Comprehensive Stock Comparison
Compare Kymera Therapeutics, Inc. (KYMR) vs Kiniksa Pharmaceuticals, Ltd. (KNSA) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | KNSA | 60.1% revenue growth vs KYMR's -16.7% |
| Quality / Margins | KNSA | 17.5% net margin vs KYMR's -7.9% |
| Stability / Safety | KNSA | Beta 0.46 vs KYMR's 1.31, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | KYMR | +191.4% vs KNSA's +119.4% |
| Efficiency (ROA) | KNSA | 15.5% ROA vs KYMR's -17.9%, ROIC 17.1% vs -24.9% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Kymera Therapeutics is a biopharmaceutical company developing targeted protein degraders — small molecules that harness the body's natural protein degradation system to eliminate disease-causing proteins. It generates revenue primarily through strategic partnerships and milestone payments from pharmaceutical collaborators — with potential future revenue from drug sales if clinical candidates succeed. The company's key advantage is its proprietary Pegasus platform for discovering novel protein degraders, which targets previously "undruggable" proteins and creates a pipeline of first-in-class therapies.
Kiniksa Pharmaceuticals is a biopharmaceutical company that develops and commercializes treatments for inflammatory and autoimmune diseases. It generates revenue primarily from sales of ARCALYST for recurrent pericarditis — its only approved product — with additional income from licensing and collaboration agreements. The company's competitive advantage lies in its targeted pipeline of monoclonal antibodies addressing specific immune pathways with high unmet medical needs.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
KNSA leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). KYMR leads in 1 (Valuation Metrics). 1 tied.
Financial Metrics (TTM)
KNSA is the larger business by revenue, generating $678M annually — 17.3x KYMR's $39M. KNSA is the more profitable business, keeping 17.5% of every revenue dollar as net income compared to KYMR's -7.9%. On growth, KNSA holds the edge at +65.0% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | KYMRKymera Therapeuti… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| RevenueTrailing 12 months | $39M | $678M |
| EBITDAEarnings before interest/tax | -$349M | $79M |
| Net IncomeAfter-tax profit | -$311M | $119M |
| Free Cash FlowCash after capex | -$234M | $136M |
| Gross MarginGross profit ÷ Revenue | +100.0% | — |
| Operating MarginEBIT ÷ Revenue | -8.9% | +11.4% |
| Net MarginNet income ÷ Revenue | -7.9% | +17.5% |
| FCF MarginFCF ÷ Revenue | -6.0% | +20.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | -61.3% | +65.0% |
| EPS Growth (YoY)Latest quarter vs prior year | -11.4% | +2.5% |
Valuation Metrics
| Metric | KYMRKymera Therapeuti… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| Market CapShares × price | $7.4B | $3.4B |
| Enterprise ValueMkt cap + debt − cash | $7.2B | $3.2B |
| Trailing P/EPrice ÷ TTM EPS | -24.76x | 59.32x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 34.78x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | 41.03x |
| Price / SalesMarket cap ÷ Revenue | 189.51x | 5.01x |
| Price / BookPrice ÷ Book value/share | 4.88x | 6.19x |
| Price / FCFMarket cap ÷ FCF | — | 133.57x |
Profitability & Efficiency
KNSA delivers a 20.9% return on equity — every $100 of shareholder capital generates $21 in annual profit, vs $-20 for KYMR. KNSA carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to KYMR's 0.05x. On the Piotroski fundamental quality scale (0–9), KNSA scores 6/9 vs KYMR's 4/9, reflecting solid financial health.
| Metric | KYMRKymera Therapeuti… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| ROE (TTM)Return on equity | -19.7% | +20.9% |
| ROA (TTM)Return on assets | -17.9% | +15.5% |
| ROICReturn on invested capital | -24.9% | +17.1% |
| ROCEReturn on capital employed | -27.2% | +14.0% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 6 |
| Debt / EquityFinancial leverage | 0.05x | 0.02x |
| Net DebtTotal debt minus cash | -$275M | -$156M |
| Cash & Equiv.Liquid assets | $357M | $166M |
| Total DebtShort + long-term debt | $82M | $9M |
| Interest CoverageEBIT ÷ Interest expense | -1403.21x | — |
Total Returns (with DRIP)
A $10,000 investment in KNSA five years ago would be worth $20,324 today (with dividends reinvested), compared to $18,851 for KYMR. Over the past 12 months, KYMR leads with a +191.4% total return vs KNSA's +119.4%. The 3-year compound annual growth rate (CAGR) favors KNSA at 51.2% vs KYMR's 42.8% — a key indicator of consistent wealth creation.
| Metric | KYMRKymera Therapeuti… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| YTD ReturnYear-to-date | +25.5% | +5.9% |
| 1-Year ReturnPast 12 months | +191.4% | +119.4% |
| 3-Year ReturnCumulative with dividends | +191.1% | +246.0% |
| 5-Year ReturnCumulative with dividends | +88.5% | +103.2% |
| 10-Year ReturnCumulative with dividends | +174.7% | +128.5% |
| CAGR (3Y)Annualised 3-year return | +42.8% | +51.2% |
Risk & Volatility
KNSA is the less volatile stock with a 0.46 beta — it tends to amplify market swings less than KYMR's 1.31 beta. A beta below 1.0 means the stock typically moves less than the S&P 500.
| Metric | KYMRKymera Therapeuti… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.31x | 0.46x |
| 52-Week HighHighest price in past year | $103.00 | $49.12 |
| 52-Week LowLowest price in past year | $19.45 | $18.26 |
| % of 52W HighCurrent price vs 52-week peak | +88.7% | +90.6% |
| RSI (14)Momentum oscillator 0–100 | 77.9 | 47.3 |
| Avg Volume (50D)Average daily shares traded | 620K | 469K |
Analyst Outlook
Wall Street rates KYMR as "Buy" and KNSA as "Buy". Consensus price targets imply 28.4% upside for KYMR (target: $117) vs 25.1% for KNSA (target: $56).
| Metric | KYMRKymera Therapeuti… | KNSAKiniksa Pharmaceu… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $117.31 | $55.67 |
| # AnalystsCovering analysts | 26 | 10 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Aug 20 | Feb 26 | Change |
|---|---|---|---|
| Kymera Therapeutics… (KYMR) | 100 | 227.36 | +127.4% |
| Kiniksa Pharmaceuti… (KNSA) | 100 | 269.1 | +169.1% |
Kiniksa Pharmaceuti… (KNSA) returned +103% over 5 years vs Kymera Therapeutics… (KYMR)'s +89%. A $10,000 investment in KNSA 5 years ago would be worth $20,324 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Kymera Therapeutics… (KYMR) | $0.00 | $39M | — |
| Kiniksa Pharmaceuti… (KNSA) | $0.00 | $678M | — |
Kiniksa Pharmaceuticals, Ltd.'s revenue grew from $0M (2016) to $678M (2025) — a 0.0% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2019 | 2025 | Change |
|---|---|---|---|
| Kymera Therapeutics… (KYMR) | -14.1% | -7.9% | +43.6% |
| Kiniksa Pharmaceuti… (KNSA) | -4.1% | 17.5% | +527.7% |
Kymera Therapeutics, Inc.'s net margin went from -14% (2019) to -8% (2025).
Chart 4P/E Ratio History — 3 Years
| Stock | 2022 | 2025 | Change |
|---|---|---|---|
| Kiniksa Pharmaceuti… (KNSA) | 5.8 | 55 | +848.3% |
Kiniksa Pharmaceuticals, Ltd. has traded in a 6x–88x P/E range over 3 years; current trailing P/E is ~59x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Kymera Therapeutics… (KYMR) | -0.48 | -3.69 | -668.8% |
| Kiniksa Pharmaceuti… (KNSA) | -0.74 | 0.75 | +201.4% |
Kiniksa Pharmaceuticals, Ltd.'s EPS grew from $-0.74 (2016) to $0.75 (2025).
Chart 6Free Cash Flow — 5 Years
Kymera Therapeutics, Inc. generated $-234M FCF in 2025 (-80% vs 2021). Kiniksa Pharmaceuticals, Ltd. generated $25M FCF in 2025 (+117% vs 2021).
KYMR vs KNSA: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is KYMR or KNSA a better buy right now?
Kiniksa Pharmaceuticals, Ltd. (KNSA) offers the better valuation at 59.3x trailing P/E (34.8x forward), making it the more compelling value choice. Analysts rate Kymera Therapeutics, Inc. (KYMR) a "Buy" — based on 26 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — KYMR or KNSA?
Over the past 5 years, Kiniksa Pharmaceuticals, Ltd. (KNSA) delivered a total return of +103.2%, compared to +88.5% for Kymera Therapeutics, Inc. (KYMR). A $10,000 investment in KNSA five years ago would be worth approximately $20K today (assuming dividends reinvested). Over 10 years, the gap is even starker: KYMR returned +174.7% versus KNSA's +128.5%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — KYMR or KNSA?
By beta (market sensitivity over 5 years), Kiniksa Pharmaceuticals, Ltd. (KNSA) is the lower-risk stock at 0.46β versus Kymera Therapeutics, Inc.'s 1.31β — meaning KYMR is approximately 183% more volatile than KNSA relative to the S&P 500. On balance sheet safety, Kiniksa Pharmaceuticals, Ltd. (KNSA) carries a lower debt/equity ratio of 2% versus 5% for Kymera Therapeutics, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — KYMR or KNSA?
Kiniksa Pharmaceuticals, Ltd. (KNSA) is the more profitable company, earning 17.5% net margin versus -794.4% for Kymera Therapeutics, Inc. — meaning it keeps 17.5% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: KNSA leads at 11.4% versus -891.3% for KYMR. At the gross margin level — before operating expenses — KYMR leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is KYMR or KNSA more undervalued right now?
Analyst consensus price targets imply the most upside for KYMR: 28.4% to $117.31.
06Which pays a better dividend — KYMR or KNSA?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is KYMR or KNSA better for a retirement portfolio?
For long-horizon retirement investors, Kiniksa Pharmaceuticals, Ltd. (KNSA) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.46), +128.5% 10Y return). Both have compounded well over 10 years (KNSA: +128.5%, KYMR: +174.7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between KYMR and KNSA?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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