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CBIOCrescent Biopharma, Inc.$18.34$506M
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CBIO logoCrescent Biopharma, Inc.(CBIO)Earnings, Financials & Key Ratios

CBIO•NASDAQ
Price updated Jun 11, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutCrescent Biopharma, Inc., an oncology company, develops therapies for cancer patients. Its pipeline includes a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates to treat solid tumors. The company is headquartered in Waltham, Massachusetts.Show more
  • Revenue$11M
  • EBITDA-$153M-205.9%
  • Net Income-$154M-217.3%
  • EPS (Diluted)-12.81-815.0%
  • Gross Margin100%
  • EBITDA Margin-1406.75%
  • Operating Margin-1407.52%
  • Net Margin-1419.61%
  • ROE-164.18%+61.2%
  • Debt/Equity0.01
  • Interest Coverage-68.54-32.1%

CBIO Key Insights

Crescent Biopharma, Inc. (CBIO) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Strong Piotroski F-Score: 7/9
  • ✓Momentum leader: RS Rating 83 (top 17%)
  • ✓Share count reduced 46.6% through buybacks
  • ✓Trading at only 0.9x book value

✗Weaknesses

  • ✗Profits declining 24.7% over 5 years
  • ✗Negative free cash flow
  • ✗Low quality earnings: Net income not backed by cash flow
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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CBIO Price & Volume

Crescent Biopharma, Inc. (CBIO) stock price & volume — 10-year historical chart

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CBIO Growth Metrics

Crescent Biopharma, Inc. (CBIO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-5.97%
5 Years1.31%
3 Years424.86%
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-206.18%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-442.79%

Return on Capital

10 Years-74.67%
5 Years-103.8%
3 Years-127.95%
Last Year-132.59%

CBIO Recent Earnings

Crescent Biopharma, Inc. (CBIO) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)●Beat Revenue 2/12 qtrs (100%)
Q2 2026Latest
Apr 29, 2026
EPS
$0.70
Est $0.85
+17.6%
Revenue
$1M
Est $357,143
+180.0%
Q1 2026
Feb 26, 2026
EPS
$4.01
Est $2.22
-80.6%
Revenue
$11M
Est $10M
+8.4%
Q4 2025
Nov 6, 2025
EPS
$1.27
Est $1.01
-25.7%
Revenue
—
Q3 2025
Jul 31, 2025
EPS
$4.93
Est $2.69
-83.3%
Revenue
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 29, 2026
$0.70vs $0.85+17.6%
$1Mvs $357,143+180.0%
Q1 2026Feb 26, 2026
$4.01vs $2.22-80.6%
$11Mvs $10M+8.4%
Q4 2025Nov 6, 2025
$1.27vs $1.01-25.7%
—
Q3 2025Jul 31, 2025
$4.93vs $2.69-83.3%
—
Based on last 12 quarters of dataView full earnings history →

CBIO Peer Comparison

Crescent Biopharma, Inc. (CBIO) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RCUS logoRCUSArcus Biosciences, Inc.Direct Competitor2.35B23.30-7.08-4.26%-156.36%-68.97%0.16
IMVT logoIMVTImmunovant, Inc.Direct Competitor6.75B32.88-11.87-68.16%0.00
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor6.77B82.96-22.48-16.72%-6.12%-25.02%0.05
TPST logoTPSTTempest Therapeutics, Inc.Direct Competitor5.55M1.25-0.20-7.3%1.22
AGEN logoAGENAgenus Inc.Direct Competitor141.17M3.39-997.0610.37%52.16%
NKTR logoNKTRNektar TherapeuticsDirect Competitor1.16B59.21-6.09-43.89%-284.18%-87%1.66
CRVS logoCRVSCorvus Pharmaceuticals, Inc.Direct Competitor975.45M11.60-21.89-38.92%0.02
EXEL logoEXELExelixis, Inc.Product Competitor13.59B53.5019.246.98%35.08%40.21%0.08

Compare CBIO vs Peers

Crescent Biopharma, Inc. (CBIO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RCUS

Most directly comparable listed peer for CBIO.

Scale Benchmark

vs MRK

Larger-name benchmark to compare CBIO against a more recognizable public peer.

Peer Set

Compare Top 5

vs RCUS, IMVT, KYMR, TPST

CBIO Income Statement

Crescent Biopharma, Inc. (CBIO) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
00010.16M1.16M75K10K010.84M11.88M
Revenue Growth %
-100%----88.59%-93.53%-86.67%-100%--
Cost of Goods Sold
263.54K275.12K899.3K0000000
COGS % of Revenue
----------
Gross Profit
-263.54K▲ 0%
-275.12K▼ 4.4%
-899.3K▼ 226.9%
0▲ 100.0%
1.16M▲ 0%
75K▼ 93.5%
10K▼ 86.7%
0▼ 100.0%
10.84M▲ 0%
11.88M▲ 0%
Gross Margin %
----100%100%100%-100%100%
Gross Profit Growth %
--4.39%-226.87%100%--93.53%-86.67%-100%--
Operating Expenses
33.67M51.51M61.39M61.67M64.61M47.48M39.29M49.9M163.48M175.02M
OpEx % of Revenue
---606.84%5570.69%63304.43%392852.93%-1507.52%-
Selling, General & Admin
9.83M11.41M14.36M16.74M17.12M19.09M19.21M16.32M25.39M29.66M
SG&A % of Revenue
---164.75%1475.76%25449.33%192130%-234.14%-
Research & Development
24.1M40.09M47.03M44.93M47.49M28.39M20.07M28.06M138.09M145.36M
R&D % of Revenue
---442.09%4094.92%37854.51%200716.56%-1273.39%-
Other Operating Expenses
-263.54K00004436375.51M00
Operating Income
-33.93M▲ 0%
-51.51M▼ 51.8%
-61.39M▼ 19.2%
-51.51M▲ 16.1%
-63.45M▼ 23.2%
-47.4M▲ 25.3%
-39.28M▲ 17.1%
-49.9M▼ 27.0%
-152.63M▼ 205.9%
-163.14M▲ 0%
Operating Margin %
----506.84%-5470.69%-63204.43%-392752.93%--1407.52%-1372.85%
Operating Income Growth %
-6.33%-51.79%-19.19%16.09%-23.18%25.29%17.15%-27.05%-205.89%-
EBITDA
-33.67M-51.23M-60.49M-51.24M-63.18M-47.2M-39.12M-49.86M-152.55M-162.99M
EBITDA Margin %
----504.17%-5447.87%-62928.24%-391219.92%--1406.75%-1371.61%
EBITDA Growth %
-6.13%-52.16%-18.07%15.29%-23.31%25.3%17.11%-27.45%-205.94%-209.73%
D&A (Non-Cash Add-back)
263.54K275.12K899.3K270.75K264.6K207.15K153.3K35.17K84K148K
EBIT
-33.93M-51.5M-57.89M-51.51M-63.45M-47.4M-39.27M-44.21M-149.76M-159M
Net Interest Income
651.21K3.23M3.5M482.49K19.77K714.52K2.38M149.17K690K3.06M
Interest Income
651.21K3.23M3.5M482.49K19.77K714.52K2.38M1M2.88M4.13M
Interest Expense
0000000852K2.19M1.07M
Other Income/Expense
651.21K3.23M3.5M482.49K19.77K714.96K2.38M1.37M690K3.06M
Pretax Income
-33.28M▲ 0%
-48.27M▼ 45.0%
-57.89M▼ 19.9%
-51.03M▲ 11.9%
-63.43M▼ 24.3%
-46.69M▲ 26.4%
-36.9M▲ 21.0%
-48.52M▼ 31.5%
-151.94M▼ 213.1%
-160.08M▲ 0%
Pretax Margin %
----502.09%-5468.98%-62251.15%-368987.83%--1401.16%-1347.11%
Income Tax
03.23M-3.78M000002M2M
Effective Tax Rate %
0%-6.69%6.52%0%0%0%0%0%-1.32%-1.25%
Net Income
-33.28M▲ 0%
-48.27M▼ 45.0%
-54.12M▼ 12.1%
-51.03M▲ 5.7%
-63.43M▼ 24.3%
-46.69M▲ 26.4%
-36.9M▲ 21.0%
-48.52M▼ 31.5%
-153.94M▼ 217.3%
-162.08M▲ 0%
Net Margin %
----502.09%-5468.98%-62251.74%-368994.2%--1419.61%-1363.94%
Net Income Growth %
-4.63%-45.05%-12.1%5.71%-24.3%26.39%20.97%-31.5%-217.25%-206.18%
Net Income (Continuing)
-33.28M-48.27M-57.89M-51.03M-63.43M-46.69M-36.9M-48.52M-153.94M-162.08M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-1.13▲ 0%
-1.18▼ 4.4%
-1.34▼ 13.6%
-1.12▲ 16.4%
-1.23▼ 9.8%
-0.89▲ 27.6%
-0.58▲ 34.8%
-1.40▼ 141.4%
-12.81▼ 815.0%
-5.33▲ 0%
EPS Growth %
24.67%-4.42%-13.56%16.42%-9.82%27.64%34.83%-141.38%-815%-442.79%
EPS (Basic)
-1.13-1.18-1.34-1.12-1.23-0.89-0.58-1.40-12.81-
Diluted Shares Outstanding
29.4M41.04M43.25M45.72M51.45M52.53M63.34M19.5M10.41M30.4M
Basic Shares Outstanding
29.4M41.04M43.25M45.72M51.45M52.53M63.34M19.5M10.41M30.4M
Dividend Payout Ratio
----------

CBIO Balance Sheet

Crescent Biopharma, Inc. (CBIO) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
127.22M212.27M162.53M138.27M90.79M50.71M43.79M34.8M236.66M195.56M
Cash & Short-Term Investments
123.92M209.92M158.2M137.04M90.25M47.87M41.79M34.77M213.19M189.16M
Cash Only
123.92M209.92M158.2M137.04M90.25M47.87M41.79M34.77M213.19M189.16M
Short-Term Investments
0000000000
Accounts Receivable
101.95K413.12K185.95K2.15K1.35K144.02K175.82K018M0
Days Sales Outstanding
---0.080.42700.886.42K-605.87138.22
Inventory
0-40500000000
Days Inventory Outstanding
----------
Other Current Assets
000000038K5.46M6.4M
Total Non-Current Assets
1.36M2.57M5.44M4.56M3.56M1.1M1.53M813K3.64M3.57M
Property, Plant & Equipment
1.11M957.23K3.83M2.95M1.95M751.17K767.83K02.31M2.3M
Fixed Asset Turnover
---3.45x0.60x0.10x0.01x-4.68x5.42x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
000000000213K
Other Non-Current Assets
256.68K1.61M1.61M1.61M1.61M344.71K757.91K813K1.32M1.27M
Total Assets
128.58M▲ 0%
214.84M▲ 67.1%
167.97M▼ 21.8%
142.83M▼ 15.0%
94.35M▼ 33.9%
51.81M▼ 45.1%
45.32M▼ 12.5%
35.62M▼ 21.4%
240.29M▲ 574.7%
199.13M▲ 0%
Asset Turnover
---0.07x0.01x0.00x0.00x-0.05x0.06x
Asset Growth %
203.35%67.08%-21.82%-14.97%-33.95%-45.08%-12.53%-21.4%574.66%6615.15%
Total Current Liabilities
8.17M8.76M10.95M12.43M11.82M8.88M6.84M9.61M36.07M14.19M
Accounts Payable
2.65M2.66M1.44M2.09M2.11M970.19K868.12K107K10M1.19M
Days Payables Outstanding
3.67K3.53K582.69-------
Short-Term Debt
00000000435K453K
Deferred Revenue (Current)
000000004.16M7.27M
Other Current Liabilities
78.03K98.77K3.03M3.91M2.5M2.97M2.96M76K21.48M9.43M
Current Ratio
15.56x24.22x14.84x11.13x7.68x5.71x6.41x3.62x6.56x13.78x
Quick Ratio
15.56x24.22x14.84x11.13x7.68x5.71x6.41x3.62x6.56x13.78x
Cash Conversion Cycle
---------138.22
Total Non-Current Liabilities
707K611.62K2.82M2.18M918.61K066.84K41.48M1.21M1.09M
Long-Term Debt
000000037.48M1.21M1.09M
Capital Lease Obligations
002.82M1.92M918.61K066.84K002.76M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
707K611.62K0264.33K0004M00
Total Liabilities
8.88M9.38M13.77M14.61M12.74M8.88M6.9M51.1M37.28M15.28M
Total Debt
003.62M2.82M1.92M918.55K808.4K37.48M1.64M1.54M
Net Debt
-123.92M-209.92M-154.58M-134.22M-88.33M-46.95M-40.98M2.72M-211.55M-187.62M
Debt / Equity
--0.02x0.02x0.02x0.02x0.02x-0.01x0.01x
Debt / EBITDA
----------0.01x
Net Debt / EBITDA
---------1.15x
Interest Coverage
--------51.89x-68.54x-148.19x
Total Equity
119.7M▲ 0%
205.46M▲ 71.6%
154.2M▼ 25.0%
128.22M▼ 16.8%
81.6M▼ 36.4%
42.93M▼ 47.4%
38.41M▼ 10.5%
-15.48M▼ 140.3%
203.01M▲ 1411.5%
183.85M▲ 0%
Equity Growth %
239.09%71.65%-24.95%-16.85%-36.36%-47.39%-10.52%-140.29%1411.53%10586.95%
Book Value per Share
4.075.013.562.801.590.820.61-0.7919.496.05
Total Shareholders' Equity
119.7M205.46M154.2M128.22M81.6M42.93M38.41M-15.48M203.01M183.85M
Common Stock
34.36K43.16K43.47K49.02K52.31K54.38K64.39K1K28K28K
Retained Earnings
-152.28M-200.55M-258.44M-309.47M-372.9M-419.59M-456.49M-17.87M-171.81M-195.09M
Treasury Stock
0000000000
Accumulated OCI
0000000000
Minority Interest
0000000000

CBIO Cash Flow Statement

Crescent Biopharma, Inc. (CBIO) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-29.77M-43.33M-51.98M-39.24M-57.49M-46.46M-34.88M-31.1M-71.53M-75.36M
Operating CF Margin %
----386.13%-4956.99%-61943.32%-348799.03%--659.65%-
Operating CF Growth %
-0.12%-45.56%-19.97%24.51%-46.5%19.19%24.92%10.84%-130.02%-741.08%
Net Income
-33.28M-48.27M-57.89M-51.03M-63.43M-46.69M-36.9M-37.88M-149.94M-162.08M
Depreciation & Amortization
263.54K275.12K899.3K270.75K264.6K207.15K153.3K35.17K84K715K
Stock-Based Compensation
3.76M4.59M6.22M6.9M6.09M3.86M3.56M4.77M13.3M11.42M
Deferred Taxes
00002.17K0000-831K
Other Non-Cash Items
01680680.85K749.04K828.51K864.87K814.48K78.4M-29.56M
Working Capital Changes
-511.64K80.11K-1.21M3.93M-1.17M-4.66M-2.56M1.16M-13.37M-10.2M
Change in Receivables
00000000-18M18M
Change in Inventory
0000000000
Change in Payables
1.06M16.49K-1.23M654.28K17.68K-1.14M-102.08K-538.81K2.08M-6.37K
Cash from Investing
-294.11K-125.62K-144.93K-68.51K-14.94K-84.19K-21.39K20.03K-72.92M-81.07M
Capital Expenditures
-294.11K-125.62K-144.93K-68.51K-14.94K-84.19K-21.39K-9.97K-919K-955K
CapEx % of Revenue
---0.67%1.29%112.25%213.94%-8.47%8.04%
Acquisitions
000000030K00
Investments
----------
Other Investing
00000000-72M-82.33M
Cash from Financing
113.95M129.45M412.91K18.14M10.72M4.16M28.82M5.4K322.98M316.04M
Debt Issued (Net)
0000000000
Equity Issued (Net)
113.57M128.43M412.91K17.82M10.7M4.16M28.71M5.4K-172K177.43M
Dividends Paid
0000000000
Share Repurchases
00000000-177K-177K
Other Financing
373.38K1.02M0319.3K25.03K0116.5K0323.16M138.6M
Net Change in Cash
83.88M▲ 0%
85.99M▲ 2.5%
-51.72M▼ 160.1%
-21.17M▲ 59.1%
-46.78M▼ 121.0%
-42.38M▲ 9.4%
-6.08M▲ 85.7%
-31.07M▼ 411.2%
178.53M▲ 674.6%
183.55M▲ 0%
Free Cash Flow
-30.06M▲ 0%
-43.46M▼ 44.6%
-52.13M▼ 20.0%
-39.31M▲ 24.6%
-57.5M▼ 46.3%
-46.54M▲ 19.1%
-34.9M▲ 25.0%
-31.11M▲ 10.9%
-72.45M▼ 132.9%
-27.36M▲ 0%
FCF Margin %
----386.8%-4958.28%-62055.57%-349012.97%--668.12%-230.27%
FCF Growth %
1.23%-44.55%-19.96%24.59%-46.28%19.06%25.01%10.87%-132.9%-1701.31%
FCF per Share
-1.02-1.06-1.21-0.86-1.12-0.89-0.55-1.60-6.96-0.90
FCF Conversion (FCF/Net Income)
0.89x0.90x0.96x0.77x0.91x1.00x0.95x0.64x0.46x0.17x
Interest Paid
0000000000
Taxes Paid
0000000000

CBIO Key Ratios

Crescent Biopharma, Inc. (CBIO) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)-42.94%-29.69%-30.09%-36.14%-60.46%-74.98%-90.72%-423.13%-164.18%-100.86%
Return on Invested Capital (ROIC)---------1352.63%
Gross Margin----100%100%100%-100%100%
Net Margin----502.09%-5468.98%-62251.74%-368994.2%--1419.61%-1363.94%
Debt / Equity--0.02x0.02x0.02x0.02x0.02x-0.01x0.01x
Interest Coverage--------51.89x-68.54x-148.19x
FCF Conversion0.89x0.90x0.96x0.77x0.91x1.00x0.95x0.64x0.46x0.17x
Revenue Growth-100%----88.59%-93.53%-86.67%-100%--
Related:CBIO Dividend History·CBIO Revenue History·CBIO Price History·CBIO P/E History·CBIO Financial Ratios·CBIO Institutional Holders

CBIO SEC Filings & Documents

Crescent Biopharma, Inc. (CBIO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 29, 2026·SEC

Material company update

Mar 23, 2026·SEC

Material company update

Mar 12, 2026·SEC

10-K Annual Reports

4
FY 2026

Mar 13, 2026·SEC

FY 2026

Feb 26, 2026·SEC

FY 2025

Mar 17, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Apr 29, 2026·SEC

FY 2025

Nov 7, 2025·SEC

FY 2025

Nov 6, 2025·SEC

CBIO Frequently Asked Questions

Crescent Biopharma, Inc. (CBIO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Crescent Biopharma, Inc. (CBIO) reported $11.9M in revenue for fiscal year 2025. This represents a 212% increase from $3.8M in 2011.

Crescent Biopharma, Inc. (CBIO) grew revenue by 0.0% over the past year. Growth has been modest.

Crescent Biopharma, Inc. (CBIO) reported a net loss of $162.1M for fiscal year 2025.

Dividend & Returns

Crescent Biopharma, Inc. (CBIO) has a return on equity (ROE) of -164.2%. Negative ROE indicates the company is unprofitable.

Crescent Biopharma, Inc. (CBIO) had negative free cash flow of $27.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CBIO back in 2011?

Total return calculator · dividends reinvested · 15+ years of data

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How much would $100/month in CBIO be worth today?

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