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PYXS
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PYXSPyxis Oncology, Inc.
$2.14$136M
Overview & Tools
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Analyst TargetsPrice History
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PYXS logo

Pyxis Oncology, Inc.

PYXS
NASDAQ · Biotechnology
$2.14
At close - Oct 2, 4:00 PM EDT - USD
Market Cap$136M
P/E-1.7x
52W High$5.55
Volume1.99M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Clinical Capital Exhaustion Threatens Pyxis Oncology Viability

Pyxis Oncology faces a precarious financial outlook as its reliance on non-recurring milestone payments fails to offset consistent, high-intensity R&D expenditures. The company's rapid erosion of total assets from $220.2 million in 2024Q1 to $64.3 million in 2...

GrowthContracting
ProfitabilityNegative
ValuationReview
TechnicalsMixed
Explore valuation models
MARKET ACTION

PYXS price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

7/12 Beats

EPS beat 7 of last 12 quarters

02

Valuation risk

-108% Peers

P/E is 108% below peer median

03

Market leadership

RS 78 · Avg

Average momentum (RS Rating: 78)

04

Mixed Trend

Mixed

Price < 50DMA but > 200DMA

Next CatalystEstimated earnings · Nov 13

Market performance

Price History →

Trailing total returns as of 10/3/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
PYXS+86.09%
S&P 500 (^GSPC)+12.66%
1-Year Return
PYXS-4.89%
S&P 500 (^GSPC)+15.01%
3-Year Return
PYXS+4.39%
S&P 500 (^GSPC)+76.65%
5-Year Return
PYXS-83.79%
S&P 500 (^GSPC)+77.00%

Growth & profitability

Annual revenue & EPS trend
Revenue
$14M-14.2% YoY
Net income
-$80M-3.0% YoY
Free cash flow
-$64M-9.7% YoY
Operating margin
-609.2%-55.1 pts YoY
ROIC (TTM)-71.1%
Avg ROIC 5Y-
ROE (TTM)-91.4%
Piotroski Score2 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate7/12 (58%)
Revenue Beat Rate3/12 (100%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 13, 2026
-$0.40-14.3%
vs -$0.35
—
vs $33,333
Q2 2026
May 14, 2026
-$0.37-5.7%
vs -$0.35
—
vs $19,440
Q2 2026
Mar 23, 2026
-$0.29+17.1%
vs -$0.35
$11M+8730.4%
vs $125,000
Q4 2025
Nov 3, 2025
-$0.35+2.8%
vs -$0.36
—
vs —
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
GlobeNewsWire·23h ago
Pyxis Oncology Announces Closing of Up to $282.6 Million Public Offering

BOSTON, Oct. 02, 2026 (GLOBE NEWSWIRE) -- Pyxis Oncology, Inc. (Nasdaq: PYXS or the “Company”), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, today announced that it closed its previously announced registered public offering (the "Offering") on October 1, 2026. The Offering generated approximately $110.0 million in upfront gross proceeds, before deducting underwriting discounts and commissions and other offering expenses. The Offering consisted of 36,047,919 shares of common stock at a public offering price of $2.90 per share and, in lieu of common stock to certain investors, pre-funded warrants to purchase 1,883,121 shares of common stock at a public offering price of $2.899 per pre-funded warrant, in each case, accompanied by common warrants to purchase an aggregate of 49,310,352 shares of common stock.

Defense World·2d ago
Critical Survey: Pyxis Oncology (NASDAQ:PYXS) versus Inovio Pharmaceuticals (NASDAQ:INO)

Pyxis Oncology (NASDAQ: PYXS - Get Free Report) and Inovio Pharmaceuticals (NASDAQ: INO - Get Free Report) are both small-cap healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their analyst recommendations, dividends, institutional ownership, earnings, profitability, risk and valuation. Earnings and Valuation This table compares Pyxis

GlobeNewsWire·3d ago
Pyxis Oncology Announces Pricing of Up to $282.6 Million Public Offering

BOSTON, Sept. 30, 2026 (GLOBE NEWSWIRE) -- Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, today announced the pricing of its previously announced registered public offering (the "Offering") of 36,047,919 shares of its common stock, or in lieu of common stock to certain investors, 1,883,121 pre-funded warrants to purchase shares of common stock, and accompanying common warrants to purchase 49,310,352 shares of common stock at an exercise price of $3.50. The combined public offering price for each share of common stock and accompanying common warrant is $2.90, and the combined public offering price for each pre-funded warrant and accompanying common warrant is $2.899 (equal to the combined public offering price per share of common stock and accompanying common warrant, minus $0.001), for expected gross proceeds to Pyxis Oncology of approximately $110 million, before deducting underwriting discounts, commissions and offering expenses. If all of the common warrants and pre-funded warrants are exercised in full, Pyxis Oncology would receive additional gross proceeds of approximately $172.6 million, before deducting applicable expenses.

GlobeNewsWire·3d ago
Pyxis Oncology Announces Proposed Public Offering

BOSTON, Sept. 29, 2026 (GLOBE NEWSWIRE) -- Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, today announced that it has commenced a registered public offering (the "Offering") of (i) shares of its common stock, or in lieu of common stock to certain investors, pre-funded warrants to purchase shares of common stock, and (ii) accompanying common warrants to purchase shares of common stock. Each share of common stock and each pre-funded warrant will be sold together with a common warrant to purchase one share of common stock.

Filtered for Pyxis Oncology, Inc.More Headlines
04

Compare before deciding

Benchmark PYXS against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Pyxis Oncology, Inc. (PYXS)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PYXS logoPYXSPyxis Oncology, Inc.Current
$2.14$135.58M-1.67-14.17%-574.55%-91.43%—
IMVT logoIMVTImmunovant, Inc.
$33.62$6.94B-12.14—-7585.86%-69.59%—
RCUS logoRCUSArcus Biosciences, Inc.
$24.44$3.07B-7.43-4.26%-386.32%-87.98%—
TPST logoTPSTTempest Therapeutics, Inc.
$0.81$12.35M-0.13——-1270.11%—
AGIO logoAGIOAgios Pharmaceuticals, Inc.
$31.80$1.89B-4.4748.03%-418.24%-35.67%—
MGNX logoMGNXMacroGenics, Inc.
$3.58$227.56M-3.030.78%-8.7%-31.27%—

Compare PYXS vs Peers

Pyxis Oncology, Inc. (PYXS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for PYXS.

Scale Benchmark

vs MRK

Larger-name benchmark to compare PYXS against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, RCUS, TPST, AGIO

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

PYXS SEC Filings & Documents

Pyxis Oncology, Inc. (PYXS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 13, 2026·SEC

Material company update

Jul 2, 2026·SEC

Material company update

Jun 15, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 23, 2026·SEC

FY 2025

Mar 18, 2025·SEC

FY 2024

Mar 21, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 13, 2026·SEC

FY 2026

May 14, 2026·SEC

FY 2025

Nov 3, 2025·SEC

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PYXS Frequently Asked Questions

Pyxis Oncology, Inc. (PYXS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Pyxis Oncology, Inc.'s revenue?

Pyxis Oncology, Inc. (PYXS) reported $11.0M in revenue for fiscal year 2025.

How fast is Pyxis Oncology, Inc. growing?

Pyxis Oncology, Inc. (PYXS) saw revenue decline by 14.2% over the past year.

Is PYXS profitable?

Pyxis Oncology, Inc. (PYXS) reported a net loss of $88.7M for fiscal year 2025.

Dividend & Returns
What is PYXS's return on equity?

Pyxis Oncology, Inc. (PYXS) has a return on equity (ROE) of -91.4%. Negative ROE indicates the company is unprofitable.

What is Pyxis Oncology, Inc.'s free cash flow?

Pyxis Oncology, Inc. (PYXS) had negative free cash flow of $67.9M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PYXS back in 2019?

Total return calculator · dividends reinvested · 7+ years of data

See returns →