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SYBX logoSynlogic, Inc.(SYBX)Earnings, Financials & Key Ratios

SYBX•NASDAQ
$0.60
$7M mkt cap·Price updated May 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMicrobiome and Phage Therapeutics
AboutSynlogic, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of synthetic biotic medicines to treat metabolic and immunological diseases in the United States. Its therapeutic programs include SYNB1618 and SYNB1934 that are orally administered, non-systemically absorbed drug candidates, which are in Phase II clinical trials to treat phenylketonuria; SYNB1353, an orally administered, non-systemically absorbed drug candidate to treat homocystinuria; and SYNB8802, an orally administered, non-systemically absorbed drug candidate that is in Phase I clinical trial for the treatment of enteric hyperoxaluria. The company is also developing SYNB1891, an intratumorally administered synthetic biotic medicine that is in Phase I clinical trial to treat solid tumors and lymphoma. It has a collaboration agreement with F. Hoffmann-La Roche Ltd; Hoffmann-La Roche Inc.; and Ginkgo Bioworks, Inc. Synlogic, Inc. is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$0-100.0%
  • EBITDA-$4M+91.1%
  • Net Income-$1M+95.7%
  • EPS (Diluted)-0.08+95.8%
  • ROE-8.17%+90.3%
Technical→

SYBX Key Insights

Synlogic, Inc. (SYBX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y profit CAGR of 55.7%
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Trading at only 0.6x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Weak momentum: RS Rating 9 (bottom 9%)
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

SYBX Price & Volume

Synlogic, Inc. (SYBX) stock price & volume — 10-year historical chart

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SYBX Growth Metrics

Synlogic, Inc. (SYBX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM96.57%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM96.92%

Return on Capital

10 Years-52.59%
5 Years-63.31%
3 Years-74.96%
Last Year-32.57%

SYBX Peer Comparison

Synlogic, Inc. (SYBX) competitors in Microbiome and Phage Therapeutics — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
IMVT logoIMVTImmunovant, Inc.Direct Competitor5.53B27.22-9.97-47.07%0.00
ACMR logoACMRACM Research, Inc.Direct Competitor3.92B59.2043.2115.24%10.44%6.11%0.16
AGEN logoAGENAgenus Inc.Direct Competitor132.45M3.75-1102.9410.37%0.1%
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.69B83.37-8.57-43.89%-297.07%-399.1%1.66
MIRM logoMIRMMirum Pharmaceuticals, Inc.Product Competitor5.17B102.93-21954.74%-194.97%-289.33%1.02
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Product Competitor10.92B77.95-6389.34232.58%-48.38%-55.47%0.73
RCKT logoRCKTRocket Pharmaceuticals, Inc.Product Competitor397.53M3.67-1.83-80.49%0.09
ILMN logoILMNIllumina, Inc.Supply Chain21.07B138.7125.45-0.78%19.43%32.84%0.94

Compare SYBX vs Peers

Synlogic, Inc. (SYBX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for SYBX.

Scale Benchmark

vs TMO

Larger-name benchmark to compare SYBX against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, ACMR, AGEN, NKTR

SYBX Income Statement

Synlogic, Inc. (SYBX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue2.44M2.52M2.22M545K1.75M1.18M3.37M8K0
Revenue Growth %450.45%3.11%-11.75%-75.49%221.83%-32.73%185.68%-99.76%-100%
Cost of Goods Sold014.9M0000000
COGS % of Revenue-591.15%-------
Gross Profit
2.44M▲ 0%
-12.38M▼ 606.4%
2.22M▲ 118.0%
545K▼ 75.5%
1.75M▲ 221.8%
1.18M▼ 32.7%
3.37M▲ 185.7%
8K▼ 99.8%
0▼ 100.0%
Gross Margin %100%-491.15%100%100%100%100%100%100%-
Gross Profit Growth %757.54%-606.42%117.97%-75.49%221.83%-32.73%185.68%-99.76%-100%
Operating Expenses43.27M53.75M56.63M61.01M62.52M68.6M58.53M40.96M4.01M
OpEx % of Revenue1770.38%2132.94%2546.45%11194.68%3564.37%5813.47%1736.34%511975%-
Selling, General & Admin12.93M15.72M14.73M13.54M15.39M16.55M14.56M6.63M3.49M
SG&A % of Revenue528.93%623.65%662.23%2483.85%877.54%1402.97%431.95%82887.5%-
Research & Development30.34M38.03M41.91M47.47M47.13M52.04M43.97M9.15M43K
R&D % of Revenue1241.45%1509.29%1884.22%8710.83%2686.83%4410.51%1304.39%114425%-
Other Operating Expenses02.79M0000025.17M476K
Operating Income
-40.82M▲ 0%
-51.23M▼ 25.5%
-54.41M▼ 6.2%
-60.47M▼ 11.1%
-60.77M▼ 0.5%
-67.42M▼ 11.0%
-55.16M▲ 18.2%
-40.95M▲ 25.8%
-4.01M▲ 90.2%
Operating Margin %-1670.38%-2032.94%-2446.45%-11094.68%-3464.37%-5713.47%-1636.34%-511875%-
Operating Income Growth %-53.37%-25.49%-6.21%-11.13%-0.49%-10.95%18.18%25.76%90.21%
EBITDA-38.51M-48.81M-51.71M-57.83M-58.32M-64.9M-53.2M-39.66M-3.53M
EBITDA Margin %-1575.86%-1936.87%-2324.95%-10611.01%-3325.09%-5499.92%-1578.26%-495687.5%-
EBITDA Growth %-48.55%-26.73%-5.94%-11.84%-0.85%-11.28%18.02%25.46%91.09%
D&A (Non-Cash Add-back)2.31M2.42M2.7M2.64M2.44M2.52M1.96M1.29M0
EBIT-40.32M-48.39M-51.35M-59.17M-60.56M-66.14M-57.27M-23.35M-3.53M
Net Interest Income447K2.8M3.04M1.3M208K1.26M2.47M1.43M695K
Interest Income504K2.84M3.06M1.3M210K1.27M2.47M1.43M695K
Interest Expense57K43K21K6K2K2K1K00
Other Income/Expense447K2.79M3.04M1.29M204K1.27M-2.11M17.6M3M
Pretax Income
-40.38M▲ 0%
-48.44M▼ 20.0%
-51.37M▼ 6.1%
-59.17M▼ 15.2%
-60.56M▼ 2.3%
-66.15M▼ 9.2%
-57.27M▲ 13.4%
-23.35M▲ 59.2%
-1M▲ 95.7%
Pretax Margin %-1652.09%-1922.02%-2309.94%-10857.43%-3452.74%-5605.68%-1698.84%-291925%-
Income Tax00000014K5K0
Effective Tax Rate %0%0%0%0%0%0%-0.02%-0.02%0%
Net Income
-40.38M▲ 0%
-48.44M▼ 20.0%
-51.37M▼ 6.1%
-59.17M▼ 15.2%
-60.56M▼ 2.3%
-66.15M▼ 9.2%
-57.28M▲ 13.4%
-23.36M▲ 59.2%
-1M▲ 95.7%
Net Margin %-1652.09%-1922.02%-2309.94%-10857.43%-3452.74%-5605.68%-1699.26%-291987.5%-
Net Income Growth %-53.71%-19.96%-6.07%-15.18%-2.35%-9.22%13.4%59.22%95.7%
Net Income (Continuing)-40.38M-48.44M-51.37M-59.17M-60.56M-66.15M-57.28M-23.36M-1M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-90.07▲ 0%
-30.42▲ 66.2%
-24.11▲ 20.7%
-23.67▲ 1.8%
-15.76▲ 33.4%
-13.57▲ 13.9%
-8.81▲ 35.1%
-1.92▲ 78.2%
-0.08▲ 95.8%
EPS Growth %-920.05%66.23%20.74%1.82%33.42%13.9%35.08%78.21%95.83%
EPS (Basic)-90.07-30.42-24.11-23.67-15.76-13.57-8.81-1.92-0.08
Diluted Shares Outstanding448.31K1.59M2.02M2.39M3.69M4.78M6.5M12.2M12.31M
Basic Shares Outstanding448.31K1.59M2.02M2.39M3.69M4.78M6.5M12.2M12.31M
Dividend Payout Ratio---------

SYBX Balance Sheet

Synlogic, Inc. (SYBX) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets87.03M122.73M133.25M106.85M133.31M79.78M49.91M19.78M15.4M
Cash & Short-Term Investments87.03M122.73M119.57M100.44M128.59M77.63M47.75M18.86M14.67M
Cash Only87.03M11.25M26.18M32.51M16.44M15.86M23.96M18.86M14.67M
Short-Term Investments0111.48M93.39M67.94M112.15M61.77M23.79M00
Accounts Receivable000000000
Days Sales Outstanding---------
Inventory000000000
Days Inventory Outstanding---------
Other Current Assets298K388K648K247K311K175K146K161K729K
Total Non-Current Assets12.67M17.61M55.33M36.99M41.43M31.08M25.64M50K50K
Property, Plant & Equipment9.78M14.84M30.28M26.3M22.98M21.68M17.7M00
Fixed Asset Turnover0.25x0.17x0.07x0.02x0.08x0.05x0.19x--
Goodwill000000000
Intangible Assets0016.38M9.59M00000
Long-Term Investments1.1M1.1M7.5M09.14M1.1M050K0
Other Non-Current Assets1.79M1.67M1.16M1.1M9.31M8.31M7.94M050K
Total Assets
99.7M▲ 0%
140.34M▲ 40.8%
188.57M▲ 34.4%
143.84M▼ 23.7%
174.74M▲ 21.5%
110.86M▼ 36.6%
75.55M▼ 31.9%
19.83M▼ 73.8%
15.45M▼ 22.1%
Asset Turnover0.02x0.02x0.01x0.00x0.01x0.01x0.04x0.00x-
Asset Growth %55.38%40.76%34.37%-23.72%21.48%-36.55%-31.85%-73.76%-22.09%
Total Current Liabilities9.03M8.34M8.86M8.3M10.08M12.12M20.4M7.08M3.58M
Accounts Payable2.68M2.38M2.17M2M1.94M1.78M1.46M164K103K
Days Payables Outstanding-58.31-------
Short-Term Debt00003.2M4.17M000
Deferred Revenue (Current)444K268K544K0531K882K000
Other Current Liabilities3.76M393K00907K1.89M11.61M6.91M3.48M
Current Ratio9.64x14.71x15.03x12.87x13.23x6.58x2.45x2.80x4.30x
Quick Ratio9.64x14.71x15.03x12.87x13.23x6.58x2.45x2.80x4.30x
Cash Conversion Cycle---------
Total Non-Current Liabilities5.63M7.9M22.81M20.4M17.39M16.13M12.49M00
Long-Term Debt466K210K0000000
Capital Lease Obligations466K210K22.81M20.27M17.39M16.13M12.49M00
Deferred Tax Liabilities-466K00000000
Other Non-Current Liabilities4.03M7.48M0131K00000
Total Liabilities14.66M16.24M31.67M28.7M27.47M28.25M32.9M7.08M3.58M
Total Debt891K476K25.01M22.81M20.59M20.3M17.27M00
Net Debt-86.13M-10.78M-1.17M-9.7M4.16M4.44M-6.68M-18.86M-14.67M
Debt / Equity0.01x0.00x0.16x0.20x0.14x0.25x0.40x--
Debt / EBITDA---------
Net Debt / EBITDA---------
Interest Coverage-707.37x-1125.40x-2445.33x-9861.17x-30279.50x-33072.50x-57267.00x--
Total Equity
85.04M▲ 0%
124.1M▲ 45.9%
156.91M▲ 26.4%
115.14M▼ 26.6%
147.27M▲ 27.9%
82.61M▼ 43.9%
42.66M▼ 48.4%
12.75M▼ 70.1%
11.86M▼ 7.0%
Equity Growth %40.9%45.93%26.44%-26.62%27.91%-43.9%-48.37%-70.11%-6.96%
Book Value per Share189.6977.9477.7248.1939.9217.286.561.050.96
Total Shareholders' Equity85.04M124.1M156.91M115.14M147.27M82.61M42.66M12.75M11.86M
Common Stock16K25K33K38K70K71K10K12K12K
Retained Earnings-71.65M-119.77M-171.14M-230.31M-290.87M-357.02M-414.3M-441.65M-442.66M
Treasury Stock00000-2.52M-2.52M-2.52M-2.52M
Accumulated OCI-9K-65K110K14K-45K-161K6K00
Minority Interest000000000

SYBX Cash Flow Statement

Synlogic, Inc. (SYBX) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-31.05M-42.47M-75.47M-39.55M-52.2M-56.89M-51.61M-31.66M-4.36M
Operating CF Margin %-1270.66%-1685.32%-3393.35%-7257.43%-2975.94%-4821.02%-1531.12%-395725%-
Operating CF Growth %-25.2%-36.76%-77.7%47.59%-31.97%-8.98%9.27%38.66%86.23%
Net Income-40.38M-48.44M-51.37M-59.17M-60.56M-66.15M-61.27M-23.36M-1M
Depreciation & Amortization2.31M2.42M2.7M2.64M2.44M2.52M1.96M347K0
Stock-Based Compensation2.65M4.32M4.13M3.91M3.36M3.64M2.81M3.17M117K
Deferred Taxes-1K00-21K261K0000
Other Non-Cash Items1.75M-1.39M88K1.74M2.1M2.38M11.06M-97K-3.47M
Working Capital Changes2.61M620K-31.02M11.36M200K723K-6.17M-11.72M0
Change in Receivables000000000
Change in Inventory000000000
Change in Payables4.07M-257K0-349K538K00-2.26M-1.18M
Cash from Investing9.28M-87.2M10.8M32.48M-53.25M58.35M38.77M25.34M167K
Capital Expenditures-2.58M-5.65M-1.25M-395K-679K-728K-214K-14K0
CapEx % of Revenue105.48%224.37%56.25%72.48%38.71%61.69%6.35%175%-
Acquisitions40.43M00-28.52M-1.27M0000
Investments---------
Other Investing11K-81.55M028.52M1.27M016K1.33M167K
Cash from Financing66.68M82.48M79.6M13.39M89.38M-2.04M20.94M172K0
Debt Issued (Net)-408K-427K-266K-208K-8K-13K-13K-4K0
Equity Issued (Net)67.08M82.67M57M13.54M89.09M-2.23M20.83M22K0
Dividends Paid000000000
Share Repurchases00000-2.52M000
Other Financing5K244K22.87M58K301K198K125K154K0
Net Change in Cash
44.9M▲ 0%
-47.19M▼ 205.1%
14.93M▲ 131.6%
6.32M▼ 57.7%
-16.07M▼ 354.1%
-577K▲ 96.4%
8.1M▲ 1503.6%
-6.15M▼ 175.9%
-4.19M▲ 31.8%
Free Cash Flow
-33.63M▲ 0%
-48.12M▼ 43.1%
-76.72M▼ 59.4%
-39.95M▲ 47.9%
-52.88M▼ 32.4%
-57.62M▼ 9.0%
-51.83M▲ 10.0%
-31.67M▲ 38.9%
-4.36M▲ 86.2%
FCF Margin %-1376.15%-1909.68%-3449.6%-7329.91%-3014.65%-4882.71%-1537.47%-395900%-
FCF Growth %-26.75%-43.09%-59.42%47.93%-32.36%-8.96%10.05%38.89%86.24%
FCF per Share-75.02-30.23-38.00-16.72-14.34-12.05-7.97-2.60-0.35
FCF Conversion (FCF/Net Income)0.77x0.88x1.47x0.67x0.86x0.86x0.90x1.36x4.34x
Interest Paid0021K002K1K00
Taxes Paid00000014K5K0

SYBX Key Ratios

Synlogic, Inc. (SYBX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-36.14%-55.54%-46.32%-36.56%-43.5%-46.16%-57.55%-91.46%-84.32%-8.17%
Return on Invested Capital (ROIC)-99.07%-139.56%-68.47%-30.33%-34.73%-35.49%-42.41%-67.26%-205.7%-
Gross Margin64.19%100%-491.15%100%100%100%100%100%100%-
Net Margin-5916.22%-1652.09%-1922.02%-2309.94%-10857.43%-3452.74%-5605.68%-1699.26%-291987.5%-
Debt / Equity0.02x0.01x0.00x0.16x0.20x0.14x0.25x0.40x--
Interest Coverage--707.37x-1125.40x-2445.33x-9861.17x-30279.50x-33072.50x-57267.00x--
FCF Conversion0.94x0.77x0.88x1.47x0.67x0.86x0.86x0.90x1.36x4.34x
Revenue Growth-450.45%3.11%-11.75%-75.49%221.83%-32.73%185.68%-99.76%-100%

SYBX SEC Filings & Documents

Synlogic, Inc. (SYBX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Jan 20, 2026·SEC

Material company update

Dec 16, 2025·SEC

Material company update

Nov 26, 2025·SEC

10-K Annual Reports

4
FY 2026

Mar 12, 2026·SEC

FY 2025

Mar 6, 2025·SEC

FY 2024

Mar 19, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 7, 2025·SEC

FY 2025

May 8, 2025·SEC

SYBX Frequently Asked Questions

Synlogic, Inc. (SYBX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Synlogic, Inc. (SYBX) saw revenue decline by 100.0% over the past year.

Synlogic, Inc. (SYBX) reported a net loss of $1.0M for fiscal year 2025.

Dividend & Returns

Synlogic, Inc. (SYBX) has a return on equity (ROE) of -8.2%. Negative ROE indicates the company is unprofitable.

Synlogic, Inc. (SYBX) had negative free cash flow of $4.4M in fiscal year 2025, likely due to heavy capital investments.

Explore More SYBX

Synlogic, Inc. (SYBX) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

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Valuation

DCF intrinsic value, peer multiples & estimates

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