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ARWRArrowhead Pharmaceuticals, Inc.
$58.16$8.2B
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
ARWR logo

Arrowhead Pharmaceuticals, Inc.

ARWR
NASDAQ · Cell & Gene Therapy
$58.16
At close - Nov 6, 4:00 PM EST - USD
Market Cap$8.19B
P/E-26.1x
52W High$95.49
Volume1.36M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q3

Milestone-Driven Revenue Masks Persistent Cash Burn

Arrowhead Pharmaceuticals' investment case hinges on its RNAi platform and episodic milestone payments, which drove a $542.7M revenue spike in 2025Q2 but left non-milestone quarters with operating losses exceeding $140M.

GrowthMixed
ProfitabilityNegative
ValuationExpensive
TechnicalsWeak
Explore valuation models
MARKET ACTION

ARWR price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

2/12 Beats

EPS beat 2 of last 12 quarters

02

Valuation risk

-177% Peers

P/E is 177% below peer median

03

Market leadership

RS 27 · Lag

Laggard (Underperforming 73% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 12
01

Build the investment case

Start with the evidence for owning the stock and the risks that can break the thesis.

EXECUTIVE THESIS

The Investment Case

Full Analysis
Fundamental Trajectory

Revenue is highly volatile, swinging from $2.5M to $542.7M in a single year, with 2025Q2 achieving a 70.2% operating margin, but non-milestone quarters show operating losses exceeding $140M, and R&D expenses have grown 104% since 2024Q2.

Analyst Consensus+74.6% target
Buy(22 analysts)
16 Buy6 Hold0 Sell

The Bull Case

Upside Catalysts

Innovative disease treatment

Arrowhead Pharmaceuticals uses cutting-edge scientific methods to develop and deliver novel therapies, potentially revolutionizing disease treatment.

Strong investor relations

The company maintains a robust investor relations platform, providing transparency and key business insights for stakeholders and analysts.

Comprehensive stock analysis

Detailed stock overviews, price targets, and earnings estimates are available, aiding informed investment decisions for ARWR.

The Bear Case

Key Downside Risks

Market performance

Price History →

Trailing total returns as of 11/8/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
ARWR-14.21%
S&P 500 (^GSPC)+7.63%
1-Year Return
ARWR+46.87%
S&P 500 (^GSPC)+9.69%
3-Year Return
ARWR+115.97%
S&P 500 (^GSPC)+70.99%
5-Year Return
ARWR-29.51%
S&P 500 (^GSPC)+58.42%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E
-26.1x
Forward P/E
N/A
EV/EBITDA
N/A
FCF YieldCash Flow
N/A

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
-26.1x
N/A
N/A
EV/EBITDA
N/A
38.9x
N/A
Price/FCF
N/A
43.8x
N/A
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
Bear$0.14-99.8%
Base (Fair)$76.48+31.5%
Bull$1.12-98.1%
$0.14 Bear$76.48 Base$1.12 Bull
Current Market Price: $58.16
Trades at a 24.0% discount to Base DCF ($76.48)
Open DCF & Valuation Models →Chart Terminal ↗

Growth & profitability

Annual revenue & EPS trend
Revenue FY25
$829M+23258.2% YoY
Net income FY25
-$2M+99.7% YoY
Free cash flow FY25
$157M+126.0% YoY
Operating margin FY25
11.9%+16938.9 pts YoY
ROIC (FY25)9.3%
Avg ROIC 5Y-32.6%
ROE (TTM)-60.1%
Piotroski Score6 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate2/12 (17%)
Revenue Beat Rate4/12 (40%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 4, 2026
-$1.36-6.3%
vs -$1.28
$75M+70.4%
vs $44M
Q2 2026
May 7, 2026
-$0.93+14.7%
vs -$1.09
$74M-0.1%
vs $74M
Q1 2026
Feb 5, 2026
$0.22-63.3%
vs $0.60
$264M+23.4%
vs $214M
Q4 2025
Nov 25, 2025
-$0.18-61.3%
vs -$0.11
$256M+46.3%
vs $175M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

4 Stories
Business Wire·3d ago
Arrowhead Pharmaceuticals Refinances Existing Credit Facility, Lowering Borrowing Costs and Extending Maturity

PASADENA, Calif.--(BUSINESS WIRE)--Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced that it has completed a refinancing with funds managed by Sixth Street that lowers its borrowing costs, improves near-term liquidity, extends its debt maturity, and increases financial and operational flexibility. The transaction retires Arrowhead's existing $400 million Sixth Street facility at a $68 million discount to the contractual minimum repayment amount and establishes a new $400 million Si.

Business Wire·5d ago
Arrowhead Pharmaceuticals to Present Important Clinical Data at the American Heart Association Scientific Sessions 2026

PASADENA, Calif.--(BUSINESS WIRE)--Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) announced today that it will present important data at this week's American Heart Association Scientific Sessions in Chicago. AHA 2026 Oral Presentations Date & Time: Saturday, November 7, 3:15 – 4:30 pm CT Session Title: FS.05: Featured Science Session on Novel Lipid Lowering Therapies Location: Learning Studio 2‚ Science and Technology Hall‚ South Hall Title: First-in-Human Trial of a Dual Functional RNAi Mo.

Business Wire·Oct 27, 2026
Adults Living with Familial Chylomicronaemia Syndrome (FCS) in England and Wales Have REDEMPLO® (Plozasiran) as a New Treatment Option to Reduce Triglycerides

PASADENA, Calif.--(BUSINESS WIRE)--Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced that adults in England and Wales who live with a rare metabolic condition called Familial Chylomicronaemia Syndrome (FCS) will have access to a newly licensed new treatment option available on the NHS to reduce extremely high levels of triglycerides (a type of fat) in their bloodstreams, if the response to diet and conventional triglyceride lowering therapies has been inadequate. REDEMPLO® (plozasi.

Defense World·Oct 17, 2026
Reviewing DBV Technologies (NASDAQ:DBVT) and Arrowhead Pharmaceuticals (NASDAQ:ARWR)

DBV Technologies (NASDAQ: DBVT - Get Free Report) and Arrowhead Pharmaceuticals (NASDAQ: ARWR - Get Free Report) are both healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their valuation, institutional ownership, risk, dividends, earnings, profitability and analyst recommendations. Risk and Volatility DBV Technologies has a beta

Filtered for Arrowhead Pharmaceuticals, Inc.More Headlines
04

Compare before deciding

Benchmark ARWR against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Arrowhead Pharmaceuticals, Inc. (ARWR)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Current
$58.16$8.19B-26.0623258.15%-47.79%-60.05%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$155.94$20.82B7.9065.19%54.34%159.72%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$11.35$1.27B-3.7316.92%-805.75%-64.73%—
BEAM logoBEAMBeam Therapeutics Inc.
$26.41$2.72B-25.82120.01%-73.04%-9.69%—
SRPT logoSRPTSarepta Therapeutics, Inc.
$17.82$1.88B127.9315.58%0.75%1.04%—
IONS logoIONSIonis Pharmaceuticals, Inc.
$39.42$6.55B-11.5533.87%-64.64%-110.84%—

Compare ARWR vs Peers

Arrowhead Pharmaceuticals, Inc. (ARWR) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ALNY

Most directly comparable listed peer for ARWR.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare ARWR against a more recognizable public peer.

Peer Set

Compare Top 5

vs ALNY, NTLA, BEAM, SRPT

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

ARWR SEC Filings & Documents

Arrowhead Pharmaceuticals, Inc. (ARWR) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 4, 2026·SEC

Material company update

Jun 16, 2026·SEC

Material company update

May 7, 2026·SEC

10-K Annual Reports

3
FY 2025

Nov 25, 2025·SEC

FY 2024

Nov 26, 2024·SEC

FY 2023

Nov 29, 2023·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 4, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2026

Feb 5, 2026·SEC

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ARWR Frequently Asked Questions

Arrowhead Pharmaceuticals, Inc. (ARWR) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Arrowhead Pharmaceuticals, Inc.'s revenue?

Arrowhead Pharmaceuticals, Inc. (ARWR) reported $669.5M in revenue over the trailing twelve months. Revenue was $829.4M in fiscal year 2025. That is 1082872% more than the $0.1M of fiscal year 1997.

How fast is Arrowhead Pharmaceuticals, Inc. growing?

Arrowhead Pharmaceuticals, Inc. (ARWR) grew revenue by 16.8% over the trailing twelve months, compared with the twelve months before.

Is ARWR profitable?

No. Arrowhead Pharmaceuticals, Inc. (ARWR) reported a net loss of $320.0M over the trailing twelve months.

Dividend & Returns
What is ARWR's return on equity?

Arrowhead Pharmaceuticals, Inc. (ARWR) had a return on equity (ROE) of -60.1% over the trailing twelve months. A negative ROE means the company lost money over the period.

What is Arrowhead Pharmaceuticals, Inc.'s free cash flow?

Arrowhead Pharmaceuticals, Inc. (ARWR) had negative free cash flow of $75.1M over the trailing twelve months.

What if you invested $1,000 in ARWR back in 1997?

Total return calculator · dividends reinvested · 29+ years of data

See returns →