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PSNL logoPersonalis, Inc.(PSNL)Earnings, Financials & Key Ratios

PSNL•NASDAQ
$6.07
$542M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryDiagnostics & ResearchSub-IndustryMolecular and Genetic Diagnostics
AboutPersonalis, Inc. operates as a cancer genomics company worldwide. The company provides sequencing and data analysis services to support the development of cancer therapies and large-scale genetic research programs. It offers NeXT Platform, which provides data analysis for tumor and its immune microenvironment, from a single limited tissue or plasma sample; ImmunoID Next for tumor profiling from tissue; NeXT Liquid Biopsy for tumor profiling from plasma; NeXT Personal, a liquid biopsy offering for personalized tumor tracking for patients; NeXT Dx Test, a genomic cancer profiling test enabling composite biomarkers for cancer treatment; and NeXT SHERPA and NeXT NEOPS for neoantigen prediction capabilities. The company also provides ACE platform for clinical and therapeutic applications such as neoantigen prediction, biomarker identification, and novel drug target selection. It serves biopharmaceutical customers, universities, non-profits, and government entities. The company has partnership with Mayo Clinic; MapKure, LLC; SpringWorks Therapeutics, Inc.; and Moores Cancer Center. Personalis, Inc. was incorporated in 2011 and is headquartered in Menlo Park, California.Show more
  • Revenue$0-100.0%
  • EBITDA-$88M-53.6%
  • Net Income-$81M
  • EPS (Diluted)-0.91+33.6%
  • ROE-35.02%+28.4%
  • ROIC-40.69%-9.7%
  • Debt/Equity0.12-44.0%
Technical→

PSNL Key Insights

Personalis, Inc. (PSNL) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

No significant strengths identified

✗Weaknesses

  • ✗Weak momentum: RS Rating 16 (bottom 16%)
  • ✗Shares diluted 50.6% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

PSNL Price & Volume

Personalis, Inc. (PSNL) stock price & volume — 10-year historical chart

Loading chart...

PSNL Growth Metrics

Personalis, Inc. (PSNL) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-38.19%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM0.02%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM33.58%

Return on Capital

10 Years-36.03%
5 Years-35.19%
3 Years-38.67%
Last Year-33%

PSNL Recent Earnings

Personalis, Inc. (PSNL) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 11/12 qtrs (92%)●Beat Revenue 9/12 qtrs (75%)
Q1 2026Latest
Feb 26, 2026
EPS
$0.26
Est $0.31
+16.1%
Revenue
$17M
Est $17M
+1.7%
Q4 2025
Nov 4, 2025
EPS
$0.24
Est $0.28
+14.3%
Revenue
$14M
Est $17M
-14.9%
Q3 2025
Aug 5, 2025
EPS
$0.23
Est $0.25
+8.0%
Revenue
$17M
Est $20M
-14.5%
Q2 2025
May 6, 2025
EPS
$0.18
Est $0.23
+21.7%
Revenue
$21M
Est $17M
+18.3%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q1 2026LatestFeb 26, 2026
$0.26vs $0.31+16.1%
$17Mvs $17M+1.7%
Q4 2025Nov 4, 2025
$0.24vs $0.28+14.3%
$14Mvs $17M-14.9%
Q3 2025Aug 5, 2025
$0.23vs $0.25+8.0%
$17Mvs $20M-14.5%
Q2 2025May 6, 2025
$0.18vs $0.23+21.7%
$21Mvs $17M+18.3%
Based on last 12 quarters of dataView full earnings history →

PSNL Peer Comparison

Personalis, Inc. (PSNL) competitors in Molecular and Genetic Diagnostics — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
NTRA logoNTRANatera, Inc.Direct Competitor29.58B215.09-140.5856.75%-14.61%-24.69%0.16
EXAS logoEXASExact Sciences CorporationDirect Competitor20.02B104.91-95.3717.69%-6.4%-8.66%1.05
GH logoGHGuardant Health, Inc.Direct Competitor11.53B92.25-27.7932.88%-44.18%
TWST logoTWSTTwist Bioscience CorporationDirect Competitor3.71B59.53-45.7920.32%-19.85%-17.46%0.29
ILMN logoILMNIllumina, Inc.Product Competitor21.66B142.5826.16-0.78%19.43%32.84%0.94
PACB logoPACBPacific Biosciences of California, Inc.Product Competitor516.17M1.71-1.60-23.19%-325.8%-13.95%1.33
CDNA logoCDNACareDx, IncProduct Competitor1.08B20.94-52.3513.79%-1.98%-2.61%0.06
VCYT logoVCYTVeracyte, Inc.Product Competitor3.29B41.1950.2316.01%16.25%6.86%0.03

Compare PSNL vs Peers

Personalis, Inc. (PSNL) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs NTRA

Most directly comparable listed peer for PSNL.

Scale Benchmark

vs TMO

Larger-name benchmark to compare PSNL against a more recognizable public peer.

Peer Set

Compare Top 5

vs NTRA, EXAS, GH, TWST

PSNL Income Statement

Personalis, Inc. (PSNL) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue9.39M37.77M65.21M78.65M85.49M65.05M73.48M84.61M0
Revenue Growth %-302.15%72.62%20.61%8.7%-23.92%12.97%15.15%-100%
Cost of Goods Sold11.74M25.97M43.13M58.53M53.84M51.7M55.27M57.79M53.87M
COGS % of Revenue124.94%68.75%66.14%74.43%62.97%79.48%75.22%68.3%-
Gross Profit
-2.34M▲ 0%
11.8M▲ 603.8%
22.08M▲ 87.0%
20.11M▼ 8.9%
31.66M▲ 57.4%
13.35M▼ 57.8%
18.21M▲ 36.4%
26.82M▲ 47.3%
-53.87M▼ 300.8%
Gross Margin %-24.94%31.25%33.86%25.57%37.03%20.52%24.78%31.7%-
Gross Profit Growth %-603.84%87.04%-8.9%57.39%-57.83%36.39%47.33%-300.82%
Operating Expenses19.82M25.57M44.5M62.26M97.01M128.88M128.14M95.09M103.83M
OpEx % of Revenue211.01%67.71%68.24%79.16%113.47%198.14%174.39%112.38%-
Selling, General & Admin9.9M11.27M22.08M33.69M47.7M63.97M49.73M46.19M53.57M
SG&A % of Revenue105.41%29.84%33.86%42.84%55.79%98.34%67.67%54.59%-
Research & Development9.92M14.3M22.42M28.57M49.31M64.91M64.78M48.91M50.26M
R&D % of Revenue105.6%37.87%34.38%36.32%57.68%99.79%88.15%57.8%-
Other Operating Expenses0-33K000013.64M00
Operating Income
-22.16M▲ 0%
-13.77M▲ 37.9%
-22.42M▼ 62.8%
-42.15M▼ 88.0%
-65.35M▼ 55.1%
-115.53M▼ 76.8%
-109.94M▲ 4.8%
-68.27M▲ 37.9%
-88.06M▼ 29.0%
Operating Margin %-235.95%-36.45%-34.38%-53.59%-76.44%-177.61%-149.61%-80.68%-
Operating Income Growth %-37.87%-62.8%-88%-55.06%-76.78%4.84%37.9%-28.99%
EBITDA-20.95M-10.7M-17.67M-36.39M-59.34M-107.1M-98.64M-57.33M-88.06M
EBITDA Margin %-223.01%-28.34%-27.1%-46.27%-69.41%-164.65%-134.24%-67.75%-
EBITDA Growth %-48.9%-65.08%-105.93%-63.07%-80.49%7.9%41.88%-53.61%
D&A (Non-Cash Add-back)1.22M3.07M4.75M5.76M6.01M8.43M11.3M10.94M0
EBIT-22.29M-17.98M-23.94M-41.22M-65.03M-113.07M-108.1M-81.24M0
Net Interest Income-1.2M-1.6M487K947K183K2.19M5.79M5.49M0
Interest Income100K293K1.62M949K367K2.4M5.9M5.51M7.16M
Interest Expense1.3M1.89M1.13M2K184K201K110K24K-205K
Other Income/Expense-1.43M-6.11M-2.66M923K141K2.26M1.72M-13M6.81M
Pretax Income
-23.59M▲ 0%
-19.88M▲ 15.7%
-25.07M▼ 26.1%
-41.22M▼ 64.4%
-65.21M▼ 58.2%
-113.28M▼ 73.7%
-108.21M▲ 4.5%
-81.27M▲ 24.9%
-81.25M▲ 0.0%
Pretax Margin %-251.18%-52.63%-38.45%-52.41%-76.28%-174.14%-147.27%-96.04%-
Income Tax5K7K9K57K14K40K83K18K21K
Effective Tax Rate %-0.02%-0.04%-0.04%-0.14%-0.02%-0.04%-0.08%-0.02%-0.03%
Net Income
-23.6M▲ 0%
-19.89M▲ 15.7%
-25.08M▼ 26.1%
-41.28M▼ 64.6%
-65.23M▼ 58.0%
-113.31M▼ 73.7%
-108.3M▲ 4.4%
-81.28M▲ 24.9%
-81.27M▲ 0.0%
Net Margin %-251.23%-52.64%-38.47%-52.49%-76.29%-174.2%-147.38%-96.06%-
Net Income Growth %-15.73%-26.14%-64.57%-58.01%-73.73%4.43%24.94%0.02%
Net Income (Continuing)-23.6M-19.89M-25.08M-41.28M-65.23M-113.31M-108.3M-81.28M-81.27M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-1.08▲ 0%
-0.91▲ 15.7%
-1.39▼ 52.7%
-1.20▲ 13.7%
-1.49▼ 24.2%
-2.48▼ 66.4%
-2.25▲ 9.3%
-1.37▲ 39.1%
-0.91▲ 33.6%
EPS Growth %-15.74%-52.75%13.67%-24.17%-66.44%9.27%39.11%33.58%
EPS (Basic)-1.08-0.91-1.39-1.20-1.49-2.48-2.25-1.37-0.91
Diluted Shares Outstanding21.75M21.75M18.01M34.37M43.89M45.7M48.18M59.25M89.24M
Basic Shares Outstanding21.75M21.75M18.01M34.37M43.89M45.7M48.18M59.25M89.24M
Dividend Payout Ratio---------

PSNL Balance Sheet

Personalis, Inc. (PSNL) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets26.73M29.56M139.58M220.72M318.23M199.7M146.74M203.01M267.95M
Cash & Short-Term Investments22.62M19.74M128.29M203.29M287.06M167.66M114.18M185.01M239.95M
Cash Only22.62M19.74M55.05M68.53M105.58M89.13M56.98M91.42M124.25M
Short-Term Investments0073.24M134.76M181.48M78.53M57.2M93.59M115.71M
Accounts Receivable1.94M4.46M3.3M6.35M18.47M16.64M17.73M8.14M16.2M
Days Sales Outstanding75.2743.0718.4729.4778.8593.3888.0735.11-
Inventory822K2.13M1.42M2.67M4.08M6.38M5.66M3.98M6.14M
Days Inventory Outstanding25.5629.9912.0516.6827.6745.0737.3825.1141.63
Other Current Assets542K1.3M3.18M2.96M1.53M9.02M9.17M5.89M5.65M
Total Non-Current Assets6.84M12.11M17.71M24.12M78.3M93M78.36M67.25M66.21M
Property, Plant & Equipment6.34M11.45M15.95M22.11M73.47M88.42M75.22M64.73M59.93M
Fixed Asset Turnover1.48x3.30x4.09x3.56x1.16x0.74x0.98x1.31x-
Goodwill000000000
Intangible Assets000000000
Long-Term Investments000000000
Other Non-Current Assets495K659K1.76M2.02M4.83M4.59M3.14M2.53M6.28M
Total Assets
33.56M▲ 0%
41.67M▲ 24.2%
157.29M▲ 277.5%
244.84M▲ 55.7%
396.53M▲ 62.0%
292.7M▼ 26.2%
225.1M▼ 23.1%
270.27M▲ 20.1%
334.16M▲ 23.6%
Asset Turnover0.28x0.91x0.41x0.32x0.22x0.22x0.33x0.31x-
Asset Growth %-24.15%277.47%55.66%61.95%-26.18%-23.1%20.07%23.64%
Total Current Liabilities48.99M57.85M49.96M40.64M31.31M33.13M47.23M31.13M39.63M
Accounts Payable4.04M6.57M7.34M8.3M9.22M12.85M14.92M6.4M12.99M
Days Payables Outstanding125.4992.2762.151.7662.5290.7598.5340.488.01
Short-Term Debt17.51M5M001.81M2.22M1.65M1.67M0
Deferred Revenue (Current)24.71M42.9M35.98M21.03M4.36M1.29M3.29M3.1M0
Other Current Liabilities718K43.18M4.39M8.45M11.19M9.55M19.62M10.86M39.63M
Current Ratio0.55x0.51x2.79x5.43x10.16x6.03x3.11x6.52x6.76x
Quick Ratio0.53x0.47x2.77x5.37x10.03x5.83x2.99x6.39x6.61x
Cash Conversion Cycle-24.66-19.21-31.57-5.624447.726.9319.82-
Total Non-Current Liabilities77.18M90.21M639K9.26M54.91M41.43M48.42M36.19M33.35M
Long-Term Debt292K683K00000031.87M
Capital Lease Obligations00639K8.54M52.8M41.04M38.32M34.88M0
Deferred Tax Liabilities000000000
Other Non-Current Liabilities76.89M89.53M0720K2.12M389K10.1M1.3M1.48M
Total Liabilities126.17M148.06M50.6M49.9M86.23M74.56M95.66M67.31M72.98M
Total Debt17.51M5M2M10.99M58.33M48.65M47.73M44.25M31.87M
Net Debt-5.11M-14.75M-53.05M-57.54M-47.25M-40.48M-9.26M-47.17M-92.38M
Debt / Equity--0.02x0.06x0.19x0.22x0.37x0.22x0.12x
Debt / EBITDA---------
Net Debt / EBITDA---------
Interest Coverage-17.01x-7.27x-19.79x-21073.00x-355.18x-574.78x-999.42x-2844.46x-
Total Equity
-92.6M▲ 0%
-106.39M▼ 14.9%
106.69M▲ 200.3%
194.94M▲ 82.7%
310.3M▲ 59.2%
218.14M▼ 29.7%
129.44M▼ 40.7%
202.96M▲ 56.8%
261.19M▲ 28.7%
Equity Growth %--14.89%200.28%82.72%59.17%-29.7%-40.66%56.79%28.69%
Book Value per Share-4.26-4.895.925.677.074.772.693.432.93
Total Shareholders' Equity-92.6M-106.39M106.69M194.94M310.3M218.14M129.44M202.96M261.19M
Common Stock1K1K3K4K4K5K5K9K10K
Retained Earnings-95.62M-115.5M-140.59M-181.87M-247.09M-360.41M-468.71M-549.99M-631.26M
Treasury Stock-3.02M-9.13M0000000
Accumulated OCI-10K-15K-6K22K-166K-912K-222K-23K104K
Minority Interest000000000

PSNL Cash Flow Statement

Personalis, Inc. (PSNL) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations290K5.57M-18.07M-42.65M-70.83M-70.23M-56.26M-45.15M-74.95M
Operating CF Margin %3.09%14.75%-27.71%-54.23%-82.85%-107.97%-76.56%-53.36%-
Operating CF Growth %-1821.38%-424.28%-136.06%-66.06%0.84%19.9%19.74%-65.99%
Net Income-23.6M-19.89M-25.08M-41.28M-65.23M-113.31M-108.3M-81.28M-81.27M
Depreciation & Amortization1.22M3.07M4.75M5.76M6.01M8.43M11.3M10.94M10.05M
Stock-Based Compensation753K1.32M4.86M8.24M14.38M19.43M14.05M10.69M9.43M
Deferred Taxes226K4.47M3.11M391K2.03M0000
Other Non-Cash Items934K1.18M1.56M1.47M3.12M4.61M13.21M17.1M-13.15M
Working Capital Changes20.76M15.42M-7.26M-17.23M-31.14M10.61M13.48M-2.59M0
Change in Receivables-1.2M-2.52M1.07M-3.05M-12.12M1.82M-1.09M9.59M-8.06M
Change in Inventory-539K-2.07M-1.17M-1.08M29K-2.98M-1.93M4.42M-204K
Change in Payables2.63M2.16M1.4M751K-1.46M3.09M5.18M-8.92M4.55M
Cash from Investing-5.16M-7.85M-81.58M-65.14M-60.07M52.54M13.1M-35.07M-22.57M
Capital Expenditures-5.16M-7.85M-8.38M-3.25M-11.08M-49.9M-10.91M-1.6M-4.5M
CapEx % of Revenue54.91%20.79%12.85%4.13%12.96%76.71%14.85%1.89%-
Acquisitions0073.2M65.14M48.99M0-24.01M00
Investments---------
Other Investing00-73.2M-65.14M-48.99M024.01M242K0
Cash from Financing16.4M-591K134.95M121.27M169.7M1.37M11.03M114.67M130.34M
Debt Issued (Net)16.4M-645K-5M03.31M-1.1M174K-1.13M0
Equity Issued (Net)001000K1000K1000K01000K1000K0
Dividends Paid000000000
Share Repurchases000000000
Other Financing2K54K-4.08M3.77M4.13M2.46M7.34M17.98M130.34M
Net Change in Cash
11.54M▲ 0%
-2.87M▼ 124.9%
35.3M▲ 1328.8%
13.48M▼ 61.8%
38.85M▲ 188.2%
-16.46M▼ 142.4%
-32.14M▼ 95.3%
34.43M▲ 207.1%
32.83M▼ 4.6%
Free Cash Flow
-4.87M▲ 0%
-2.28M▲ 53.2%
-26.45M▼ 1060.1%
-45.9M▼ 73.5%
-81.91M▼ 78.5%
-120.13M▼ 46.7%
-67.17M▲ 44.1%
-46.75M▲ 30.4%
-79.45M▼ 69.9%
FCF Margin %-51.83%-6.04%-40.56%-58.36%-95.81%-184.68%-91.41%-55.25%-
FCF Growth %-53.16%-1060.13%-73.52%-78.46%-46.66%44.09%30.39%-69.94%
FCF per Share-0.22-0.10-1.47-1.34-1.87-2.63-1.39-0.79-0.89
FCF Conversion (FCF/Net Income)-0.01x-0.28x0.72x1.03x1.09x0.62x0.52x0.56x0.92x
Interest Paid321K698K1.26M000000
Taxes Paid-5K-7K6K35K39K47K64K38K0

PSNL Key Ratios

Personalis, Inc. (PSNL) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025
Return on Equity (ROE)---16611.92%-27.37%-25.82%-42.89%-62.31%-48.91%-35.02%
Return on Invested Capital (ROIC)---31.34%-33.09%-24.48%-39.32%-55.37%-37.11%-40.69%
Gross Margin-24.94%31.25%33.86%25.57%37.03%20.52%24.78%31.7%-
Net Margin-251.23%-52.64%-38.47%-52.49%-76.29%-174.2%-147.38%-96.06%-
Debt / Equity--0.02x0.06x0.19x0.22x0.37x0.22x0.12x
Interest Coverage-17.01x-7.27x-19.79x-21073.00x-355.18x-574.78x-999.42x-2844.46x-
FCF Conversion-0.01x-0.28x0.72x1.03x1.09x0.62x0.52x0.56x0.92x
Revenue Growth-302.15%72.62%20.61%8.7%-23.92%12.97%15.15%-100%

PSNL SEC Filings & Documents

Personalis, Inc. (PSNL) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Mar 17, 2026·SEC

Material company update

Feb 26, 2026·SEC

Material company update

Jan 8, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 5, 2025·SEC

FY 2025

May 6, 2025·SEC

PSNL Frequently Asked Questions

Personalis, Inc. (PSNL) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Personalis, Inc. (PSNL) reported $52.3M in revenue for fiscal year 2025. This represents a 457% increase from $9.4M in 2017.

Personalis, Inc. (PSNL) saw revenue decline by 100.0% over the past year.

Personalis, Inc. (PSNL) reported a net loss of $81.3M for fiscal year 2025.

Dividend & Returns

Personalis, Inc. (PSNL) has a return on equity (ROE) of -35.0%. Negative ROE indicates the company is unprofitable.

Personalis, Inc. (PSNL) had negative free cash flow of $79.5M in fiscal year 2025, likely due to heavy capital investments.

Explore More PSNL

Personalis, Inc. (PSNL) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

→

Revenue History

Sales growth patterns & revenue breakdown

→

Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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