Comprehensive Stock Comparison
Compare CytomX Therapeutics, Inc. (CTMX) vs Agios Pharmaceuticals, Inc. (AGIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
Selected Stocks
Add up to 10 tickers. Use presets or search to get started.
Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | AGIO | 48.0% revenue growth vs CTMX's 36.4% |
| Quality / Margins | CTMX | 24.7% net margin vs AGIO's -9.0% |
| Stability / Safety | AGIO | Beta 0.91 vs CTMX's 1.08 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | CTMX | +6.9% vs AGIO's -14.9% |
| Efficiency (ROA) | CTMX | 17.7% ROA vs AGIO's -29.0% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
CytomX Therapeutics is an oncology-focused biopharmaceutical company that develops conditionally activated antibody therapeutics using its proprietary Probody technology platform. It generates revenue primarily through strategic collaborations and licensing deals with major pharmaceutical partners — including AbbVie, Amgen, and Bristol-Myers Squibb — which provide upfront payments, milestone payments, and potential future royalties on any commercialized products. The company's key competitive advantage is its Probody platform technology, which creates conditionally activated therapeutics that remain inactive until they reach the tumor microenvironment, potentially improving safety and efficacy compared to traditional antibody therapies.
Agios Pharmaceuticals is a biopharmaceutical company focused on developing treatments for rare genetic diseases related to cellular metabolism. It generates revenue primarily from sales of its lead drug PYRUKYND for pyruvate kinase deficiency — with additional income from research collaborations and milestone payments — while advancing a pipeline of other metabolic therapies. The company's competitive advantage lies in its deep expertise in cellular metabolism science and proprietary platform for targeting metabolic pathways in rare diseases.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
CTMX leads in 3 of 6 categories — strongest in Financial Metrics and Profitability & Efficiency. 2 categories are tied.
Financial Metrics (TTM)
CTMX is the larger business by revenue, generating $114M annually — 2.5x AGIO's $45M. CTMX is the more profitable business, keeping 24.7% of every revenue dollar as net income compared to AGIO's -9.0%. On growth, AGIO holds the edge at +43.7% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | CTMXCytomX Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| RevenueTrailing 12 months | $114M | $45M |
| EBITDAEarnings before interest/tax | $25M | -$470M |
| Net IncomeAfter-tax profit | $28M | -$401M |
| Free Cash FlowCash after capex | -$72M | -$414M |
| Gross MarginGross profit ÷ Revenue | +100.0% | +84.4% |
| Operating MarginEBIT ÷ Revenue | +20.5% | -10.6% |
| Net MarginNet income ÷ Revenue | +24.7% | -9.0% |
| FCF MarginFCF ÷ Revenue | -63.7% | -9.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | -82.2% | +43.7% |
| EPS Growth (YoY)Latest quarter vs prior year | -2.3% | -111.0% |
Valuation Metrics
| Metric | CTMXCytomX Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Market CapShares × price | $430M | $2.25T |
| Enterprise ValueMkt cap + debt − cash | $401M | $2.25T |
| Trailing P/EPrice ÷ TTM EPS | 14.13x | -4.25x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 15.00x | — |
| Price / SalesMarket cap ÷ Revenue | 3.11x | 9999.00x |
| Price / BookPrice ÷ Book value/share | — | 1.47x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
CTMX delivers a 26.1% return on equity — every $100 of shareholder capital generates $26 in annual profit, vs $-31 for AGIO. On the Piotroski fundamental quality scale (0–9), CTMX scores 4/9 vs AGIO's 3/9, reflecting mixed financial health.
| Metric | CTMXCytomX Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| ROE (TTM)Return on equity | +26.1% | -31.2% |
| ROA (TTM)Return on assets | +17.7% | -29.0% |
| ROICReturn on invested capital | — | -26.6% |
| ROCEReturn on capital employed | +62.0% | -33.8% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 3 |
| Debt / EquityFinancial leverage | — | 0.03x |
| Net DebtTotal debt minus cash | -$29M | -$49M |
| Cash & Equiv.Liquid assets | $38M | $89M |
| Total DebtShort + long-term debt | $9M | $40M |
| Interest CoverageEBIT ÷ Interest expense | — | — |
Total Returns (with DRIP)
A $10,000 investment in AGIO five years ago would be worth $6,363 today (with dividends reinvested), compared to $6,355 for CTMX. Over the past 12 months, CTMX leads with a +693.0% total return vs AGIO's -14.9%. The 3-year compound annual growth rate (CAGR) favors CTMX at 35.7% vs AGIO's 6.1% — a key indicator of consistent wealth creation.
| Metric | CTMXCytomX Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| YTD ReturnYear-to-date | +26.4% | +11.2% |
| 1-Year ReturnPast 12 months | +693.0% | -14.9% |
| 3-Year ReturnCumulative with dividends | +149.8% | +19.4% |
| 5-Year ReturnCumulative with dividends | -36.4% | -36.4% |
| 10-Year ReturnCumulative with dividends | -58.4% | -21.2% |
| CAGR (3Y)Annualised 3-year return | +35.7% | +6.1% |
Risk & Volatility
AGIO is the less volatile stock with a 0.91 beta — it tends to amplify market swings less than CTMX's 1.08 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. CTMX currently trades 84.6% from its 52-week high vs AGIO's 65.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CTMXCytomX Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.08x | 0.91x |
| 52-Week HighHighest price in past year | $6.35 | $46.00 |
| 52-Week LowLowest price in past year | $0.40 | $22.24 |
| % of 52W HighCurrent price vs 52-week peak | +84.6% | +65.7% |
| RSI (14)Momentum oscillator 0–100 | 52.0 | 62.3 |
| Avg Volume (50D)Average daily shares traded | 2.6M | 948K |
Analyst Outlook
Wall Street rates CTMX as "Buy" and AGIO as "Buy". Consensus price targets imply 86.2% upside for CTMX (target: $10) vs 37.3% for AGIO (target: $42).
| Metric | CTMXCytomX Therapeuti… | AGIOAgios Pharmaceuti… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $10.00 | $41.50 |
| # AnalystsCovering analysts | 21 | 29 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | 1 | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| CytomX Therapeutics… (CTMX) | 100 | 85.71 | -14.3% |
| Agios Pharmaceutica… (AGIO) | 100 | 57.07 | -42.9% |
Agios Pharmaceutica… (AGIO) returned -36% over 5 years vs CytomX Therapeutics… (CTMX)'s -36%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CytomX Therapeutics… (CTMX) | $15M | $138M | +818.1% |
| Agios Pharmaceutica… (AGIO) | $70M | $54M | -22.7% |
Agios Pharmaceuticals, Inc.'s revenue grew from $70M (2016) to $54M (2025) — a -2.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CytomX Therapeutics… (CTMX) | -3.9% | 23.1% | +689.4% |
| Agios Pharmaceutica… (AGIO) | -2.8% | -7.6% | -169.0% |
Agios Pharmaceuticals, Inc.'s net margin went from -3% (2016) to -8% (2025).
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| CytomX Therapeutics… (CTMX) | -1.63 | 0.38 | +123.3% |
| Agios Pharmaceutica… (AGIO) | -5.07 | -7.12 | -40.4% |
Agios Pharmaceuticals, Inc.'s EPS grew from $-5.07 (2016) to $-7.12 (2025).
Chart 5Free Cash Flow — 5 Years
CytomX Therapeutics, Inc. generated $-87M FCF in 2024 (+28% vs 2021). Agios Pharmaceuticals, Inc. generated $-377M FCF in 2025 (+9% vs 2021).
CTMX vs AGIO: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is CTMX or AGIO a better buy right now?
CytomX Therapeutics, Inc. (CTMX) offers the better valuation at 14.1x trailing P/E, making it the more compelling value choice. Analysts rate CytomX Therapeutics, Inc. (CTMX) a "Buy" — based on 21 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CTMX or AGIO?
Over the past 5 years, Agios Pharmaceuticals, Inc. (AGIO) delivered a total return of -36.4%, compared to -36.4% for CytomX Therapeutics, Inc. (CTMX). A $10,000 investment in AGIO five years ago would be worth approximately $6K today (assuming dividends reinvested). Over 10 years, the gap is even starker: AGIO returned -21.2% versus CTMX's -58.4%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CTMX or AGIO?
By beta (market sensitivity over 5 years), Agios Pharmaceuticals, Inc. (AGIO) is the lower-risk stock at 0.91β versus CytomX Therapeutics, Inc.'s 1.08β — meaning CTMX is approximately 19% more volatile than AGIO relative to the S&P 500.
04Which has better profit margins — CTMX or AGIO?
CytomX Therapeutics, Inc. (CTMX) is the more profitable company, earning 23.1% net margin versus -764.0% for Agios Pharmaceuticals, Inc. — meaning it keeps 23.1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: CTMX leads at 18.1% versus -873.9% for AGIO. At the gross margin level — before operating expenses — CTMX leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — CTMX or AGIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is CTMX or AGIO better for a retirement portfolio?
For long-horizon retirement investors, Agios Pharmaceuticals, Inc. (AGIO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.91)). Both have compounded well over 10 years (AGIO: -21.2%, CTMX: -58.4%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between CTMX and AGIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. In terms of investment character: CTMX is a small-cap deep-value stock; AGIO is a mega-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
Find Stocks Like These
Explore pre-built screens for each stock's profile, or build a custom screen to find stocks that beat both.