Comprehensive Stock Comparison
Compare TG Therapeutics, Inc. (TGTX) vs argenx SE (ARGX) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | ARGX | 78.6% revenue growth vs TGTX's 40.8% |
| Value | TGTX | Lower P/E (19.4x vs 25.6x) |
| Quality / Margins | ARGX | 23.3% net margin vs TGTX's 13.3% |
| Stability / Safety | TGTX | Beta 0.43 vs ARGX's 0.44 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | ARGX | +22.8% vs TGTX's 0.0% |
| Efficiency (ROA) | ARGX | 12.9% ROA vs TGTX's 8.6%, ROIC -0.5% vs 13.3% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
TG Therapeutics is a commercial-stage biopharmaceutical company developing and commercializing novel treatments for B-cell malignancies and autoimmune diseases. It generates revenue primarily from sales of its FDA-approved multiple sclerosis drug BRIUMVI (ublituximab) — its first commercial product — with future revenue expected from its pipeline of oncology candidates. The company's competitive advantage lies in its glycoengineered antibody platform technology, which creates potentially more effective and convenient treatments for complex diseases.
argenx is a biotechnology company that develops antibody-based therapies for autoimmune diseases. It generates nearly all its revenue from VYVGART — its FcRn blocker for conditions like myasthenia gravis — with additional income from partnerships and licensing. The company's key advantage is its proprietary antibody engineering platform that creates differentiated therapies with potentially better safety and efficacy profiles.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
ARGX leads in 2 of 6 categories — strongest in Profitability & Efficiency and Total Returns. 3 categories are tied.
Financial Metrics (TTM)
ARGX is the larger business by revenue, generating $4.0B annually — 8.7x TGTX's $454M. ARGX is the more profitable business, keeping 23.3% of every revenue dollar as net income compared to TGTX's 13.3%. On growth, TGTX holds the edge at +92.1% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | TGTXTG Therapeutics, … | ARGXargenx SE |
|---|---|---|
| RevenueTrailing 12 months | $454M | $4.0B |
| EBITDAEarnings before interest/tax | $86M | $95M |
| Net IncomeAfter-tax profit | $60M | $923M |
| Free Cash FlowCash after capex | -$59M | $213M |
| Gross MarginGross profit ÷ Revenue | +87.0% | +75.5% |
| Operating MarginEBIT ÷ Revenue | +18.9% | -1.0% |
| Net MarginNet income ÷ Revenue | +13.3% | +23.3% |
| FCF MarginFCF ÷ Revenue | -13.0% | +5.4% |
| Rev. Growth (YoY)Latest quarter vs prior year | +92.1% | +5.1% |
| EPS Growth (YoY)Latest quarter vs prior year | +2.9% | +12.6% |
Valuation Metrics
At 60.0x trailing earnings, ARGX trades at a 70% valuation discount to TGTX's 200.6x P/E.
| Metric | TGTXTG Therapeutics, … | ARGXargenx SE |
|---|---|---|
| Market CapShares × price | $4.8B | $47.5B |
| Enterprise ValueMkt cap + debt − cash | $4.8B | $46.0B |
| Trailing P/EPrice ÷ TTM EPS | 200.60x | 60.01x |
| Forward P/EPrice ÷ next-FY EPS est. | 19.40x | 25.57x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 114.40x | — |
| Price / SalesMarket cap ÷ Revenue | 14.45x | 21.67x |
| Price / BookPrice ÷ Book value/share | 21.70x | 9.09x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
TGTX delivers a 21.9% return on equity — every $100 of shareholder capital generates $22 in annual profit, vs $15 for ARGX. ARGX carries lower financial leverage with a 0.01x debt-to-equity ratio, signaling a more conservative balance sheet compared to TGTX's 1.14x.
| Metric | TGTXTG Therapeutics, … | ARGXargenx SE |
|---|---|---|
| ROE (TTM)Return on equity | +21.9% | +15.1% |
| ROA (TTM)Return on assets | +8.6% | +12.9% |
| ROICReturn on invested capital | +13.3% | -0.5% |
| ROCEReturn on capital employed | +11.0% | -0.4% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 3 |
| Debt / EquityFinancial leverage | 1.14x | 0.01x |
| Net DebtTotal debt minus cash | $74M | -$1.5B |
| Cash & Equiv.Liquid assets | $180M | $1.5B |
| Total DebtShort + long-term debt | $254M | $39M |
| Interest CoverageEBIT ÷ Interest expense | 3.11x | 166.64x |
Total Returns (with DRIP)
A $10,000 investment in ARGX five years ago would be worth $22,521 today (with dividends reinvested), compared to $6,687 for TGTX. Over the past 12 months, ARGX leads with a +22.8% total return vs TGTX's 0.0%. The 3-year compound annual growth rate (CAGR) favors ARGX at 28.0% vs TGTX's 23.4% — a key indicator of consistent wealth creation.
| Metric | TGTXTG Therapeutics, … | ARGXargenx SE |
|---|---|---|
| YTD ReturnYear-to-date | +2.8% | -8.7% |
| 1-Year ReturnPast 12 months | 0.0% | +22.8% |
| 3-Year ReturnCumulative with dividends | +87.8% | +109.5% |
| 5-Year ReturnCumulative with dividends | -33.1% | +125.2% |
| 10-Year ReturnCumulative with dividends | +261.2% | +3234.4% |
| CAGR (3Y)Annualised 3-year return | +23.4% | +28.0% |
Risk & Volatility
TGTX is the less volatile stock with a 0.43 beta — it tends to amplify market swings less than ARGX's 0.44 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ARGX currently trades 82.1% from its 52-week high vs TGTX's 64.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | TGTXTG Therapeutics, … | ARGXargenx SE |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.43x | 0.44x |
| 52-Week HighHighest price in past year | $46.48 | $934.62 |
| 52-Week LowLowest price in past year | $25.28 | $510.06 |
| % of 52W HighCurrent price vs 52-week peak | +64.7% | +82.1% |
| RSI (14)Momentum oscillator 0–100 | 58.1 | 33.9 |
| Avg Volume (50D)Average daily shares traded | 1.7M | 301K |
Analyst Outlook
Wall Street rates TGTX as "Buy" and ARGX as "Buy". Consensus price targets imply 64.5% upside for TGTX (target: $50) vs 33.9% for ARGX (target: $1027).
| Metric | TGTXTG Therapeutics, … | ARGXargenx SE |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $49.50 | $1026.71 |
| # AnalystsCovering analysts | 13 | 35 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | 0 | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +0.2% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| TG Therapeutics, In… (TGTX) | 100 | 208.43 | +108.4% |
| argenx SE (ARGX) | 100 | 564.69 | +464.7% |
argenx SE (ARGX) returned +125% over 5 years vs TG Therapeutics, In… (TGTX)'s -33%. A $10,000 investment in ARGX 5 years ago would be worth $22,521 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| TG Therapeutics, In… (TGTX) | $152381.00 | $329M | +215808.8% |
| argenx SE (ARGX) | $7M | $2.2B | +29130.4% |
TG Therapeutics, Inc.'s revenue grew from $0M (2015) to $329M (2024) — a 134.7% CAGR. argenx SE's revenue grew from $7M (2015) to $2.2B (2024) — a 87.9% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| TG Therapeutics, In… (TGTX) | -413.1% | 7.1% | +101.7% |
| argenx SE (ARGX) | -2.2% | 38.0% | +1802.4% |
TG Therapeutics, Inc.'s net margin went from -413% (2015) to 7% (2024). argenx SE's net margin went from -2% (2015) to 38% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| TG Therapeutics, In… (TGTX) | -1.38 | 0.15 | +110.9% |
| argenx SE (ARGX) | -1.06 | 12.78 | +1305.7% |
TG Therapeutics, Inc.'s EPS grew from $-1.38 (2015) to $0.15 (2024). argenx SE's EPS grew from $-1.06 (2015) to $12.78 (2024).
Chart 5Free Cash Flow — 5 Years
TG Therapeutics, Inc. generated $-41M FCF in 2024 (+86% vs 2021). argenx SE generated $-151M FCF in 2024 (+79% vs 2021).
TGTX vs ARGX: Frequently Asked Questions
9 questions · data-driven answers · updated daily
01Is TGTX or ARGX a better buy right now?
argenx SE (ARGX) offers the better valuation at 60.0x trailing P/E (25.6x forward), making it the more compelling value choice. Analysts rate TG Therapeutics, Inc. (TGTX) a "Buy" — based on 13 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — TGTX or ARGX?
On trailing P/E, argenx SE (ARGX) is the cheapest at 60.0x versus TG Therapeutics, Inc. at 200.6x. On forward P/E, TG Therapeutics, Inc. is actually cheaper at 19.4x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — TGTX or ARGX?
Over the past 5 years, argenx SE (ARGX) delivered a total return of +125.2%, compared to -33.1% for TG Therapeutics, Inc. (TGTX). A $10,000 investment in ARGX five years ago would be worth approximately $23K today (assuming dividends reinvested). Over 10 years, the gap is even starker: ARGX returned +32.3% versus TGTX's +261.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — TGTX or ARGX?
By beta (market sensitivity over 5 years), TG Therapeutics, Inc. (TGTX) is the lower-risk stock at 0.43β versus argenx SE's 0.44β — meaning ARGX is approximately 1% more volatile than TGTX relative to the S&P 500. On balance sheet safety, argenx SE (ARGX) carries a lower debt/equity ratio of 1% versus 114% for TG Therapeutics, Inc. — giving it more financial flexibility in a downturn.
05Which has better profit margins — TGTX or ARGX?
argenx SE (ARGX) is the more profitable company, earning 38.0% net margin versus 7.1% for TG Therapeutics, Inc. — meaning it keeps 38.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: TGTX leads at 12.7% versus -1.0% for ARGX. At the gross margin level — before operating expenses — ARGX leads at 89.6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is TGTX or ARGX more undervalued right now?
On forward earnings alone, TG Therapeutics, Inc. (TGTX) trades at 19.4x forward P/E versus 25.6x for argenx SE — 6.2x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for TGTX: 64.5% to $49.50.
07Which pays a better dividend — TGTX or ARGX?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is TGTX or ARGX better for a retirement portfolio?
For long-horizon retirement investors, TG Therapeutics, Inc. (TGTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.43), +261.2% 10Y return). Both have compounded well over 10 years (TGTX: +261.2%, ARGX: +32.3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between TGTX and ARGX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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