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Alnylam Pharmaceuticals, Inc. (ALNY) 10-Year Financial Performance & Capital Metrics

ALNY • • Industrial / General
HealthcareBiotechnologyRare Genetic DiseasesGene Therapy & Rare Diseases
AboutAlnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. The company's pipeline of investigational RNAi therapeutics focuses on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS)/ocular diseases. Its marketed products include ONPATTRO (patisiran), a lipid complex injection for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria (AHP); and OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1 (PH1). In addition, the company is developing givosiran for the treatment of adolescent patients with AHP; patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; ALN-AAT02 for the treatment of AAT deficiency-associated liver disease; ALN-HBV02 to treat chronic HBV infection; Zilebesiran to treat hypertension; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia and rare bleeding disorders, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1 and recurrent renal stones, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Sanofi Genzyme to discover, develop, and commercialize RNAi therapeutics. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue $2.25B +23.0%
  • EBITDA -$120M +47.3%
  • Net Income -$278M +36.8%
  • EPS (Diluted) -2.18 +38.1%
  • Gross Margin 85.62% +3.1%
  • EBITDA Margin -5.35% +57.1%
  • Operating Margin -7.87% +49.0%
  • Net Margin -12.37% +48.6%
  • ROE -414.62%
  • ROIC -12.54% +83.2%
  • Debt/Equity 40.89
  • Interest Coverage -1.25 +46.4%
Technical Analysis

Key Insights

Based on financial data analysis

✓Strengths

  • ✓Strong 5Y sales CAGR of 59.2%

✗Weaknesses

  • ✗High debt to equity ratio of 40.9x
  • ✗Negative free cash flow
  • ✗Low quality earnings: Net income not backed by cash flow
  • ✗Expensive at 683.6x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

Price & Volume

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Growth Metrics

Revenue CAGR

10Y46.15%
5Y59.21%
3Y38.61%
TTM53.24%

Profit (Net Income) CAGR

10Y-
5Y-
3Y-
TTM113.11%

EPS CAGR

10Y-
5Y-
3Y-
TTM109.16%

ROCE

10Y Avg-30.07%
5Y Avg-20.41%
3Y Avg-14.47%
Latest-5.98%

Peer Comparison

Gene Therapy & Rare Diseases
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Sector-Specific
NameMarket CapCurrent PriceP/E RatioRevenue Growth 1YNet MarginROEFCF YieldDebt/Equity
KRYSKrystal Biotech, Inc.8.18B282.0194.00473.02%53.3%17.48%1.46%0.01
BMRNBioMarin Pharmaceutical Inc.10.58B55.0724.9217.97%16.82%8.59%4.49%0.11
SRPTSarepta Therapeutics, Inc.2.23B21.319.1152.97%-11.25%-20.57%0.88
RAREUltragenyx Pharmaceutical Inc.2.27B23.50-3.7429.01%-91.95%-35.88%0.15
DYNDyne Therapeutics, Inc.2.7B16.42-4.87-61.26%0.04
TVTXTravere Therapeutics, Inc.2.54B28.40-6.9660.55%-20.32%-120.36%6.80
BEAMBeam Therapeutics Inc.3.25B32.05-7.00-83.18%-7.44%-42.92%0.22
SLNOSoleno Therapeutics, Inc.2.25B41.95-9.58-79.5%-15.85%0.22

Profit & Loss

Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Sales/Revenue+41.1M47.16M89.91M74.91M219.75M492.85M844.29M1.04B1.83B2.25B
Revenue Growth %-0.19%0.15%0.91%-0.17%1.93%1.24%0.71%0.23%0.76%0.23%
Cost of Goods Sold+0013.37M1.8M25.06M78.05M140.14M168.82M310.41M323.37M
COGS % of Revenue--0.15%0.02%0.11%0.16%0.17%0.16%0.17%0.14%
Gross Profit+41.1M47.16M76.55M73.11M194.69M414.8M704.14M868.6M1.52B1.92B
Gross Margin %1%1%0.85%0.98%0.89%0.84%0.83%0.84%0.83%0.86%
Gross Profit Growth %-0.19%0.15%0.62%-0.04%1.66%1.13%0.7%0.23%0.75%0.27%
Operating Expenses+337.11M471.75M590M887.78M1.13B1.24B1.41B1.65B1.8B2.1B
OpEx % of Revenue8.2%10%6.56%11.85%5.16%2.52%1.67%1.59%0.98%0.93%
Selling, General & Admin60.61M89.35M199.37M382.36M479M588.42M620.64M770.66M795.65M975.53M
SG&A % of Revenue1.47%1.89%2.22%5.1%2.18%1.19%0.74%0.74%0.44%0.43%
Research & Development276.5M382.39M390.63M505.42M655.11M654.82M792.16M883.01M1B1.13B
R&D % of Revenue6.73%8.11%4.34%6.75%2.98%1.33%0.94%0.85%0.55%0.5%
Other Operating Expenses76K0-3.02M4.17M00-2.05M000
Operating Income+-296.01M-424.59M-500.09M-814.67M-939.43M-828.44M-708.65M-785.07M-282.18M-176.88M
Operating Margin %-7.2%-9%-5.56%-10.88%-4.27%-1.68%-0.84%-0.76%-0.15%-0.08%
Operating Income Growth %0.27%-0.43%-0.18%-0.63%-0.15%0.12%0.14%-0.11%0.64%0.37%
EBITDA+-276.96M-409.46M-486.72M-808.24M-922.26M-793.67M-661.09M-740.6M-228.12M-120.22M
EBITDA Margin %-6.74%-8.68%-5.41%-10.79%-4.2%-1.61%-0.78%-0.71%-0.12%-0.05%
EBITDA Growth %0.3%-0.48%-0.19%-0.66%-0.14%0.14%0.17%-0.12%0.69%0.47%
D&A (Non-Cash Add-back)19.05M15.13M13.37M6.43M17.18M34.77M47.57M44.47M54.05M56.67M
EBIT-296.01M-424.59M-500.09M-760.67M-885.25M-771.1M-709.12M-971.02M-312.3M-235.52M
Net Interest Income+5.86M8.31M12.24M29.26M33.45M-72.69M-141.44M-131.16M-25.66M-19.87M
Interest Income5.86M8.31M12.24M29.26M33.45M11.81M1.58M24.81M95.56M121.99M
Interest Expense0000084.5M143.02M155.97M121.22M141.86M
Other Income/Expense5.93M14.48M9.21M54M54.18M-27.16M-143.49M-341.92M-151.34M-200.49M
Pretax Income+-290.07M-410.11M-490.87M-760.67M-885.25M-855.6M-852.14M-1.13B-433.52M-377.38M
Pretax Margin %-7.06%-8.7%-5.46%-10.15%-4.03%-1.74%-1.01%-1.09%-0.24%-0.17%
Income Tax+000823K863K2.68M680K4.16M6.72M-99.22M
Effective Tax Rate %1%1%1%1%1%1%1%1%1.02%0.74%
Net Income+-290.07M-410.11M-490.87M-761.5M-886.12M-858.28M-852.82M-1.13B-440.24M-278.16M
Net Margin %-7.06%-8.7%-5.46%-10.17%-4.03%-1.74%-1.01%-1.09%-0.24%-0.12%
Net Income Growth %0.2%-0.41%-0.2%-0.55%-0.16%0.03%0.01%-0.33%0.61%0.37%
Net Income (Continuing)-290.07M-410.11M-490.87M-761.5M-886.12M-858.28M-852.82M-1.13B-440.24M-278.16M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)+-3.45-4.79-5.42-7.57-8.11-7.46-7.20-9.30-3.52-2.18
EPS Growth %0.29%-0.39%-0.13%-0.4%-0.07%0.08%0.03%-0.29%0.62%0.38%
EPS (Basic)-3.45-4.79-5.42-7.57-8.11-7.46-7.20-9.30-3.52-2.18
Diluted Shares Outstanding83.99M85.6M90.55M100.59M109.26M114.99M118.45M121.69M124.91M127.65M
Basic Shares Outstanding83.99M85.6M90.55M100.59M109.26M114.99M118.45M121.69M124.91M127.65M
Dividend Payout Ratio----------

Balance Sheet

Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Total Current Assets+1.11B671.88M1.76B1.2B1.72B2.61B2.81B2.69B2.98B3.3B
Cash & Short-Term Investments1.08B626.8M1.69B1.08B1.54B1.87B2.44B2.19B2.44B2.69B
Cash Only180.9M193.62M645.36M420.15M547.18M496.58M819.98M866.39M812.69M966.43M
Short-Term Investments899.64M433.18M1.05B664.01M988.98M1.38B1.62B1.33B1.63B1.73B
Accounts Receivable8.3M23.33M34M18.76M43.01M602.41M198.57M237.96M327.79M405.31M
Days Sales Outstanding73.7180.6138.0391.4171.44446.1485.8583.7265.4465.8
Inventory00024.07M56.35M75.2M86.36M128.96M89.15M78.51M
Days Inventory Outstanding---4.88K820.65351.67224.93278.83104.8288.62
Other Current Assets0000000132.92M126.38M116.96M
Total Non-Current Assets+281.12M590.93M229.99M374.11M679.27M792.28M834.73M854.11M847.18M944.7M
Property, Plant & Equipment27.81M114.57M181.9M320.66M646.38M706.51M733.63M738.63M725.79M693.93M
Fixed Asset Turnover1.48x0.41x0.49x0.23x0.34x0.70x1.15x1.40x2.52x3.24x
Goodwill0000000000
Intangible Assets0000000000
Long-Term Investments251.84M324.8M13.92M44.83M14.82M00000
Other Non-Current Assets1.47M151.56M34.17M8.62M18.07M85.77M101.09M115.48M111.29M133.9M
Total Assets+1.39B1.26B1.99B1.57B2.4B3.41B3.64B3.55B3.83B4.24B
Asset Turnover0.03x0.04x0.05x0.05x0.09x0.14x0.23x0.29x0.48x0.53x
Asset Growth %0.28%-0.09%0.58%-0.21%0.52%0.42%0.07%-0.03%0.08%0.11%
Total Current Liabilities+62.1M131.7M144.25M179.49M352.59M585.27M695.71M767.91M967.79M1.19B
Accounts Payable16.79M54.47M28.36M59.71M49.88M51.97M73.43M98.09M55.52M88.42M
Days Payables Outstanding--774.2612.09K726.5243.01191.24212.0965.2899.8
Short-Term Debt000000000113.02M
Deferred Revenue (Current)1000K1000K1000K1000K1000K1000K1000K1000K1000K1000K
Other Current Liabilities12.32M15.27M35.81M40.87M68.3M110.75M130.66M170.98M177.16M214.4M
Current Ratio17.80x5.10x12.23x6.69x4.87x4.47x4.04x3.51x3.08x2.78x
Quick Ratio17.80x5.10x12.23x6.56x4.71x4.34x3.91x3.34x2.99x2.71x
Cash Conversion Cycle----7.13K165.58554.8119.54150.46104.9854.62
Total Non-Current Liabilities+59.7M210.89M84.05M93.34M603.85M1.81B2.36B2.94B3.08B2.99B
Long-Term Debt0150M30M30M0191.28M675.7M1.02B1.02B2.36B
Capital Lease Obligations0000276.13M293.04M281.35M261.34M243.1M229.54M
Deferred Tax Liabilities0000000000
Other Non-Current Liabilities6.73M11.5M10.97M62.88M9.33M1.1B1.25B1.46B1.63B398.11M
Total Liabilities121.8M342.59M228.3M272.84M956.44M2.39B3.06B3.7B4.05B4.17B
Total Debt+0150M30M30M303.82M521.19M997.59M1.32B1.31B2.74B
Net Debt-1.28B-43.62M-615.36M-390.15M-243.35M24.61M177.62M453.85M492.7M1.78B
Debt / Equity-0.16x0.02x0.02x0.21x0.51x1.70x--40.89x
Debt / EBITDA----------
Net Debt / EBITDA----------
Interest Coverage------9.80x-4.95x-5.03x-2.33x-1.25x
Total Equity+1.26B920.22M1.77B1.3B1.44B1.02B588.2M-158.22M-220.64M67.09M
Equity Growth %0.35%-0.27%0.92%-0.26%0.11%-0.29%-0.42%-1.27%-0.39%1.3%
Book Value per Share15.0610.7519.5112.9413.178.844.97-1.30-1.770.53
Total Shareholders' Equity1.26B920.22M1.77B1.3B1.44B1.02B588.2M-158.22M-220.64M67.09M
Common Stock851K859K997K1.01M1.12M1.16M1.2M1.24M1.26M1.29M
Retained Earnings-1.25B-1.66B-2.15B-2.84B-3.73B-4.59B-5.44B-6.57B-7.01B-7.29B
Treasury Stock0000000000
Accumulated OCI4.37M-33.44M-34.43M-33.21M-36.52M-43.62M-33.26M-44.65M-23.38M-34.52M
Minority Interest0000000000

Cash Flow

Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Cash from Operations+-189.14M-307.7M-382.79M-562.62M-278.43M-614.96M-641.69M-541.27M104.16M-8.31M
Operating CF Margin %-4.6%-6.52%-4.26%-7.51%-1.27%-1.25%-0.76%-0.52%0.06%-0%
Operating CF Growth %-0.14%-0.63%-0.24%-0.47%0.51%-1.21%-0.04%0.16%1.19%-1.08%
Net Income-290.07M-410.11M-490.87M-761.5M-886.12M-858.28M-852.82M-1.13B-440.24M-278.16M
Depreciation & Amortization19.05M15.13M13.37M6.43M54.37M74.44M89.69M85.55M97.03M56.67M
Stock-Based Compensation45.78M75.53M92.82M157.75M174.84M139.87M165.72M230.65M221.68M272.08M
Deferred Taxes0-6.98M1.89M-3.56M-11.29M-54.04M-55.7M00-106.76M
Other Non-Cash Items984K1.51M2.91M-6.84M-12.61M95.75M174.24M309.24M214.93M261.94M
Working Capital Changes35.12M17.22M-2.9M45.1M402.38M-12.7M-162.82M-35.55M10.76M-214.08M
Change in Receivables31.64M-15.04M-10.67M15.24M-24.24M-56.24M-101.8M-45.6M-87.94M-86.55M
Change in Inventory000-22.64M-32.41M-35.43M-26.41M-34.14M18.37M13.59M
Change in Payables1.68M10.1M-4.94M15.48M36.61M117.38M88.24M191.77M80.84M91.09M
Cash from Investing+-321.32M142.59M-290.36M272.94M-417.68M-435.52M-273.3M169.35M-336.35M-116.84M
Capital Expenditures-12.95M-64.56M-104.21M-126.89M-140.16M-70.36M-76.37M-72.06M-62.21M-34.28M
CapEx % of Revenue0.32%1.37%1.16%1.69%0.64%0.14%0.09%0.07%0.03%0.02%
Acquisitions----------
Investments----------
Other Investing-1.47M-150M120M-14.82M23M-31.2M-4.36M-13.19M-4.44M57.76M
Cash from Financing+616.18M177.83M1.12B65.47M823.18M994.98M1.25B425.75M172.13M294.16M
Debt Issued (Net)----------
Equity Issued (Net)----------
Dividends Paid0000000000
Share Repurchases----------
Other Financing31.14M14.13M83.89M071.28M695.48M500.85M-87.61M24.67M-8.79M
Net Change in Cash----------
Free Cash Flow+-202.09M-372.26M-487M-689.5M-418.58M-685.32M-718.07M-613.33M41.95M-42.59M
FCF Margin %-4.92%-7.89%-5.42%-9.2%-1.9%-1.39%-0.85%-0.59%0.02%-0.02%
FCF Growth %-0.16%-0.84%-0.31%-0.42%0.39%-0.64%-0.05%0.15%1.07%-2.02%
FCF per Share-2.41-4.35-5.38-6.85-3.83-5.96-6.06-5.040.34-0.33
FCF Conversion (FCF/Net Income)0.65x0.75x0.78x0.74x0.31x0.72x0.75x0.48x-0.24x0.03x
Interest Paid01.1M2.43M775K172K000067.58M
Taxes Paid66K111K114K1.07M2.57M000014.36M

Key Ratios

Metric2015201620172018201920202021202220232024
Return on Equity (ROE)-26.36%-37.54%-36.54%-49.63%-64.66%-69.92%-106.31%-526.14%--414.62%
Return on Invested Capital (ROIC)-22.83%-32.49%-36.99%-59.24%-66.87%-55.57%-58.84%-110.94%-74.56%-12.54%
Gross Margin100%100%85.13%97.59%88.6%84.16%83.4%83.73%83.02%85.62%
Net Margin-705.83%-869.63%-545.95%-1016.58%-403.24%-174.15%-101.01%-109.04%-24.08%-12.37%
Debt / Equity-0.16x0.02x0.02x0.21x0.51x1.70x--40.89x
Interest Coverage------9.80x-4.95x-5.03x-2.33x-1.25x
FCF Conversion0.65x0.75x0.78x0.74x0.31x0.72x0.75x0.48x-0.24x0.03x
Revenue Growth-18.72%14.75%90.66%-16.69%193.36%124.28%71.31%22.88%76.23%22.97%

Revenue by Segment

2018201920202021202220232024
Product12.54M166.54M361.52M662.14M894.33M1.24B1.65B
Product Growth-1228.58%117.08%83.15%35.07%38.82%32.60%
GIVLAARI-----219.25M255.87M
GIVLAARI Growth------16.70%
Royalty---1.2M8.18M--
Royalty Growth----583.70%--

Revenue by Geography

2018201920202021202220232024
UNITED STATES-116.45M151.57M18.88M27.7M411.17M630.61M
UNITED STATES Growth--30.16%-87.55%46.74%1384.47%53.37%
Europe--333K38.95M37.91M210.92M235.44M
Europe Growth---11596.40%-2.65%456.29%11.63%
Non-US Or Europe-50.09M46.75M1.76M4.17M75.77M104.4M
Non-US Or Europe Growth---6.65%-96.23%136.74%1717.49%37.78%

Frequently Asked Questions

Growth & Financials

Alnylam Pharmaceuticals, Inc. (ALNY) reported $3.21B in revenue for fiscal year 2024. This represents a 3779% increase from $82.8M in 2011.

Alnylam Pharmaceuticals, Inc. (ALNY) grew revenue by 23.0% over the past year. This is strong growth.

Yes, Alnylam Pharmaceuticals, Inc. (ALNY) is profitable, generating $43.6M in net income for fiscal year 2024 (-12.4% net margin).

Dividend & Returns

Alnylam Pharmaceuticals, Inc. (ALNY) has a return on equity (ROE) of -414.6%. Negative ROE indicates the company is unprofitable.

Alnylam Pharmaceuticals, Inc. (ALNY) generated $221.4M in free cash flow for fiscal year 2024. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

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