Ionis Pharmaceuticals operates a high-margin, capital-light RNA-targeting platform, with gross margins consistently above 96% and a 99.0% gross margin in 2026Q2. However, the company's financial profile is dominated by extreme revenue volatility—quarterly reve...
Price trend, volume and key moving averages
Start with the evidence for owning the stock and the risks that can break the thesis.
Revenue is highly episodic, with a 40.7% year-over-year decline in 2026Q2 to $267.9M, while gross margins remain exceptionally high at 99.0%, yet operating losses persist at -$102.3M due to R&D and SG&A costs that have outpaced revenue growth.
Ionis Pharmaceuticals specializes in discovering and developing antisense therapy, as well as RNA interference and CRISPR therapeutics, positioning it as a leader in innovative biotechnology.
The company maintains a dedicated Investor Relations website, providing detailed business information for stockholders, potential investors, and financial analysts, indicating transparency and engagement with the investment community.
Latest stock analysis, price targets, earnings estimates, and headlines for Ionis Pharmaceuticals are readily available, facilitating informed investment decisions and market interest.
Trailing total returns as of 10/3/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).
Recent results and news deserve attention only when they alter the forward view.
| Quarter | EPS (Act vs Est) | Revenue (Act vs Est) |
|---|---|---|
Q3 2026Latest Jul 29, 2026 | -$0.69+36.7% vs -$1.09 | $268M+41.7% vs $189M |
Q2 2026 Apr 29, 2026 | -$0.56+34.1% vs -$0.85 | $246M+25.8% vs $196M |
Q1 2026 Feb 25, 2026 | -$1.41-14.0% vs -$1.24 | $203M+30.1% vs $156M |
Q4 2025 Oct 29, 2025 | -$0.61+47.0% vs -$1.15 | $157M+2.1% vs $154M |
Alector (NASDAQ: ALEC - Get Free Report) and Ionis Pharmaceuticals (NASDAQ: IONS - Get Free Report) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their institutional ownership, analyst recommendations, earnings, dividends, profitability, valuation and risk. Institutional and Insider Ownership 85.8% of Alector shares are
RNA therapeutics are gaining momentum as Alnylam, Ionis, Wave Life Sciences and Arcturus advance innovative treatments targeting a range of diseases.
IONS posts positive phase III results for two partnered drugs, with ulefnersen meeting its ALS endpoint and sefaxersen cutting proteinuria.
Ionis Pharmaceuticals Inc. (NASDAQ:IONS) and licensing partner Roche Holdings AG (OTC:RHHBY) on Wednesday shared prespecified interim outcomes from their ongoing Phase 3 IMAgINATION trial of investigational sefaxersen in adults diagnosed with primary IgA nephropathy (IgAN).
Benchmark IONS against direct peers instead of judging its metrics in isolation.
Key metrics vs top competitors for Ionis Pharmaceuticals, Inc. (IONS)
| Company | Price | Market Cap | P/E Ratio | Rev Growth (1Y) | Net Margin | ROE | Div Yield |
|---|---|---|---|---|---|---|---|
| $43.54 | $7.24B | -18.29 | 33.87% | -40.36% | -70.72% | — | |
| $219.72 | $29.34B | 94.30 | 65.19% | 16.82% | 93.61% | — | |
| $17.50 | $1.85B | -2.45 | 15.58% | -6.93% | -9.96% | — | |
| $57.18 | $11.05B | 31.77 | 12.87% | 2.14% | 1.18% | — | |
| $15.22 | $1.5B | -2.61 | 20.13% | -81.79% | — | — | |
| $54.65 | $4.5B | -14.57 | — | — | -30.58% | — |
Ionis Pharmaceuticals, Inc. (IONS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.
Verify the primary filings, follow material updates, and answer the remaining questions.
Ionis Pharmaceuticals, Inc. (IONS) SEC filings — annual & quarterly reports (10-K, 10-Q)
Jul 29, 2026·SEC
Jul 10, 2026·SEC
Jul 9, 2026·SEC
Get notified when IONS posts new earnings or crosses analyst targets
Free. No account needed. Unsubscribe any time.
Ionis Pharmaceuticals, Inc. (IONS) stock FAQ — growth, dividends, profitability & financials explained
Ionis Pharmaceuticals, Inc. (IONS) reported $873.8M in revenue for fiscal year 2025. This represents a 3749% increase from $22.7M in 1996.
Ionis Pharmaceuticals, Inc. (IONS) grew revenue by 33.9% over the past year. This is strong growth.
Ionis Pharmaceuticals, Inc. (IONS) reported a net loss of $564.8M for fiscal year 2025.
Ionis Pharmaceuticals, Inc. (IONS) has a return on equity (ROE) of -70.7%. Negative ROE indicates the company is unprofitable.
Ionis Pharmaceuticals, Inc. (IONS) had negative free cash flow of $558.9M in fiscal year 2025, likely due to heavy capital investments.
