Comprehensive Stock Comparison
Compare Pelthos Therapeutics Inc. (PTHS) vs Regeneron Pharmaceuticals, Inc. (REGN) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Quality / Margins | REGN | 31.4% net margin vs PTHS's -318.4% |
| Stability / Safety | REGN | Beta 0.58 vs PTHS's 0.76 |
| Dividends | REGN | 0.4% yield; 1-year raise streak; PTHS pays no meaningful dividend |
| Momentum (1Y) | PTHS | +123.4% vs REGN's +12.4% |
| Efficiency (ROA) | REGN | 11.1% ROA vs PTHS's -18.7% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Pelthos Therapeutics is a biopharmaceutical company that develops and commercializes therapeutic products for patients with unmet medical needs. It generates revenue primarily from sales of its FDA-approved treatment ZELSUVMI for molluscum contagiosum — a viral skin infection — with additional potential from its proprietary NITRICIL nitric oxide technology platform. The company's competitive advantage lies in its first-mover position with the only FDA-approved prescription treatment for molluscum contagiosum, addressing a significant market gap.
Regeneron Pharmaceuticals is a biotechnology company that discovers, develops, and commercializes innovative medicines for serious diseases. It generates revenue primarily from sales of its flagship products — EYLEA for eye diseases (~60% of revenue) and Dupixent for inflammatory conditions (~30%) — with additional income from collaborations and royalties. The company's competitive advantage lies in its proprietary VelocImmune technology platform for creating human antibodies and its deep expertise in genetic research, which enables rapid drug discovery and development.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
REGN leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). PTHS leads in 2 (Valuation Metrics, Total Returns).
Financial Metrics (TTM)
REGN is the larger business by revenue, generating $14.3B annually — 1936.7x PTHS's $7M. REGN is the more profitable business, keeping 31.4% of every revenue dollar as net income compared to PTHS's -3.2%.
| Metric | PTHSPelthos Therapeut… | REGNRegeneron Pharmac… |
|---|---|---|
| RevenueTrailing 12 months | $7M | $14.3B |
| EBITDAEarnings before interest/tax | -$21M | $4.2B |
| Net IncomeAfter-tax profit | -$24M | $4.5B |
| Free Cash FlowCash after capex | -$17M | $3.2B |
| Gross MarginGross profit ÷ Revenue | +54.3% | +86.3% |
| Operating MarginEBIT ÷ Revenue | -3.0% | +25.7% |
| Net MarginNet income ÷ Revenue | -3.2% | +31.4% |
| FCF MarginFCF ÷ Revenue | -2.3% | +22.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +2.5% |
| EPS Growth (YoY)Latest quarter vs prior year | -7.7% | -2.5% |
Valuation Metrics
| Metric | PTHSPelthos Therapeut… | REGNRegeneron Pharmac… |
|---|---|---|
| Market CapShares × price | $85M | $107.6B |
| Enterprise ValueMkt cap + debt − cash | $87M | $91.4B |
| Trailing P/EPrice ÷ TTM EPS | -1.95x | 18.84x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 17.25x |
| PEG RatioP/E ÷ EPS growth rate | — | 2.98x |
| EV / EBITDAEnterprise value multiple | — | 21.64x |
| Price / SalesMarket cap ÷ Revenue | — | 7.50x |
| Price / BookPrice ÷ Book value/share | — | 2.72x |
| Price / FCFMarket cap ÷ FCF | — | 26.36x |
Profitability & Efficiency
REGN delivers a 14.4% return on equity — every $100 of shareholder capital generates $14 in annual profit, vs $-40 for PTHS. On the Piotroski fundamental quality scale (0–9), REGN scores 7/9 vs PTHS's 4/9, reflecting strong financial health.
| Metric | PTHSPelthos Therapeut… | REGNRegeneron Pharmac… |
|---|---|---|
| ROE (TTM)Return on equity | -40.5% | +14.4% |
| ROA (TTM)Return on assets | -18.7% | +11.1% |
| ROICReturn on invested capital | — | +12.4% |
| ROCEReturn on capital employed | — | +10.8% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 7 |
| Debt / EquityFinancial leverage | — | 0.09x |
| Net DebtTotal debt minus cash | $2M | -$16.2B |
| Cash & Equiv.Liquid assets | $513,443 | $18.9B |
| Total DebtShort + long-term debt | $2M | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | -12.31x | 120.42x |
Total Returns (with DRIP)
A $10,000 investment in PTHS five years ago would be worth $22,339 today (with dividends reinvested), compared to $16,977 for REGN. Over the past 12 months, PTHS leads with a +123.4% total return vs REGN's +12.4%. The 3-year compound annual growth rate (CAGR) favors PTHS at 30.7% vs REGN's 1.1% — a key indicator of consistent wealth creation.
| Metric | PTHSPelthos Therapeut… | REGNRegeneron Pharmac… |
|---|---|---|
| YTD ReturnYear-to-date | -10.5% | +0.8% |
| 1-Year ReturnPast 12 months | +123.4% | +12.4% |
| 3-Year ReturnCumulative with dividends | +123.4% | +3.4% |
| 5-Year ReturnCumulative with dividends | +123.4% | +69.8% |
| 10-Year ReturnCumulative with dividends | +123.4% | +104.7% |
| CAGR (3Y)Annualised 3-year return | +30.7% | +1.1% |
Risk & Volatility
REGN is the less volatile stock with a 0.58 beta — it tends to amplify market swings less than PTHS's 0.76 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 95.2% from its 52-week high vs PTHS's 48.6% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | PTHSPelthos Therapeut… | REGNRegeneron Pharmac… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.76x | 0.58x |
| 52-Week HighHighest price in past year | $54.29 | $821.11 |
| 52-Week LowLowest price in past year | $11.20 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +48.6% | +95.2% |
| RSI (14)Momentum oscillator 0–100 | 51.5 | 49.1 |
| Avg Volume (50D)Average daily shares traded | 11K | 687K |
Analyst Outlook
REGN is the only dividend payer here at 0.44% yield — a key consideration for income-focused portfolios.
| Metric | PTHSPelthos Therapeut… | REGNRegeneron Pharmac… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $857.17 |
| # AnalystsCovering analysts | — | 48 |
| Dividend YieldAnnual dividend ÷ price | — | +0.4% |
| Dividend StreakConsecutive years of raises | — | 1 |
| Dividend / ShareAnnual DPS | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | +0.2% | +3.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Pelthos Therapeutic… (PTHS) | $0.00 | $0.00 | — |
| Regeneron Pharmaceu… (REGN) | $4.9B | $14.3B | +195.1% |
Regeneron Pharmaceuticals, Inc.'s revenue grew from $4.9B (2016) to $14.3B (2025) — a 12.8% CAGR.
Chart 2P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Regeneron Pharmaceu… (REGN) | 36.4 | 18.6 | -48.9% |
Regeneron Pharmaceuticals, Inc. has traded in a 9x–36x P/E range over 9 years; current trailing P/E is ~19x.
Chart 3EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Pelthos Therapeutic… (PTHS) | -4.26 | -13.54 | -217.8% |
| Regeneron Pharmaceu… (REGN) | 7.7 | 41.48 | +438.7% |
Regeneron Pharmaceuticals, Inc.'s EPS grew from $7.70 (2016) to $41.48 (2025) — a 21% CAGR.
Chart 4Free Cash Flow — 5 Years
Pelthos Therapeutics Inc. generated $-6M FCF in 2024 (-270% vs 2022). Regeneron Pharmaceuticals, Inc. generated $4B FCF in 2025 (-38% vs 2021).
PTHS vs REGN: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is PTHS or REGN a better buy right now?
Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 18.8x trailing P/E (17.3x forward), making it the more compelling value choice. Analysts rate Regeneron Pharmaceuticals, Inc. (REGN) a "Buy" — based on 48 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — PTHS or REGN?
Over the past 5 years, Pelthos Therapeutics Inc. (PTHS) delivered a total return of +123.4%, compared to +69.8% for Regeneron Pharmaceuticals, Inc. (REGN). A $10,000 investment in PTHS five years ago would be worth approximately $22K today (assuming dividends reinvested). Over 10 years, the gap is even starker: PTHS returned +123.4% versus REGN's +104.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — PTHS or REGN?
By beta (market sensitivity over 5 years), Regeneron Pharmaceuticals, Inc. (REGN) is the lower-risk stock at 0.58β versus Pelthos Therapeutics Inc.'s 0.76β — meaning PTHS is approximately 31% more volatile than REGN relative to the S&P 500.
04Which has better profit margins — PTHS or REGN?
Regeneron Pharmaceuticals, Inc. (REGN) is the more profitable company, earning 31.4% net margin versus -318.4% for Pelthos Therapeutics Inc. — meaning it keeps 31.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REGN leads at 25.7% versus -300.5% for PTHS. At the gross margin level — before operating expenses — REGN leads at 86.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — PTHS or REGN?
In this comparison, REGN (0.4% yield) pays a dividend. PTHS does not pay a meaningful dividend and should not be held primarily for income.
06Is PTHS or REGN better for a retirement portfolio?
For long-horizon retirement investors, Regeneron Pharmaceuticals, Inc. (REGN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.58), +104.7% 10Y return). Both have compounded well over 10 years (REGN: +104.7%, PTHS: +123.4%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between PTHS and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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