Comprehensive Stock Comparison
Compare Cross Country Healthcare, Inc. (CCRN) vs Agios Pharmaceuticals, Inc. (AGIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | AGIO | 48.0% revenue growth vs CCRN's -33.5% |
| Quality / Margins | CCRN | -1.4% net margin vs AGIO's -9.0% |
| Stability / Safety | CCRN | Beta 0.43 vs AGIO's 0.91, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | AGIO | -14.9% vs CCRN's -49.3% |
| Efficiency (ROA) | CCRN | -2.9% ROA vs AGIO's -29.0%, ROIC -3.2% vs -26.6% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Cross Country Healthcare is a healthcare staffing and workforce solutions company that provides temporary and permanent placement of clinical professionals. It generates revenue primarily from nurse and allied staffing services — which account for the majority of its business — along with physician staffing and workforce management solutions. The company's competitive advantage lies in its extensive national network and deep healthcare industry expertise, which enables it to efficiently match qualified professionals with healthcare facilities facing staffing shortages.
Agios Pharmaceuticals is a biopharmaceutical company focused on developing treatments for rare genetic diseases related to cellular metabolism. It generates revenue primarily from sales of its lead drug PYRUKYND for pyruvate kinase deficiency — with additional income from research collaborations and milestone payments — while advancing a pipeline of other metabolic therapies. The company's competitive advantage lies in its deep expertise in cellular metabolism science and proprietary platform for targeting metabolic pathways in rare diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
CCRN leads in 2 of 6 categories (Valuation Metrics, Profitability & Efficiency). AGIO leads in 1 (Total Returns). 2 tied.
Financial Metrics (TTM)
CCRN is the larger business by revenue, generating $1.1B annually — 25.2x AGIO's $45M. CCRN is the more profitable business, keeping -1.4% of every revenue dollar as net income compared to AGIO's -9.0%. On growth, AGIO holds the edge at +43.7% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | CCRNCross Country Hea… | AGIOAgios Pharmaceuti… |
|---|---|---|
| RevenueTrailing 12 months | $1.1B | $45M |
| EBITDAEarnings before interest/tax | $360,000 | -$470M |
| Net IncomeAfter-tax profit | -$16M | -$401M |
| Free Cash FlowCash after capex | $46M | -$414M |
| Gross MarginGross profit ÷ Revenue | +20.2% | +84.4% |
| Operating MarginEBIT ÷ Revenue | -1.4% | -10.6% |
| Net MarginNet income ÷ Revenue | -1.4% | -9.0% |
| FCF MarginFCF ÷ Revenue | +4.1% | -9.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | -20.6% | +43.7% |
| EPS Growth (YoY)Latest quarter vs prior year | -2.9% | -111.0% |
Valuation Metrics
| Metric | CCRNCross Country Hea… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Market CapShares × price | $281M | $2.25T |
| Enterprise ValueMkt cap + debt − cash | $203M | $2.25T |
| Trailing P/EPrice ÷ TTM EPS | -19.77x | -4.25x |
| Forward P/EPrice ÷ next-FY EPS est. | 106.36x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 319.77x | — |
| Price / SalesMarket cap ÷ Revenue | 0.21x | 9999.00x |
| Price / BookPrice ÷ Book value/share | 0.69x | 1.47x |
| Price / FCFMarket cap ÷ FCF | 2.52x | — |
Profitability & Efficiency
CCRN delivers a -3.8% return on equity — every $100 of shareholder capital generates $-4 in annual profit, vs $-31 for AGIO. CCRN carries lower financial leverage with a 0.01x debt-to-equity ratio, signaling a more conservative balance sheet compared to AGIO's 0.03x. On the Piotroski fundamental quality scale (0–9), CCRN scores 4/9 vs AGIO's 3/9, reflecting mixed financial health.
| Metric | CCRNCross Country Hea… | AGIOAgios Pharmaceuti… |
|---|---|---|
| ROE (TTM)Return on equity | -3.8% | -31.2% |
| ROA (TTM)Return on assets | -2.9% | -29.0% |
| ROICReturn on invested capital | -3.2% | -26.6% |
| ROCEReturn on capital employed | -3.4% | -33.8% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 3 |
| Debt / EquityFinancial leverage | 0.01x | 0.03x |
| Net DebtTotal debt minus cash | -$78M | -$49M |
| Cash & Equiv.Liquid assets | $82M | $89M |
| Total DebtShort + long-term debt | $4M | $40M |
| Interest CoverageEBIT ÷ Interest expense | -4.55x | — |
Total Returns (with DRIP)
A $10,000 investment in CCRN five years ago would be worth $7,336 today (with dividends reinvested), compared to $6,363 for AGIO. Over the past 12 months, AGIO leads with a -14.9% total return vs CCRN's -49.3%. The 3-year compound annual growth rate (CAGR) favors AGIO at 6.1% vs CCRN's -31.0% — a key indicator of consistent wealth creation.
| Metric | CCRNCross Country Hea… | AGIOAgios Pharmaceuti… |
|---|---|---|
| YTD ReturnYear-to-date | +7.9% | +11.2% |
| 1-Year ReturnPast 12 months | -49.3% | -14.9% |
| 3-Year ReturnCumulative with dividends | -67.1% | +19.4% |
| 5-Year ReturnCumulative with dividends | -26.6% | -36.4% |
| 10-Year ReturnCumulative with dividends | -29.9% | -21.2% |
| CAGR (3Y)Annualised 3-year return | -31.0% | +6.1% |
Risk & Volatility
CCRN is the less volatile stock with a 0.43 beta — it tends to amplify market swings less than AGIO's 0.91 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. AGIO currently trades 65.7% from its 52-week high vs CCRN's 50.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CCRNCross Country Hea… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.43x | 0.91x |
| 52-Week HighHighest price in past year | $17.30 | $46.00 |
| 52-Week LowLowest price in past year | $7.43 | $22.24 |
| % of 52W HighCurrent price vs 52-week peak | +50.3% | +65.7% |
| RSI (14)Momentum oscillator 0–100 | 53.2 | 62.3 |
| Avg Volume (50D)Average daily shares traded | 490K | 948K |
Analyst Outlook
Wall Street rates CCRN as "Hold" and AGIO as "Buy". Consensus price targets imply 37.3% upside for AGIO (target: $42) vs 14.1% for CCRN (target: $10).
| Metric | CCRNCross Country Hea… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Hold | Buy |
| Price TargetConsensus 12-month target | $9.93 | $41.50 |
| # AnalystsCovering analysts | 13 | 29 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | 1 | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +13.3% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Cross Country Healt… (CCRN) | 100 | 97.16 | -2.8% |
| Agios Pharmaceutica… (AGIO) | 100 | 57.07 | -42.9% |
Cross Country Healt… (CCRN) returned -27% over 5 years vs Agios Pharmaceutica… (AGIO)'s -36%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Cross Country Healt… (CCRN) | $834M | $1.3B | +61.2% |
| Agios Pharmaceutica… (AGIO) | $70M | $54M | -22.7% |
Agios Pharmaceuticals, Inc.'s revenue grew from $70M (2016) to $54M (2025) — a -2.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Cross Country Healt… (CCRN) | 1.0% | -1.1% | -213.3% |
| Agios Pharmaceutica… (AGIO) | -2.8% | -7.6% | -169.0% |
Agios Pharmaceuticals, Inc.'s net margin went from -3% (2016) to -8% (2025).
Chart 4P/E Ratio History — 4 Years
| Stock | 2017 | 2023 | Change |
|---|---|---|---|
| Cross Country Healt… (CCRN) | 12.6 | 11 | -12.7% |
Cross Country Healthcare, Inc. has traded in a 5x–13x P/E range over 4 years; current trailing P/E is ~-20x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Cross Country Healt… (CCRN) | 0.15 | -0.44 | -393.3% |
| Agios Pharmaceutica… (AGIO) | -5.07 | -7.12 | -40.4% |
Agios Pharmaceuticals, Inc.'s EPS grew from $-5.07 (2016) to $-7.12 (2025).
Chart 6Free Cash Flow — 5 Years
Cross Country Healthcare, Inc. generated $111M FCF in 2024 (+220% vs 2021). Agios Pharmaceuticals, Inc. generated $-377M FCF in 2025 (+9% vs 2021).
CCRN vs AGIO: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is CCRN or AGIO a better buy right now?
Analysts rate Agios Pharmaceuticals, Inc. (AGIO) a "Buy" — based on 29 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CCRN or AGIO?
Over the past 5 years, Cross Country Healthcare, Inc. (CCRN) delivered a total return of -26.6%, compared to -36.4% for Agios Pharmaceuticals, Inc. (AGIO). A $10,000 investment in CCRN five years ago would be worth approximately $7K today (assuming dividends reinvested). Over 10 years, the gap is even starker: AGIO returned -21.2% versus CCRN's -29.9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CCRN or AGIO?
By beta (market sensitivity over 5 years), Cross Country Healthcare, Inc. (CCRN) is the lower-risk stock at 0.43β versus Agios Pharmaceuticals, Inc.'s 0.91β — meaning AGIO is approximately 112% more volatile than CCRN relative to the S&P 500. On balance sheet safety, Cross Country Healthcare, Inc. (CCRN) carries a lower debt/equity ratio of 1% versus 3% for Agios Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — CCRN or AGIO?
Cross Country Healthcare, Inc. (CCRN) is the more profitable company, earning -1.1% net margin versus -764.0% for Agios Pharmaceuticals, Inc. — meaning it keeps -1.1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: CCRN leads at -1.3% versus -873.9% for AGIO. At the gross margin level — before operating expenses — AGIO leads at 88.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is CCRN or AGIO more undervalued right now?
Analyst consensus price targets imply the most upside for AGIO: 37.3% to $41.50.
06Which pays a better dividend — CCRN or AGIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is CCRN or AGIO better for a retirement portfolio?
For long-horizon retirement investors, Cross Country Healthcare, Inc. (CCRN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.43)). Both have compounded well over 10 years (CCRN: -29.9%, AGIO: -21.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between CCRN and AGIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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