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IOVA logoIovance Biotherapeutics, Inc.(IOVA)Earnings, Financials & Key Ratios

IOVA•NASDAQ
$4.09
$1.68B mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutIovance Biotherapeutics, Inc., a clinical-stage biotechnology company, focuses on developing and commercializing cancer immunotherapy products to harness the power of a patient's immune system to eradicate cancer cells. It has six ongoing phase 2 clinical studies, including C-144-01, of its lead product candidate, lifileucel, for the treatment of metastatic melanoma; C-145-04, of its product candidate lifileucel for recurrent, metastatic, or persistent cervical cancer; and C-145-03, of its product candidate LN-145, for recurrent and/or metastatic head and neck squamous cell carcinoma. Iovance Biotherapeutics, Inc. has collaborations and licensing agreements with H. Lee Moffitt Cancer Center; M.D. Anderson Cancer Center; Ohio State University; Centre hospitalier de l'Université de Montreal; Cellectis S.A.; and Novartis Pharma AG. The company was formerly known as Lion Biotechnologies, Inc. and changed its name to Iovance Biotherapeutics, Inc. in June 2017. Iovance Biotherapeutics, Inc. was incorporated in 2007 and is headquartered in San Carlos, California.Show more
  • Revenue$264M+60.6%
  • EBITDA-$367M-4.5%
  • Net Income-$391M-5.1%
  • EPS (Diluted)-1.09+14.8%
  • Gross Margin97.23%+298.1%
  • EBITDA Margin-139.44%+34.9%
  • Operating Margin-153.08%+36.5%
  • Net Margin-148.38%+34.6%
  • ROE-55.5%+3.4%
  • ROIC-48.91%+1.1%
  • Debt/Equity0.07-15.4%
Technical→

IOVA Key Insights

Iovance Biotherapeutics, Inc. (IOVA) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Shares diluted 23.3% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

IOVA Price & Volume

Iovance Biotherapeutics, Inc. (IOVA) stock price & volume — 10-year historical chart

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IOVA Growth Metrics

Iovance Biotherapeutics, Inc. (IOVA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM60.6%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-5.05%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM16.15%

Return on Capital

10 Years-53.81%
5 Years-58.43%
3 Years-59.99%
Last Year-51.62%

IOVA Recent Earnings

Iovance Biotherapeutics, Inc. (IOVA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 3/12 qtrs (27%)
Q1 2026Latest
Feb 24, 2026
EPS
$0.18
Est $0.22
+18.2%
Revenue
$87M
Est $81M
+7.4%
Q4 2025
Nov 6, 2025
EPS
$0.25
Est $0.29
+13.8%
Revenue
$67M
Est $82M
-17.9%
Q3 2025
Aug 7, 2025
EPS
$0.33
Est $0.29
-13.8%
Revenue
$60M
Est $78M
-23.5%
Q2 2025
May 8, 2025
EPS
$0.36
Est $0.25
-44.0%
Revenue
$49M
Est $82M
-40.1%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q1 2026LatestFeb 24, 2026
$0.18vs $0.22+18.2%
$87Mvs $81M+7.4%
Q4 2025Nov 6, 2025
$0.25vs $0.29+13.8%
$67Mvs $82M-17.9%
Q3 2025Aug 7, 2025
$0.33vs $0.29-13.8%
$60Mvs $78M-23.5%
Q2 2025May 8, 2025
$0.36vs $0.25-44.0%
$49Mvs $82M-40.1%
Based on last 12 quarters of dataView full earnings history →

IOVA Peer Comparison

Iovance Biotherapeutics, Inc. (IOVA) competitors in Cell and Gene Therapy Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ADCT logoADCTADC Therapeutics S.A.Direct Competitor490.96M3.86-3.4514.85%-173.02%
FATE logoFATEFate Therapeutics, Inc.Direct Competitor264.17M2.29-1.99-51.24%-20.51%-65.79%0.38
CRSP logoCRSPCRISPR Therapeutics AGDirect Competitor5.31B55.08-8.51-89.97%-138.57%-30.88%0.21
NTLA logoNTLAIntellia Therapeutics, Inc.Direct Competitor1.61B13.85-3.64-100%-61.47%0.14
BEAM logoBEAMBeam Therapeutics Inc.Direct Competitor3.32B32.33-39.92120.01%-57.24%-7.31%0.24
TGTX logoTGTXTG Therapeutics, Inc.Direct Competitor6.7B41.9715.1587.32%65.95%87.36%0.40
KYMR logoKYMRKymera Therapeutics, Inc.Product Competitor7.04B86.26-23.38-16.72%-6.12%-25.02%0.05
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Product Competitor40.43B303.00130.0465.19%13.46%98.29%1.62

Compare IOVA vs Peers

Iovance Biotherapeutics, Inc. (IOVA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ADCT

Most directly comparable listed peer for IOVA.

Scale Benchmark

vs TMO

Larger-name benchmark to compare IOVA against a more recognizable public peer.

Peer Set

Compare Top 5

vs ADCT, FATE, CRSP, NTLA

IOVA Income Statement

Iovance Biotherapeutics, Inc. (IOVA) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue0000001.19M164.07M263.5M
Revenue Growth %-------13698.99%60.6%
Cost of Goods Sold952K956K8.12M00010.76M124M7.29M
COGS % of Revenue------904.54%75.57%2.77%
Gross Profit
-952K▲ 0%
-956K▼ 0.4%
-8.12M▼ 749.7%
0▲ 100.0%
0▲ 0%
0▲ 0%
-9.57M▲ 0%
40.08M▲ 518.9%
256.22M▲ 539.3%
Gross Margin %-------804.54%24.43%97.23%
Gross Profit Growth %2.66%-0.42%-749.69%100%---518.93%539.34%
Operating Expenses92.88M128.26M206.87M261.94M342.7M398.88M450.99M435.35M659.57M
OpEx % of Revenue------37930.45%265.35%250.31%
Selling, General & Admin21.26M28.43M40.85M60.21M83.66M104.1M106.92M153.02M152.32M
SG&A % of Revenue------8992.09%93.26%57.81%
Research & Development71.61M99.83M166.02M201.73M259.04M294.78M344.08M282.34M300.27M
R&D % of Revenue------28938.35%172.08%113.95%
Other Operating Expenses00000000206.98M
Operating Income
-92.88M▲ 0%
-128.26M▼ 38.1%
-206.87M▼ 61.3%
-261.94M▼ 26.6%
-342.7M▼ 30.8%
-398.88M▼ 16.4%
-460.56M▼ 15.5%
-395.28M▲ 14.2%
-403.36M▼ 2.0%
Operating Margin %-------38734.99%-240.92%-153.08%
Operating Income Growth %-73.15%-38.09%-61.29%-26.62%-30.83%-16.39%-15.46%14.17%-2.04%
EBITDA-91.92M-127.3M-198.75M-260.8M-328.72M-377.74M-427.43M-351.67M-367.42M
EBITDA Margin %-------35948.86%-214.34%-139.44%
EBITDA Growth %-74.56%-38.48%-56.12%-31.22%-26.05%-14.91%-13.15%17.72%-4.48%
D&A (Non-Cash Add-back)952K956K8.12M1.14M13.98M21.14M33.13M43.61M35.94M
EBIT-92.06M-123.58M-197.56M-261.94M-342.7M-398.88M-460.56M-395.28M-393.05M
Net Interest Income009.32M2.36M451K013.04M20.27M0
Interest Income813K09.32M2.36M451K2.98M13.04M20.27M0
Interest Expense000002.98M000
Other Income/Expense813K4.68M9.32M2.36M451K2.98M13.04M20.27M10.31M
Pretax Income
-92.06M▲ 0%
-123.58M▼ 34.2%
-197.56M▼ 59.9%
-259.58M▼ 31.4%
-342.25M▼ 31.8%
-395.89M▼ 15.7%
-447.52M▼ 13.0%
-375M▲ 16.2%
-393.05M▼ 4.8%
Pretax Margin %-------37638.02%-228.56%-149.16%
Income Tax000000-3.48M-2.83M-2.07M
Effective Tax Rate %0%0%0%0%0%0%0.78%0.75%0.53%
Net Income
-92.06M▲ 0%
-123.58M▼ 34.2%
-197.56M▼ 59.9%
-259.58M▼ 31.4%
-342.25M▼ 31.8%
-395.89M▼ 15.7%
-444.04M▼ 12.2%
-372.18M▲ 16.2%
-390.98M▼ 5.1%
Net Margin %-------37345.42%-226.84%-148.38%
Net Income Growth %-74.05%-34.23%-59.86%-31.4%-31.85%-15.67%-12.16%16.18%-5.05%
Net Income (Continuing)-92.06M-123.58M-197.56M-259.58M-342.25M-395.89M-444.04M-372.18M-390.98M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-1.41▲ 0%
-1.27▲ 9.9%
-1.50▼ 18.1%
-1.88▼ 25.3%
-2.23▼ 18.6%
-2.49▼ 11.7%
-1.89▲ 24.1%
-1.28▲ 32.3%
-1.09▲ 14.8%
EPS Growth %-46.88%9.93%-18.11%-25.33%-18.62%-11.66%24.1%32.28%14.84%
EPS (Basic)-1.41-1.27-1.50-1.88-2.23-2.49-1.89-1.28-1.09
Diluted Shares Outstanding65.24M97.28M124.34M138.3M153.41M159.26M235.13M289.88M357.35M
Basic Shares Outstanding65.24M97.28M124.34M138.3M153.41M159.26M235.13M289.88M357.35M
Dividend Payout Ratio---------

IOVA Balance Sheet

Iovance Biotherapeutics, Inc. (IOVA) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets149.29M475.37M316.49M636.1M507.96M479.12M307.85M457.02M442.69M
Cash & Short-Term Investments145.37M468.52M307.08M629.44M504.41M471.85M279.87M323.78M296.98M
Cash Only145.37M82.15M13.97M67.33M78.23M231.73M114.89M115.69M163.08M
Short-Term Investments0386.37M293.11M562.11M426.18M240.11M164.98M208.09M133.9M
Accounts Receivable000000151K69.34M82.45M
Days Sales Outstanding------46.35154.26114.21
Inventory00000010.37M51.52M51.68M
Days Inventory Outstanding------352151.662.59K
Other Current Assets3.92M6.85M0007.27M17.46M12.38M11.58M
Total Non-Current Assets6.08M5.45M28.16M132.36M269.38M184.87M472.5M453.41M470.48M
Property, Plant & Equipment2.45M2.68M19.23M113.92M169.92M178.25M176.54M164.28M177.01M
Fixed Asset Turnover------0.01x1.00x1.49x
Goodwill000000000
Intangible Assets000000229.26M282.4M279.32M
Long-Term Investments000091.59M066.43M00
Other Non-Current Assets3.63M2.76M8.93M18.44M7.87M6.62M270K6.73M14.15M
Total Assets
155.37M▲ 0%
480.82M▲ 209.5%
344.65M▼ 28.3%
768.46M▲ 123.0%
777.33M▲ 1.2%
663.98M▼ 14.6%
780.35M▲ 17.5%
910.43M▲ 16.7%
913.17M▲ 0.3%
Asset Turnover------0.00x0.18x0.29x
Asset Growth %-9.61%209.46%-28.32%122.96%1.15%-14.58%17.53%16.67%0.3%
Total Current Liabilities9.89M14.4M39.08M54.87M89.2M91.48M110.31M122.34M138.36M
Accounts Payable1.23M2.74M15.57M13.51M27.38M26.6M33.12M27.51M22.16M
Days Payables Outstanding472.351.05K699.49---1.12K80.981.11K
Short-Term Debt000000004.04M
Deferred Revenue (Current)000000000
Other Current Liabilities5.75M7.55M000034.59M50.03M112.16M
Current Ratio15.09x33.02x8.10x11.59x5.69x5.24x2.79x3.74x3.20x
Quick Ratio15.09x33.02x8.10x11.59x5.69x5.24x2.70x3.31x2.83x
Cash Conversion Cycle-------725.76224.941.59K
Total Non-Current Liabilities297K230K6.6M57.09M66.47M72.86M85.43M77.68M76.23M
Long-Term Debt00001M1M1M1M44.4M
Capital Lease Obligations004.25M45.38M65.47M71.86M67.08M44.37M0
Deferred Tax Liabilities00000017.35M32.31M31.83M
Other Non-Current Liabilities297K230K2.35M11.71M00000
Total Liabilities9.89M14.63M45.68M111.96M155.67M164.34M195.74M200.02M214.59M
Total Debt0011.5M51.66M71.53M85.45M75.86M58.26M48.44M
Net Debt-145.37M-82.15M-2.47M-15.67M-6.7M-146.28M-39.03M-57.43M-114.63M
Debt / Equity--0.04x0.08x0.12x0.17x0.13x0.08x0.07x
Debt / EBITDA---------
Net Debt / EBITDA---------
Interest Coverage------133.63x---
Total Equity
145.48M▲ 0%
466.19M▲ 220.4%
298.97M▼ 35.9%
656.5M▲ 119.6%
621.66M▼ 5.3%
499.64M▼ 19.6%
584.61M▲ 17.0%
710.4M▲ 21.5%
698.58M▼ 1.7%
Equity Growth %-12.84%220.45%-35.87%119.59%-5.31%-19.63%17.01%21.52%-1.66%
Book Value per Share2.234.792.404.754.053.142.492.451.95
Total Shareholders' Equity145.48M466.19M298.97M656.5M621.66M499.64M584.61M710.4M698.58M
Common Stock3K5K5K6K7K8K11K13K17K
Retained Earnings-249.18M-372.76M-570.61M-830.19M-1.17B-1.57B-2.01B-2.38B-2.78B
Treasury Stock000000000
Accumulated OCI0-42K220K19K-601K-902K2.53M-1.05M16.44M
Minority Interest000000000

IOVA Cash Flow Statement

Iovance Biotherapeutics, Inc. (IOVA) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-78.71M-101.25M-158.89M-205.13M-227.94M-292.76M-361.82M-352.98M-302.41M
Operating CF Margin %-------30430.61%-215.14%-114.77%
Operating CF Growth %-140.94%-28.64%-56.93%-29.11%-11.12%-28.44%-23.59%2.44%14.33%
Net Income-92.06M-123.58M-197.56M-259.58M-342.25M-395.89M-444.04M-372.18M-390.98M
Depreciation & Amortization952K956K8.12M1.14M13.98M21.14M33.13M43.61M34.46M
Stock-Based Compensation11.97M20.03M24.28M40.89M69.77M84.02M62.63M109.63M61.58M
Deferred Taxes0001.86M00-3.48M-2.83M-2.07M
Other Non-Cash Items19K-1.32M8.97M7.57M6.01M871K-3.54M-8.65M18.87M
Working Capital Changes416K2.67M-2.7M2.98M24.55M-2.89M-6.52M-122.56M-24.27M
Change in Receivables000000-149K-69.19M-13.11M
Change in Inventory000000-10.12M-39.92M-14.21M
Change in Payables369K1.51M0-2.96M6.98M5.88M4.83M-7.84M-6.66M
Cash from Investing58.68M-386.28M90.03M-317.85M132K256.45M-155.24M-96.41M47.5M
Capital Expenditures-1.03M-1.2M-6.92M-46.79M-37.57M-20.43M-22.29M-11.07M-33.84M
CapEx % of Revenue------1874.68%6.75%12.84%
Acquisitions000271.06M-37.71M-276.88M-212.63M-52.57M0
Investments---------
Other Investing59.7M-385.08M96.94M-271.06M37.71M276.88M000
Cash from Financing58.69M424.31M6.13M576.42M239.27M190.15M462.96M390.66M300.77M
Debt Issued (Net)00001M0000
Equity Issued (Net)1000K1000K-312K1000K1000K1000K1000K1000K1000K
Dividends Paid000000000
Share Repurchases-1.25M0-312K000000
Other Financing5.03M-373.33M6.44M9.38M35.11M648K-322K-6.64M-7.06M
Net Change in Cash
38.66M▲ 0%
-63.22M▼ 263.5%
-62.73M▲ 0.8%
53.44M▲ 185.2%
11.46M▼ 78.6%
153.85M▲ 1242.6%
-56.84M▼ 136.9%
-59.27M▼ 4.3%
47.38M▲ 180.0%
Free Cash Flow
-79.74M▲ 0%
-102.45M▼ 28.5%
-165.81M▼ 61.8%
-251.93M▼ 51.9%
-265.51M▼ 5.4%
-313.18M▼ 18.0%
-384.11M▼ 22.6%
-364.05M▲ 5.2%
-336.24M▲ 7.6%
FCF Margin %-------32305.3%-221.88%-127.61%
FCF Growth %-133.22%-28.48%-61.85%-51.94%-5.39%-17.95%-22.65%5.22%7.64%
FCF per Share-1.22-1.05-1.33-1.82-1.73-1.97-1.63-1.26-0.94
FCF Conversion (FCF/Net Income)0.85x0.82x0.80x0.79x0.67x0.74x0.81x0.95x0.77x
Interest Paid000000000
Taxes Paid000000000

IOVA Key Ratios

Iovance Biotherapeutics, Inc. (IOVA) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-39.04%-58.94%-40.41%-51.64%-54.34%-53.55%-70.61%-81.91%-57.48%-55.5%
Return on Invested Capital (ROIC)-10435.6%-25056.74%-50.08%-45.6%-41.92%-40.93%-61.79%-76.85%-49.47%-48.91%
Gross Margin--------804.54%24.43%97.23%
Net Margin--------37345.42%-226.84%-148.38%
Debt / Equity---0.04x0.08x0.12x0.17x0.13x0.08x0.07x
Interest Coverage-------133.63x---
FCF Conversion0.62x0.85x0.82x0.80x0.79x0.67x0.74x0.81x0.95x0.77x
Revenue Growth--------13698.99%60.6%

IOVA SEC Filings & Documents

Iovance Biotherapeutics, Inc. (IOVA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Mar 20, 2026·SEC

Material company update

Feb 24, 2026·SEC

Material company update

Jan 9, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 24, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

FY 2025

May 8, 2025·SEC

IOVA Frequently Asked Questions

Iovance Biotherapeutics, Inc. (IOVA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Iovance Biotherapeutics, Inc. (IOVA) reported $263.5M in revenue for fiscal year 2025.

Iovance Biotherapeutics, Inc. (IOVA) grew revenue by 60.6% over the past year. This is strong growth.

Iovance Biotherapeutics, Inc. (IOVA) reported a net loss of $391.0M for fiscal year 2025.

Dividend & Returns

Iovance Biotherapeutics, Inc. (IOVA) has a return on equity (ROE) of -55.5%. Negative ROE indicates the company is unprofitable.

Iovance Biotherapeutics, Inc. (IOVA) had negative free cash flow of $336.2M in fiscal year 2025, likely due to heavy capital investments.

Explore More IOVA

Iovance Biotherapeutics, Inc. (IOVA) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

→

Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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