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SNTISenti Biosciences, Inc.
$0.97$30M
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SNTI logoSenti Biosciences, Inc.(SNTI)Earnings, Financials & Key Ratios

SNTI•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutSenti Biosciences, Inc. operates as a gene circuit company. The company develops cell and gene therapies engineered with gene circuits that are designed to reprogram cells with biological logic to sense inputs, compute decisions, and respond to respective cellular environments. Its synthetic biology platform utilizes off-the-shelf chimeric antigen receptor natural killer (CAR-NK) cells to target particularly challenging liquid and solid tumor oncology indications. The company's lead programs include SENTI-202, a Logic Gated OR+NOT off-the-shelf CAR-NK cell therapy designed to target and eliminate acute myeloid leukemia (AML) cells, while sparing the healthy bone marrow; and SENTI-301, a multi-armed off-the-shelf CAR-NK cell therapy designed for the treatment of hepatocellular carcinoma (HCC). It also develops SENTI-401, a Logic Gated (NOT) off-the-shelf CAR-NK cell therapy designed to target and eliminate colorectal cancer (CRC) cells, while sparing healthy cells in the body. The company was founded in 2016 and is based in South San Francisco, California.Show more
  • Revenue$22K
  • EBITDA-$60M-8.9%
  • Net Income-$61M-16.4%
  • EPS (Diluted)-2.73+76.2%
  • Gross Margin-16431.82%
  • EBITDA Margin-273136.36%
  • Operating Margin-289668.18%
  • Net Margin-279263.64%
  • ROE-393.35%-244.9%

SNTI Key Insights

Senti Biosciences, Inc. (SNTI) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

No significant strengths identified

✗Weaknesses

  • ✗High debt to equity ratio of 5.2x
  • ✗Profits declining 25.3% over 5 years
  • ✗Weak Piotroski F-Score: 3/9
  • ✗Negative free cash flow
  • ✗Sales declining 43.8% over 5 years
  • ✗Shares diluted 100.0% in last year

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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SNTI Price & Volume

Senti Biosciences, Inc. (SNTI) stock price & volume — 10-year historical chart

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SNTI Growth Metrics

Senti Biosciences, Inc. (SNTI) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-43.85%
3 Years-81.15%
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM5.92%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM83.95%

Return on Capital

10 Years-69.58%
5 Years-70.43%
3 Years-79.02%
Last Year-104.52%

SNTI Recent Earnings

Senti Biosciences, Inc. (SNTI) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (67%)●Beat Revenue 3/12 qtrs (60%)
Q2 2026Latest
May 14, 2026
Metric
Actual
Est
EPS
$0.14+61.1%
$0.36
Rev
—
$20,534
Q2 2026
Mar 27, 2026
Metric
Actual
Est
EPS
$0.38+11.6%
$0.43
Rev
$22,000-97.8%
$1M
Q4 2025
Nov 13, 2025
Metric
Actual
Est
EPS
$0.69-16.9%
$0.59
Rev
—
$250,000
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$0.56+37.8%
$0.90
Rev
—
$500,000
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 14, 2026
$0.14vs $0.36+61.1%
—vs $20,534
Q2 2026Mar 27, 2026
$0.38vs $0.43+11.6%
$22,000vs $1M-97.8%
Q4 2025Nov 13, 2025
$0.69vs $0.59-16.9%
—vs $250,000
Q3 2025Aug 7, 2025
$0.56vs $0.90+37.8%
—vs $500,000
Based on last 12 quarters of dataView full earnings history →

SNTI Peer Comparison

Senti Biosciences, Inc. (SNTI) competitors in Cell and Gene Therapy Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
FATE logoFATEFate Therapeutics, Inc.Direct Competitor243.61M2.09-1.82-51.24%-20.57%-58.89%0.38
CRSP logoCRSPCRISPR Therapeutics AGDirect Competitor5.22B54.09-8.36-89.97%-138.57%-30.88%0.21
NTLA logoNTLAIntellia Therapeutics, Inc.Direct Competitor1.76B15.67-4.1116.92%-5.97%-57.27%0.14
BEAM logoBEAMBeam Therapeutics Inc.Direct Competitor3.51B34.14-42.15120.01%-49.17%-5.89%0.24
SGMO logoSGMOSangamo Therapeutics, Inc.Product Competitor74.57M0.18-0.41-31.57%-356.89%-28.92%
EDIT logoEDITEditas Medicine, Inc.Product Competitor263.37M2.69-1.4925.39%-281.59%-6.77%2.81
ILMN logoILMNIllumina, Inc.Supply Chain24.6B161.9329.71-0.78%19.43%32.84%0.94
TMO logoTMOThermo Fisher Scientific Inc.Supply Chain172.66B464.6126.193.91%15.18%13.23%0.76

Compare SNTI vs Peers

Senti Biosciences, Inc. (SNTI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs FATE

Most directly comparable listed peer for SNTI.

Scale Benchmark

vs TMO

Larger-name benchmark to compare SNTI against a more recognizable public peer.

Peer Set

Compare Top 5

vs FATE, CRSP, NTLA, BEAM

SNTI Income Statement

Senti Biosciences, Inc. (SNTI) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
85K394K2.29M3.29M1.98M022K38K
Revenue Growth %
-363.53%481.47%43.43%-39.81%-100%--
Cost of Goods Sold
14.52M000003.64M2.37M
COGS % of Revenue
17087.06%-----16531.82%-
Gross Profit
-14.44M▲ 0%
394K▲ 102.7%
2.29M▲ 481.5%
3.29M▲ 43.4%
1.98M▼ 39.8%
0▼ 100.0%
-3.62M▲ 0%
-2.33M▲ 0%
Gross Margin %
-16987.06%100%100%100%100%--16431.82%-6134.21%
Gross Profit Growth %
-102.73%481.47%43.43%-39.81%-100%--
Operating Expenses
7.39M25.09M42.74M65.37M94.7M61.04M60.11M56.5M
OpEx % of Revenue
8696.47%6367.51%1865.43%1989.35%4787.92%-273236.36%-
Selling, General & Admin
7.34M9.3M21.25M37.63M34.87M23.51M26.16M24.13M
SG&A % of Revenue
8638.82%2361.42%927.54%1145.25%1762.79%-118922.73%-
Research & Development
14.52M15.96M21.96M28.14M32.15M34.36M37.59M33.36M
R&D % of Revenue
17087.06%4049.75%958.4%856.51%1625.38%-170845.45%-
Other Operating Expenses
0-172K-470K-408K27.69M3.17M-3.64M-747K
Operating Income
-21.78M▲ 0%
-24.69M▼ 13.4%
-40.45M▼ 63.8%
-62.08M▼ 53.5%
-92.73M▼ 49.4%
-61.04M▲ 34.2%
-63.73M▼ 4.4%
-58.83M▲ 0%
Operating Margin %
-25625.88%-6267.51%-1765.43%-1889.35%-4687.92%--289668.18%-154810.53%
Operating Income Growth %
--13.37%-63.79%-53.5%-49.36%34.17%-4.4%-
EBITDA
-21.36M-22.71M-37.44M-58.16M-87.3M-55.19M-60.09M-55.09M
EBITDA Margin %
-25123.53%-5763.71%-1634.05%-1770.05%-4413.45%--273136.36%-144984.21%
EBITDA Growth %
--6.34%-64.85%-55.37%-50.09%36.78%-8.88%0.33%
D&A (Non-Cash Add-back)
427K1.99M3.01M3.92M5.43M5.85M3.64M3.73M
EBIT
-21.78M-24.69M-40.45M-62.08M-66.77M-60.73M-63.73M-56.76M
Net Interest Income
674K88K11K1.7M2.86M0927K634K
Interest Income
674K88K11K1.7M2.86M0927K634K
Interest Expense
00000000
Other Income/Expense
625K4.83M-14.87M12.42M9.32M8.25M2.29M7.28M
Pretax Income
-21.16M▲ 0%
-19.86M▲ 6.1%
-55.32M▼ 178.5%
-49.66M▲ 10.2%
-83.41M▼ 67.9%
-52.79M▲ 36.7%
-61.44M▼ 16.4%
-51.55M▲ 0%
Pretax Margin %
-24890.59%-5041.12%-2414.62%-1511.41%-4216.68%--279263.64%-135650%
Income Tax
00000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%
Net Income
-21.16M▲ 0%
-19.86M▲ 6.1%
-55.32M▼ 178.5%
-58.21M▼ 5.2%
-71.06M▼ 22.1%
-52.79M▲ 25.7%
-61.44M▼ 16.4%
-51.55M▲ 0%
Net Margin %
-24890.59%-5041.12%-2414.62%-1771.45%-3592.42%--279263.64%-135650%
Net Income Growth %
-6.12%-178.52%-5.23%-22.07%25.71%-16.38%5.92%
Net Income (Continuing)
-21.16M-19.86M-55.32M-49.66M-83.41M-52.79M-61.44M-51.55M
Discontinued Operations
000-8.54M12.35M000
Minority Interest
00000000
EPS (Diluted)
-15.57▲ 0%
-4.55▲ 70.8%
-12.67▼ 178.5%
-13.25▼ 4.6%
-20.94▼ 58.0%
-11.49▲ 45.1%
-2.73▲ 76.2%
-1.66▲ 0%
EPS Growth %
-70.78%-178.46%-4.58%-58.04%45.13%76.24%83.95%
EPS (Basic)
-15.57-4.55-12.67-13.25-20.94-11.49-2.73-
Diluted Shares Outstanding
1.36M4.37M4.37M4.39M4.44M4.6M224.83M30.97M
Basic Shares Outstanding
1.36M4.37M4.37M4.39M4.44M4.6M224.83M30.97M
Dividend Payout Ratio
--------

SNTI Balance Sheet

Senti Biosciences, Inc. (SNTI) balance sheet — assets, liabilities & shareholders' equity

MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
18.76M31.71M58.75M102.58M71.2M58.96M23.27M14.79M
Cash & Short-Term Investments
17.83M30.54M56.03M98.56M35.93M48.28M16.42M8.94M
Cash Only
5.3M30.54M56.03M57.62M35.93M48.28M16.42M8.94M
Short-Term Investments
12.53M0040.94M0000
Accounts Receivable
78K317K483K626K17.7M1.8M323K172K
Days Sales Outstanding
334.94293.6776.9569.533.27K-5.36K10.41K
Inventory
00000000
Days Inventory Outstanding
--------
Other Current Assets
853K830K1.43M1.52M237K584K6.53M5.68M
Total Non-Current Assets
16.59M16.64M37.95M78.21M48.28M38.88M27.95M23.45M
Property, Plant & Equipment
16.59M16.14M33.08M74.55M41.61M35.24M24.4M0
Fixed Asset Turnover
0.01x0.02x0.07x0.04x0.05x-0.00x0.00x
Goodwill
00000000
Intangible Assets
00000000
Long-Term Investments
003.26M3.37M4.64M03.53M3.53M
Other Non-Current Assets
-16.59M497K1.62M293K2.03M3.64M19K23.45M
Total Assets
35.84M▲ 0%
48.34M▲ 34.9%
96.7M▲ 100.0%
180.79M▲ 87.0%
119.48M▼ 33.9%
97.84M▼ 18.1%
51.22M▼ 47.6%
38.24M▲ 0%
Asset Turnover
0.00x0.01x0.02x0.02x0.02x-0.00x0.00x
Asset Growth %
-34.88%100.02%86.96%-33.91%-18.11%-47.65%-131.31%
Total Current Liabilities
4.31M4.87M14.54M18.05M12.67M13.15M13.97M14.27M
Accounts Payable
1.2M914K5.19M2.27M1.25M1.45M2.94M0
Days Payables Outstanding
30.08-----295.35220.86
Short-Term Debt
001.74M0005.33M5.89M
Deferred Revenue (Current)
001.66M799K989K660K43K403K
Other Current Liabilities
3.11M2.37M3.29M9.26M3.94M2.55M5.66M8.38M
Current Ratio
4.36x6.52x4.04x5.68x5.62x4.49x1.67x1.04x
Quick Ratio
4.36x6.52x4.04x5.68x5.62x4.49x1.67x1.04x
Cash Conversion Cycle
-------10.19K
Total Non-Current Liabilities
0102.19M21.78M35.48M39.9M59.05M31.66M21.41M
Long-Term Debt
000000013.25M
Capital Lease Obligations
012.53M20.99M35.1M33.54M28.89M23.56M26.33M
Deferred Tax Liabilities
00000000
Other Non-Current Liabilities
089.66M619K373K6.36M30.16M8.1M8.16M
Total Liabilities
17.88M107.06M36.33M53.53M52.57M72.19M45.63M35.68M
Total Debt
014.05M22.73M37.09M37.67M33.64M28.89M19.14M
Net Debt
-5.3M-16.49M-33.3M-20.53M1.74M-14.64M12.47M10.21M
Debt / Equity
--0.38x0.29x0.56x1.31x5.17x7.46x
Debt / EBITDA
--------0.35x
Net Debt / EBITDA
--------0.19x
Interest Coverage
--------
Total Equity
17.96M▲ 0%
-58.71M▼ 426.8%
60.38M▲ 202.8%
127.26M▲ 110.8%
66.91M▼ 47.4%
25.65M▼ 61.7%
5.59M▼ 78.2%
2.56M▲ 0%
Equity Growth %
--426.82%202.83%110.78%-47.42%-61.67%-78.21%-264.82%
Book Value per Share
13.22-13.4513.8328.9615.085.580.020.08
Total Shareholders' Equity
17.96M-58.71M60.38M127.26M66.91M25.65M5.59M2.56M
Common Stock
1K1K04K5K1K3K3K
Retained Earnings
-39.9M-59.76M-115.08M-173.29M-244.34M-297.13M-358.57M-362.79M
Treasury Stock
00000000
Accumulated OCI
0001K0000
Minority Interest
00000000

SNTI Cash Flow Statement

Senti Biosciences, Inc. (SNTI) cash flow — operating, investing & free cash flow history

MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-18.38M-24.17M-34.63M-34.9M-52.4M-41.4M-43.44M-36.88M
Operating CF Margin %
-21621.18%-6135.28%-1511.79%-1061.96%-2648.89%--197472.73%-
Operating CF Growth %
--31.53%-43.28%-0.75%-50.15%20.99%-4.94%19.1%
Net Income
-21.16M-19.86M-55.32M-58.22M-71.06M-52.79M-61.44M-51.55M
Depreciation & Amortization
1.4M1.99M3.01M3.92M5.43M5.85M3.64M4.52M
Stock-Based Compensation
205K272K2.29M16.39M9.67M1.75M5.71M4.27M
Deferred Taxes
-329K0000000
Other Non-Cash Items
1.38M-4.79M14.76M-10.89M-1.1M-256K5.09M-1.73M
Working Capital Changes
124K-1.77M615K13.9M4.67M4.04M3.56M7.62M
Change in Receivables
124K-10K-395K-131K-929K-727K210K1.45M
Change in Inventory
00000000
Change in Payables
0-324K-617K186K-290K797K1.74M-505K
Cash from Investing
3.75M11.36M-5.54M-81.96M30.08M34K-184K-58K
Capital Expenditures
-2M-1.16M-5.54M-41.37M-12.04M-26K-196K-196K
CapEx % of Revenue
2348.24%294.67%241.95%1259.1%608.59%-890.91%515.79%
Acquisitions
00000012K24K
Investments
--------
Other Investing
5.75M000105K60K0114K
Cash from Financing
14.01M38.05M68.44M118.55M779K53.73M11.76M12.06M
Debt Issued (Net)
08M05.17M-108K000
Equity Issued (Net)
030M66.95M728K512K49.06M8.71M9.12M
Dividends Paid
00000000
Share Repurchases
00000000
Other Financing
14.01M51K1.48M112.65M375K4.67M3.05M2.93M
Net Change in Cash
5.8M▲ 0%
25.24M▲ 335.3%
28.26M▲ 12.0%
1.7M▼ 94.0%
-21.54M▼ 1370.0%
12.37M▲ 157.4%
-31.87M▼ 357.7%
-24.88M▲ 0%
Free Cash Flow
-20.37M▲ 0%
-25.33M▼ 24.3%
-40.18M▼ 58.6%
-76.27M▼ 89.8%
-64.43M▲ 15.5%
-41.42M▲ 35.7%
-43.64M▼ 5.4%
-37.07M▲ 0%
FCF Margin %
-23969.41%-6429.95%-1753.73%-2321.06%-3257.48%--198363.64%-97555.26%
FCF Growth %
--24.34%-58.59%-89.83%15.52%35.71%-5.35%15.32%
FCF per Share
-15.00-5.80-9.20-17.35-14.52-9.01-0.19-1.20
FCF Conversion (FCF/Net Income)
0.87x1.22x0.63x0.60x0.74x0.78x0.71x0.72x
Interest Paid
00000000
Taxes Paid
00000000

SNTI Key Ratios

Senti Biosciences, Inc. (SNTI) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric202020212022202320242025TTM
Return on Equity (ROE)
--6652.92%-62.04%-73.19%-114.06%-393.35%-503.79%
Return on Invested Capital (ROIC)
---69.6%-79.31%-114.93%-328.79%-193.48%
Gross Margin
100%100%100%100%--16431.82%-6134.21%
Net Margin
-5041.12%-2414.62%-1771.45%-3592.42%--279263.64%-135650%
Debt / Equity
-0.38x0.29x0.56x1.31x5.17x7.46x
FCF Conversion
1.22x0.63x0.60x0.74x0.78x0.71x0.72x
Revenue Growth
363.53%481.47%43.43%-39.81%-100%--
Related:SNTI Dividend History·SNTI Revenue History·SNTI Price History·SNTI P/E History·SNTI Financial Ratios·SNTI Institutional Holders

SNTI SEC Filings & Documents

Senti Biosciences, Inc. (SNTI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 26, 2026·SEC

Material company update

May 14, 2026·SEC

Material company update

May 1, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 27, 2026·SEC

FY 2025

Mar 20, 2025·SEC

FY 2024

Mar 21, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 14, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 7, 2025·SEC

SNTI Frequently Asked Questions

Senti Biosciences, Inc. (SNTI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Senti Biosciences, Inc. (SNTI) reported $0.0M in revenue for fiscal year 2025. This represents a 55% decrease from $0.1M in 2019.

Senti Biosciences, Inc. (SNTI) grew revenue by 0.0% over the past year. Growth has been modest.

Senti Biosciences, Inc. (SNTI) reported a net loss of $51.5M for fiscal year 2025.

Dividend & Returns

Senti Biosciences, Inc. (SNTI) has a return on equity (ROE) of -393.4%. Negative ROE indicates the company is unprofitable.

Senti Biosciences, Inc. (SNTI) had negative free cash flow of $37.1M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SNTI back in 2019?

Total return calculator · dividends reinvested · 7+ years of data

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