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CTMX logoCytomX Therapeutics, Inc.(CTMX)Earnings, Financials & Key Ratios

CTMX•NASDAQ
$4.13
$703M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryDrug Discovery and Antibody Platforms
AboutCytomX Therapeutics, Inc. operates as an oncology-focused biopharmaceutical company in the United States. The company develops antibody therapeutics based on its Probody technology platform for the treatment of cancer. The company's product candidates include CX-2009, an antibody drug conjugates (ADC) against CD166, which is in Phase II clinical trials for the treatment of breast cancer; CX-2029 that is in Phase II clinical trials for the treatment of squamous non-small cell lung cancer, head and neck squamous cell carcinoma, esophageal and gastro-esophageal junction cancers, and diffuse large B-cell lymphoma; BMS-986249, a CTLA-4 Probody therapeutic drug, which is in Phase I/II clinical trials for the treatment of metastatic melanoma; and BMS-986288, an anti-CTLA-4 Probody drug, which is in Phase I clinical trials for the treatment of solid tumors. It also develops CX-2043, a conditionally activated ADC targeting the epithelial cell adhesion molecule, as well as CX-904, a conditionally activated epidermal growth factor receptor for the treatment of solid tumor. The company has strategic collaborations with AbbVie Ireland Unlimited Company, Amgen, Inc., Bristol-Myers Squibb Company, ImmunoGen, Inc., Pfizer Inc., and Astellas Pharma Inc. to develop Probody therapeutics. CytomX Therapeutics, Inc. was founded in 2008 and is headquartered in South San Francisco, California.Show more
  • Revenue$76M-44.8%
  • EBITDA-$18M-168.0%
  • Net Income-$17M-154.5%
  • EPS (Diluted)-0.15-139.5%
  • Gross Margin100%
  • EBITDA Margin-23.87%-223.2%
  • Operating Margin-25.67%-241.9%
  • Net Margin-22.79%-198.8%
  • ROE-35.25%
  • ROIC-47.75%
  • Debt/Equity0.04
Technical→

CTMX Key Insights

CytomX Therapeutics, Inc. (CTMX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓High quality earnings: Operating CF exceeds net income

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Shares diluted 62.8% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

CTMX Price & Volume

CytomX Therapeutics, Inc. (CTMX) stock price & volume — 10-year historical chart

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CTMX Growth Metrics

CytomX Therapeutics, Inc. (CTMX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years25.74%
5 Years2.18%
3 Years12.75%
TTM-44.82%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-154.5%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-97.8%

Return on Capital

10 Years-21.23%
5 Years-14.25%
3 Years8.52%
Last Year-28.01%

CTMX Recent Earnings

CytomX Therapeutics, Inc. (CTMX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 10/12 qtrs (83%)●Beat Revenue 10/12 qtrs (83%)
Q2 2026Latest
Mar 16, 2026
EPS
$0.22
Est $0.08
-175.0%
Revenue
$661,000
Est $7M
-91.0%
Q4 2025
Nov 6, 2025
EPS
$0.09
Est $0.05
-82.5%
Revenue
$6M
Est $7M
-18.6%
Q3 2025
Aug 7, 2025
EPS
$0.00
Est $0.06
+98.1%
Revenue
$19M
Est $18M
+2.1%
Q2 2025
May 12, 2025
EPS
$0.27
Est $0.12
+116.3%
Revenue
$51M
Est $35M
+43.7%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMar 16, 2026
$0.22vs $0.08-175.0%
$661,000vs $7M-91.0%
Q4 2025Nov 6, 2025
$0.09vs $0.05-82.5%
$6Mvs $7M-18.6%
Q3 2025Aug 7, 2025
$0.00vs $0.06+98.1%
$19Mvs $18M+2.1%
Q2 2025May 12, 2025
$0.27vs $0.12+116.3%
$51Mvs $35M+43.7%
Based on last 12 quarters of dataView full earnings history →

CTMX Peer Comparison

CytomX Therapeutics, Inc. (CTMX) competitors in Drug Discovery and Antibody Platforms — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
IMVT logoIMVTImmunovant, Inc.Direct Competitor5.83B28.67-10.50-47.07%0.00
RCUS logoRCUSArcus Biosciences, Inc.Direct Competitor2.62B26.00-7.90-4.26%-156.36%-68.97%0.16
PBYI logoPBYIPuma Biotechnology, Inc.Direct Competitor379.14M7.4512.21-0.91%13.6%27.78%0.22
TPST logoTPSTTempest Therapeutics, Inc.Direct Competitor56.36M2.02-1.35-5.68%0.80
AGEN logoAGENAgenus Inc.Direct Competitor137.4M3.89-1144.1210.37%0.1%
XNCR logoXNCRXencor, Inc.Product Competitor954.14M13.01-10.4913.65%-185.71%-23.68%0.30
MGNX logoMGNXMacroGenics, Inc.Product Competitor190.59M3.01-2.550.78%-49.91%-120.2%0.66
ALXO logoALXOALX Oncology Holdings Inc.Product Competitor111.98M2.09-0.81-241.09%0.15

Compare CTMX vs Peers

CytomX Therapeutics, Inc. (CTMX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for CTMX.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare CTMX against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, RCUS, PBYI, TPST

CTMX Income Statement

CytomX Therapeutics, Inc. (CTMX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue71.62M59.5M57.49M68.43M37.31M53.16M101.21M138.1M76.2M
Revenue Growth %376.12%-16.92%-3.38%19.03%-45.47%42.48%90.38%36.45%-44.82%
Cost of Goods Sold000000000
COGS % of Revenue---------
Gross Profit
71.62M▲ 0%
59.5M▼ 16.9%
57.49M▼ 3.4%
68.43M▲ 19.0%
37.31M▼ 45.5%
53.16M▲ 42.5%
101.21M▲ 90.4%
138.1M▲ 36.4%
76.2M▼ 44.8%
Gross Margin %100%100%100%100%100%100%100%100%100%
Gross Profit Growth %376.12%-16.92%-3.38%19.03%-45.47%42.48%90.38%36.45%-44.82%
Operating Expenses117.88M137.38M168.38M148.97M153.35M154.5M107.7M113.11M95.77M
OpEx % of Revenue164.59%230.88%292.9%217.7%411%290.61%106.41%81.9%125.67%
Selling, General & Admin25.61M33.51M36.77M36.03M39.16M42.85M30.02M29.73M29.97M
SG&A % of Revenue35.75%56.32%63.95%52.66%104.95%80.6%29.66%21.52%39.33%
Research & Development92.28M103.87M131.62M112.94M114.19M111.65M77.68M83.38M65.8M
R&D % of Revenue128.84%174.56%228.95%165.05%306.05%210.01%76.75%60.38%86.35%
Other Operating Expenses-27K-68K-135K000000
Operating Income
-46.26M▲ 0%
-77.87M▼ 68.3%
-110.89M▼ 42.4%
-80.54M▲ 27.4%
-116.04M▼ 44.1%
-101.33M▲ 12.7%
-6.48M▲ 93.6%
25M▲ 485.5%
-19.56M▼ 178.3%
Operating Margin %-64.59%-130.88%-192.9%-117.7%-311%-190.61%-6.41%18.1%-25.67%
Operating Income Growth %22.37%-68.34%-42.4%27.37%-44.08%12.67%93.6%485.49%-178.27%
EBITDA-44.61M-75.99M-108.29M-77.97M-113.34M-98.89M-4.31M26.76M-18.19M
EBITDA Margin %-62.29%-127.71%-188.37%-113.94%-303.75%-186.02%-4.26%19.38%-23.87%
EBITDA Growth %22.88%-70.33%-42.51%28%-45.36%12.74%95.64%721.1%-167.96%
D&A (Non-Cash Add-back)1.65M1.88M2.6M2.57M2.71M2.44M2.17M1.77M1.38M
EBIT-43.61M-77.87M-102.67M-80.54M-116.04M-101.33M-6.48M25M-19.56M
Net Interest Income2.67M7.64M8.37M1.84M255K1.68M9.84M7.14M5.21M
Interest Income2.67M7.64M8.37M1.84M255K1.68M9.84M7.14M5.21M
Interest Expense000000000
Other Income/Expense2.65M7.57M8.23M29.63M172K2.02M9.81M7.1M2.43M
Pretax Income
-43.61M▲ 0%
-70.3M▼ 61.2%
-102.67M▼ 46.0%
-50.91M▲ 50.4%
-115.87M▼ 127.6%
-99.32M▲ 14.3%
3.32M▲ 103.3%
32.09M▲ 865.8%
-17.13M▼ 153.4%
Pretax Margin %-60.89%-118.15%-178.58%-74.4%-310.54%-186.82%3.28%23.24%-22.48%
Income Tax-513K14.3M-427K13.91M003.89M224K238K
Effective Tax Rate %1.18%-20.35%0.42%-27.33%0%0%117.12%0.7%-1.39%
Net Income
-43.1M▲ 0%
-84.6M▼ 96.3%
-102.24M▼ 20.8%
-64.82M▲ 36.6%
-115.87M▼ 78.8%
-99.32M▲ 14.3%
-569K▲ 99.4%
31.87M▲ 5700.9%
-17.37M▼ 154.5%
Net Margin %-60.17%-142.19%-177.84%-94.73%-310.54%-186.82%-0.56%23.08%-22.79%
Net Income Growth %26.83%-96.3%-20.84%36.6%-78.76%14.29%99.43%5700.88%-154.5%
Net Income (Continuing)-43.1M-84.6M-102.24M-64.82M-115.87M-99.32M-569K31.87M-17.37M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-1.16▲ 0%
-2.03▼ 75.0%
-2.26▼ 11.3%
-0.71▲ 68.6%
-1.26▼ 77.5%
-1.48▼ 17.5%
-0.01▲ 99.5%
0.38▲ 5035.1%
-0.15▼ 139.5%
EPS Growth %28.83%-75%-11.33%68.58%-77.46%-17.46%99.48%--139.47%
EPS (Basic)-1.16-2.03-2.26-0.71-1.26-1.48-0.010.38-0.15
Diluted Shares Outstanding37.17M41.66M45.34M46.15M64.15M65.74M73.81M84.75M137.94M
Basic Shares Outstanding37.17M41.66M45.34M46.15M64.15M65.74M73.81M84.44M137.94M
Dividend Payout Ratio---------

CTMX Balance Sheet

CytomX Therapeutics, Inc. (CTMX) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets388.6M445.48M303.33M324.01M310.3M237.1M182.94M107.31M143.92M
Cash & Short-Term Investments374.11M436.13M296.14M316.12M305.23M193.65M174.51M100.62M137.05M
Cash Only177.55M247.58M188.43M191.86M205.53M193.65M17.17M38.05M12.67M
Short-Term Investments196.56M188.55M107.72M124.26M99.7M0157.34M62.57M124.39M
Accounts Receivable10.14M97K13K798K790K35.99M3.43M3.1M2.01M
Days Sales Outstanding51.670.590.084.267.73247.0712.388.29.64
Inventory000000000
Days Inventory Outstanding---------
Other Current Assets4.35M9.25M0007.47M5M3.58M4.86M
Total Non-Current Assets9.04M11.63M37.95M34.65M29.11M23.79M18.86M13.23M7.64M
Property, Plant & Equipment4.22M6.93M32.75M29.45M25.32M21.02M16.18M10.6M4.7M
Fixed Asset Turnover16.98x8.58x1.76x2.32x1.47x2.53x6.26x13.02x16.21x
Goodwill949K949K949K949K949K949K949K949K949K
Intangible Assets1.6M1.46M1.31M1.17M1.02M875K729K583K438K
Long-Term Investments917K917K0000000
Other Non-Current Assets957K238K2.93M3.09M1.82M944K1M1.09M1.56M
Total Assets
397.64M▲ 0%
457.11M▲ 15.0%
341.28M▼ 25.3%
358.66M▲ 5.1%
339.41M▼ 5.4%
260.89M▼ 23.1%
201.79M▼ 22.7%
120.53M▼ 40.3%
151.57M▲ 25.7%
Asset Turnover0.18x0.13x0.17x0.19x0.11x0.20x0.50x1.15x0.50x
Asset Growth %99.69%14.95%-25.34%5.09%-5.37%-23.13%-22.65%-40.27%25.75%
Total Current Liabilities61.15M97.91M85.59M68.11M77.87M152.61M155.91M85.77M46.62M
Accounts Payable4.21M5.13M4.16M3M2.82M2.81M1.46M1.09M1.3M
Days Payables Outstanding---------
Short-Term Debt000000004.24M
Deferred Revenue (Current)40.56M52.71M51.38M42.06M40.82M121.27M132.27M67.2M26.88M
Other Current Liabilities11.86M20.14M00009.44M05.99M
Current Ratio6.36x4.55x3.54x4.76x3.98x1.55x1.17x1.25x3.09x
Quick Ratio6.36x4.55x3.54x4.76x3.98x1.55x1.17x1.25x3.09x
Cash Conversion Cycle---------
Total Non-Current Liabilities266.6M228.32M204.58M298.33M262M194.03M93.33M35.22M5.94M
Long-Term Debt000000000
Capital Lease Obligations0024.87M21.68M18.06M13.97M9.38M4.24M0
Deferred Tax Liabilities398K1.14M0000000
Other Non-Current Liabilities1.9M3.05M850K0003.89M4.12M5.94M
Total Liabilities327.75M326.23M290.17M366.44M339.87M346.64M249.24M120.99M52.56M
Total Debt0027.68M24.87M21.67M18.06M13.97M9.38M4.24M
Net Debt-177.55M-247.58M-160.74M-166.99M-183.86M-175.59M-3.2M-28.67M-8.43M
Debt / Equity--0.54x-----0.04x
Debt / EBITDA-------0.35x-
Net Debt / EBITDA--------1.07x-
Interest Coverage---------
Total Equity
69.9M▲ 0%
130.88M▲ 87.3%
51.11M▼ 60.9%
-7.77M▼ 115.2%
-459K▲ 94.1%
-85.75M▼ 18582.1%
-47.45M▲ 44.7%
-456K▲ 99.0%
99.01M▲ 21812.3%
Equity Growth %-10.94%87.25%-60.95%-115.21%94.1%-18582.14%44.67%99.04%21812.28%
Book Value per Share1.883.141.13-0.17-0.01-1.30-0.64-0.010.72
Total Shareholders' Equity69.9M130.88M51.11M-7.77M-459K-85.75M-47.45M-456K99.01M
Common Stock1K1K1K1K1K1K1K1K2K
Retained Earnings-219.47M-314.98M-417.23M-507.69M-623.56M-722.88M-723.45M-691.58M-711.95M
Treasury Stock000000000
Accumulated OCI-94K-93K57K-47K-242K10K95K27K111K
Minority Interest000000000

CTMX Cash Flow Statement

CytomX Therapeutics, Inc. (CTMX) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations170.37M-75.52M-140.48M5.26M-119.03M-110.79M-56.03M-86.23M-75.59M
Operating CF Margin %237.87%-126.92%-244.36%7.69%-319.02%-208.39%-55.36%-62.44%-99.19%
Operating CF Growth %8484.5%-144.33%-86.01%103.74%-2363.38%6.93%49.42%-53.89%12.34%
Net Income-43.1M-84.6M-132.82M-32.88M-83.61M-99.32M-569K31.87M-20.37M
Depreciation & Amortization1.65M1.88M2.6M2.57M2.71M5.86M2.17M1.77M146K
Stock-Based Compensation11.29M16.88M19.1M14.79M13.17M08.56M7.67M6.3M
Deferred Taxes-513K00-236K272K0000
Other Non-Cash Items11.09M-1.7M2.05M2.89M3.13M13.33M-3.69M-1.12M6.91M
Working Capital Changes189.97M-7.98M-31.41M18.13M-54.7M-30.65M-62.51M-126.42M-68.58M
Change in Receivables-7.83M10.04M84K-785K8K-35.2M32.55M329K1.09M
Change in Inventory10.32M19.91M0-11.12M11.64M0000
Change in Payables-2.44M261K-374K-857K-139K68K-1.43M-297K221K
Cash from Investing-121.27M5.93M79.7M-18.72M22.49M98.26M-150.67M99.7M-59.74M
Capital Expenditures-1.56M-3.79M-3.5M-2.31M-1.61M-1.74M-840K-310K-220K
CapEx % of Revenue2.18%6.37%6.08%3.37%4.31%3.27%0.83%0.22%0.29%
Acquisitions121.27M-5.93M016.41M-24.1M0000
Investments---------
Other Investing-121.27M5.93M0-16.41M24.1M0000
Cash from Financing23.8M139.62M1.63M16.89M110.21M648K30.23M7.52M110.45M
Debt Issued (Net)000000000
Equity Issued (Net)1000K1000K01000K1000K648K1000K1000K1000K
Dividends Paid00000000-3M
Share Repurchases000000000
Other Financing3.84M5.03M1.63M5.61M2.5M00613K3M
Net Change in Cash
72.9M▲ 0%
70.03M▼ 3.9%
-59.15M▼ 184.5%
3.43M▲ 105.8%
13.67M▲ 298.1%
-11.88M▼ 186.9%
-176.48M▼ 1385.5%
20.99M▲ 111.9%
-24.89M▼ 218.6%
Free Cash Flow
168.81M▲ 0%
-79.31M▼ 147.0%
-143.98M▼ 81.5%
2.95M▲ 102.0%
-120.64M▼ 4189.5%
-112.53M▲ 6.7%
-56.88M▲ 49.5%
-86.54M▼ 52.2%
-75.81M▲ 12.4%
FCF Margin %235.7%-133.29%-250.44%4.31%-323.33%-211.67%-56.19%-62.66%-99.48%
FCF Growth %4111.74%-146.98%-81.54%102.05%-4189.49%6.72%49.46%-52.16%12.4%
FCF per Share4.54-1.90-3.180.06-1.88-1.71-0.77-1.02-0.55
FCF Conversion (FCF/Net Income)-3.95x0.89x1.37x-0.08x1.03x1.12x98.48x-2.71x4.35x
Interest Paid000000000
Taxes Paid0013.06M000000

CTMX Key Ratios

CytomX Therapeutics, Inc. (CTMX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-57.59%-58.09%-84.28%-112.35%-299.13%-----35.25%
Return on Invested Capital (ROIC)-223%---------47.75%
Gross Margin100%100%100%100%100%100%100%100%100%100%
Net Margin-391.54%-60.17%-142.19%-177.84%-94.73%-310.54%-186.82%-0.56%23.08%-22.79%
Debt / Equity---0.54x-----0.04x
Interest Coverage-35.28x---------
FCF Conversion0.03x-3.95x0.89x1.37x-0.08x1.03x1.12x98.48x-2.71x4.35x
Revenue Growth95.06%376.12%-16.92%-3.38%19.03%-45.47%42.48%90.38%36.45%-44.82%

CTMX SEC Filings & Documents

CytomX Therapeutics, Inc. (CTMX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Mar 19, 2026·SEC

Material company update

Mar 16, 2026·SEC

Material company update

Nov 6, 2025·SEC

10-K Annual Reports

4
FY 2026

Mar 16, 2026·SEC

FY 2025

Mar 6, 2025·SEC

FY 2024

Mar 11, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

FY 2025

May 12, 2025·SEC

CTMX Frequently Asked Questions

CytomX Therapeutics, Inc. (CTMX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

CytomX Therapeutics, Inc. (CTMX) reported $76.2M in revenue for fiscal year 2025. This represents a 8481% increase from $0.9M in 2013.

CytomX Therapeutics, Inc. (CTMX) saw revenue decline by 44.8% over the past year.

CytomX Therapeutics, Inc. (CTMX) reported a net loss of $17.4M for fiscal year 2025.

Dividend & Returns

Yes, CytomX Therapeutics, Inc. (CTMX) pays a dividend with a yield of 0.53%. This makes it attractive for income-focused investors.

CytomX Therapeutics, Inc. (CTMX) has a return on equity (ROE) of -35.2%. Negative ROE indicates the company is unprofitable.

CytomX Therapeutics, Inc. (CTMX) had negative free cash flow of $75.8M in fiscal year 2025, likely due to heavy capital investments.

Explore More CTMX

CytomX Therapeutics, Inc. (CTMX) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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