Comprehensive Stock Comparison
Compare Sanofi (SNY) vs Grifols, S.A. (GRFS) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | GRFS | 9.4% revenue growth vs SNY's 5.5% |
| Value | GRFS | Lower P/E (10.0x vs 11.5x) |
| Quality / Margins | SNY | 16.7% net margin vs GRFS's 5.0% |
| Stability / Safety | SNY | Beta 0.35 vs GRFS's 0.90, lower leverage |
| Dividends | GRFS | 0.0% yield; 1-year raise streak; SNY pays no meaningful dividend |
| Momentum (1Y) | GRFS | +9.5% vs SNY's -6.6% |
| Efficiency (ROA) | SNY | 6.2% ROA vs GRFS's 1.9%, ROIC 5.5% vs 5.0% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Sanofi is a global pharmaceutical company that develops and markets prescription drugs, vaccines, and consumer healthcare products. It generates revenue primarily from its Pharmaceuticals segment — including specialty care and diabetes treatments — along with Vaccines and Consumer Healthcare divisions. The company's competitive advantage stems from its diversified portfolio, strong R&D pipeline, and established global commercial infrastructure.
Grifols is a global healthcare company that specializes in plasma-derived medicines and diagnostic solutions. It generates revenue primarily from plasma-derived therapies (~70% of sales) and diagnostic products, with additional income from hospital supplies and biological materials for research. The company's competitive advantage lies in its vertically integrated plasma collection network—one of the world's largest—which provides a reliable supply of raw plasma for its proprietary manufacturing processes.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
SNY leads in 4 of 6 categories (Financial Metrics, Profitability & Efficiency). GRFS leads in 1 (Valuation Metrics). 1 tied.
Financial Metrics (TTM)
SNY is the larger business by revenue, generating $46.7B annually — 6.2x GRFS's $7.5B. SNY is the more profitable business, keeping 16.7% of every revenue dollar as net income compared to GRFS's 5.0%. On growth, SNY holds the edge at +59.9% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | SNYSanofi | GRFSGrifols, S.A. |
|---|---|---|
| RevenueTrailing 12 months | $46.7B | $7.5B |
| EBITDAEarnings before interest/tax | $9.6B | $1.7B |
| Net IncomeAfter-tax profit | $7.8B | $373M |
| Free Cash FlowCash after capex | $8.3B | $851M |
| Gross MarginGross profit ÷ Revenue | +72.3% | +39.5% |
| Operating MarginEBIT ÷ Revenue | +13.6% | +18.3% |
| Net MarginNet income ÷ Revenue | +16.7% | +5.0% |
| FCF MarginFCF ÷ Revenue | +17.7% | +11.3% |
| Rev. Growth (YoY)Latest quarter vs prior year | +59.9% | +4.0% |
| EPS Growth (YoY)Latest quarter vs prior year | -5.2% | +149.7% |
Valuation Metrics
At 20.3x trailing earnings, SNY trades at a 39% valuation discount to GRFS's 33.5x P/E. On an enterprise value basis, GRFS's 6.8x EV/EBITDA is more attractive than SNY's 11.9x.
| Metric | SNYSanofi | GRFSGrifols, S.A. |
|---|---|---|
| Market CapShares × price | $117.5B | $2.3B |
| Enterprise ValueMkt cap + debt − cash | $134.2B | $13.1B |
| Trailing P/EPrice ÷ TTM EPS | 20.32x | 33.54x |
| Forward P/EPrice ÷ next-FY EPS est. | 11.47x | 9.97x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 11.91x | 6.81x |
| Price / SalesMarket cap ÷ Revenue | 2.13x | 0.28x |
| Price / BookPrice ÷ Book value/share | 1.40x | 0.61x |
| Price / FCFMarket cap ÷ FCF | 11.21x | 3.75x |
Profitability & Efficiency
SNY delivers a 10.9% return on equity — every $100 of shareholder capital generates $11 in annual profit, vs $5 for GRFS. SNY carries lower financial leverage with a 0.30x debt-to-equity ratio, signaling a more conservative balance sheet compared to GRFS's 1.17x. On the Piotroski fundamental quality scale (0–9), GRFS scores 8/9 vs SNY's 7/9, reflecting strong financial health.
| Metric | SNYSanofi | GRFSGrifols, S.A. |
|---|---|---|
| ROE (TTM)Return on equity | +10.9% | +4.9% |
| ROA (TTM)Return on assets | +6.2% | +1.9% |
| ROICReturn on invested capital | +5.5% | +5.0% |
| ROCEReturn on capital employed | +6.3% | +6.3% |
| Piotroski ScoreFundamental quality 0–9 | 7 | 8 |
| Debt / EquityFinancial leverage | 0.30x | 1.17x |
| Net DebtTotal debt minus cash | $14.1B | $9.1B |
| Cash & Equiv.Liquid assets | $7.7B | $980M |
| Total DebtShort + long-term debt | $21.8B | $10.1B |
| Interest CoverageEBIT ÷ Interest expense | 17.51x | 2.58x |
Total Returns (with DRIP)
A $10,000 investment in SNY five years ago would be worth $12,799 today (with dividends reinvested), compared to $5,827 for GRFS. Over the past 12 months, GRFS leads with a +9.5% total return vs SNY's -6.6%. The 3-year compound annual growth rate (CAGR) favors SNY at 5.4% vs GRFS's 2.2% — a key indicator of consistent wealth creation.
| Metric | SNYSanofi | GRFSGrifols, S.A. |
|---|---|---|
| YTD ReturnYear-to-date | +0.9% | -1.5% |
| 1-Year ReturnPast 12 months | -6.6% | +9.5% |
| 3-Year ReturnCumulative with dividends | +17.0% | +6.7% |
| 5-Year ReturnCumulative with dividends | +28.0% | -41.7% |
| 10-Year ReturnCumulative with dividends | +70.2% | -31.4% |
| CAGR (3Y)Annualised 3-year return | +5.4% | +2.2% |
Risk & Volatility
SNY is the less volatile stock with a 0.35 beta — it tends to amplify market swings less than GRFS's 0.90 beta. A beta below 1.0 means the stock typically moves less than the S&P 500.
| Metric | SNYSanofi | GRFSGrifols, S.A. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.35x | 0.90x |
| 52-Week HighHighest price in past year | $60.12 | $11.14 |
| 52-Week LowLowest price in past year | $44.62 | $6.19 |
| % of 52W HighCurrent price vs 52-week peak | +80.9% | +81.7% |
| RSI (14)Momentum oscillator 0–100 | 56.3 | 43.0 |
| Avg Volume (50D)Average daily shares traded | 3.2M | 390K |
Analyst Outlook
Wall Street rates SNY as "Buy" and GRFS as "Buy".
| Metric | SNYSanofi | GRFSGrifols, S.A. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $57.02 | — |
| # AnalystsCovering analysts | 27 | 8 |
| Dividend YieldAnnual dividend ÷ price | — | +0.0% |
| Dividend StreakConsecutive years of raises | 13 | 1 |
| Dividend / ShareAnnual DPS | — | $0.00 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 20 | Feb 26 | Change |
|---|---|---|---|
| Sanofi (SNY) | 100 | 102.21 | +2.2% |
| Grifols, S.A. (GRFS) | 100 | 43.9 | -56.1% |
Sanofi (SNY) returned +28% over 5 years vs Grifols, S.A. (GRFS)'s -42%. A $10,000 investment in SNY 5 years ago would be worth $12,799 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Sanofi (SNY) | $34.7B | $46.7B | +34.6% |
| Grifols, S.A. (GRFS) | $4.0B | $7.2B | +78.1% |
Sanofi's revenue grew from $34.7B (2016) to $46.7B (2025) — a 3.4% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Sanofi (SNY) | 13.6% | 16.7% | +23.2% |
| Grifols, S.A. (GRFS) | 13.5% | 2.2% | -83.8% |
Sanofi's net margin went from 14% (2016) to 17% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Sanofi (SNY) | 12.8 | 23.9 | +86.7% |
| Grifols, S.A. (GRFS) | 23.6 | 32.3 | +36.9% |
Sanofi has traded in a 10x–44x P/E range over 9 years; current trailing P/E is ~20x. Grifols, S.A. has traded in a 21x–128x P/E range over 8 years; current trailing P/E is ~34x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Sanofi (SNY) | 1.83 | 2.03 | +10.9% |
| Grifols, S.A. (GRFS) | 0.8 | 0.23 | -71.3% |
Sanofi's EPS grew from $1.83 (2016) to $2.03 (2025) — a 1% CAGR.
Chart 6Free Cash Flow — 5 Years
Sanofi generated $9B FCF in 2025 (+5% vs 2021). Grifols, S.A. generated $531M FCF in 2024 (+52% vs 2021).
SNY vs GRFS: Frequently Asked Questions
9 questions · data-driven answers · updated daily
01Is SNY or GRFS a better buy right now?
Sanofi (SNY) offers the better valuation at 20.3x trailing P/E (11.5x forward), making it the more compelling value choice. Analysts rate Sanofi (SNY) a "Buy" — based on 27 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — SNY or GRFS?
On trailing P/E, Sanofi (SNY) is the cheapest at 20.3x versus Grifols, S.A. at 33.5x. On forward P/E, Grifols, S.A. is actually cheaper at 10.0x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — SNY or GRFS?
Over the past 5 years, Sanofi (SNY) delivered a total return of +28.0%, compared to -41.7% for Grifols, S.A. (GRFS). A $10,000 investment in SNY five years ago would be worth approximately $13K today (assuming dividends reinvested). Over 10 years, the gap is even starker: SNY returned +70.2% versus GRFS's -31.4%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — SNY or GRFS?
By beta (market sensitivity over 5 years), Sanofi (SNY) is the lower-risk stock at 0.35β versus Grifols, S.A.'s 0.90β — meaning GRFS is approximately 156% more volatile than SNY relative to the S&P 500. On balance sheet safety, Sanofi (SNY) carries a lower debt/equity ratio of 30% versus 117% for Grifols, S.A. — giving it more financial flexibility in a downturn.
05Which has better profit margins — SNY or GRFS?
Sanofi (SNY) is the more profitable company, earning 16.7% net margin versus 2.2% for Grifols, S.A. — meaning it keeps 16.7% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: GRFS leads at 16.5% versus 13.6% for SNY. At the gross margin level — before operating expenses — SNY leads at 72.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is SNY or GRFS more undervalued right now?
On forward earnings alone, Grifols, S.A. (GRFS) trades at 10.0x forward P/E versus 11.5x for Sanofi — 1.5x cheaper on a one-year earnings basis.
07Which pays a better dividend — SNY or GRFS?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is SNY or GRFS better for a retirement portfolio?
For long-horizon retirement investors, Sanofi (SNY) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.35)). Both have compounded well over 10 years (SNY: +70.2%, GRFS: -31.4%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between SNY and GRFS?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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