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GYRE logoGyre Therapeutics, Inc.(GYRE)Earnings, Financials & Key Ratios

GYRE•NASDAQ
$8.04
$780M mkt cap·357.3× P/E·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutGyre Therapeutics, Inc., a pharmaceutical company, engages in the development and commercialization of small-molecule, anti-inflammatory, and anti-fibrotic drugs targeting organ fibrosis. It offers ETUARY (Pirfenidone), an anti-fibrotic drug approved for the treatment of idiopathic pulmonary fibrosis; and under phase 3 studies for dermatomyositis and systemic sclerosis-associated interstitial lung disease, pneumoconiosis, and diabetic kidney disease. The company is also involved the development of F351 (Hydronidone), a structural derivative of ETUARY (Pirfenidone), under Phase 3 studies for the treatment of chronic hepatitis B liver fibrosis; and under Phase 1 studies for liver fibrosis associated with nonalcoholic associated steatohepatitis. In addition, its development pipeline includes F573, under Phase 2 studies for the treatment of acute/acute-on-chronic liver failure; F528, under preclinical stage for the treatment of chronic obstructive pulmonary disease; and F230, under preclinical stage for the treatment of pulmonary arterial hypertension. The company was founded in 2002 and is headquartered in San Diego, California. Gyre Therapeutics, Inc. operates as a subsidiary of GNI USA, Inc.Show more
  • Revenue$117M+10.2%
  • EBITDA$14M-21.1%
  • Net Income$5M-58.4%
  • EPS (Diluted)0.02-55.0%
  • Gross Margin95.35%-1.0%
  • EBITDA Margin12.01%-28.4%
  • Operating Margin9.85%-35.5%
  • Net Margin4.31%-62.3%
  • ROE4.18%-80.6%
  • ROIC8.87%-74.8%
  • Debt/Equity0.01-59.4%
Technical→

GYRE Key Insights

Gyre Therapeutics, Inc. (GYRE) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Strong 5Y sales CAGR of 41.0%

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Low quality earnings: Net income not backed by cash flow
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

GYRE Price & Volume

Gyre Therapeutics, Inc. (GYRE) stock price & volume — 10-year historical chart

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GYRE Growth Metrics

Gyre Therapeutics, Inc. (GYRE) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years52.18%
5 Years40.96%
3 Years4.46%
TTM10.24%

Profit CAGR

10 Years-
5 Years-
3 Years29.74%
TTM-58.4%

EPS CAGR

10 Years-
5 Years-
3 Years-9.14%
TTM662.5%

Return on Capital

10 Years-54.14%
5 Years-35.93%
3 Years-18.18%
Last Year9.05%

GYRE Recent Earnings

Gyre Therapeutics, Inc. (GYRE) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 2/12 qtrs (22%)●Beat Revenue 2/12 qtrs (33%)
Q2 2026Latest
Mar 12, 2026
EPS
$0.04
Est $0.06
-29.4%
Revenue
$37M
Est $35M
+5.0%
Q4 2025
Nov 7, 2025
EPS
$0.06
Est $0.05
+20.0%
Revenue
$31M
Est $36M
-15.8%
Q3 2025
Aug 11, 2025
EPS
$0.02
Est $0.03
-33.3%
Revenue
$27M
Est $34M
-22.0%
Q2 2025
May 9, 2025
EPS
$0.03
Est $0.03
+0.0%
Revenue
$22M
Est $29M
-23.1%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMar 12, 2026
$0.04vs $0.06-29.4%
$37Mvs $35M+5.0%
Q4 2025Nov 7, 2025
$0.06vs $0.05+20.0%
$31Mvs $36M-15.8%
Q3 2025Aug 11, 2025
$0.02vs $0.03-33.3%
$27Mvs $34M-22.0%
Q2 2025May 9, 2025
$0.03vs $0.03+0.0%
$22Mvs $29M-23.1%
Based on last 12 quarters of dataView full earnings history →

GYRE Peer Comparison

Gyre Therapeutics, Inc. (GYRE) competitors in Immunology and Inflammation Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
HALO logoHALOHalozyme Therapeutics, Inc.Direct Competitor7.81B66.3525.9237.55%22.69%6.49%8.25%
ARDX logoARDXArdelyx, Inc.Direct Competitor1.74B7.10-27.3122.09%-13.58%-38.11%1.27
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor7.61B337.95-25.07-100%-58.74%0.00
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.63B21.4815.7931.85%24.94%28.47%4.33%0.07
INVA logoINVAInnoviva, Inc.Direct Competitor1.68B22.526.8218.52%65.38%23.12%11.65%
IDYA logoIDYAIDEAYA Biosciences, Inc.Product Competitor2.52B28.74-22.4530.24%-51.99%-11.11%0.03
RCUS logoRCUSArcus Biosciences, Inc.Product Competitor2.62B26.00-7.90-4.26%-156.36%-68.97%0.16
TGTX logoTGTXTG Therapeutics, Inc.Product Competitor6.63B41.97279.8040.8%13.31%21.87%1.14

Compare GYRE vs Peers

Gyre Therapeutics, Inc. (GYRE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs HALO

Most directly comparable listed peer for GYRE.

Scale Benchmark

vs REGN

Larger-name benchmark to compare GYRE against a more recognizable public peer.

Peer Set

Compare Top 5

vs HALO, ARDX, PRAX, ACAD

GYRE Income Statement

Gyre Therapeutics, Inc. (GYRE) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue1.02M6K020.95M7.34M102.29M113.45M105.76M116.59M
Revenue Growth %155.14%-99.41%-100%--64.97%1293.98%10.91%-6.78%10.24%
Cost of Goods Sold12.85M21.47M146K9.16M7.67M4.79M4.64M3.88M5.42M
COGS % of Revenue1261.98%357900%-43.74%104.52%4.69%4.09%3.67%4.65%
Gross Profit
-11.83M▲ 0%
-21.47M▼ 81.5%
-146K▲ 99.3%
11.79M▲ 8171.9%
-332K▼ 102.8%
97.5M▲ 29466.6%
108.81M▲ 11.6%
101.87M▼ 6.4%
111.17M▲ 9.1%
Gross Margin %-1161.98%-357800%-56.26%-4.52%95.31%95.91%96.33%95.35%
Gross Profit Growth %-16.47%-81.49%99.32%8171.92%-102.82%29466.57%11.61%-6.38%9.13%
Operating Expenses22.84M33.83M57.13M69.16M83.39M88.29M176.04M85.71M99.69M
OpEx % of Revenue2243.61%563800%-330.13%1136.47%86.32%155.17%81.04%85.5%
Selling, General & Admin9.99M12.35M13.27M16.18M18.82M71.61M75.82M73.62M85.98M
SG&A % of Revenue981.63%205900%-77.24%256.47%70%66.83%69.61%73.75%
Research & Development12.85M21.47M43.86M52.98M64.57M16.69M13.78M12.02M13.7M
R&D % of Revenue1261.98%357900%-252.89%879.99%16.31%12.15%11.37%11.75%
Other Operating Expenses261K1.65M000086.44M66K4K
Operating Income
-21.82M▲ 0%
-33.82M▼ 55.0%
-57.28M▼ 69.3%
-57.37M▼ 0.2%
-83.73M▼ 45.9%
9.2M▲ 111.0%
-67.23M▼ 830.5%
16.16M▲ 124.0%
11.49M▼ 28.9%
Operating Margin %-2143.61%-563700%--273.87%-1140.99%9%-59.26%15.28%9.85%
Operating Income Growth %-6.88%-54.99%-69.35%-0.16%-45.94%110.99%-830.52%124.04%-28.93%
EBITDA-21.65M-33.67M-57.13M-57.23M-83.44M10.33M-66.12M17.75M14.01M
EBITDA Margin %-2126.62%-561216.67%--273.21%-1137.04%10.1%-58.28%16.78%12.01%
EBITDA Growth %-8.09%-55.54%-69.66%-0.18%-45.79%112.38%-739.91%126.85%-21.09%
D&A (Non-Cash Add-back)173K149K146K138K290K1.13M1.11M1.59M2.52M
EBIT-21.56M-30.05M-55.18M-56.24M-87.93M9.2M19.21M16.23M11.49M
Net Interest Income002.15M561K39K726K1.04M1.55M1.75M
Interest Income261K3.77M2.15M561K39K726K1.04M1.55M1.75M
Interest Expense000000000
Other Income/Expense261K3.77M2.1M1.13M-4.21M209K-9.73M7.05M2.95M
Pretax Income
-21.56M▲ 0%
-30.05M▼ 39.4%
-55.18M▼ 83.6%
-56.24M▼ 1.9%
-87.93M▼ 56.4%
9.41M▲ 110.7%
-76.97M▼ 917.7%
23.22M▲ 130.2%
14.44M▼ 37.8%
Pretax Margin %-2117.98%-500916.67%--268.48%-1198.32%9.2%-67.84%21.95%12.38%
Income Tax-173K00-699K05.1M8.52M5.32M-4.56M
Effective Tax Rate %0.8%0%0%1.24%0%54.16%-11.06%22.91%-31.56%
Net Income
-21.56M▲ 0%
-30.05M▼ 39.4%
-55.18M▼ 83.6%
-55.54M▼ 0.7%
-87.93M▼ 58.3%
2.3M▲ 102.6%
-92.93M▼ 4137.1%
12.09M▲ 113.0%
5.03M▼ 58.4%
Net Margin %-2117.98%-500916.67%--265.14%-1198.32%2.25%-81.92%11.43%4.31%
Net Income Growth %-27.24%-39.4%-83.59%-0.66%-58.32%102.62%-4137.05%113%-58.4%
Net Income (Continuing)-21.56M-30.05M-55.18M-55.54M-87.93M4.31M-85.48M17.9M9.88M
Discontinued Operations000000000
Minority Interest0000029.7M29.78M35.08M36.25M
EPS (Diluted)
-6.30▲ 0%
-2.68▲ 57.5%
-4.41▼ 64.6%
-2.93▲ 33.6%
-2.87▲ 2.0%
0.03▲ 101.0%
-1.41▼ 4800.0%
0.05▲ 103.5%
0.02▼ 55.0%
EPS Growth %71.05%57.46%-64.55%33.56%2.05%101.05%-4800%103.55%-55%
EPS (Basic)-6.30-2.68-4.41-2.93-2.870.03-1.410.140.06
Diluted Shares Outstanding3.42M11.21M12M19.18M30.64M75.69M65.83M102.29M103.18M
Basic Shares Outstanding3.42M11.21M12M19.18M30.64M76.74M65.83M85.09M89.34M
Dividend Payout Ratio---------

GYRE Balance Sheet

Gyre Therapeutics, Inc. (GYRE) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets39.11M123.99M96.07M89.51M51.48M49.65M57.22M64.79M102.37M
Cash & Short-Term Investments32.44M120.13M76.86M79.35M46.85M25.18M33.51M26.67M52.42M
Cash Only14.47M31.21M15.37M30.36M44.35M25.18M33.51M11.81M37.07M
Short-Term Investments17.97M88.91M61.5M48.99M2.5M0014.86M15.36M
Accounts Receivable24K015M3.31M1.82M15.61M16.84M29.15M36.95M
Days Sales Outstanding8.61--57.7390.4355.7254.18100.62115.67
Inventory5.31M00006.12M4.28M6.34M10.17M
Days Inventory Outstanding150.84----466.21337.05595.52685.45
Other Current Assets1.33M3.86M4.2M6.84M2.81M2.37M1.04M1.44M2.83M
Total Non-Current Assets404K929K2.49M5.34M4.19M35.1M59.32M60.62M63.76M
Property, Plant & Equipment276K386K2.23M2.27M3.71M18.38M23.78M25.7M24.73M
Fixed Asset Turnover3.69x0.02x-9.25x1.98x5.57x4.77x4.12x4.71x
Goodwill000000000
Intangible Assets000001.86M1.7M1.71M4.73M
Long-Term Investments0002.54M07.39M23.43M24.57M0
Other Non-Current Assets128K543K257K528K472K7.47M5.72M3.03M27.43M
Total Assets
39.51M▲ 0%
124.92M▲ 216.1%
98.55M▼ 21.1%
94.85M▼ 3.8%
55.66M▼ 41.3%
84.75M▲ 52.3%
116.54M▲ 37.5%
125.41M▲ 7.6%
166.13M▲ 32.5%
Asset Turnover0.03x0.00x-0.22x0.13x1.21x0.97x0.84x0.70x
Asset Growth %3.74%216.15%-21.11%-3.76%-41.31%52.26%37.5%7.61%32.48%
Total Current Liabilities8.74M4.8M28.9M17.8M14.16M12.24M20.05M19.52M18.29M
Accounts Payable747K1.25M4.28M5.93M6.42M122K355K108K124K
Days Payables Outstanding21.2221.2110.7K236.26305.479.2927.9510.158.36
Short-Term Debt5.08M0483K663K1.98M000636K
Deferred Revenue (Current)212K015M1.98M230K079K156K14K
Other Current Liabilities2.69M3.55M7.03M6.74M4.07M4.86M648K5.7M14.57M
Current Ratio4.48x25.83x3.32x5.03x3.63x4.06x2.85x3.32x5.60x
Quick Ratio3.87x25.83x3.32x5.03x3.63x3.56x2.64x2.99x5.04x
Cash Conversion Cycle138.22----512.63363.28685.99792.76
Total Non-Current Liabilities0174K1.32M981K408K294K82.54M7.49M5.56M
Long-Term Debt000000000
Capital Lease Obligations001.32M981K408K121K199K885K303K
Deferred Tax Liabilities000000000
Other Non-Current Liabilities0174K000173K82.13M5.67M4.41M
Total Liabilities8.74M4.97M30.22M18.78M14.57M12.54M102.59M27M23.85M
Total Debt5.08M01.8M1.64M2.38M613K409K1.6M939K
Net Debt-9.39M-31.21M-13.57M-28.72M-41.96M-24.56M-33.1M-10.21M-36.13M
Debt / Equity0.17x-0.03x0.02x0.06x0.01x0.03x0.02x0.01x
Debt / EBITDA-----0.06x-0.09x0.07x
Net Debt / EBITDA------2.38x--0.58x-2.58x
Interest Coverage---------
Total Equity
30.77M▲ 0%
119.94M▲ 289.8%
68.34M▼ 43.0%
76.07M▲ 11.3%
41.09M▼ 46.0%
72.22M▲ 75.8%
13.95M▼ 80.7%
98.4M▲ 605.4%
142.28M▲ 44.6%
Equity Growth %91.49%289.76%-43.03%11.32%-45.98%75.76%-80.68%605.44%44.59%
Book Value per Share8.9910.705.693.971.340.950.210.961.38
Total Shareholders' Equity30.77M119.94M68.34M76.07M41.09M42.52M-15.83M63.32M106.03M
Common Stock6K12K12K22K31K64K77K86K91
Retained Earnings-173.49M-203.34M-258.52M-314.76M-402.69M10.05M-85.54M-73.45M-68.43M
Treasury Stock000000000
Accumulated OCI0-4K34K5K0-392K1.45M501K2.32M
Minority Interest0000029.7M29.78M35.08M36.25M

GYRE Cash Flow Statement

Gyre Therapeutics, Inc. (GYRE) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-19.94M-28.55M-43.61M-55.05M-83.75M10.68M25.89M-3.64M1.01M
Operating CF Margin %-1958.74%-475883.33%--262.78%-1141.39%10.44%22.82%-3.44%0.87%
Operating CF Growth %-7.95%-43.19%-52.74%-26.22%-52.15%112.75%142.5%-114.06%127.74%
Net Income-21.56M-30.05M-55.18M-56.24M-87.93M4.31M-85.48M17.9M9.88M
Depreciation & Amortization173K149K146K138K290K1.13M1.11M1.59M2.48M
Stock-Based Compensation863K2.61M3.2M3.63M3.4M13.37M7.28M831K7.16M
Deferred Taxes00-11.42M0-3.89M-838K-1.16M-1M-1.11M
Other Non-Cash Items18K116K11.42M03.89M503K96.68M-7.27M-1.84M
Working Capital Changes567K-1.37M8.21M-2.57M483K-7.8M7.46M-15.69M-15.55M
Change in Receivables7K0-15M11.69M1.5M-7.92M1.3M-9.29M-11.95M
Change in Inventory-479K0-490K03.88M-879K1.75M-2.14M-3.63M
Change in Payables-90K500K3.03M1.65M500K-112K192K-245K13K
Cash from Investing-11.25M-71.32M27.39M9.66M48.19M-13.81M-19.76M-19.88M-474K
Capital Expenditures-23K-376K-64K-267K-839K-4.99M-8.52M-2.31M-1.19M
CapEx % of Revenue2.26%6266.67%-1.27%11.43%4.87%7.51%2.19%1.02%
Acquisitions00-27.46M00-1.33M4.02M-1.69M30K
Investments---------
Other Investing-57K-70.94M27.46M00-13K471K-412K686K
Cash from Financing35.4M111.33M327K60.38M49.55M02.5M2.1M24.38M
Debt Issued (Net)-14.32M-5.08M00-6.7M0000
Equity Issued (Net)35.4M116.41M327K60.38M49.55M02.5M773K25.86M
Dividends Paid-3.95M00000000
Share Repurchases000000000
Other Financing18.27M0006.7M001.33M-1.49M
Net Change in Cash
4.21M▲ 0%
11.46M▲ 172.3%
-15.89M▼ 238.7%
14.99M▲ 194.3%
13.99M▼ 6.7%
-5.03M▼ 135.9%
8.33M▲ 265.8%
-21.7M▼ 360.3%
25.26M▲ 216.4%
Free Cash Flow
-19.96M▲ 0%
-28.93M▼ 44.9%
-43.68M▼ 51.0%
-55.31M▼ 26.6%
-84.59M▼ 52.9%
5.68M▲ 106.7%
17.31M▲ 204.7%
-6.77M▼ 139.1%
-180K▲ 97.3%
FCF Margin %-1961%-482150%--264.06%-1152.82%5.55%15.25%-6.4%-0.15%
FCF Growth %-5.4%-44.91%-50.98%-26.65%-52.93%106.71%204.74%-139.11%97.34%
FCF per Share-5.83-2.58-3.64-2.88-2.760.080.26-0.07-0.00
FCF Conversion (FCF/Net Income)0.92x0.95x0.79x0.99x0.95x4.64x-0.28x-0.30x0.20x
Interest Paid000000000
Taxes Paid0000006.35M8.52M0

GYRE Key Ratios

Gyre Therapeutics, Inc. (GYRE) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-71.35%-92.05%-39.88%-58.61%-76.93%-150.11%4.06%-215.71%21.51%4.18%
Return on Invested Capital (ROIC)-49.98%-70.25%-46.07%-59.87%-84.27%-270.2%29.51%-353.79%35.12%8.87%
Gross Margin-2545.36%-1161.98%-357800%-56.26%-4.52%95.31%95.91%96.33%95.35%
Net Margin-4246.87%-2117.98%-500916.67%--265.14%-1198.32%2.25%-81.92%11.43%4.31%
Debt / Equity1.21x0.17x-0.03x0.02x0.06x0.01x0.03x0.02x0.01x
FCF Conversion1.09x0.92x0.95x0.79x0.99x0.95x4.64x-0.28x-0.30x0.20x
Revenue Growth-77.2%155.14%-99.41%-100%--64.97%1293.98%10.91%-6.78%10.24%

GYRE SEC Filings & Documents

Gyre Therapeutics, Inc. (GYRE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 4, 2026·SEC

Material company update

Mar 23, 2026·SEC

Material company update

Mar 12, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 13, 2026·SEC

FY 2025

Mar 17, 2025·SEC

10-Q Quarterly Reports

5
FY 2025

Nov 7, 2025·SEC

FY 2025

Aug 11, 2025·SEC

FY 2025

May 9, 2025·SEC

GYRE Frequently Asked Questions

Gyre Therapeutics, Inc. (GYRE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Gyre Therapeutics, Inc. (GYRE) reported $116.6M in revenue for fiscal year 2025. This represents a 3019% increase from $3.7M in 2004.

Gyre Therapeutics, Inc. (GYRE) grew revenue by 10.2% over the past year. This is steady growth.

Yes, Gyre Therapeutics, Inc. (GYRE) is profitable, generating $5.0M in net income for fiscal year 2025 (4.3% net margin).

Dividend & Returns

Gyre Therapeutics, Inc. (GYRE) has a return on equity (ROE) of 4.2%. This is below average, suggesting room for improvement.

Gyre Therapeutics, Inc. (GYRE) had negative free cash flow of $0.9M in fiscal year 2025, likely due to heavy capital investments.

Explore More GYRE

Gyre Therapeutics, Inc. (GYRE) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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