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ALNYAlnylam Pharmaceuticals, Inc.
$251.65$32.9B
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
ALNY logo

Alnylam Pharmaceuticals, Inc.

ALNY
NASDAQ · Biotechnology
$251.65
At close - Sep 22, 4:00 PM EDT - USD
Market Cap$33.6B
P/E108.0x
52W High$495.55
Volume1.13M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Revenue Inflection Drives Profitability, Leverage Normalizes

Alnylam has achieved a significant commercial inflection, with revenue surging 66.9% YoY to $1.3B in 2026Q2, driven by the TTR franchise and milestone payments. This growth has propelled the company to GAAP profitability, with net income of $164.5M in 2026Q2, ...

GrowthAccelerating
ProfitabilityStrong
ValuationExpensive
TechnicalsWeak
Explore valuation models
MARKET ACTION

ALNY price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

9/12 Beats

EPS beat 9 of last 12 quarters

02

Valuation risk

+323% Peers

P/E is 323% above peer median

03

Market leadership

RS 20 · Lag

Laggard (Underperforming 80% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystEstimated earnings · Oct 30
01

Build the investment case

Start with the evidence for owning the stock and the risks that can break the thesis.

EXECUTIVE THESIS

The Investment Case

Full Analysis
Fundamental Trajectory

Revenue accelerated to $1.3B in 2026Q2 (up 66.9% YoY), with gross margin at 76.9% and operating margin at 17.9%, reflecting strong top-line growth and emerging operating leverage.

Analyst Consensus+40.9% target
Buy(52 analysts)
39 Buy12 Hold1 Sell

The Bull Case

Upside Catalysts

RNAi therapeutics focus

Alnylam Pharmaceuticals specializes in RNA interference (RNAi) therapeutics for genetically defined diseases, positioning it as a leader in this innovative biopharmaceutical field.

Investor resources availability

The company provides comprehensive investor resources, including financial filings, releases, and reports, facilitating informed investment decisions.

Stock analysis accessibility

Detailed stock analysis, price targets, and earnings estimates for Alnylam Pharmaceuticals are readily available, aiding investors in evaluating the stock's potential.

The Bear Case

Key Downside Risks

Market performance

Price History →

Trailing total returns as of 9/23/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
ALNY-37.11%
S&P 500 (^GSPC)+13.20%
1-Year Return
ALNY-45.16%
S&P 500 (^GSPC)+15.98%
3-Year Return
ALNY+46.69%
S&P 500 (^GSPC)+86.93%
5-Year Return
ALNY+38.11%
S&P 500 (^GSPC)+83.45%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E5Y Low
105.8x
Forward P/EExpansion
36.9x
EV/EBITDA0th %ile
58.4x
FCF YieldCash Flow
1.4%

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
105.8x
170.7x
0th· Low
EV/EBITDA
58.4x
95.4x
0th· Low
Price/FCF
70.7x
115.1x
0th· Low
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
Bear$164.32-34.7%
Base (Fair)$286.37+19.5%
Bull$418.05+66.1%
$164.32 Bear$286.37 Base$418.05 Bull
Current Market Price: $251.65
Trades at a 12.1% discount to Base DCF ($286.37)
Open DCF & Valuation Models →Chart Terminal ↗

Growth & profitability

Annual revenue & EPS trend
Revenue
$3.71B+65.2% YoY
Net income
$314M+212.8% YoY
Free cash flow
$465M+1192.7% YoY
Operating margin
13.5%+21.4 pts YoY
ROIC (TTM)33.4%
Avg ROIC 5Y-
ROE (TTM)73.3%
Piotroski Score6 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate9/12 (75%)
Revenue Beat Rate9/12 (75%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Jul 30, 2026
$1.21-25.8%
vs $1.63
$1.3B-2.4%
vs $1.3B
Q2 2026
Apr 30, 2026
$1.51+73.2%
vs $0.87
$1.2B+4.6%
vs $1.1B
Q1 2026
Feb 12, 2026
$0.82-29.3%
vs $1.16
$1.1B-4.5%
vs $1.1B
Q4 2025
Oct 30, 2025
$1.84+228.0%
vs $0.56
$1.2B+30.2%
vs $959M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Defense World·16h ago
Alnylam Pharmaceuticals (NASDAQ:ALNY) & Tango Therapeutics (NASDAQ:TNGX) Head to Head Survey

Alnylam Pharmaceuticals (NASDAQ: ALNY - Get Free Report) and Tango Therapeutics (NASDAQ: TNGX - Get Free Report) are both healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their dividends, valuation, profitability, earnings, institutional ownership, analyst recommendations and risk. Analyst Recommendations This is a breakdown of current

Defense World·1d ago
Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) Receives Average Rating of “Moderate Buy” from Analysts

Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY - Get Free Report) has been assigned an average recommendation of "Moderate Buy" from the twenty-three research firms that are presently covering the stock, Marketbeat reports. Five research analysts have rated the stock with a hold rating, sixteen have issued a buy rating and two have assigned a strong buy rating

Zacks Investment Research·2d ago
4 Alzheimer's Drug Stocks to Watch on World Alzheimer's Day

Four biotech stocks advance Alzheimer's therapies, from marketed treatments to experimental programs targeting amyloid and tau.

Defense World·2d ago
Alnylam Highlights AMVUTTRA Momentum, Resets 2026 TTR Revenue Outlook

Alnylam Pharmaceuticals (NASDAQ: ALNY) highlighted continued momentum for its AMVUTTRA treatment in transthyretin-mediated cardiomyopathy, while outlining a pipeline of upcoming clinical catalysts and discussing changes in the market that prompted a revision to its 2026 TTR franchise revenue outlook. Speaking at the Morgan Stanley Global Healthcare Conference, Chief Executive Officer Yvonne Greenstreet said Alnylam's TTR franchise

Filtered for Alnylam Pharmaceuticals, Inc.More Headlines
04

Compare before deciding

Benchmark ALNY against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Alnylam Pharmaceuticals, Inc. (ALNY)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Current
$251.65$33.6B108.0065.19%8.45%73.28%—
IONS logoIONSIonis Pharmaceuticals, Inc.
$45.75$7.6B-19.2233.87%-64.64%-110.84%—
ARWR logoARWRArrowhead Pharmaceuticals, Inc.
$71.86$10.12B-5890.1623258.15%-47.79%-60.05%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$12.69$1.42B-3.3316.92%-672.16%-57.79%—
BEAM logoBEAMBeam Therapeutics Inc.
$25.93$2.67B-32.01120.01%-54.75%-7.7%—
MRNA logoMRNAModerna, Inc.
$182.56$72.44B-25.15-39.23%-141.43%-39.2%—

Compare ALNY vs Peers

Alnylam Pharmaceuticals, Inc. (ALNY) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IONS

Most directly comparable listed peer for ALNY.

Scale Benchmark

vs NVS

Larger-name benchmark to compare ALNY against a more recognizable public peer.

Peer Set

Compare Top 5

vs IONS, ARWR, NTLA, BEAM

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

ALNY SEC Filings & Documents

Alnylam Pharmaceuticals, Inc. (ALNY) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Jul 30, 2026·SEC

Material company update

May 27, 2026·SEC

Material company update

Apr 30, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 12, 2026·SEC

FY 2025

Feb 13, 2025·SEC

FY 2024

Feb 15, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Jul 30, 2026·SEC

FY 2026

Apr 30, 2026·SEC

FY 2025

Oct 30, 2025·SEC

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ALNY Frequently Asked Questions

Alnylam Pharmaceuticals, Inc. (ALNY) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Alnylam Pharmaceuticals, Inc.'s revenue?

Alnylam Pharmaceuticals, Inc. (ALNY) reported $4.80B in revenue for fiscal year 2025.

How fast is Alnylam Pharmaceuticals, Inc. growing?

Alnylam Pharmaceuticals, Inc. (ALNY) grew revenue by 65.2% over the past year. This is strong growth.

Is ALNY profitable?

Yes, Alnylam Pharmaceuticals, Inc. (ALNY) is profitable, generating $808.0M in net income for fiscal year 2025 (8.4% net margin).

Dividend & Returns
What is ALNY's return on equity?

Alnylam Pharmaceuticals, Inc. (ALNY) has a return on equity (ROE) of 73.3%. This is excellent, indicating efficient use of shareholder capital.

What is Alnylam Pharmaceuticals, Inc.'s free cash flow?

Alnylam Pharmaceuticals, Inc. (ALNY) generated $542.5M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in ALNY back in 2002?

Total return calculator · dividends reinvested · 24+ years of data

See returns →