/1 metricsAGIO2/3 metricsAGIO5/6 metricsAGIO leads in 4 of 6 categories — strongest in Financial Metrics and Valuation Metrics. 1 category is tied.
Financial Metrics (TTM)
AGIO is the larger business by revenue, generating $45M annually — 23076.2x ASBPW's $1,941. AGIO is the more profitable business, keeping -9.0% of every revenue dollar as net income compared to ASBPW's -16351.8%.
| Metric | ASBPWAspire Biopharma … | AGIOAgios Pharmaceuti… |
|---|---|---|
| RevenueTrailing 12 months | $1,941 | $45M |
| EBITDAEarnings before interest/tax | -$28M | -$470M |
| Net IncomeAfter-tax profit | -$32M | -$401M |
| Free Cash FlowCash after capex | -$4M | -$414M |
| Gross MarginGross profit ÷ Revenue | +45.5% | +84.4% |
| Operating MarginEBIT ÷ Revenue | -10314.0% | -10.6% |
| Net MarginNet income ÷ Revenue | -16351.8% | -9.0% |
| FCF MarginFCF ÷ Revenue | -1811.5% | -9.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +43.7% |
| EPS Growth (YoY)Latest quarter vs prior year | +46.0% | -111.0% |
Valuation Metrics
| Metric | ASBPWAspire Biopharma … | AGIOAgios Pharmaceuti… |
|---|---|---|
| Market CapShares × price | $178,899 | $1.6B |
| Enterprise ValueMkt cap + debt − cash | $1M | $1.6B |
| Trailing P/EPrice ÷ TTM EPS | -0.01x | -3.96x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | 30.25x |
| Price / BookPrice ÷ Book value/share | — | 1.37x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
| Metric | ASBPWAspire Biopharma … | AGIOAgios Pharmaceuti… |
|---|---|---|
| ROE (TTM)Return on equity | — | -31.2% |
| ROA (TTM)Return on assets | -13.2% | -29.0% |
| ROICReturn on invested capital | — | -26.6% |
| ROCEReturn on capital employed | — | -33.8% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 3 |
| Debt / EquityFinancial leverage | — | 0.03x |
| Net DebtTotal debt minus cash | $1M | -$49M |
| Cash & Equiv.Liquid assets | $3,633 | $89M |
| Total DebtShort + long-term debt | $1M | $40M |
| Interest CoverageEBIT ÷ Interest expense | -10.51x | — |
Total Returns (with DRIP)
A $10,000 investment in AGIO five years ago would be worth $5,766 today (with dividends reinvested), compared to $2,583 for ASBPW. Over the past 12 months, AGIO leads with a -17.0% total return vs ASBPW's -63.8%. The 3-year compound annual growth rate (CAGR) favors AGIO at 5.3% vs ASBPW's -36.3% — a key indicator of consistent wealth creation.
| Metric | ASBPWAspire Biopharma … | AGIOAgios Pharmaceuti… |
|---|---|---|
| YTD ReturnYear-to-date | +16.7% | +3.7% |
| 1-Year ReturnPast 12 months | -63.8% | -17.0% |
| 3-Year ReturnCumulative with dividends | -74.2% | +16.6% |
| 5-Year ReturnCumulative with dividends | -74.2% | -42.3% |
| 10-Year ReturnCumulative with dividends | -74.2% | -40.9% |
| CAGR (3Y)Annualised 3-year return | -36.3% | +5.3% |
Risk & Volatility
ASBPW is the less volatile stock with a 0.76 beta — it tends to amplify market swings less than AGIO's 0.91 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. AGIO currently trades 61.3% from its 52-week high vs ASBPW's 24.1% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ASBPWAspire Biopharma … | AGIOAgios Pharmaceuti… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.76x | 0.91x |
| 52-Week HighHighest price in past year | $0.09 | $46.00 |
| 52-Week LowLowest price in past year | $0.01 | $22.24 |
| % of 52W HighCurrent price vs 52-week peak | +24.1% | +61.3% |
| RSI (14)Momentum oscillator 0–100 | 49.0 | 48.8 |
| Avg Volume (50D)Average daily shares traded | 41K | 896K |
Analyst Outlook
| Metric | ASBPWAspire Biopharma … | AGIOAgios Pharmaceuti… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $41.50 |
| # AnalystsCovering analysts | — | 29 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 25 | Mar 26 | Change |
|---|---|---|---|
| Aspire Biopharma Ho… (ASBPW) | 100 | 28.81 | -71.2% |
| Agios Pharmaceutica… (AGIO) | 100 | 88.16 | -11.8% |
Agios Pharmaceutica… (AGIO) returned -42% over 5 years vs Aspire Biopharma Ho… (ASBPW)'s -74%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Aspire Biopharma Ho… (ASBPW) | $0.00 | $0.00 | — |
| Agios Pharmaceutica… (AGIO) | $70M | $54M | -22.7% |
Agios Pharmaceuticals, Inc.'s revenue grew from $70M (2016) to $54M (2025) — a -2.8% CAGR.
Chart 3EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Aspire Biopharma Ho… (ASBPW) | -0.07 | -1.52 | -1999.4% |
| Agios Pharmaceutica… (AGIO) | -5.07 | -7.12 | -40.4% |
Agios Pharmaceuticals, Inc.'s EPS grew from $-5.07 (2016) to $-7.12 (2025).
Chart 4Free Cash Flow — 5 Years
Aspire Biopharma Holdings, Inc. generated $-0M FCF in 2024 (+95% vs 2022). Agios Pharmaceuticals, Inc. generated $-377M FCF in 2025 (+9% vs 2021).
ASBPW vs AGIO: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is ASBPW or AGIO a better buy right now?
Analysts rate Agios Pharmaceuticals, Inc. (AGIO) a "Buy" — based on 29 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ASBPW or AGIO?
Over the past 5 years, Agios Pharmaceuticals, Inc. (AGIO) delivered a total return of -42.3%, compared to -74.2% for Aspire Biopharma Holdings, Inc. (ASBPW). A $10,000 investment in AGIO five years ago would be worth approximately $6K today (assuming dividends reinvested). Over 10 years, the gap is even starker: AGIO returned -40.9% versus ASBPW's -74.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ASBPW or AGIO?
By beta (market sensitivity over 5 years), Aspire Biopharma Holdings, Inc. (ASBPW) is the lower-risk stock at 0.76β versus Agios Pharmaceuticals, Inc.'s 0.91β — meaning AGIO is approximately 19% more volatile than ASBPW relative to the S&P 500.
04Which has better profit margins — ASBPW or AGIO?
Agios Pharmaceuticals, Inc. (AGIO) is the more profitable company, earning -764.0% net margin versus -16351.8% for Aspire Biopharma Holdings, Inc. — meaning it keeps -764.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: AGIO leads at -873.9% versus -10314.0% for ASBPW. At the gross margin level — before operating expenses — AGIO leads at 88.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — ASBPW or AGIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is ASBPW or AGIO better for a retirement portfolio?
For long-horizon retirement investors, Aspire Biopharma Holdings, Inc. (ASBPW) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.76)). Both have compounded well over 10 years (ASBPW: -74.2%, AGIO: -40.9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between ASBPW and AGIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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