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MCRBSeres Therapeutics, Inc.
$6.61$64M
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MCRB logoSeres Therapeutics, Inc.(MCRB)Earnings, Financials & Key Ratios

MCRB•NASDAQ
10.3× P/E·Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMicrobiome and Phage Therapeutics
AboutSeres Therapeutics, Inc., a microbiome therapeutics platform company, engages in developing bacterial consortia that are designed to functionally interact with host cells and tissues to treat disease. The company's lead product candidate is the SER-109, an oral microbiome therapeutic candidate that has completed Phase III clinical trial for the treatment of clostridium difficile infection (CDI). It is also developing SER-155, a cultivated bacteria microbiome drug, which is Phase Ib clinical trial to reduce incidences of gastrointestinal infections, bloodstream infections, and graft versus host diseases in immunocompromised patients receiving allogeneic hematopoietic stem cell transplantation and solid organ transplants. In addition, the company engages in the development of SER-287 and SER-301 that are in Phase Ib to treat ulcerative colitis; SER-401 for patients with metastatic melanoma; and SER-262 to treat Clostridioides difficile infection. It has license and collaboration agreements with Nestec Ltd. and Memorial Sloan Kettering Cancer Center. The company was formerly known as Seres Health, Inc. and changed its name to Seres Therapeutics, Inc. in May 2015. Seres Therapeutics, Inc. was incorporated in 2010 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$789K
  • EBITDA-$90M+22.5%
  • Net Income$6M+4088.2%
  • EPS (Diluted)0.64+103.4%
  • Gross Margin-423.83%
  • EBITDA Margin-11386.31%
  • Operating Margin-11910.14%
  • Net Margin721.93%
  • ROE19.64%+1890.5%

MCRB Key Insights

Seres Therapeutics, Inc. (MCRB) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong Piotroski F-Score: 7/9
  • ✓FCF machine: 109.6% free cash flow margin
  • ✓Healthy 5Y average net margin of 338.3%
  • ✓Trading at only 1.3x book value

✗Weaknesses

  • ✗Weak momentum: RS Rating 9 (bottom 9%)
  • ✗Low quality earnings: Net income not backed by cash flow
  • ✗Sales declining 52.7% over 5 years
  • ✗Shares diluted 14.2% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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MCRB Price & Volume

Seres Therapeutics, Inc. (MCRB) stock price & volume — 10-year historical chart

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MCRB Growth Metrics

Seres Therapeutics, Inc. (MCRB) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-52.67%
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-164.29%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM48.25%

Return on Capital

10 Years-62.37%
5 Years-63.7%
3 Years-76.23%
Last Year-86.43%

MCRB Recent Earnings

Seres Therapeutics, Inc. (MCRB) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 1/12 qtrs (17%)
Q2 2026Latest
May 5, 2026
Metric
Actual
Est
EPS
$2.08-10.6%
$1.88
Rev
$358,000+0.0%
$358,000
Q2 2026
Mar 12, 2026
Metric
Actual
Est
EPS
$1.89+20.9%
$2.39
Rev
$438,000-91.7%
$5M
Q4 2025
Nov 5, 2025
Metric
Actual
Est
EPS
$0.94+1780.0%
$0.05
Rev
$351,000-95.5%
$8M
Q3 2025
Aug 6, 2025
Metric
Actual
Est
EPS
$2.27+16.5%
$2.72
Rev
—
$6M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$2.08vs $1.88-10.6%
$358,000vs $358,000+0.0%
Q2 2026Mar 12, 2026
$1.89vs $2.39+20.9%
$438,000vs $5M-91.7%
Q4 2025Nov 5, 2025
$0.94vs $0.05+1780.0%
$351,000vs $8M-95.5%
Q3 2025Aug 6, 2025
$2.27vs $2.72+16.5%
—vs $6M
Based on last 12 quarters of dataView full earnings history →

MCRB Peer Comparison

Seres Therapeutics, Inc. (MCRB) competitors in Microbiome and Phage Therapeutics — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
NKTR logoNKTRNektar TherapeuticsDirect Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66
MIRM logoMIRMMirum Pharmaceuticals, Inc.Direct Competitor5.38B107.13-227.9454.74%-194.97%-289.33%1.02
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Direct Competitor11.52B81.82-6706.56232.58%-48.38%-55.09%0.73
RCKT logoRCKTRocket Pharmaceuticals, Inc.Direct Competitor365.8M3.35-1.67-70.79%0.09
EVGN logoEVGNEvogene Ltd.Product Competitor4.52M0.53-0.49-30.91%-255.9%-110.7%0.18
ACAD logoACADACADIA Pharmaceuticals Inc.Product Competitor3.7B21.629.4411.87%34.3%35.65%0.04
PRAX logoPRAXPraxis Precision Medicines, Inc.Product Competitor8.15B282.31-20.94-100%-43.02%0.00
NBIX logoNBIXNeurocrine Biosciences, Inc.Product Competitor15.89B158.2933.9021.45%21.55%21.64%0.13

Compare MCRB vs Peers

Seres Therapeutics, Inc. (MCRB) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs NKTR

Most directly comparable listed peer for MCRB.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare MCRB against a more recognizable public peer.

Peer Set

Compare Top 5

vs NKTR, MIRM, ARWR, RCKT

MCRB Income Statement

Seres Therapeutics, Inc. (MCRB) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
32.1M28.27M34.51M33.22M144.93M000789K1.15M
Revenue Growth %
47.48%-11.94%22.07%-3.74%336.33%-100%----
Cost of Goods Sold
89.45M95.95M090.57M0003.53M4.13M606K
COGS % of Revenue
278.68%339.46%-272.68%----523.83%-
Gross Profit
-57.35M▲ 0%
-67.69M▼ 18.0%
34.51M▲ 151.0%
-57.35M▼ 266.2%
144.93M▲ 352.7%
0▼ 100.0%
0▲ 0%
-3.53M▲ 0%
-3.34M▲ 5.3%
183K▲ 0%
Gross Margin %
-178.68%-239.46%100%-172.68%100%----423.83%15.95%
Gross Profit Growth %
4.76%-18.02%150.98%-266.22%352.68%-100%--5.32%-
Operating Expenses
123.5M128.55M106.38M30.77M209.42M179.91M195.1M117.78M90.63M88.18M
OpEx % of Revenue
384.72%454.77%308.31%92.65%144.5%---11486.31%-
Selling, General & Admin
34.04M32.6M24.75M30.77M69.26M70.26M77.5M53.18M39.16M35.34M
SG&A % of Revenue
106.04%115.31%71.72%92.65%47.79%---4962.74%-
Research & Development
89.45M95.95M80.14M90.57M141.89M109.65M117.6M64.6M49.06M37.82M
R&D % of Revenue
278.68%339.46%232.26%272.68%97.91%---6218%-
Other Operating Expenses
425K170K1.49M-90.57M-1.73M0002.41M1.63M
Operating Income
-91.39M▲ 0%
-100.28M▼ 9.7%
-71.88M▲ 28.3%
-88.13M▼ 22.6%
-64.49M▲ 26.8%
-179.91M▼ 179.0%
-195.1M▼ 8.4%
-121.31M▲ 37.8%
-93.97M▲ 22.5%
-87.64M▲ 0%
Operating Margin %
-284.72%-354.77%-208.31%-265.33%-44.5%----11910.14%-7640.98%
Operating Income Growth %
1.56%-9.73%28.33%-22.61%26.82%-178.97%-8.44%37.82%22.54%-
EBITDA
-84.14M-92.42M-64.27M-79.24M-58.55M-173.28M-188.85M-115.85M-89.84M-83.39M
EBITDA Margin %
-262.11%-326.96%-186.27%-238.56%-40.4%----11386.31%-7270.18%
EBITDA Growth %
5.07%-9.85%30.46%-23.28%26.11%-195.98%-8.98%38.66%22.45%23.59%
D&A (Non-Cash Add-back)
7.26M7.86M7.6M8.89M5.95M6.63M6.24M5.47M4.13M4.25M
EBIT
-89.38M-98.94M-69.78M-86.2M-62.67M-177.56M-187.66M-125.77M-93.97M-31.03M
Net Interest Income
1.59M1.17M531K-1.98M-40K-2.96M-5.88M3.97M2.23M1.61M
Interest Income
001.03M946K2.87M3.06M7.3M3.97M2.23M1.93M
Interest Expense
1.59M1.17M502K2.92M2.91M6.02M13.18M000
Other Income/Expense
2.02M1.34M1.6M-997K-1.08M-3.67M4.97M-4.46M99.67M40.74M
Pretax Income
-89.38M▲ 0%
-98.94M▼ 10.7%
-70.28M▲ 29.0%
-89.13M▼ 26.8%
-65.58M▲ 26.4%
-183.58M▼ 179.9%
-190.13M▼ 3.6%
-125.77M▲ 33.8%
5.7M▲ 104.5%
-46.9M▲ 0%
Pretax Margin %
-278.44%-350.03%-203.68%-268.33%-45.25%---721.93%-4088.84%
Income Tax
0000000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%0%0%
Net Income
-89.38M▲ 0%
-98.94M▼ 10.7%
-70.28M▲ 29.0%
-89.13M▼ 26.8%
-65.58M▲ 26.4%
-250.16M▼ 281.5%
-113.72M▲ 54.5%
136K▲ 100.1%
5.7M▲ 4088.2%
-46.9M▲ 0%
Net Margin %
-278.44%-350.03%-203.68%-268.33%-45.25%---721.93%-4088.84%
Net Income Growth %
2.4%-10.7%28.97%-26.82%26.42%-281.46%54.54%100.12%4088.24%-164.29%
Net Income (Continuing)
-89.38M-98.94M-70.28M-89.13M-65.58M-183.58M-190.13M-125.77M5.7M-46.9M
Discontinued Operations
00000-66.58M76.41M125.91M00
Minority Interest
0000000000
EPS (Diluted)
-44.19▲ 0%
-48.57▼ 9.9%
-24.81▲ 48.9%
-22.34▲ 10.0%
-14.30▲ 36.0%
-46.29▼ 223.7%
-17.77▲ 61.6%
-18.86▼ 6.1%
0.64▲ 103.4%
-4.89▲ 0%
EPS Growth %
3.93%-9.9%48.91%9.96%35.99%-223.71%61.61%-6.13%103.39%48.25%
EPS (Basic)
-44.19-48.57-24.81-22.34-14.30-46.29-17.77-18.860.64-
Diluted Shares Outstanding
2.02M2.04M2.83M3.99M4.59M5.4M6.4M7.77M8.87M9.58M
Basic Shares Outstanding
2.02M2.04M2.83M3.99M4.59M5.4M6.4M7.77M8.86M9.58M
Dividend Payout Ratio
----------

MCRB Balance Sheet

Seres Therapeutics, Inc. (MCRB) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
155.08M92.67M100.19M268.78M303.63M194.76M175.41M38.67M49.38M31.84M
Cash & Short-Term Investments
149.98M85.82M94.82M253.62M290.71M181.34M127.97M30.79M45.77M29.83M
Cash Only
36.09M85.82M65.13M116.05M180M163.03M127.97M30.79M45.77M29.83M
Short-Term Investments
113.89M029.69M137.57M110.7M18.31M0000
Accounts Receivable
001.78M9.39M0004.75M360K233K
Days Sales Outstanding
--18.88103.15----166.54179.16
Inventory
00000029.65M000
Days Inventory Outstanding
----------
Other Current Assets
06.84M00013.42M17.8M3.13M3.25M1.77M
Total Non-Current Assets
34.44M27.81M32.25M74.16M51.23M154.02M183.19M101.14M88.82M85.78M
Property, Plant & Equipment
32.93M26.29M30.85M22.94M36.15M133.97M108.03M92.44M80.12M77.08M
Fixed Asset Turnover
0.97x1.08x1.12x1.45x4.01x---0.01x0.01x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
1.51M1.4M049.83M495K9.59M008.67M26M
Other Non-Current Assets
0113K1.4M1.4M14.59M10.46M75.16M8.7M31K8.7M
Total Assets
189.52M▲ 0%
120.47M▼ 36.4%
132.44M▲ 9.9%
342.94M▲ 158.9%
354.86M▲ 3.5%
348.78M▼ 1.7%
358.6M▲ 2.8%
139.81M▼ 61.0%
138.19M▼ 1.2%
117.62M▲ 0%
Asset Turnover
0.17x0.23x0.26x0.10x0.41x---0.01x0.01x
Asset Growth %
-30.49%-36.43%9.93%158.94%3.48%-1.71%2.81%-61.01%-1.16%-104.55%
Total Current Liabilities
31.63M42.04M45.99M46.41M82.26M85.6M98.66M41.22M19.32M19.34M
Accounts Payable
7.03M6.42M4.86M4.02M13.73M17.44M3.64M4.08M1.68M2.34M
Days Payables Outstanding
28.724.4-16.19---421.53148.541.19K
Short-Term Debt
000454K0456K0010.39M10.87M
Deferred Revenue (Current)
12.08M20.42M25.79M22.6M16.82M4.26M7.73M000
Other Current Liabilities
000021.1M34.77M59.19M04.57M6.14M
Current Ratio
4.90x2.20x2.18x5.79x3.69x2.28x1.78x0.94x2.56x1.65x
Quick Ratio
4.90x2.20x2.18x5.79x3.69x2.28x1.48x0.94x2.56x1.65x
Cash Conversion Cycle
----------1.01K
Total Non-Current Liabilities
97.2M126.48M134.77M121.78M141.09M252.41M304.8M84.8M74.65M71.78M
Long-Term Debt
0024.65M24.64M24.64M50.59M101.54M0069.63M
Capital Lease Obligations
0015.68M10.56M17.96M107.94M91.65M82.97M72.58M225.87M
Deferred Tax Liabilities
-6.76M-5.03M00000000
Other Non-Current Liabilities
12.35M9.64M502K1M11.49M1.44M16.24M1.84M2.08M2.14M
Total Liabilities
128.82M168.52M180.76M168.19M223.35M338M403.46M126.03M93.97M91.12M
Total Debt
8.99M7.25M44.78M40.77M49.21M162.59M198.78M91.64M82.97M80.5M
Net Debt
-27.1M-78.57M-20.35M-75.28M-130.79M-440K70.82M60.85M37.2M50.66M
Debt / Equity
0.15x--0.23x0.37x15.08x-6.65x1.88x3.04x
Debt / EBITDA
----------0.97x
Net Debt / EBITDA
----------0.61x
Interest Coverage
-56.21x-84.42x-139.00x-29.48x-21.54x-29.50x-14.24x---
Total Equity
60.7M▲ 0%
-48.05M▼ 179.2%
-48.32M▼ 0.6%
174.75M▲ 461.6%
131.51M▼ 24.7%
10.78M▼ 91.8%
-44.86M▼ 516.0%
13.78M▲ 130.7%
44.22M▲ 220.8%
26.5M▲ 0%
Equity Growth %
-54.23%-179.15%-0.58%461.62%-24.75%-91.8%-515.99%130.73%220.79%393.83%
Book Value per Share
30.01-23.58-17.0643.8028.682.00-7.011.774.992.77
Total Shareholders' Equity
60.7M-48.05M-48.32M174.75M131.51M10.78M-44.86M13.78M44.22M26.5M
Common Stock
40K41K70K91K92K125K135K173K10K10K
Retained Earnings
-263.57M-389.37M-459.65M-548.78M-614.35M-864.51M-978.24M-978.1M-972.4M-992.32M
Treasury Stock
0000000000
Accumulated OCI
-146K-20.3M0-47K-60K-12K0000
Minority Interest
0000000000

MCRB Cash Flow Statement

Seres Therapeutics, Inc. (MCRB) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-75.52M-62.85M-76.52M-93.61M6.69M-228.82M-117.35M-148.61M1.12M-42.15M
Operating CF Margin %
-235.27%-222.36%-221.76%-281.83%4.61%---141.57%-
Operating CF Growth %
-271.95%16.78%-21.74%-22.33%107.14%-3521.29%48.71%-26.63%100.75%74.35%
Net Income
-89.38M-98.94M-70.28M-89.13M-65.58M-250.16M-113.72M136K5.7M-46.9M
Depreciation & Amortization
7.26M7.86M7.6M6.58M5.95M6.63M6.24M5.47M4.13M3.84M
Stock-Based Compensation
17.36M16.64M8.34M8.82M20.22M25.48M34.1M20.97M10.84M7.3M
Deferred Taxes
00103K0000000
Other Non-Cash Items
-213K-214K2.34M3.31M4.57M7.62M15M-109.67M8.23M9.67M
Working Capital Changes
-10.55M11.8M-24.63M-23.2M41.53M-18.39M-58.98M-65.51M-27.78M-16.07M
Change in Receivables
00-1.78M-7.6M9.39M0-8.67M-2.07M1.55M2.6M
Change in Inventory
00-3.86M-2.87M00-29.65M-33.8M00
Change in Payables
-856K-353K-1.46M-1.16M9.36M2.2M-11.58M-2.94M-2.4M225K
Cash from Investing
56.99M112.32M-30.52M-158.89M64.09M82.43M10.58M142.29M-42K-8K
Capital Expenditures
-4.68M-1.94M-1M-591K-9.57M-9.82M-7.97M-380K-252K-218K
CapEx % of Revenue
14.57%6.85%2.9%1.78%6.6%---31.94%19.01%
Acquisitions
0029.52M19.9M0-92.25M00210K210K
Investments
----------
Other Investing
-113K114.25M-29.52M-19.9M092.25M0-13.52M00
Cash from Financing
83K268K86.23M303.42M1.18M129.6M71.7M-90.37M13.9M13.15M
Debt Issued (Net)
0025M19.9M-948K25.7M50.52M-127.91M00
Equity Issued (Net)
-33K-136K61.22M268.64M0101.17M18.16M23.53M13.9M12.72M
Dividends Paid
0000000000
Share Repurchases
-33K-197K00000000
Other Financing
116K404K16K14.88M2.13M2.73M3.03M14M0428K
Net Change in Cash
-18.45M▲ 0%
49.73M▲ 369.5%
-20.81M▼ 141.8%
50.92M▲ 344.7%
71.95M▲ 41.3%
-16.79M▼ 123.3%
-35.06M▼ 108.9%
-96.69M▼ 175.7%
14.97M▲ 115.5%
-29.02M▲ 0%
Free Cash Flow
-80.2M▲ 0%
-64.79M▲ 19.2%
-77.52M▼ 19.6%
-94.2M▼ 21.5%
-2.88M▲ 96.9%
-238.64M▼ 8191.8%
-125.33M▲ 47.5%
-148.99M▼ 18.9%
865K▲ 100.6%
-42.37M▲ 0%
FCF Margin %
-249.84%-229.21%-224.67%-283.61%-1.99%---109.63%-3694.07%
FCF Growth %
-457.57%19.21%-19.65%-21.52%96.94%-8191.77%47.48%-18.88%100.58%51.19%
FCF per Share
-39.65-31.80-27.37-23.61-0.63-44.16-19.58-19.170.10-4.42
FCF Conversion (FCF/Net Income)
0.84x0.64x1.09x1.05x-0.10x0.91x1.03x-1092.71x0.20x0.90x
Interest Paid
00002.45M00000
Taxes Paid
0000000000

MCRB Key Ratios

Seres Therapeutics, Inc. (MCRB) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-92.46%-1563.81%--140.99%-42.83%-351.62%-0.99%19.64%-127.3%
Return on Invested Capital (ROIC)
-111.98%---429.2%-96.56%-2440.28%-806.07%-180.9%-90.33%-83.5%
Gross Margin
-178.68%-239.46%100%-172.68%100%----423.83%15.95%
Net Margin
-278.44%-350.03%-203.68%-268.33%-45.25%---721.93%-4088.84%
Debt / Equity
0.15x--0.23x0.37x15.08x-6.65x1.88x3.04x
Interest Coverage
-56.21x-84.42x-139.00x-29.48x-21.54x-29.50x-14.24x---
FCF Conversion
0.84x0.64x1.09x1.05x-0.10x0.91x1.03x-1092.71x0.20x0.90x
Revenue Growth
47.48%-11.94%22.07%-3.74%336.33%-100%----
Related:MCRB Dividend History·MCRB Revenue History·MCRB Price History·MCRB P/E History·MCRB Financial Ratios·MCRB Institutional Holders

MCRB SEC Filings & Documents

Seres Therapeutics, Inc. (MCRB) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 5, 2026·SEC

Material company update

Mar 16, 2026·SEC

Material company update

Mar 12, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 12, 2026·SEC

FY 2025

Mar 13, 2025·SEC

FY 2024

Mar 5, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 5, 2026·SEC

FY 2025

Nov 5, 2025·SEC

FY 2025

Aug 6, 2025·SEC

MCRB Frequently Asked Questions

Seres Therapeutics, Inc. (MCRB) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Seres Therapeutics, Inc. (MCRB) reported $1.1M in revenue for fiscal year 2025.

Seres Therapeutics, Inc. (MCRB) grew revenue by 0.0% over the past year. Growth has been modest.

Seres Therapeutics, Inc. (MCRB) reported a net loss of $46.9M for fiscal year 2025.

Dividend & Returns

Seres Therapeutics, Inc. (MCRB) has a return on equity (ROE) of 19.6%. This is reasonable for most industries.

Seres Therapeutics, Inc. (MCRB) had negative free cash flow of $42.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in MCRB back in 2012?

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