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Twist Bioscience Corporation (TWST) 10-Year Financial Performance & Capital Metrics

TWST • • Industrial / General
HealthcareDiagnostics & ResearchLife Sciences Instrumentation & ToolsLaboratory Equipment & Consumables
AboutTwist Bioscience Corporation, a synthetic biology company, manufactures and sells synthetic DNA-based products. The company's DNA synthesis platform enables the manufacturing of synthetic DNA by writing DNA on a silicon chip. It offers synthetic DNA-based products, including synthetic genes, tools for sample preparation, antibody libraries for drug discovery and development, and DNA as a digital data storage medium. The company has collaboration agreements with Victorian Clinical Genetic Services; Vivlion GmbH.; Kyowa Kirin Pharmaceutical Research, Inc.; deepCDR Biologics AG; and Centogene N.V to develop advanced sequencing tools. It also has a research collaboration with Boehringer Ingelheim International GmbH to use proprietary antibody libraries to discover therapeutic antibodies against multiple targets. Twist Bioscience Corporation was incorporated in 2013 and is headquartered in South San Francisco, California.Show more
  • Revenue $377M +20.3%
  • EBITDA -$111M +41.2%
  • Net Income -$78M +62.8%
  • EPS (Diluted) -1.30 +63.9%
  • Gross Margin 50.72% +19.0%
  • EBITDA Margin -29.58% +51.1%
  • Operating Margin -36.18% +48.7%
  • Net Margin -20.63% +69.1%
  • ROE -16.43% +56.9%
  • ROIC -29.33% +32.5%
  • Debt/Equity 0.16 -11.2%
  • Interest Coverage -
Technical Analysis

Key Insights

Based on financial data analysis

✓Strengths

  • ✓Strong 5Y sales CAGR of 33.1%

✗Weaknesses

  • ✗Negative free cash flow

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

Price & Volume

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Growth Metrics

Revenue CAGR

10Y-
5Y33.11%
3Y22.76%
TTM22.72%

Profit (Net Income) CAGR

10Y-
5Y-
3Y-
TTM61.33%

EPS CAGR

10Y-
5Y-
3Y-
TTM61.78%

ROCE

10Y Avg-51.62%
5Y Avg-29.91%
3Y Avg-29.32%
Latest-24.92%

Peer Comparison

Laboratory Equipment & Consumables
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Sector-Specific
NameMarket CapCurrent PriceP/E RatioRevenue Growth 1YNet MarginROEFCF YieldDebt/Equity
QGENQiagen N.V.9.97B48.38127.320.66%19.58%11.11%5.08%0.40
RVTYRevvity, Inc.13.08B115.3347.850.16%8.47%3.23%4.14%0.43
DHRDanaher Corporation169.45B239.8945.35-0.06%14.43%6.86%3.13%0.35
TMOThermo Fisher Scientific Inc.234.69B624.6537.790.05%15.02%12.84%3.1%0.66
WATWaters Corporation23.5B394.5936.840.07%20.89%27.84%2.64%0.93
MTDMettler-Toledo International Inc.30.57B1496.6136.802.22%21.2%2.83%
AAgilent Technologies, Inc.41.06B144.8331.696.73%18.75%19.33%2.81%0.50
TWSTTwist Bioscience Corporation2.53B41.27-31.7520.32%-23.51%-17.81%0.16

Profit & Loss

Sep 2016Sep 2017Sep 2018Sep 2019Sep 2020Sep 2021Sep 2022Sep 2023Sep 2024Sep 2025
Sales/Revenue+2.27M10.77M25.43M54.38M90.1M132.33M203.56M245.11M312.97M376.57M
Revenue Growth %-3.75%1.36%1.14%0.66%0.47%0.54%0.2%0.28%0.2%
Cost of Goods Sold+9.42M24.02M32.19M47.43M61.41M80.62M119.33M155.38M179.63M185.57M
COGS % of Revenue4.15%2.23%1.27%0.87%0.68%0.61%0.59%0.63%0.57%0.49%
Gross Profit+-7.15M-13.25M-6.76M6.96M28.69M51.71M84.23M89.73M133.35M191M
Gross Margin %-3.15%-1.23%-0.27%0.13%0.32%0.39%0.41%0.37%0.43%0.51%
Gross Profit Growth %--0.85%0.49%2.03%3.12%0.8%0.63%0.07%0.49%0.43%
Operating Expenses+36.5M45.23M63.8M115.81M168.77M204.44M319.01M306.89M354.18M327.26M
OpEx % of Revenue16.09%4.2%2.51%2.13%1.87%1.54%1.57%1.25%1.13%0.87%
Selling, General & Admin18.27M26.06M43.45M80.13M103.27M135.9M212.95M189.74M218.4M246.98M
SG&A % of Revenue8.05%2.42%1.71%1.47%1.15%1.03%1.05%0.77%0.7%0.66%
Research & Development18.23M19.17M20.35M35.68M43.01M69.07M120.31M106.89M90.85M80.28M
R&D % of Revenue8.03%1.78%0.8%0.66%0.48%0.52%0.59%0.44%0.29%0.21%
Other Operating Expenses73K-55K-121K-265K22.5M-534K-14.24M10.26M44.93M0
Operating Income+-43.66M-58.48M-70.56M-108.85M-140.08M-152.73M-234.78M-217.16M-220.83M-136.26M
Operating Margin %-19.24%-5.43%-2.77%-2%-1.55%-1.15%-1.15%-0.89%-0.71%-0.36%
Operating Income Growth %--0.34%-0.21%-0.54%-0.29%-0.09%-0.54%0.08%-0.02%0.38%
EBITDA+-39.43M-53.46M-64.83M-102.54M-133.4M-142.98M-218.26M-187.85M-189.4M-111.41M
EBITDA Margin %-17.38%-4.97%-2.55%-1.89%-1.48%-1.08%-1.07%-0.77%-0.61%-0.3%
EBITDA Growth %--0.36%-0.21%-0.58%-0.3%-0.07%-0.53%0.14%-0.01%0.41%
D&A (Non-Cash Add-back)4.23M5.02M5.73M6.31M6.68M9.75M16.51M29.31M31.43M24.85M
EBIT-43.34M-58.13M-69.68M-106.08M-138.76M-153.66M-228.19M-203.46M-208.14M-76.95M
Net Interest Income+-505K-493K-314K1.74M712K68K2.98M14.36M15.31M11.36M
Interest Income241K412K999K3.03M1.5M435K3.06M14.37M15.34M11.36M
Interest Expense746K905K1.31M1.29M787K367K80K5K29K0
Other Income/Expense-432K-548K-435K1.47M530K-1.3M6.5M13.69M12.66M59.31M
Pretax Income+-44.09M-59.03M-70.99M-107.38M-139.55M-154.03M-228.27M-203.47M-208.17M-76.95M
Pretax Margin %-19.43%-5.48%-2.79%-1.97%-1.55%-1.16%-1.12%-0.83%-0.67%-0.2%
Income Tax+0280K242K292K382K-1.93M-10.41M1.15M560K719K
Effective Tax Rate %1%1%1%1%1%0.99%0.95%1.01%1%1.01%
Net Income+-44.09M-59.31M-71.24M-107.67M-139.93M-152.1M-217.86M-204.62M-208.73M-77.67M
Net Margin %-19.43%-5.51%-2.8%-1.98%-1.55%-1.15%-1.07%-0.83%-0.67%-0.21%
Net Income Growth %--0.35%-0.2%-0.51%-0.3%-0.09%-0.43%0.06%-0.02%0.63%
Net Income (Continuing)-44.09M-59.31M-71.24M-107.67M-139.93M-152.1M-217.86M-204.62M-208.73M-77.67M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)+-2.35-3.16-2.68-3.92-3.57-3.15-4.04-3.60-3.60-1.30
EPS Growth %--0.34%0.15%-0.46%0.09%0.12%-0.28%0.11%0%0.64%
EPS (Basic)-2.35-3.16-2.68-3.92-3.57-3.15-4.04-3.60-3.60-1.30
Diluted Shares Outstanding18.78M18.78M26.61M27.46M39.19M48.25M53.88M56.88M58.02M59.81M
Basic Shares Outstanding18.78M18.78M26.61M27.46M39.19M48.25M53.88M56.88M58.02M59.81M
Dividend Payout Ratio----------

Balance Sheet

Sep 2016Sep 2017Sep 2018Sep 2019Sep 2020Sep 2021Sep 2022Sep 2023Sep 2024Sep 2025
Total Current Assets+59.04M67.87M95.67M160.13M334.87M546.5M596.48M424.26M346.78M332.97M
Cash & Short-Term Investments55.92M62.2M80.76M138.11M290M477.86M504.97M336.41M276.4M232.43M
Cash Only28.6M31.23M80.76M46.73M93.67M465.83M378.69M286.47M226.32M183.05M
Short-Term Investments27.32M30.98M091.37M196.34M12.03M126.28M49.94M50.08M49.38M
Accounts Receivable723K2.35M5.42M12.1M25.43M28.55M40.29M44.06M34.9M57.02M
Days Sales Outstanding116.379.5377.7981.2310378.7472.2565.6240.755.27
Inventory1.23M1.83M6.03M7.33M12.29M31.8M39.31M32.06M24.08M28.31M
Days Inventory Outstanding47.5827.7668.3556.4173.05143.97120.2375.3248.9355.68
Other Current Assets003.47M0951K0011.72M11.4M15.2M
Total Non-Current Assets+17.42M17.79M20.12M26.86M64.01M155.6M364.9M352.15M267.55M308.89M
Property, Plant & Equipment14.62M14.83M12.33M20.84M59.16M105.7M214.39M203.36M161.35M151.66M
Fixed Asset Turnover0.16x0.73x2.06x2.61x1.52x1.25x0.95x1.21x1.94x2.48x
Goodwill1.14M1.14M1.14M1.14M1.14M22.43M85.81M85.81M85.81M82.19M
Intangible Assets1.13M920K712K508K307K18.26M59.74M54.48M14.48M13.43M
Long-Term Investments322K202K579K579K0000054.34M
Other Non-Current Assets536K896K5.94M4.38M3.4M9.2M4.96M8.49M5.91M7.28M
Total Assets+76.46M85.66M115.79M186.99M398.88M702.1M961.38M776.4M614.32M641.86M
Asset Turnover0.03x0.13x0.22x0.29x0.23x0.19x0.21x0.32x0.51x0.59x
Asset Growth %-0.12%0.35%0.61%1.13%0.76%0.37%-0.19%-0.21%0.04%
Total Current Liabilities+8.68M9.48M18.54M30.35M36.03M63.05M90.66M73.32M71.01M91.41M
Accounts Payable2.34M2.85M7.53M9.76M4.83M14.9M20.09M14.05M1.63M11.09M
Days Payables Outstanding90.5443.2985.475.1128.7167.4661.4633.013.3121.82
Short-Term Debt1.37M02.5M3.33M3.33M1.55M00013.82M
Deferred Revenue (Current)1000K01000K1000K01000K1000K01000K0
Other Current Liabilities353K3.16M3.1M817K2.61M28.42M39.62M18.56M34.61M66.49M
Current Ratio6.80x7.16x5.16x5.28x9.29x8.67x6.58x5.79x4.88x3.64x
Quick Ratio6.66x6.97x4.84x5.03x8.95x8.16x6.15x5.35x4.54x3.33x
Cash Conversion Cycle73.346460.7562.53147.33155.26131.02107.9386.3289.13
Total Non-Current Liabilities+144.4M209.54M298.68M4.56M26.59M58.22M81.33M79.65M70.63M77.5M
Long-Term Debt9.81M9.15M7.22M4.4M1.4M000061.75M
Capital Lease Obligations000024.84M53.16M81.27M79.17M70.22M0
Deferred Tax Liabilities0000000000
Other Non-Current Liabilities134.58M200.38M291.46M158K351K5.07M60K475K407K15.75M
Total Liabilities153.07M219.01M317.21M34.91M62.62M121.28M171.99M152.97M141.63M168.9M
Total Debt+11.18M9.15M9.72M7.73M35.98M62.92M94.91M94.07M85.03M75.57M
Net Debt-17.41M-22.07M-71.04M-39M-57.69M-402.91M-283.77M-192.4M-141.29M-107.48M
Debt / Equity---0.05x0.11x0.11x0.12x0.15x0.18x0.16x
Debt / EBITDA----------
Net Debt / EBITDA----------
Interest Coverage-58.52x-64.62x-53.74x-84.12x-177.99x-416.15x-2934.70x-43431.80x-7614.86x-
Total Equity+-76.61M-133.36M-201.42M152.08M336.26M580.82M789.38M623.43M472.69M472.96M
Equity Growth %--0.74%-0.51%1.76%1.21%0.73%0.36%-0.21%-0.24%0%
Book Value per Share-4.08-7.10-7.575.548.5812.0414.6510.968.157.91
Total Shareholders' Equity-76.61M-133.36M-201.42M152.08M336.26M580.82M789.38M623.43M472.69M472.96M
Common Stock0000000000
Retained Earnings-80.31M-139.62M-210.85M-318.52M-458.45M-610.55M-828.42M-1.03B-1.24B-1.32B
Treasury Stock0000000000
Accumulated OCI9K33K87K181K87K546K-1.84M-756K-522K-627K
Minority Interest0000000000

Cash Flow

Sep 2016Sep 2017Sep 2018Sep 2019Sep 2020Sep 2021Sep 2022Sep 2023Sep 2024Sep 2025
Cash from Operations+-38.59M-51.3M-66.16M-87.94M-142.25M-112.24M-124.39M-142.47M-64.09M-47.63M
Operating CF Margin %-17.01%-4.76%-2.6%-1.62%-1.58%-0.85%-0.61%-0.58%-0.2%-0.13%
Operating CF Growth %--0.33%-0.29%-0.33%-0.62%0.21%-0.11%-0.15%0.55%0.26%
Net Income-44.09M-59.31M-71.24M-107.67M-139.93M-152.1M-217.86M-204.62M-208.73M-77.67M
Depreciation & Amortization4.23M5.02M5.73M6.11M6.68M9.75M16.51M29.31M31.43M24.85M
Stock-Based Compensation857K1.89M2.96M11.17M17.1M37M79.66M30.28M50.92M0
Deferred Taxes-68K768K42K-1.06M-214K00-410K00
Other Non-Cash Items238K458K562K515K-707K2.49M2.66M3.98M46.86M17.8M
Working Capital Changes240K-129K-4.22M3M-25.18M-9.38M-5.36M-1.01M15.41M-12.61M
Change in Receivables-702K-1.62M-3.07M-6.68M-14.27M-2.2M-9.62M-4.32M8.44M-22.38M
Change in Inventory-1.23M-599K-4.2M-1.3M-4.96M-19.49M-7.54M7.24M7.99M-4.23M
Change in Payables466K560K3.76M3.28M-5.51M8.54M7.38M-2.51M-11.8M9.33M
Cash from Investing+-33.34M-9.87M26.87M-104.81M-114.65M156.16M-232.93M50.61M-3.07M-24.76M
Capital Expenditures-6.23M-6.59M-3.69M-14.76M-9.87M-27.06M-101.86M-27.78M-5.08M-28M
CapEx % of Revenue2.75%0.61%0.15%0.27%0.11%0.2%0.5%0.11%0.02%0.07%
Acquisitions----------
Investments----------
Other Investing174K120K-434K-90.05M-104.78M0-5.75M-5.86M00
Cash from Financing+69.65M63.8M88.82M158.58M303.73M329.18M270.53M911K6.89M28.54M
Debt Issued (Net)----------
Equity Issued (Net)----------
Dividends Paid0000000000
Share Repurchases----------
Other Financing62.42M205K-2.03M4.87M13.92M19.5M10.02M5.32M10.87M15M
Net Change in Cash----------
Free Cash Flow+-44.82M-57.9M-69.85M-102.69M-152.12M-139.31M-226.24M-170.25M-69.17M-75.63M
FCF Margin %-19.75%-5.38%-2.75%-1.89%-1.69%-1.05%-1.11%-0.69%-0.22%-0.2%
FCF Growth %--0.29%-0.21%-0.47%-0.48%0.08%-0.62%0.25%0.59%-0.09%
FCF per Share-2.39-3.08-2.63-3.74-3.88-2.89-4.20-2.99-1.19-1.26
FCF Conversion (FCF/Net Income)0.88x0.86x0.93x0.82x1.02x0.74x0.57x0.70x0.31x0.61x
Interest Paid391K702K751K779K438K167K9K000
Taxes Paid14K6K179K291K172K101K246K420K344K0

Key Ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)----70.8%-57.31%-33.17%-31.8%-28.97%-38.08%-16.43%
Return on Invested Capital (ROIC)----72.19%-53.65%-50.18%-51.52%-34.78%-43.45%-29.33%
Gross Margin-315.2%-123.09%-26.59%12.8%31.85%39.08%41.38%36.61%42.61%50.72%
Net Margin-1943.06%-550.85%-280.16%-197.98%-155.31%-114.94%-107.02%-83.48%-66.69%-20.63%
Debt / Equity---0.05x0.11x0.11x0.12x0.15x0.18x0.16x
Interest Coverage-58.52x-64.62x-53.74x-84.12x-177.99x-416.15x-2934.70x-43431.80x-7614.86x-
FCF Conversion0.88x0.86x0.93x0.82x1.02x0.74x0.57x0.70x0.31x0.61x
Revenue Growth-374.53%136.16%113.89%65.67%46.87%53.83%20.41%27.69%20.32%

Revenue by Segment

2019202020212022202320242025
Ngs Tools--72.67M99.31M123.71M169.13M208.1M
Ngs Tools Growth---36.67%24.56%36.72%23.05%
Synthetic Genes26.71M35.19M38.96M61.51M73.54M92.68M113.6M
Synthetic Genes Growth-31.75%10.72%57.86%19.56%26.02%22.58%
Antibody Discovery---24.17M23.17M20.33M23.45M
Antibody Discovery Growth-----4.13%-12.27%15.37%
Oligo Pools4.59M4.54M8.04M12.42M14.49M16.91M20.23M
Oligo Pools Growth--1.07%76.88%54.55%16.62%16.68%19.66%
Dna And Biopharma Libraries--12.66M6.15M10.2M13.93M11.18M
Dna And Biopharma Libraries Growth----51.44%65.90%36.58%-19.73%
NGS Tools21.04M44.02M-----
NGS Tools Growth-109.17%-----
DNA And Biopharma Libraries-6.35M-----
DNA And Biopharma Libraries Growth-------
DNA Libraries2.04M------
DNA Libraries Growth-------

Revenue by Geography

2019202020212022202320242025
Americas-1.08M77.91M122.47M151.26M193.88M225.58M
Americas Growth--7087.18%57.20%23.51%28.18%16.35%
EMEA14.69M25.82M-62.08M71.39M92.57M124.24M
EMEA Growth-75.75%--15.00%29.67%34.22%
Asia Pacific2.76M5.12M10.3M19.01M22.46M26.52M26.75M
Asia Pacific Growth-85.26%101.37%84.60%18.11%18.11%0.86%
E M E A--44.12M----
E M E A Growth-------
UNITED STATES35.94M58.08M-----
UNITED STATES Growth-61.62%-----
North America996K------
North America Growth-------

Frequently Asked Questions

Growth & Financials

Twist Bioscience Corporation (TWST) reported $362.3M in revenue for fiscal year 2025. This represents a 15866% increase from $2.3M in 2016.

Twist Bioscience Corporation (TWST) grew revenue by 20.3% over the past year. This is strong growth.

Twist Bioscience Corporation (TWST) reported a net loss of $85.2M for fiscal year 2025.

Dividend & Returns

Twist Bioscience Corporation (TWST) has a return on equity (ROE) of -16.4%. Negative ROE indicates the company is unprofitable.

Twist Bioscience Corporation (TWST) had negative free cash flow of $68.7M in fiscal year 2025, likely due to heavy capital investments.

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