Comprehensive Stock Comparison
Compare Gyre Therapeutics, Inc. (GYRE) vs TG Therapeutics, Inc. (TGTX) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | TGTX | 40.8% revenue growth vs GYRE's -6.8% |
| Value | TGTX | Lower P/E (19.4x vs 45.0x) |
| Quality / Margins | TGTX | 13.3% net margin vs GYRE's 6.2% |
| Stability / Safety | TGTX | Beta 0.43 vs GYRE's 1.31 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | TGTX | 0.0% vs GYRE's -29.0% |
| Efficiency (ROA) | TGTX | 8.6% ROA vs GYRE's 4.2%, ROIC 13.3% vs 35.1% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Gyre Therapeutics is a pharmaceutical company developing and commercializing small-molecule anti-inflammatory and anti-fibrotic drugs targeting organ fibrosis. It generates revenue primarily from its approved drug ETUARY (Pirfenidone) for idiopathic pulmonary fibrosis, with additional pipeline drugs in various clinical stages targeting liver, lung, and kidney diseases. The company's competitive advantage lies in its specialized focus on fibrosis treatments and its structural derivatives platform that builds on proven anti-fibrotic mechanisms.
TG Therapeutics is a commercial-stage biopharmaceutical company developing and commercializing novel treatments for B-cell malignancies and autoimmune diseases. It generates revenue primarily from sales of its FDA-approved multiple sclerosis drug BRIUMVI (ublituximab) — its first commercial product — with future revenue expected from its pipeline of oncology candidates. The company's competitive advantage lies in its glycoengineered antibody platform technology, which creates potentially more effective and convenient treatments for complex diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
GYRE leads in 3 of 6 categories (Valuation Metrics, Profitability & Efficiency). TGTX leads in 2 (Total Returns, Risk & Volatility). 1 tied.
Financial Metrics (TTM)
TGTX is the larger business by revenue, generating $454M annually — 4.2x GYRE's $107M. TGTX is the more profitable business, keeping 13.3% of every revenue dollar as net income compared to GYRE's 6.2%. On growth, TGTX holds the edge at +92.1% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | GYREGyre Therapeutics… | TGTXTG Therapeutics, … |
|---|---|---|
| RevenueTrailing 12 months | $107M | $454M |
| EBITDAEarnings before interest/tax | $14M | $86M |
| Net IncomeAfter-tax profit | $7M | $60M |
| Free Cash FlowCash after capex | $1M | -$59M |
| Gross MarginGross profit ÷ Revenue | +95.5% | +87.0% |
| Operating MarginEBIT ÷ Revenue | +11.2% | +18.9% |
| Net MarginNet income ÷ Revenue | +6.2% | +13.3% |
| FCF MarginFCF ÷ Revenue | +1.3% | -13.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | +19.9% | +92.1% |
| EPS Growth (YoY)Latest quarter vs prior year | +3.7% | +2.9% |
Valuation Metrics
At 164.8x trailing earnings, GYRE trades at a 18% valuation discount to TGTX's 200.6x P/E. On an enterprise value basis, GYRE's 39.5x EV/EBITDA is more attractive than TGTX's 114.4x.
| Metric | GYREGyre Therapeutics… | TGTXTG Therapeutics, … |
|---|---|---|
| Market CapShares × price | $711M | $4.8B |
| Enterprise ValueMkt cap + debt − cash | $701M | $4.8B |
| Trailing P/EPrice ÷ TTM EPS | 164.80x | 200.60x |
| Forward P/EPrice ÷ next-FY EPS est. | 44.95x | 19.40x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 39.49x | 114.40x |
| Price / SalesMarket cap ÷ Revenue | 6.72x | 14.45x |
| Price / BookPrice ÷ Book value/share | 8.57x | 21.70x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
TGTX delivers a 21.9% return on equity — every $100 of shareholder capital generates $22 in annual profit, vs $5 for GYRE. GYRE carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to TGTX's 1.14x. On the Piotroski fundamental quality scale (0–9), GYRE scores 4/9 vs TGTX's 3/9, reflecting mixed financial health.
| Metric | GYREGyre Therapeutics… | TGTXTG Therapeutics, … |
|---|---|---|
| ROE (TTM)Return on equity | +4.8% | +21.9% |
| ROA (TTM)Return on assets | +4.2% | +8.6% |
| ROICReturn on invested capital | +35.1% | +13.3% |
| ROCEReturn on capital employed | +16.0% | +11.0% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 3 |
| Debt / EquityFinancial leverage | 0.02x | 1.14x |
| Net DebtTotal debt minus cash | -$10M | $74M |
| Cash & Equiv.Liquid assets | $12M | $180M |
| Total DebtShort + long-term debt | $2M | $254M |
| Interest CoverageEBIT ÷ Interest expense | — | 3.11x |
Total Returns (with DRIP)
A $10,000 investment in TGTX five years ago would be worth $6,687 today (with dividends reinvested), compared to $3,562 for GYRE. Over the past 12 months, TGTX leads with a 0.0% total return vs GYRE's -29.0%. The 3-year compound annual growth rate (CAGR) favors TGTX at 23.4% vs GYRE's 22.3% — a key indicator of consistent wealth creation.
| Metric | GYREGyre Therapeutics… | TGTXTG Therapeutics, … |
|---|---|---|
| YTD ReturnYear-to-date | +21.0% | +2.8% |
| 1-Year ReturnPast 12 months | -29.0% | 0.0% |
| 3-Year ReturnCumulative with dividends | +83.1% | +87.8% |
| 5-Year ReturnCumulative with dividends | -64.4% | -33.1% |
| 10-Year ReturnCumulative with dividends | -92.6% | +261.2% |
| CAGR (3Y)Annualised 3-year return | +22.3% | +23.4% |
Risk & Volatility
TGTX is the less volatile stock with a 0.43 beta — it tends to amplify market swings less than GYRE's 1.31 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. TGTX currently trades 64.7% from its 52-week high vs GYRE's 59.9% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | GYREGyre Therapeutics… | TGTXTG Therapeutics, … |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.31x | 0.43x |
| 52-Week HighHighest price in past year | $13.75 | $46.48 |
| 52-Week LowLowest price in past year | $6.11 | $25.28 |
| % of 52W HighCurrent price vs 52-week peak | +59.9% | +64.7% |
| RSI (14)Momentum oscillator 0–100 | 59.8 | 58.1 |
| Avg Volume (50D)Average daily shares traded | 60K | 1.7M |
Analyst Outlook
Wall Street rates GYRE as "Buy" and TGTX as "Buy". Consensus price targets imply 94.2% upside for GYRE (target: $16) vs 64.5% for TGTX (target: $50).
| Metric | GYREGyre Therapeutics… | TGTXTG Therapeutics, … |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $16.00 | $49.50 |
| # AnalystsCovering analysts | 1 | 13 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | 1 | 0 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Gyre Therapeutics, … (GYRE) | 100 | 9.42 | -90.6% |
| TG Therapeutics, In… (TGTX) | 100 | 208.43 | +108.4% |
TG Therapeutics, In… (TGTX) returned -33% over 5 years vs Gyre Therapeutics, … (GYRE)'s -64%.
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Gyre Therapeutics, … (GYRE) | $2M | $106M | +5943.3% |
| TG Therapeutics, In… (TGTX) | $152381.00 | $329M | +215808.8% |
Gyre Therapeutics, Inc.'s revenue grew from $2M (2015) to $106M (2024) — a 57.7% CAGR. TG Therapeutics, Inc.'s revenue grew from $0M (2015) to $329M (2024) — a 134.7% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Gyre Therapeutics, … (GYRE) | -8.4% | 11.4% | +235.5% |
| TG Therapeutics, In… (TGTX) | -413.1% | 7.1% | +101.7% |
Gyre Therapeutics, Inc.'s net margin went from -8% (2015) to 11% (2024). TG Therapeutics, Inc.'s net margin went from -413% (2015) to 7% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Gyre Therapeutics, … (GYRE) | -49.99 | 0.05 | +100.1% |
| TG Therapeutics, In… (TGTX) | -1.38 | 0.15 | +110.9% |
Gyre Therapeutics, Inc.'s EPS grew from $-49.99 (2015) to $0.05 (2024). TG Therapeutics, Inc.'s EPS grew from $-1.38 (2015) to $0.15 (2024).
Chart 5Free Cash Flow — 5 Years
Gyre Therapeutics, Inc. generated $-7M FCF in 2024 (+92% vs 2021). TG Therapeutics, Inc. generated $-41M FCF in 2024 (+86% vs 2021).
GYRE vs TGTX: Frequently Asked Questions
9 questions · data-driven answers · updated daily
01Is GYRE or TGTX a better buy right now?
Gyre Therapeutics, Inc. (GYRE) offers the better valuation at 164.8x trailing P/E (45.0x forward), making it the more compelling value choice. Analysts rate Gyre Therapeutics, Inc. (GYRE) a "Buy" — based on 1 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — GYRE or TGTX?
On trailing P/E, Gyre Therapeutics, Inc. (GYRE) is the cheapest at 164.8x versus TG Therapeutics, Inc. at 200.6x. On forward P/E, TG Therapeutics, Inc. is actually cheaper at 19.4x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — GYRE or TGTX?
Over the past 5 years, TG Therapeutics, Inc. (TGTX) delivered a total return of -33.1%, compared to -64.4% for Gyre Therapeutics, Inc. (GYRE). A $10,000 investment in TGTX five years ago would be worth approximately $7K today (assuming dividends reinvested). Over 10 years, the gap is even starker: TGTX returned +261.2% versus GYRE's -92.6%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — GYRE or TGTX?
By beta (market sensitivity over 5 years), TG Therapeutics, Inc. (TGTX) is the lower-risk stock at 0.43β versus Gyre Therapeutics, Inc.'s 1.31β — meaning GYRE is approximately 201% more volatile than TGTX relative to the S&P 500. On balance sheet safety, Gyre Therapeutics, Inc. (GYRE) carries a lower debt/equity ratio of 2% versus 114% for TG Therapeutics, Inc. — giving it more financial flexibility in a downturn.
05Which has better profit margins — GYRE or TGTX?
Gyre Therapeutics, Inc. (GYRE) is the more profitable company, earning 11.4% net margin versus 7.1% for TG Therapeutics, Inc. — meaning it keeps 11.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: GYRE leads at 15.3% versus 12.7% for TGTX. At the gross margin level — before operating expenses — GYRE leads at 96.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is GYRE or TGTX more undervalued right now?
On forward earnings alone, TG Therapeutics, Inc. (TGTX) trades at 19.4x forward P/E versus 45.0x for Gyre Therapeutics, Inc. — 25.6x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for GYRE: 94.2% to $16.00.
07Which pays a better dividend — GYRE or TGTX?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is GYRE or TGTX better for a retirement portfolio?
For long-horizon retirement investors, TG Therapeutics, Inc. (TGTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.43), +261.2% 10Y return). Both have compounded well over 10 years (TGTX: +261.2%, GYRE: -92.6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between GYRE and TGTX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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