Comprehensive Stock Comparison
Compare CRISPR Therapeutics AG (CRSP) vs Agios Pharmaceuticals, Inc. (AGIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
Selected Stocks
Add up to 10 tickers. Use presets or search to get started.
Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | AGIO | 48.0% revenue growth vs CRSP's -90.0% |
| Quality / Margins | AGIO | -9.0% net margin vs CRSP's -13.3% |
| Stability / Safety | AGIO | Beta 0.91 vs CRSP's 1.25, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | CRSP | +36.9% vs AGIO's -14.9% |
| Efficiency (ROA) | CRSP | -21.7% ROA vs AGIO's -29.0%, ROIC -27.4% vs -26.6% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
CRISPR Therapeutics is a clinical-stage biotechnology company developing transformative gene-editing therapies for serious diseases using its proprietary CRISPR/Cas9 platform. It generates revenue primarily through research collaborations and milestone payments from partners like Vertex Pharmaceuticals — with its lead therapy for sickle cell disease and beta-thalassemia now approved and generating product sales. The company's key advantage is its foundational CRISPR/Cas9 intellectual property and extensive expertise in developing ex vivo gene-edited cell therapies.
Agios Pharmaceuticals is a biopharmaceutical company focused on developing treatments for rare genetic diseases related to cellular metabolism. It generates revenue primarily from sales of its lead drug PYRUKYND for pyruvate kinase deficiency — with additional income from research collaborations and milestone payments — while advancing a pipeline of other metabolic therapies. The company's competitive advantage lies in its deep expertise in cellular metabolism science and proprietary platform for targeting metabolic pathways in rare diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
CRSP leads in 2 of 6 categories (Valuation Metrics, Total Returns). AGIO leads in 1 (Financial Metrics). 2 tied.
Financial Metrics (TTM)
AGIO and CRSP operate at a comparable scale, with $45M and $37M in trailing revenue. Profitability is closely matched — net margins range from -9.0% (AGIO) to -13.3% (CRSP).
| Metric | CRSPCRISPR Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| RevenueTrailing 12 months | $37M | $45M |
| EBITDAEarnings before interest/tax | -$556M | -$470M |
| Net IncomeAfter-tax profit | -$488M | -$401M |
| Free Cash FlowCash after capex | -$303M | -$414M |
| Gross MarginGross profit ÷ Revenue | -3.6% | +84.4% |
| Operating MarginEBIT ÷ Revenue | -15.6% | -10.6% |
| Net MarginNet income ÷ Revenue | -13.3% | -9.0% |
| FCF MarginFCF ÷ Revenue | -8.2% | -9.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +43.7% |
| EPS Growth (YoY)Latest quarter vs prior year | -15.8% | -111.0% |
Valuation Metrics
| Metric | CRSPCRISPR Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Market CapShares × price | $5.6B | $2.25T |
| Enterprise ValueMkt cap + debt − cash | $5.5B | $2.25T |
| Trailing P/EPrice ÷ TTM EPS | -9.30x | -4.25x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 1608.41x | 9999.00x |
| Price / BookPrice ÷ Book value/share | 2.81x | 1.47x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
CRSP delivers a -25.5% return on equity — every $100 of shareholder capital generates $-25 in annual profit, vs $-31 for AGIO. AGIO carries lower financial leverage with a 0.03x debt-to-equity ratio, signaling a more conservative balance sheet compared to CRSP's 0.11x. On the Piotroski fundamental quality scale (0–9), AGIO scores 3/9 vs CRSP's 2/9, reflecting mixed financial health.
| Metric | CRSPCRISPR Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| ROE (TTM)Return on equity | -25.5% | -31.2% |
| ROA (TTM)Return on assets | -21.7% | -29.0% |
| ROICReturn on invested capital | -27.4% | -26.6% |
| ROCEReturn on capital employed | -31.1% | -33.8% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 3 |
| Debt / EquityFinancial leverage | 0.11x | 0.03x |
| Net DebtTotal debt minus cash | -$141M | -$49M |
| Cash & Equiv.Liquid assets | $348M | $89M |
| Total DebtShort + long-term debt | $207M | $40M |
| Interest CoverageEBIT ÷ Interest expense | — | — |
Total Returns (with DRIP)
A $10,000 investment in AGIO five years ago would be worth $6,363 today (with dividends reinvested), compared to $4,617 for CRSP. Over the past 12 months, CRSP leads with a +36.9% total return vs AGIO's -14.9%. The 3-year compound annual growth rate (CAGR) favors CRSP at 6.8% vs AGIO's 6.1% — a key indicator of consistent wealth creation.
| Metric | CRSPCRISPR Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| YTD ReturnYear-to-date | +11.8% | +11.2% |
| 1-Year ReturnPast 12 months | +36.9% | -14.9% |
| 3-Year ReturnCumulative with dividends | +21.9% | +19.4% |
| 5-Year ReturnCumulative with dividends | -53.8% | -36.4% |
| 10-Year ReturnCumulative with dividends | +326.8% | -21.2% |
| CAGR (3Y)Annualised 3-year return | +6.8% | +6.1% |
Risk & Volatility
AGIO is the less volatile stock with a 0.91 beta — it tends to amplify market swings less than CRSP's 1.25 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. CRSP currently trades 76.6% from its 52-week high vs AGIO's 65.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CRSPCRISPR Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.25x | 0.91x |
| 52-Week HighHighest price in past year | $78.48 | $46.00 |
| 52-Week LowLowest price in past year | $30.04 | $22.24 |
| % of 52W HighCurrent price vs 52-week peak | +76.6% | +65.7% |
| RSI (14)Momentum oscillator 0–100 | 66.2 | 62.3 |
| Avg Volume (50D)Average daily shares traded | 1.4M | 948K |
Analyst Outlook
Wall Street rates CRSP as "Buy" and AGIO as "Buy". Consensus price targets imply 37.3% upside for AGIO (target: $42) vs 8.1% for CRSP (target: $65).
| Metric | CRSPCRISPR Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $65.00 | $41.50 |
| # AnalystsCovering analysts | 38 | 29 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +1.3% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| CRISPR Therapeutics… (CRSP) | 100 | 96.18 | -3.8% |
| Agios Pharmaceutica… (AGIO) | 100 | 57.07 | -42.9% |
Agios Pharmaceutica… (AGIO) returned -36% over 5 years vs CRISPR Therapeutics… (CRSP)'s -54%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CRISPR Therapeutics… (CRSP) | $5M | $4M | -32.0% |
| Agios Pharmaceutica… (AGIO) | $70M | $54M | -22.7% |
CRISPR Therapeutics AG's revenue grew from $5M (2016) to $4M (2025) — a -4.2% CAGR. Agios Pharmaceuticals, Inc.'s revenue grew from $70M (2016) to $54M (2025) — a -2.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CRISPR Therapeutics… (CRSP) | -4.5% | -165.7% | -3587.9% |
| Agios Pharmaceutica… (AGIO) | -2.8% | -7.6% | -169.0% |
CRISPR Therapeutics AG's net margin went from -4% (2016) to -166% (2025). Agios Pharmaceuticals, Inc.'s net margin went from -3% (2016) to -8% (2025).
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CRISPR Therapeutics… (CRSP) | -1.89 | -6.47 | -242.3% |
| Agios Pharmaceutica… (AGIO) | -5.07 | -7.12 | -40.4% |
CRISPR Therapeutics AG's EPS grew from $-1.89 (2016) to $-6.47 (2025). Agios Pharmaceuticals, Inc.'s EPS grew from $-5.07 (2016) to $-7.12 (2025).
Chart 5Free Cash Flow — 5 Years
CRISPR Therapeutics AG generated $-346M FCF in 2025 (-176% vs 2021). Agios Pharmaceuticals, Inc. generated $-377M FCF in 2025 (+9% vs 2021).
CRSP vs AGIO: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is CRSP or AGIO a better buy right now?
Analysts rate CRISPR Therapeutics AG (CRSP) a "Buy" — based on 38 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CRSP or AGIO?
Over the past 5 years, Agios Pharmaceuticals, Inc. (AGIO) delivered a total return of -36.4%, compared to -53.8% for CRISPR Therapeutics AG (CRSP). A $10,000 investment in AGIO five years ago would be worth approximately $6K today (assuming dividends reinvested). Over 10 years, the gap is even starker: CRSP returned +326.8% versus AGIO's -21.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CRSP or AGIO?
By beta (market sensitivity over 5 years), Agios Pharmaceuticals, Inc. (AGIO) is the lower-risk stock at 0.91β versus CRISPR Therapeutics AG's 1.25β — meaning CRSP is approximately 38% more volatile than AGIO relative to the S&P 500. On balance sheet safety, Agios Pharmaceuticals, Inc. (AGIO) carries a lower debt/equity ratio of 3% versus 11% for CRISPR Therapeutics AG — giving it more financial flexibility in a downturn.
04Which has better profit margins — CRSP or AGIO?
Agios Pharmaceuticals, Inc. (AGIO) is the more profitable company, earning -764.0% net margin versus -165.7% for CRISPR Therapeutics AG — meaning it keeps -764.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: AGIO leads at -873.9% versus -189.3% for CRSP. At the gross margin level — before operating expenses — AGIO leads at 88.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — CRSP or AGIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is CRSP or AGIO better for a retirement portfolio?
For long-horizon retirement investors, Agios Pharmaceuticals, Inc. (AGIO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.91)). Both have compounded well over 10 years (AGIO: -21.2%, CRSP: +326.8%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between CRSP and AGIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
Find Stocks Like These
Explore pre-built screens for each stock's profile, or build a custom screen to find stocks that beat both.