Comprehensive Stock Comparison
Compare Nautilus Biotechnology, Inc. (NAUT) vs BiomX Inc. (PHGE) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety |  PHGE | Beta 0.93 vs NAUT's 1.71 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) |  NAUT | +118.3% vs PHGE's -48.8% |
| Efficiency (ROA) | NAUT | -31.3% ROA vs PHGE's -142.8% |
Who Each Stock Is For
Income & stability
PHGEbeta 0.93
Growth exposure
PHGEEPS growth 71.2%
Long-term compounding (10Y)
NAUT-74.9% 10Y total return vs PHGE's -99.7%
Sleep-well-at-night portfolio
NAUTLower volatility, beta 1.71, Low D/E 19.1%, current ratio 13.33x
Defensive / Recession hedge
PHGEBeta 0.93, current ratio 2.48x
Business Model
What each company does and how it makes money
Nautilus Biotechnology is a life sciences company developing a proteomics platform to analyze proteins at unprecedented scale and depth. It aims to generate revenue through sales of its integrated platform — including instruments, consumables, and software — though it remains pre-revenue as it develops its technology. The company's potential moat lies in its proprietary single-molecule protein analysis technology, which could enable comprehensive proteome mapping that existing methods cannot achieve.
BiomX is a clinical-stage biotechnology company developing targeted phage therapies — viruses that kill specific harmful bacteria — for chronic diseases and skin conditions. It generates no commercial revenue yet but is funded through equity offerings and partnerships to advance its pipeline, which includes therapies for cystic fibrosis, inflammatory bowel diseases, and atopic dermatitis. The company's key advantage is its proprietary platform for discovering and engineering natural phages that precisely target disease-causing bacteria while sparing beneficial microbes.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
NAUT 3PHGE 0NAUT1/1 metricsNAUT2/2 metricsNAUT5/6 metricsNAUT leads in 3 of 6 categories — strongest in Financial Metrics and Valuation Metrics. 2 categories are tied.
Financial Metrics (TTM)
NAUT and PHGE operate at a comparable scale, with $0 and $0 in trailing revenue.
| Metric | NAUTNautilus Biotechn… | PHGEBiomX Inc. |
|---|---|---|
| RevenueTrailing 12 months | $0 | $0 |
| EBITDAEarnings before interest/tax | -$60M | -$6M |
| Net IncomeAfter-tax profit | -$63M | -$37M |
| Free Cash FlowCash after capex | -$54M | -$28M |
| Gross MarginGross profit ÷ Revenue | — | — |
| Operating MarginEBIT ÷ Revenue | — | — |
| Net MarginNet income ÷ Revenue | — | — |
| FCF MarginFCF ÷ Revenue | — | — |
| Rev. Growth (YoY)Latest quarter vs prior year | — | — |
| EPS Growth (YoY)Latest quarter vs prior year | +15.4% | -6.5% |
Valuation Metrics
| Metric | NAUTNautilus Biotechn… | PHGEBiomX Inc. |
|---|---|---|
| Market CapShares × price | $331M | $82.8B |
| Enterprise ValueMkt cap + debt − cash | $349M | $82.8B |
| Trailing P/EPrice ÷ TTM EPS | -5.57x | -4.29x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | — |
| Price / BookPrice ÷ Book value/share | 2.11x | 3427.64x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
NAUT delivers a -37.1% return on equity — every $100 of shareholder capital generates $-37 in annual profit, vs $-4 for PHGE. NAUT carries lower financial leverage with a 0.19x debt-to-equity ratio, signaling a more conservative balance sheet compared to PHGE's 0.40x. On the Piotroski fundamental quality scale (0–9), PHGE scores 3/9 vs NAUT's 1/9, reflecting mixed financial health.
| Metric | NAUTNautilus Biotechn… | PHGEBiomX Inc. |
|---|---|---|
| ROE (TTM)Return on equity | -37.1% | -3.6% |
| ROA (TTM)Return on assets | -31.3% | -142.8% |
| ROICReturn on invested capital | — | -3.1% |
| ROCEReturn on capital employed | — | -159.9% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 3 |
| Debt / EquityFinancial leverage | 0.19x | 0.40x |
| Net DebtTotal debt minus cash | $18M | -$8M |
| Cash & Equiv.Liquid assets | $12M | $18M |
| Total DebtShort + long-term debt | $30M | $10M |
| Interest CoverageEBIT ÷ Interest expense | — | -36.86x |
Total Returns (with DRIP)
A $10,000 investment in NAUT five years ago would be worth $1,808 today (with dividends reinvested), compared to $47 for PHGE. Over the past 12 months, NAUT leads with a +118.3% total return vs PHGE's -48.8%. The 3-year compound annual growth rate (CAGR) favors NAUT at 6.8% vs PHGE's -59.1% — a key indicator of consistent wealth creation.
| Metric | NAUTNautilus Biotechn… | PHGEBiomX Inc. |
|---|---|---|
| YTD ReturnYear-to-date | +37.2% | +194.4% |
| 1-Year ReturnPast 12 months | +118.3% | -48.8% |
| 3-Year ReturnCumulative with dividends | +21.9% | -93.2% |
| 5-Year ReturnCumulative with dividends | -81.9% | -99.5% |
| 10-Year ReturnCumulative with dividends | -74.9% | -99.7% |
| CAGR (3Y)Annualised 3-year return | +6.8% | -59.1% |
Risk & Volatility
PHGE is the less volatile stock with a 0.93 beta — it tends to amplify market swings less than NAUT's 1.71 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. NAUT currently trades 85.1% from its 52-week high vs PHGE's 42.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | NAUTNautilus Biotechn… | PHGEBiomX Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.71x | 0.93x |
| 52-Week HighHighest price in past year | $3.08 | $14.71 |
| 52-Week LowLowest price in past year | $0.62 | $1.56 |
| % of 52W HighCurrent price vs 52-week peak | +85.1% | +42.8% |
| RSI (14)Momentum oscillator 0–100 | 51.4 | 51.0 |
| Avg Volume (50D)Average daily shares traded | 197K | 1.3M |
Analyst Outlook
| Metric | NAUTNautilus Biotechn… | PHGEBiomX Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | — |
| Price TargetConsensus 12-month target | $2.50 | — |
| # AnalystsCovering analysts | 5 | — |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Aug 20 | Mar 26 | Change |
|---|---|---|---|
| Nautilus Biotechnol… (NAUT) | 100 | 22.22 | -77.8% |
| BiomX Inc. (PHGE) | 100 | 0.38 | -99.6% |
Nautilus Biotechnol… (NAUT) returned -82% over 5 years vs BiomX Inc. (PHGE)'s -100%.
Chart 2Revenue Growth — 10 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Nautilus Biotechnol… (NAUT) | $0.00 | $0.00 | — |
| BiomX Inc. (PHGE) | $0.00 | $0.00 | — |
Chart 3EPS Growth — 10 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Nautilus Biotechnol… (NAUT) | 87.18 | -0.47 | -100.5% |
| BiomX Inc. (PHGE) | -3.27 | -1.47 | +55.0% |
Chart 4Free Cash Flow — 5 Years
Nautilus Biotechnology, Inc. generated $-52M FCF in 2025 (-25% vs 2021). BiomX Inc. generated $-37M FCF in 2024 (-18% vs 2021).
NAUT vs PHGE: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is NAUT or PHGE a better buy right now?
Analysts rate Nautilus Biotechnology, Inc. (NAUT) a "Buy" — based on 5 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — NAUT or PHGE?
Over the past 5 years, Nautilus Biotechnology, Inc. (NAUT) delivered a total return of -81.9%, compared to -99.5% for BiomX Inc. (PHGE). A $10,000 investment in NAUT five years ago would be worth approximately $2K today (assuming dividends reinvested). Over 10 years, the gap is even starker: NAUT returned -74.9% versus PHGE's -99.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — NAUT or PHGE?
By beta (market sensitivity over 5 years), BiomX Inc. (PHGE) is the lower-risk stock at 0.93β versus Nautilus Biotechnology, Inc.'s 1.71β — meaning NAUT is approximately 85% more volatile than PHGE relative to the S&P 500. On balance sheet safety, Nautilus Biotechnology, Inc. (NAUT) carries a lower debt/equity ratio of 19% versus 40% for BiomX Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — NAUT or PHGE?
Nautilus Biotechnology, Inc. (NAUT) is the more profitable company, earning 0.0% net margin versus 0.0% for BiomX Inc. — meaning it keeps 0.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: NAUT leads at 0.0% versus 0.0% for PHGE. At the gross margin level — before operating expenses — NAUT leads at 0.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — NAUT or PHGE?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is NAUT or PHGE better for a retirement portfolio?
For long-horizon retirement investors, BiomX Inc. (PHGE) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.93)). Nautilus Biotechnology, Inc. (NAUT) carries a higher beta of 1.71 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (PHGE: -99.7%, NAUT: -74.9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between NAUT and PHGE?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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