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GYRE
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GYREGyre Therapeutics, Inc.
$5.90$539M
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
GYRE logo

Gyre Therapeutics, Inc.

GYRE
NASDAQ · Biotechnology
$5.90
At close - Oct 21, 4:00 PM EDT - USD
Market Cap$539M
P/E262.2x
52W High$9.14
Volume131.36K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Elite Margins Mask Severe Operating Losses and Cash Burn

Gyre Therapeutics presents a paradoxical profile, combining elite gross margins consistently above 92% with a deteriorating operational model that generated a -49.3% operating margin in 2026Q2. The company's growth trajectory is highly volatile, with revenue g...

GrowthMixed
ProfitabilityStrained
ValuationExpensive
TechnicalsWeak
Explore valuation models
MARKET ACTION

GYRE price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

2/12 Beats

EPS beat 2 of last 12 quarters

02

Valuation risk

+643% Peers

P/E is 643% above peer median

03

Market leadership

RS 42 · Lag

Laggard (Underperforming 58% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 6

Market performance

Price History →

Trailing total returns as of 10/22/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
GYRE-13.36%
S&P 500 (^GSPC)+13.16%
1-Year Return
GYRE-29.09%
S&P 500 (^GSPC)+15.16%
3-Year Return
GYRE-16.31%
S&P 500 (^GSPC)+86.29%
5-Year Return
GYRE-41.38%
S&P 500 (^GSPC)+68.86%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/EMedian
262.2x
Forward P/E
N/A
EV/EBITDA0th %ile
35.9x
FCF YieldCash Flow
N/A

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
262.2x
265.0x
33rd· Fair
EV/EBITDA
35.9x
55.9x
0th· Low
Price/FCF
N/A
106.0x
N/A
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
No DCF Model AvailableIntrinsic value modeling is not supported for this equity.

Growth & profitability

Annual revenue & EPS trend
Revenue
$117M+10.2% YoY
Net income
$5M-58.4% YoY
Free cash flow
-$180K+97.3% YoY
Operating margin
9.9%-5.4 pts YoY
ROIC (TTM)8.9%
Avg ROIC 5Y-
ROE (TTM)4.2%
Piotroski Score4 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate2/12 (25%)
Revenue Beat Rate3/12 (30%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 7, 2026
-$0.12-111.8%
vs -$0.06
$29M+9.9%
vs $26M
Q2 2026
May 7, 2026
-$0.05+16.7%
vs -$0.06
$23M-28.8%
vs $32M
Q2 2026
Mar 12, 2026
-$0.02-133.4%
vs $0.06
$37M+5.0%
vs $35M
Q4 2025
Nov 7, 2025
$0.06+20.0%
vs $0.05
$31M-7.2%
vs $33M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

4 Stories
Defense World·Sep 29, 2026
Comparing Gyre Therapeutics (NASDAQ:GYRE) and Traws Pharma (NASDAQ:TRAW)

Gyre Therapeutics (NASDAQ: GYRE - Get Free Report) and Traws Pharma (NASDAQ: TRAW - Get Free Report) are both small-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their dividends, valuation, profitability, earnings, risk, institutional ownership and analyst recommendations. Analyst Recommendations This is a breakdown of

GlobeNewsWire·Sep 3, 2026
Gyre Therapeutics to Participate in Upcoming September Investor Conferences

SAN DIEGO, Sept. 03, 2026 (GLOBE NEWSWIRE) -- Gyre Therapeutics, Inc. (Gyre, Gyre Therapeutics or the Company) (Nasdaq: GYRE), an innovative, commercial-stage biopharmaceutical company with operations in the United States and China, today announced that Company management will participate in the Cantor Global Healthcare Conference and the Morgan Stanley Healthcare Conference, both being held this month in New York, NY.

Zacks Investment Research·Aug 7, 2026
Gyre Therapeutics, Inc. (GYRE) Reports Q2 Loss, Beats Revenue Estimates

Gyre Therapeutics, Inc. (GYRE) came out with a quarterly loss of $0.12 per share versus the Zacks Consensus Estimate of a loss of $0.08. This compares to earnings of $0.02 per share a year ago.

GlobeNewsWire·Aug 7, 2026
Gyre Therapeutics Reports Second Quarter 2026 and Year-to-Date Financial Results and Provides Business Update

Q2 2026 revenue of $29.1 million; GAAP basic EPS: $(0.12) Full year 2026 revenue guidance of $100.5 to $111.0 million affirmed NDA for F351 (hydronidone) for CHB-induced liver fibrosis accepted by China's CDE in May 2026 SAN DIEGO, Aug. 07, 2026 (GLOBE NEWSWIRE) -- Gyre Therapeutics, Inc. (Gyre, Gyre Therapeutics or the Company) (Nasdaq: GYRE), an innovative, commercial-stage biopharmaceutical company with operations in the United States and China, today announced financial results for the second quarter ended June 30, 2026, and provided a business update. Dr. Ying Luo, President and Chief Executive Officer of Gyre Therapeutics, commented, “I am very pleased with Gyre's progress over this last quarter, the highlights of which include the acquisition of Cullgen with its robust degrader pipeline and strong executive team, the NMPA acceptance of an NDA for F351 for CHB liver fibrosis, Gyre's second major product candidate after ETUARY™, and increased sales from our Gyre Pharmaceuticals division, which demonstrates our commercialization capabilities.

Filtered for Gyre Therapeutics, Inc.More Headlines
04

Compare before deciding

Benchmark GYRE against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Gyre Therapeutics, Inc. (GYRE)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
GYRE logoGYREGyre Therapeutics, Inc.Current
$5.90$539.21M262.2210.24%4.31%4.18%—
HALO logoHALOHalozyme Therapeutics, Inc.
$124.83$14.81B48.7637.55%24.86%180.63%—
ARDX logoARDXArdelyx, Inc.
$3.13$773.2M-12.0422.09%-12.35%-36%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$256.86$7.16B-19.05-100%—-34.15%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$20.19$3.46B8.8211.87%33.42%32.39%—
INVA logoINVAInnoviva, Inc.
$20.91$1.54B6.3418.52%80.56%30.03%—

Compare GYRE vs Peers

Gyre Therapeutics, Inc. (GYRE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs HALO

Most directly comparable listed peer for GYRE.

Scale Benchmark

vs REGN

Larger-name benchmark to compare GYRE against a more recognizable public peer.

Peer Set

Compare Top 5

vs HALO, ARDX, PRAX, ACAD

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

GYRE SEC Filings & Documents

Gyre Therapeutics, Inc. (GYRE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 7, 2026·SEC

Material company update

Jul 16, 2026·SEC

Material company update

Jun 16, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 13, 2026·SEC

FY 2025

Mar 17, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 7, 2026·SEC

FY 2026

May 8, 2026·SEC

FY 2025

Nov 7, 2025·SEC

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GYRE Frequently Asked Questions

Gyre Therapeutics, Inc. (GYRE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Gyre Therapeutics, Inc.'s revenue?

Gyre Therapeutics, Inc. (GYRE) reported $119.4M in revenue for fiscal year 2025. This represents a 3093% increase from $3.7M in 2004.

How fast is Gyre Therapeutics, Inc. growing?

Gyre Therapeutics, Inc. (GYRE) grew revenue by 10.2% over the past year. This is steady growth.

Is GYRE profitable?

Gyre Therapeutics, Inc. (GYRE) reported a net loss of $17.3M for fiscal year 2025.

Dividend & Returns
What is GYRE's return on equity?

Gyre Therapeutics, Inc. (GYRE) has a return on equity (ROE) of 4.2%. This is below average, suggesting room for improvement.

What is Gyre Therapeutics, Inc.'s free cash flow?

Gyre Therapeutics, Inc. (GYRE) had negative free cash flow of $16.8M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in GYRE back in 2004?

Total return calculator · dividends reinvested · 22+ years of data

See returns →