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CRBUCaribou Biosciences, Inc.
$1.64$163M
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CRBU logoCaribou Biosciences, Inc.(CRBU)Earnings, Financials & Key Ratios

CRBU•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutCaribou Biosciences, Inc., a clinical-stage biopharmaceutical company, engages in the development of genome-edited allogeneic cell therapies for the treatment of hematologic malignancies and solid tumors in the United States and internationally. Its lead product candidates are CB-010, an allogeneic anti-CD19 CAR-T cell therapy that is in phase 1 clinical trial to treat relapsed or refractory B cell non-Hodgkin lymphoma; and CB-011, an allogeneic anti-BCMA CAR-T cell therapy for the treatment of relapsed or refractory multiple myeloma. The company also develops CB-012, an allogeneic anti-CD371 CAR-T cell therapy for the treatment of relapsed or refractory acute myeloid leukemia; and CB-020, an allogeneic CAR-NK cell therapy for the treatment of solid tumors. It has collaboration with AbbVie Manufacturing Management Unlimited Company to develop CAR-T cell therapies. The company was incorporated in 2011 and is headquartered in Berkeley, California.Show more
  • Revenue$11M+11.7%
  • EBITDA-$133M+18.5%
  • Net Income-$148M+0.7%
  • EPS (Diluted)-1.59+3.6%
  • Gross Margin67.34%+10.9%
  • EBITDA Margin-1187.82%+27.0%
  • Operating Margin-1220.49%+26.8%
  • Net Margin-1327.4%+11.0%
  • ROE-78.97%-64.5%

CRBU Key Insights

Caribou Biosciences, Inc. (CRBU) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Trading at only 1.3x book value

✗Weaknesses

  • ✗Profits declining 34.0% over 5 years
  • ✗Weak Piotroski F-Score: 3/9
  • ✗Negative free cash flow
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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CRBU Price & Volume

Caribou Biosciences, Inc. (CRBU) stock price & volume — 10-year historical chart

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CRBU Growth Metrics

Caribou Biosciences, Inc. (CRBU) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-2.03%
3 Years-6.95%
TTM12.96%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM9.9%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM12.35%

Return on Capital

10 Years-51.81%
5 Years-40.16%
3 Years-47.49%
Last Year-62.96%

CRBU Recent Earnings

Caribou Biosciences, Inc. (CRBU) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 9/12 qtrs (75%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.26+21.2%
$0.33
Rev
$2M+8.3%
$2M
Q2 2026
Mar 5, 2026
Metric
Actual
Est
EPS
$0.28+15.2%
$0.33
Rev
$4M+78.6%
$2M
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.30+16.7%
$0.36
Rev
$2M+12.3%
$2M
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.35+12.5%
$0.40
Rev
$3M+74.1%
$2M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.26vs $0.33+21.2%
$2Mvs $2M+8.3%
Q2 2026Mar 5, 2026
$0.28vs $0.33+15.2%
$4Mvs $2M+78.6%
Q4 2025Nov 12, 2025
$0.30vs $0.36+16.7%
$2Mvs $2M+12.3%
Q3 2025Aug 12, 2025
$0.35vs $0.40+12.5%
$3Mvs $2M+74.1%
Based on last 12 quarters of dataView full earnings history →

CRBU Peer Comparison

Caribou Biosciences, Inc. (CRBU) competitors in Cell and Gene Therapy Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
EDIT logoEDITEditas Medicine, Inc.Direct Competitor263.37M2.69-1.4925.39%-281.59%-6.77%2.81
BEAM logoBEAMBeam Therapeutics Inc.Direct Competitor3.51B34.14-42.15120.01%-49.17%-5.89%0.24
NTLA logoNTLAIntellia Therapeutics, Inc.Direct Competitor1.76B15.67-4.1116.92%-5.97%-57.27%0.14
CRSP logoCRSPCRISPR Therapeutics AGDirect Competitor5.22B54.09-8.36-89.97%-138.57%-30.88%0.21
FATE logoFATEFate Therapeutics, Inc.Product Competitor243.61M2.09-1.82-51.24%-20.57%-58.89%0.38
ALLO logoALLOAllogene Therapeutics, Inc.Product Competitor487.74M2.00-2.30-100%-56.45%0.26
ILMN logoILMNIllumina, Inc.Supply Chain24.6B161.9329.71-0.78%19.43%32.84%0.94
TMO logoTMOThermo Fisher Scientific Inc.Supply Chain172.66B464.6126.193.91%15.18%13.23%0.76

Compare CRBU vs Peers

Caribou Biosciences, Inc. (CRBU) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs EDIT

Most directly comparable listed peer for CRBU.

Scale Benchmark

vs TMO

Larger-name benchmark to compare CRBU against a more recognizable public peer.

Peer Set

Compare Top 5

vs EDIT, BEAM, NTLA, CRSP

CRBU Income Statement

Caribou Biosciences, Inc. (CRBU) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
5.79M12.36M9.6M13.85M34.48M9.99M11.16M11.2M
Revenue Growth %
-113.56%-22.35%44.31%148.91%-71.01%11.66%12.96%
Cost of Goods Sold
034.42M984K3.64M3.52M3.93M3.65M649K
COGS % of Revenue
-278.5%10.25%26.29%10.22%39.29%32.66%-
Gross Profit
5.79M▲ 0%
-22.06M▼ 481.2%
8.61M▲ 139.0%
10.21M▲ 18.5%
30.95M▲ 203.2%
6.07M▼ 80.4%
7.51M▲ 23.9%
10.55M▲ 0%
Gross Margin %
100%-178.5%89.75%73.71%89.78%60.71%67.34%94.21%
Gross Profit Growth %
--481.2%139.04%18.53%203.15%-80.4%23.85%-
Operating Expenses
40.09M14.06M75.59M116.61M147.01M172.68M143.71M142.26M
OpEx % of Revenue
692.69%113.74%787.59%841.88%426.4%1727.87%1287.82%-
Selling, General & Admin
16.46M14.06M23.34M38.02M38.46M46.46M37.91M36.24M
SG&A % of Revenue
284.35%113.74%243.15%274.49%111.56%464.85%339.76%-
Research & Development
23.64M34.42M52.26M82.23M112.08M130.15M109.44M94.52M
R&D % of Revenue
408.34%278.5%544.44%593.68%325.07%1302.31%980.72%-
Other Operating Expenses
0-34.42M0-3.64M-3.52M-3.93M-3.65M351K
Operating Income
-34.3M▲ 0%
-36.12M▼ 5.3%
-66.98M▼ 85.4%
-106.4M▼ 58.9%
-116.06M▼ 9.1%
-166.62M▼ 43.6%
-136.19M▲ 18.3%
-131.71M▲ 0%
Operating Margin %
-592.69%-292.24%-697.84%-768.17%-336.63%-1667.16%-1220.49%-1175.68%
Operating Income Growth %
--5.3%-85.41%-58.85%-9.08%-43.56%18.26%-
EBITDA
-33.55M-35.22M-66M-102.76M-112.53M-162.69M-132.55M-128.58M
EBITDA Margin %
-579.72%-284.96%-687.59%-741.88%-326.4%-1627.87%-1187.82%-1147.75%
EBITDA Growth %
--4.98%-87.36%-55.71%-9.51%-44.57%18.53%19.2%
D&A (Non-Cash Add-back)
751K900K984K3.64M3.52M3.93M3.65M3.13M
EBIT
-30.96M-36.11M-66.59M-99.35M-116.06M-166.62M-136.19M-119.56M
Net Interest Income
1.04M216K140K4.6M10.7M08M0
Interest Income
1.05M236K148K4.6M10.7M08M0
Interest Expense
4K20K8K00000
Other Income/Expense
3.34M-3K377K7.05M14.18M17.5M-12.48M-2.06M
Pretax Income
-30.97M▲ 0%
-36.13M▼ 16.7%
-66.6M▼ 84.4%
-99.35M▼ 49.2%
-101.88M▼ 2.5%
-149.11M▼ 46.4%
-148.68M▲ 0.3%
-133.77M▲ 0%
Pretax Margin %
-535.04%-292.27%-693.92%-717.28%-295.49%-1492.04%-1332.33%-1194.05%
Income Tax
-7.54M-1.82M321K70K193K-9K-550K-550K
Effective Tax Rate %
24.34%5.04%-0.48%-0.07%-0.19%0.01%0.37%0.41%
Net Income
-23.43M▲ 0%
-34.31M▼ 46.4%
-66.92M▼ 95.1%
-99.42M▼ 48.6%
-102.07M▼ 2.7%
-149.1M▼ 46.1%
-148.13M▲ 0.7%
-133.22M▲ 0%
Net Margin %
-404.82%-277.55%-697.26%-717.79%-296.05%-1491.95%-1327.4%-1189.14%
Net Income Growth %
--46.42%-95.07%-48.56%-2.66%-46.08%0.66%9.9%
Net Income (Continuing)
-23.43M-34.31M-66.92M-99.42M-102.07M-149.1M-148.13M-133.22M
Discontinued Operations
00000000
Minority Interest
00000000
EPS (Diluted)
-0.85▲ 0%
-1.24▼ 45.9%
-1.11▲ 10.5%
-1.64▼ 47.7%
-1.38▲ 15.9%
-1.65▼ 19.6%
-1.59▲ 3.6%
-1.39▲ 0%
EPS Growth %
--45.88%10.48%-47.75%15.85%-19.57%3.64%12.35%
EPS (Basic)
-0.85-1.24-1.11-1.64-1.38-1.65-1.59-
Diluted Shares Outstanding
27.66M27.66M60.26M60.8M73.81M90.32M93.39M95.86M
Basic Shares Outstanding
27.66M27.66M60.26M60.8M73.81M90.32M93.39M95.86M
Dividend Payout Ratio
--------

CRBU Balance Sheet

Caribou Biosciences, Inc. (CRBU) balance sheet — assets, liabilities & shareholders' equity

MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
57.01M24.31M391.19M260.25M338.84M219.38M145.23M122.38M
Cash & Short-Term Investments
49.47M15.95M375.83M247.66M328.83M209.54M139.34M117.63M
Cash Only
41.07M15.95M240.42M58.34M51.16M16.29M12.36M12.06M
Short-Term Investments
8.4M0135.41M189.32M277.67M193.24M126.98M105.57M
Accounts Receivable
3.98M5.16M8.12M4.66M3.86M3.25M2.98M2.36M
Days Sales Outstanding
251.11152.37308.95122.9140.85118.7397.4483.02
Inventory
00000000
Days Inventory Outstanding
--------
Other Current Assets
373K423K671K1.12M1.22M1.78M2.91M2.39M
Total Non-Current Assets
4.92M11.74M51.16M113.52M93.37M93.94M30.14M26.62M
Property, Plant & Equipment
4.33M3.5M4.89M34.91M40.45M39.29M24.43M23.48M
Fixed Asset Turnover
1.34x3.53x1.96x0.40x0.85x0.25x0.46x0.47x
Goodwill
00000000
Intangible Assets
00000000
Long-Term Investments
07.63M45.3M77.07M51.33M49.13M3.55M4.83M
Other Non-Current Assets
593K612K975K1.54M1.59M5.52M2.15M2.14M
Total Assets
61.93M▲ 0%
36.05M▼ 41.8%
442.36M▲ 1127.2%
373.76M▼ 15.5%
432.21M▲ 15.6%
313.31M▼ 27.5%
175.37M▼ 44.0%
149M▲ 0%
Asset Turnover
0.09x0.34x0.02x0.04x0.08x0.03x0.06x0.06x
Asset Growth %
--41.8%1127.2%-15.51%15.64%-27.51%-44.03%-172.36%
Total Current Liabilities
10.08M12.39M25.83M28.13M28.3M30.65M25.41M19.67M
Accounts Payable
2.54M2.6M3.99M1.15M3.12M2.48M5.78M3.5M
Days Payables Outstanding
-27.581.48K114.88323.06230.13579.092.3K
Short-Term Debt
532K654K259K00001.29M
Deferred Revenue (Current)
717K161K8.7M9.94M2.85M3.13M1.9M7.93M
Other Current Liabilities
496K629K4.75M7.12M10.62M10.22M16.54M10.18M
Current Ratio
5.66x1.96x15.15x9.25x11.97x7.16x5.71x6.22x
Quick Ratio
5.66x1.96x15.15x9.25x11.97x7.16x5.71x6.22x
Cash Conversion Cycle
--------2.21K
Total Non-Current Liabilities
44.39M47.09M28.7M44.77M35.51M29.71M27.78M27.31M
Long-Term Debt
0924K000000
Capital Lease Obligations
00026.78M25.91M25.06M26.03M98.03M
Deferred Tax Liabilities
650K155K476K381K557K548K4.26M5.36M
Other Non-Current Liabilities
42.76M45.08M6.19M1.65M2.94M785K-4.26M0
Total Liabilities
54.47M59.48M54.53M72.89M63.81M60.36M53.19M46.98M
Total Debt
532K1.58M259K27.75M27.11M26.49M27.23M26.95M
Net Debt
-40.54M-14.38M-240.42M-30.59M-24.05M10.19M14.87M14.89M
Debt / Equity
0.07x-0.00x0.09x0.07x0.10x0.22x0.26x
Debt / EBITDA
--------0.21x
Net Debt / EBITDA
--------0.12x
Interest Coverage
-7741.00x-1805.35x-8324.25x-----
Total Equity
7.46M▲ 0%
-23.44M▼ 414.0%
387.82M▲ 1754.8%
300.87M▼ 22.4%
368.4M▲ 22.4%
252.95M▼ 31.3%
122.17M▼ 51.7%
102.02M▲ 0%
Equity Growth %
--414.04%1754.76%-22.42%22.44%-31.34%-51.7%-200.78%
Book Value per Share
0.27-0.856.444.954.992.801.311.06
Total Shareholders' Equity
7.46M-23.44M387.82M300.87M368.4M252.95M122.17M102.02M
Common Stock
1K1K6K6K8K9K9K10K
Retained Earnings
3.44M-30.87M-97.79M-197.22M-299.29M-448.39M-596.51M-621.6M
Treasury Stock
00000000
Accumulated OCI
00-135K-1.52M30K255K103K-23K
Minority Interest
00000000

CRBU Cash Flow Statement

Caribou Biosciences, Inc. (CRBU) cash flow — operating, investing & free cash flow history

MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-32.01M-33.22M-32.52M-90.97M-93.29M-138.2M-110.99M-101.25M
Operating CF Margin %
-552.97%-268.71%-338.81%-656.75%-270.59%-1382.83%-994.64%-
Operating CF Growth %
--3.78%2.1%-179.73%-2.56%-48.14%19.69%104.73%
Net Income
-23.43M-34.31M-66.92M-99.42M-102.07M-149.1M-148.13M-133.22M
Depreciation & Amortization
751K900K984K3.64M3.52M3.93M3.65M3.13M
Stock-Based Compensation
1.23M1M3.45M013.75M16.71M12.68M8.42M
Deferred Taxes
000-95K00-548K0
Other Non-Cash Items
-2.29M-986K904K9.02M-1.18M-4.61M21.84M24.36M
Working Capital Changes
-8.27M177K29.07M-4.11M-7.32M-5.11M-484K-3.94M
Change in Receivables
-1.09M-1.18M-2.96M3.46M805K608K272K378K
Change in Inventory
00000000
Change in Payables
1.18M43K1.14M-2.72M1.82M-354K3.25M-370K
Cash from Investing
27.23M6.36M-176.4M-93.25M-68.18M86.61M102.24M76.84M
Capital Expenditures
-884K-317K-2.12M-6.45M-11.61M-4.88M-1.36M-389K
CapEx % of Revenue
15.27%2.56%22.1%46.6%33.68%48.83%12.18%3.47%
Acquisitions
00000000
Investments
--------
Other Investing
0-988K-1M-600K0-1.61M1.14M269K
Cash from Financing
172K1.74M433.43M2.13M154.3M16.72M4.82M7.05M
Debt Issued (Net)
-45K1.47M1.03M00000
Equity Issued (Net)
217K270K429.85M2.13M152.72M15.19M4.82M7.51M
Dividends Paid
00000000
Share Repurchases
00000000
Other Financing
002.55M01.58M1.53M0-462K
Net Change in Cash
-4.6M▲ 0%
-25.12M▼ 445.9%
224.51M▲ 993.9%
-182.08M▼ 181.1%
-7.18M▲ 96.1%
-34.87M▼ 385.9%
-3.93M▲ 88.7%
-17.36M▲ 0%
Free Cash Flow
-32.89M▲ 0%
-34.53M▼ 5.0%
-35.64M▼ 3.2%
-97.42M▼ 173.3%
-104.9M▼ 7.7%
-144.71M▼ 37.9%
-112.35M▲ 22.4%
-101.64M▲ 0%
FCF Margin %
-568.24%-279.35%-371.33%-703.34%-304.27%-1447.92%-1006.82%-907.26%
FCF Growth %
--4.99%-3.21%-173.34%-7.68%-37.94%22.36%28.58%
FCF per Share
-1.19-1.25-0.59-1.60-1.42-1.60-1.20-1.06
FCF Conversion (FCF/Net Income)
1.37x0.97x0.49x0.91x0.91x0.93x0.75x0.76x
Interest Paid
00000000
Taxes Paid
1.81M21K11K0170K000

CRBU Key Ratios

Caribou Biosciences, Inc. (CRBU) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric202020212022202320242025TTM
Return on Equity (ROE)
--36.73%-28.87%-30.5%-47.99%-78.97%-100.13%
Return on Invested Capital (ROIC)
--91.46%-38.19%-28.32%-41.14%-51.05%-68.49%
Gross Margin
-178.5%89.75%73.71%89.78%60.71%67.34%94.21%
Net Margin
-277.55%-697.26%-717.79%-296.05%-1491.95%-1327.4%-1189.14%
Debt / Equity
-0.00x0.09x0.07x0.10x0.22x0.26x
Interest Coverage
-1805.35x-8324.25x-----
FCF Conversion
0.97x0.49x0.91x0.91x0.93x0.75x0.76x
Revenue Growth
113.56%-22.35%44.31%148.91%-71.01%11.66%12.96%
Related:CRBU Dividend History·CRBU Revenue History·CRBU Price History·CRBU P/E History·CRBU Financial Ratios·CRBU Institutional Holders

CRBU SEC Filings & Documents

Caribou Biosciences, Inc. (CRBU) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Mar 31, 2026·SEC

Material company update

Mar 5, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 5, 2026·SEC

FY 2025

Mar 10, 2025·SEC

FY 2024

Mar 11, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 12, 2025·SEC

CRBU Frequently Asked Questions

Caribou Biosciences, Inc. (CRBU) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Caribou Biosciences, Inc. (CRBU) reported $11.2M in revenue for fiscal year 2025. This represents a 94% increase from $5.8M in 2019.

Caribou Biosciences, Inc. (CRBU) grew revenue by 11.7% over the past year. This is steady growth.

Caribou Biosciences, Inc. (CRBU) reported a net loss of $133.2M for fiscal year 2025.

Dividend & Returns

Caribou Biosciences, Inc. (CRBU) has a return on equity (ROE) of -79.0%. Negative ROE indicates the company is unprofitable.

Caribou Biosciences, Inc. (CRBU) had negative free cash flow of $101.6M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CRBU back in 2019?

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