Comprehensive Stock Comparison
Compare Can-Fite BioPharma Ltd. (CANF) vs Kiniksa Pharmaceuticals, Ltd. (KNSA) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | KNSA | 60.1% revenue growth vs CANF's -9.3% |
| Quality / Margins | KNSA | 17.5% net margin vs CANF's -15.7% |
| Stability / Safety | CANF | Beta 0.36 vs KNSA's 0.46 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | CANF | +169.9% vs KNSA's +119.4% |
| Efficiency (ROA) | KNSA | 15.5% ROA vs CANF's -114.0%, ROIC 17.1% vs -448.3% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Can-Fite BioPharma is a clinical-stage biopharmaceutical company developing small molecule drugs targeting inflammatory diseases and cancer. It generates revenue primarily through licensing agreements and milestone payments from partners — with no commercial products yet — as it advances its lead candidates through clinical trials. The company's competitive advantage lies in its proprietary A3 adenosine receptor platform, which targets a novel pathway for treating autoimmune and inflammatory conditions.
Kiniksa Pharmaceuticals is a biopharmaceutical company that develops and commercializes treatments for inflammatory and autoimmune diseases. It generates revenue primarily from sales of ARCALYST for recurrent pericarditis — its only approved product — with additional income from licensing and collaboration agreements. The company's competitive advantage lies in its targeted pipeline of monoclonal antibodies addressing specific immune pathways with high unmet medical needs.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
KNSA leads in 4 of 6 categories (Financial Metrics, Valuation Metrics). CANF leads in 1 (Risk & Volatility).
Financial Metrics (TTM)
KNSA is the larger business by revenue, generating $678M annually — 1209.9x CANF's $560,000. KNSA is the more profitable business, keeping 17.5% of every revenue dollar as net income compared to CANF's -15.7%. On growth, KNSA holds the edge at +65.0% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | CANFCan-Fite BioPharm… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| RevenueTrailing 12 months | $560,000 | $678M |
| EBITDAEarnings before interest/tax | -$9M | $79M |
| Net IncomeAfter-tax profit | -$9M | $119M |
| Free Cash FlowCash after capex | -$8M | $136M |
| Gross MarginGross profit ÷ Revenue | +100.0% | — |
| Operating MarginEBIT ÷ Revenue | -16.0% | +11.4% |
| Net MarginNet income ÷ Revenue | -15.7% | +17.5% |
| FCF MarginFCF ÷ Revenue | -14.9% | +20.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | -36.1% | +65.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +36.4% | +2.5% |
Valuation Metrics
| Metric | CANFCan-Fite BioPharm… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| Market CapShares × price | $14.2B | $3.4B |
| Enterprise ValueMkt cap + debt − cash | $14.2B | $3.2B |
| Trailing P/EPrice ÷ TTM EPS | -4.40x | 59.32x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 34.78x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | 41.03x |
| Price / SalesMarket cap ÷ Revenue | 9999.00x | 5.01x |
| Price / BookPrice ÷ Book value/share | 6.34x | 6.19x |
| Price / FCFMarket cap ÷ FCF | — | 133.57x |
Profitability & Efficiency
KNSA delivers a 20.9% return on equity — every $100 of shareholder capital generates $21 in annual profit, vs $-2 for CANF. KNSA carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to CANF's 0.02x. On the Piotroski fundamental quality scale (0–9), KNSA scores 6/9 vs CANF's 1/9, reflecting solid financial health.
| Metric | CANFCan-Fite BioPharm… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| ROE (TTM)Return on equity | -2.1% | +20.9% |
| ROA (TTM)Return on assets | -114.0% | +15.5% |
| ROICReturn on invested capital | -4.5% | +17.1% |
| ROCEReturn on capital employed | -108.1% | +14.0% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 6 |
| Debt / EquityFinancial leverage | 0.02x | 0.02x |
| Net DebtTotal debt minus cash | -$5M | -$156M |
| Cash & Equiv.Liquid assets | $5M | $166M |
| Total DebtShort + long-term debt | $104,000 | $9M |
| Interest CoverageEBIT ÷ Interest expense | -580.71x | — |
Total Returns (with DRIP)
A $10,000 investment in KNSA five years ago would be worth $20,324 today (with dividends reinvested), compared to $2,351 for CANF. Over the past 12 months, CANF leads with a +169.9% total return vs KNSA's +119.4%. The 3-year compound annual growth rate (CAGR) favors KNSA at 51.2% vs CANF's 20.6% — a key indicator of consistent wealth creation.
| Metric | CANFCan-Fite BioPharm… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| YTD ReturnYear-to-date | +2059.1% | +5.9% |
| 1-Year ReturnPast 12 months | +169.9% | +119.4% |
| 3-Year ReturnCumulative with dividends | +75.3% | +246.0% |
| 5-Year ReturnCumulative with dividends | -76.5% | +103.2% |
| 10-Year ReturnCumulative with dividends | -98.5% | +128.5% |
| CAGR (3Y)Annualised 3-year return | +20.6% | +51.2% |
Risk & Volatility
CANF is the less volatile stock with a 0.36 beta — it tends to amplify market swings less than KNSA's 0.46 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. CANF currently trades 96.3% from its 52-week high vs KNSA's 90.6% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CANFCan-Fite BioPharm… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.36x | 0.46x |
| 52-Week HighHighest price in past year | $4.93 | $49.12 |
| 52-Week LowLowest price in past year | $0.17 | $18.26 |
| % of 52W HighCurrent price vs 52-week peak | +96.3% | +90.6% |
| RSI (14)Momentum oscillator 0–100 | 68.6 | 47.3 |
| Avg Volume (50D)Average daily shares traded | 4.3M | 469K |
Analyst Outlook
Wall Street rates CANF as "Buy" and KNSA as "Buy". Consensus price targets imply 52.6% upside for CANF (target: $7) vs 25.1% for KNSA (target: $56).
| Metric | CANFCan-Fite BioPharm… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $7.25 | $55.67 |
| # AnalystsCovering analysts | 4 | 10 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 20 | Feb 26 | Change |
|---|---|---|---|
| Can-Fite BioPharma … (CANF) | 100 | 33.04 | -67.0% |
| Kiniksa Pharmaceuti… (KNSA) | 100 | 241.98 | +142.0% |
Kiniksa Pharmaceuti… (KNSA) returned +103% over 5 years vs Can-Fite BioPharma … (CANF)'s -76%. A $10,000 investment in KNSA 5 years ago would be worth $20,324 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Can-Fite BioPharma … (CANF) | $169500.00 | $674000.00 | +297.6% |
| Kiniksa Pharmaceuti… (KNSA) | $0.00 | $678M | — |
Kiniksa Pharmaceuticals, Ltd.'s revenue grew from $0M (2016) to $678M (2025) — a 0.0% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Can-Fite BioPharma … (CANF) | -40.7% | -11.7% | +71.3% |
| Kiniksa Pharmaceuti… (KNSA) | -4.1% | 17.5% | +527.7% |
Chart 4P/E Ratio History — 3 Years
| Stock | 2022 | 2025 | Change |
|---|---|---|---|
| Kiniksa Pharmaceuti… (KNSA) | 5.8 | 55 | +848.3% |
Kiniksa Pharmaceuticals, Ltd. has traded in a 6x–88x P/E range over 3 years; current trailing P/E is ~59x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Can-Fite BioPharma … (CANF) | -90 | -1.08 | +98.8% |
| Kiniksa Pharmaceuti… (KNSA) | -0.74 | 0.75 | +201.4% |
Kiniksa Pharmaceuticals, Ltd.'s EPS grew from $-0.74 (2016) to $0.75 (2025).
Chart 6Free Cash Flow — 5 Years
Can-Fite BioPharma Ltd. generated $-8M FCF in 2024 (+23% vs 2021). Kiniksa Pharmaceuticals, Ltd. generated $25M FCF in 2025 (+117% vs 2021).
CANF vs KNSA: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is CANF or KNSA a better buy right now?
Kiniksa Pharmaceuticals, Ltd. (KNSA) offers the better valuation at 59.3x trailing P/E (34.8x forward), making it the more compelling value choice. Analysts rate Can-Fite BioPharma Ltd. (CANF) a "Buy" — based on 4 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CANF or KNSA?
Over the past 5 years, Kiniksa Pharmaceuticals, Ltd. (KNSA) delivered a total return of +103.2%, compared to -76.5% for Can-Fite BioPharma Ltd. (CANF). A $10,000 investment in KNSA five years ago would be worth approximately $20K today (assuming dividends reinvested). Over 10 years, the gap is even starker: KNSA returned +128.5% versus CANF's -98.5%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CANF or KNSA?
By beta (market sensitivity over 5 years), Can-Fite BioPharma Ltd. (CANF) is the lower-risk stock at 0.36β versus Kiniksa Pharmaceuticals, Ltd.'s 0.46β — meaning KNSA is approximately 29% more volatile than CANF relative to the S&P 500. On balance sheet safety, Kiniksa Pharmaceuticals, Ltd. (KNSA) carries a lower debt/equity ratio of 2% versus 2% for Can-Fite BioPharma Ltd. — giving it more financial flexibility in a downturn.
04Which has better profit margins — CANF or KNSA?
Kiniksa Pharmaceuticals, Ltd. (KNSA) is the more profitable company, earning 17.5% net margin versus -1169.1% for Can-Fite BioPharma Ltd. — meaning it keeps 17.5% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: KNSA leads at 11.4% versus -1206.2% for CANF. At the gross margin level — before operating expenses — CANF leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is CANF or KNSA more undervalued right now?
Analyst consensus price targets imply the most upside for CANF: 52.6% to $7.25.
06Which pays a better dividend — CANF or KNSA?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is CANF or KNSA better for a retirement portfolio?
For long-horizon retirement investors, Kiniksa Pharmaceuticals, Ltd. (KNSA) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.46), +128.5% 10Y return). Both have compounded well over 10 years (KNSA: +128.5%, CANF: -98.5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between CANF and KNSA?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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