Comprehensive Stock Comparison
Compare Cardio Diagnostics Holdings, Inc. (CDIO) vs Adaptive Biotechnologies Corporation (ADPT) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  CDIO | 104.5% revenue growth vs ADPT's 5.1% |
| Quality / Margins |  ADPT | -31.5% net margin vs CDIO's -415.2% |
| Stability / Safety | ADPT | Beta 1.31 vs CDIO's 2.02 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | ADPT | +104.7% vs CDIO's -62.1% |
| Efficiency (ROA) | ADPT | -16.2% ROA vs CDIO's -74.5%, ROIC -41.6% vs -222.7% |
Who Each Stock Is For
Income & stability
ADPTbeta 1.31
Growth exposure
CDIORev growth 104.5%, EPS growth 53.0%, 3Y rev CAGR 238.3%
Long-term compounding (10Y)
ADPT-59.2% 10Y total return vs CDIO's -98.2%
Sleep-well-at-night portfolio
CDIOLower volatility, beta 2.02, Low D/E 10.1%, current ratio 13.92x
Defensive / Recession hedge
ADPTBeta 1.31, current ratio 2.89x
Business Model
What each company does and how it makes money
Cardio Diagnostics develops and commercializes epigenetics-based clinical tests for cardiovascular disease risk assessment. It generates revenue primarily from sales of its Epi+Gen CHD test—a three-year symptomatic coronary heart disease risk assessment—to healthcare providers and through laboratory services. The company's moat lies in its proprietary epigenetic technology platform that offers more personalized cardiovascular risk prediction than traditional methods.
Adaptive Biotechnologies is a biotechnology company that develops immune medicine platforms for diagnosing and treating diseases like cancer, autoimmune disorders, and infectious diseases. It generates revenue primarily through its clinical diagnostics segment — including its clonoSEQ test for minimal residual disease monitoring — and its translational and clinical genomics research services, with diagnostics contributing roughly 60% of revenue. The company's key advantage lies in its proprietary immune medicine platform that maps and translates the genetics of the adaptive immune system into clinical diagnostics and therapies.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
ADPT 5CDIO 0ADPT6/6 metricsADPT3/3 metricsADPT5/8 metricsADPT5/6 metricsADPT2/2 metricsADPT leads in 5 of 6 categories — strongest in Financial Metrics and Valuation Metrics.
Financial Metrics (TTM)
ADPT is the larger business by revenue, generating $253M annually — 16015.3x CDIO's $15,782. ADPT is the more profitable business, keeping -31.5% of every revenue dollar as net income compared to CDIO's -415.2%. On growth, ADPT holds the edge at +102.4% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | CDIOCardio Diagnostic… | ADPTAdaptive Biotechn… |
|---|---|---|
| RevenueTrailing 12 months | $15,782 | $253M |
| EBITDAEarnings before interest/tax | -$6M | -$62M |
| Net IncomeAfter-tax profit | -$7M | -$80M |
| Free Cash FlowCash after capex | -$6M | -$63M |
| Gross MarginGross profit ÷ Revenue | -10.3% | +71.8% |
| Operating MarginEBIT ÷ Revenue | -414.2% | -30.9% |
| Net MarginNet income ÷ Revenue | -415.2% | -31.5% |
| FCF MarginFCF ÷ Revenue | -379.5% | -24.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | -56.6% | +102.4% |
| EPS Growth (YoY)Latest quarter vs prior year | -15.3% | +126.6% |
Valuation Metrics
| Metric | CDIOCardio Diagnostic… | ADPTAdaptive Biotechn… |
|---|---|---|
| Market CapShares × price | $9M | $2.5B |
| Enterprise ValueMkt cap + debt − cash | $2M | $2.5B |
| Trailing P/EPrice ÷ TTM EPS | -0.57x | -15.22x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 266.33x | 14.02x |
| Price / BookPrice ÷ Book value/share | 14.80x | 11.94x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
ADPT delivers a -39.0% return on equity — every $100 of shareholder capital generates $-39 in annual profit, vs $-80 for CDIO. CDIO carries lower financial leverage with a 0.10x debt-to-equity ratio, signaling a more conservative balance sheet compared to ADPT's 0.44x.
| Metric | CDIOCardio Diagnostic… | ADPTAdaptive Biotechn… |
|---|---|---|
| ROE (TTM)Return on equity | -80.4% | -39.0% |
| ROA (TTM)Return on assets | -74.5% | -16.2% |
| ROICReturn on invested capital | -2.2% | -41.6% |
| ROCEReturn on capital employed | -123.0% | -32.0% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 4 |
| Debt / EquityFinancial leverage | 0.10x | 0.44x |
| Net DebtTotal debt minus cash | -$7M | $41M |
| Cash & Equiv.Liquid assets | $8M | $48M |
| Total DebtShort + long-term debt | $969,863 | $89M |
| Interest CoverageEBIT ÷ Interest expense | -418.04x | -6.25x |
Total Returns (with DRIP)
A $10,000 investment in ADPT five years ago would be worth $3,893 today (with dividends reinvested), compared to $179 for CDIO. Over the past 12 months, ADPT leads with a +104.7% total return vs CDIO's -62.1%. The 3-year compound annual growth rate (CAGR) favors ADPT at 24.8% vs CDIO's -68.0% — a key indicator of consistent wealth creation.
| Metric | CDIOCardio Diagnostic… | ADPTAdaptive Biotechn… |
|---|---|---|
| YTD ReturnYear-to-date | +85.2% | +3.3% |
| 1-Year ReturnPast 12 months | -62.1% | +104.7% |
| 3-Year ReturnCumulative with dividends | -96.7% | +94.3% |
| 5-Year ReturnCumulative with dividends | -98.2% | -61.1% |
| 10-Year ReturnCumulative with dividends | -98.2% | -59.2% |
| CAGR (3Y)Annualised 3-year return | -68.0% | +24.8% |
Risk & Volatility
ADPT is the less volatile stock with a 1.31 beta — it tends to amplify market swings less than CDIO's 2.02 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ADPT currently trades 79.2% from its 52-week high vs CDIO's 30.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CDIOCardio Diagnostic… | ADPTAdaptive Biotechn… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 2.02x | 1.31x |
| 52-Week HighHighest price in past year | $17.39 | $20.76 |
| 52-Week LowLowest price in past year | $0.97 | $6.26 |
| % of 52W HighCurrent price vs 52-week peak | +30.2% | +79.2% |
| RSI (14)Momentum oscillator 0–100 | 64.3 | 46.2 |
| Avg Volume (50D)Average daily shares traded | 3.3M | 1.8M |
Analyst Outlook
| Metric | CDIOCardio Diagnostic… | ADPTAdaptive Biotechn… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $21.25 |
| # AnalystsCovering analysts | — | 17 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Jan 22 | Mar 26 | Change |
|---|---|---|---|
| Cardio Diagnostics … (CDIO) | 100 | 1.77 | -98.2% |
| Adaptive Biotechnol… (ADPT) | 100 | 103.31 | +3.3% |
Adaptive Biotechnol… (ADPT) returned -61% over 5 years vs Cardio Diagnostics … (CDIO)'s -98%.
Chart 2Revenue Growth — 10 Years
| Stock | 2017 | 2024 | Change |
|---|---|---|---|
| Cardio Diagnostics … (CDIO) | $0.00 | $34890.00 | — |
| Adaptive Biotechnol… (ADPT) | $38M | $179M | +365.5% |
Adaptive Biotechnologies Corporation's revenue grew from $38M (2017) to $179M (2024) — a 24.6% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2017 | 2024 | Change |
|---|---|---|---|
| Cardio Diagnostics … (CDIO) | -688.6% | -240.3% | +65.1% |
| Adaptive Biotechnol… (ADPT) | -111.4% | -89.1% | +20.0% |
Adaptive Biotechnologies Corporation's net margin went from -111% (2017) to -89% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2017 | 2024 | Change |
|---|---|---|---|
| Cardio Diagnostics … (CDIO) | -0.06 | -9.3 | -14522.6% |
| Adaptive Biotechnol… (ADPT) | -0.41 | -1.08 | -163.4% |
Adaptive Biotechnologies Corporation's EPS grew from $-0.41 (2017) to $-1.08 (2024).
Chart 5Free Cash Flow — 5 Years
Cardio Diagnostics Holdings, Inc. generated $-5M FCF in 2024 (-672% vs 2021). Adaptive Biotechnologies Corporation generated $-99M FCF in 2024 (+61% vs 2021).
CDIO vs ADPT: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is CDIO or ADPT a better buy right now?
Analysts rate Adaptive Biotechnologies Corporation (ADPT) a "Buy" — based on 17 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CDIO or ADPT?
Over the past 5 years, Adaptive Biotechnologies Corporation (ADPT) delivered a total return of -61.1%, compared to -98.2% for Cardio Diagnostics Holdings, Inc. (CDIO). A $10,000 investment in ADPT five years ago would be worth approximately $4K today (assuming dividends reinvested). Over 10 years, the gap is even starker: ADPT returned -61.0% versus CDIO's -98.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CDIO or ADPT?
By beta (market sensitivity over 5 years), Adaptive Biotechnologies Corporation (ADPT) is the lower-risk stock at 1.31β versus Cardio Diagnostics Holdings, Inc.'s 2.02β — meaning CDIO is approximately 54% more volatile than ADPT relative to the S&P 500. On balance sheet safety, Cardio Diagnostics Holdings, Inc. (CDIO) carries a lower debt/equity ratio of 10% versus 44% for Adaptive Biotechnologies Corporation — giving it more financial flexibility in a downturn.
04Which has better profit margins — CDIO or ADPT?
Adaptive Biotechnologies Corporation (ADPT) is the more profitable company, earning -89.1% net margin versus -240.3% for Cardio Diagnostics Holdings, Inc. — meaning it keeps -89.1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ADPT leads at -90.8% versus -239.8% for CDIO. At the gross margin level — before operating expenses — CDIO leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — CDIO or ADPT?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is CDIO or ADPT better for a retirement portfolio?
For long-horizon retirement investors, Adaptive Biotechnologies Corporation (ADPT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding. Cardio Diagnostics Holdings, Inc. (CDIO) carries a higher beta of 2.02 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (ADPT: -61.0%, CDIO: -98.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between CDIO and ADPT?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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